Medicine and Health Sciences Commons^™

Salud Mesoamérica 2015 Initiative: Design, Implementation, And Baseline Findings, Ali H. Mokdad, Katherine Elliott Colson, Paola Zuniga-Brenes, Diego Rios-Zertuche, Erin B. Palmisano, Catherine W. Gillespie, +27 Additional Authors

Pediatrics Faculty Publications

Background

Health has improved markedly in Mesoamerica, the region consisting of southern Mexico and Central America, over the past decade. Despite this progress, there remain substantial inequalities in health outcomes, access, and quality of medical care between and within countries. Poor, indigenous, and rural populations have considerably worse health indicators than national or regional averages. In an effort to address these health inequalities, the Salud Mesoamérica 2015 Initiative (SM2015), a results-based financing initiative, was established.

Methods

For each of the eight participating countries, health targets were set to measure the progress of improvements in maternal and child health produced by …

The Significance Of Macrophage Polarization Subtypes For Animal Models Of Tissue Fibrosis And Human Fibrotic Diseases., Peter J. Wermuth, Sergio A. Jimenez

Jefferson Institute of Molecular Medicine Papers and Presentations

The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality. The molecular pathways involved in their pathogenesis are complex and despite intensive investigations have not been fully elucidated. Whereas chronic inflammatory cell infiltration is universally present in fibrotic lesions, the central role of monocytes and macrophages as regulators of inflammation and fibrosis has only recently become apparent. However, the precise mechanisms involved in the contribution of monocytes/macrophages to the initiation, establishment, or progression of the fibrotic process remain largely unknown. Several monocyte and …

Prostate Cancer And Li-Fraumeni Syndrome: Implications For Screening And Therapy., Colleen K Spees, Kelly J Kelleher, Ronney Abaza, Steven K Clinton

Oncology Articles

Li-Fraumeni Syndrome (LFS) is an autosomal dominant genetic disorder associated with mutations in the TP53 gene and characterized by a propensity to develop a variety of malignancies resulting in a shortened lifespan. We report a case of prostate cancer in a 50 year old male with LFS. Experimental studies suggest that TP53 mutations in prostate cancer are associated with therapeutic resistance to radiation, chemotherapy, and anti-androgens, implying that LFS men may experience more aggressive cancer biology with implications for therapeutic decisions. The potential of prostate cancer to develop earlier in LFS favors institution of screening at earlier ages.

Attention Deficit Hyperactivity Disorder: Comparison Of Medication Efficacy And Cost, Karlen E. Luthy, Robert M. David, Janelle L B Macintosh, Lacey M. Eden, Renea L. Beckstrand

Faculty Publications

Although a common psychological disorder, pharmacological treatment of Attention Deficit Hyperactivity Disorder can be a costly endeavor. Among 4-5 year olds, methylphenidate is a safe, efficacious, and cost-effective option for short-, intermediate-, and long-acting medication options. Short-acting methylphenidate, intermediate-acting methylphenidate ER and SR, and long-acting methylphenidate LA are the most efficacious and cost-effective medications. Selection of non-stimulant medications should be based upon recommended guidelines rather than primarily on cost. For children incapable of swallowing pills, the most efficacious and cost-effective treatments are short-acting dextroamphetamine liquid and long-acting methylphenidate LA capsules that can be opened and sprinkled over food.

Becoming A Competent Doctor: Ongoing Responsibilities, Stephen Simmer

Clinical Research in Practice: The Journal of Team Hippocrates

The author reflects on the experience surrounding his critical appraisal of DeVore GR, Owens O, Kase N. Use of intravenous Premarin in the treatment of dysfunctional uterine bleeding--a double-blind randomized control study. Obstet Gynecol. 1982 Mar;59(3):285-91.

Comparing The Experiences And Withdrawal Considerations Of Treatment And Regular Foster Care Parents: The Canadian Perspective, Jessica Smith, Susan Rodger, Jason Brown, Laurel E. Pickel, Wendy Den Dunnen, Alan W. Leschied Dr.

Journal Articles

This study investigated differences in the experiences of Canadian foster parents providing regular and treatment foster care and their consideration to withdraw from their position. Survey responses from 852 foster parents were analyzed subsequent to separating the participants into two groups based on the primary type of care they provided (regular N = 454; treatment N = 398). Results revealed that treatment foster care parents considered withdrawing at a higher rate compared to regular foster care parents. Subsequent analysis revealed numerous differences between the two groups regarding foster parents’ experiences in fostering and reasons to withdraw. The results are discussed …

Évaluation De L’Exposition Des Travailleurs Aux Sous-Produits De Désinfection En Piscine Intérieure Au Québec, Robert Tardif, Cyril Catto, Sami Haddad, Manuel Rodriguez

Rapports de recherche scientifique

Les sous-produits de désinfection (SPD) par chloration sont le résultat inévitable des réactions chimiques survenant entre le chlore ajouté à l’eau des piscines et les matières organiques et/ou azotées qui y sont naturellement présentes ou introduites par le biais des baigneurs.

Les SPD se déclinent en de nombreuses catégories et en bien plus de composés encore (>600), ce qui suscite, à l’échelle internationale, les préoccupations des législateurs et des scientifiques au regard de l’impact sanitaire de ces substances sur les travailleurs. Les problèmes d’irritation associés à l’exposition aux chloramines (CAM) qui polluent l’air ambiant sont les plus souvent pointés …

Impact De Quatre Filières De Traitement De L’Eau En Piscine Sur Les Concentrations Des Sous-Produits De Désinfection : Une Étude Exploratoire, Robert Tardif, Cyril Catto, Manuel Rodriguez

Rapports de recherche scientifique

Dans les piscines, l’exposition des populations au sous-produits de désinfection (SPD) est l’objet d’une préoccupation croissante à l’échelle internationale. Les SPD sont le résultat inévitable des réactions chimiques entre les agents désinfectants ajoutés à l’eau des piscines et les matières organiques ou azotées qui y sont naturellement présentes ou introduites par le biais des baigneurs. La production et les niveaux de SPD dans l’eau du bassin et, pour ceux susceptibles de se volatiliser, dans l’air ambiant varient en fonction des approches de traitement. Cependant, il n’existe actuellement pas de données permettant une comparaison systématique de ces approches dans des conditions …

Maternal Characteristics And Clinical Diagnoses Influence Obstetrical Outcomes In Indonesia, Asri Adisasmita, Carl V. Smith, Ayman A.E. El-Mohandes, Poppy Elvira Deviany, Judith J. Ryon, Michele Kiely, Quail Rogers-Bloch, Reginald F. Gipson

Publications and Research

This Indonesian study evaluates associations between near-miss status/death with maternal demographic, health care characteristics, and obstetrical complications, comparing results using retrospective and prospective data. The main outcome measures were obstetric conditions and socio-economic factors to predict near-miss/death. We abstracted all obstetric admissions (1,358 retrospective and 1,240 prospective) from two district hospitals in East Java, Indonesia between 4/1/2009 and 5/15/2010. Prospective data added socio-economic status, access to care and referral patterns. Reduced logistic models were constructed, and multivariate analyses used to assess association of risk variables to outcome. Using multivariate analysis, variables associated with risk of near-miss/death include postpartum hemorrhage (retrospective …

Health Related Quality Of Life In Persons With Type 2 Diabetes In A Rural Community Served By A Critical Access Hospital, Betsy J. Becker, Terry F. Nelson, Robin High, Pat Hauer

Posters and Presentations: Physical Therapy

Purpose

Type 2 diabetes poses significant health concerns and severe complications can result. The prevalence of type 2 diabetes is greater in rural than urban areas with rural populations exhibiting higher blood glucose (A1C). The purpose of this study was to determine whether health related quality of life (QOL) varies by gender and diabetes control (A1C) in rural persons with type 2 diabetes.

Subjects

We surveyed 615 persons with type 2 diabetes who receive care at a critical access hospital that serves a seven county rural area in a Midwestern state.

Methods

This study was a cross-sectional mail survey including …

Delivering A “Dose Of Hope”: A Faith-Based Program To Increase Older African Americans’ Participation In Clinical Trials, Paula M. Frew, Saad B. Omer, Kimberly Parker, Marcus Bolton, Jay Schamel, Eve Shapiro, Lauren Owens, Diane Saint-Victor, Sahithi Boggavarapu, Nikia Braxton, Matthew Archibald, Ameeta S. Kalokhe, Takeia Horton, Christin M. Root, Vincent L. Fenimore, Aaron M. Anderson

Environmental & Global Health Faculty Research

Background: Underrepresentation of older-age racial and ethnic minorities in clinical research is a significant barrier to health in the United States, as it impedes medical research advancement of effective preventive and therapeutic strategies. Objective: The objective of the study was to develop and test the feasibility of a community-developed faith-based intervention and evaluate its potential to increase the number of older African Americans in clinical research. Methods: Using a cluster-randomized design, we worked with six matched churches to enroll at least 210 persons. We provided those in the intervention group churches with three educational sessions on the role of clinical …

Parkinson’S Disease-Related Circulating Microrna Biomarkers - A Validation Study, David Petillo, Stephen Orey, Aik Choon Tan, Lars Forsgren, Sok Kean Khoo

Peer Reviewed Articles

Parkinson’s disease (PD) is the second most common neurodegenerative disease. One of the major challenges in studying this progressive neurological disorder is to identify and develop biomarkers for early detection. Recently, several blood-based microRNA (miRNA) biomarkers for PD have been reported. However, follow-up studies with new, independent cohorts have been rare. Previously, we identified a panel of four circulating miRNA biomarkers for PD (miR-1826, miR-450b-3p, miR-505, and miR-626) with biomarker performance of 91% sensitivity and 100% specificity. However, the expression of miR-450b-3p could not be detected in a new, independent validation set. In our current study, we improved the detection …

Biofluid-Based Microrna Biomarkers For Parkinson’S Disease: An Overview And Update, Sapana Shinde, Sayantoni Mukhopadhyay, Ghada Mohsen, Sok Kean Khoo

Peer Reviewed Articles

Parkinson’s disease (PD) is a highly debilitating motor disorder and is the second most common neurodegenerative disease after Alzheimer’s disease. Its current method of diagnosis mainly relies on subjective clinical rating scales in the presence of clinical motor features. Early detection of PD is a known challenge as neuronal cell death may range from 50% to 80% when a patient is first diagnosed with PD. Therefore, there is an urgent need to identify and develop biomarkers for early detection of this progressive disease. This mini review focuses on the recent developments of biofluid-based microRNAs (miRNAs) as molecular biomarkers for PD. …

The Role Of Il-27 In Susceptibility To Post-Influenza Staphylococcus Aureus Pneumonia, Keven M. Robinson, Benjamin Lee, Erich V Scheller, Sivanarayana Mandalapu, Richard I. Enelow

Dartmouth Scholarship

Influenza is a common respiratory virus and Staphylococcus aureus frequently causes secondary pneumonia during influenza infection, leading to increased morbidity and mortality. Influenza has been found to attenuate subsequent Type 17 immunity, enhancing susceptibility to secondary bacterial infections. IL-27 is known to inhibit Type 17 immunity, suggesting a potential critical role for IL-27 in viral and bacterial co-infection.

Tsc2/Mtorc1 Signaling Controls Paneth And Goblet Cell Differentiation In The Intestinal Epithelium, Y. Zhou, Piotr G. Rychahou, Q. Wang, Heidi L. Weiss, B. Mark Evers

Markey Cancer Center Faculty Publications

The intestinal mucosa undergoes a continual process of proliferation, differentiation and apoptosis, which is regulated by multiple signaling pathways. Notch signaling is critical for the control of intestinal stem cell maintenance and differentiation. However, the precise mechanisms involved in the regulation of differentiation are not fully understood. Previously, we have shown that tuberous sclerosis 2 (TSC2) positively regulates the expression of the goblet cell differentiation marker, MUC2, in intestinal cells. Using transgenic mice constitutively expressing a dominant negative TSC2 allele, we observed that TSC2 inactivation increased mTORC1 and Notch activities, and altered differentiation throughout the intestinal epithelium, with a marked …

Differ In Socio-Cognitive Processes? Some Comparisons Between Paper And Video Triggered Pbl, Jingyan Lu, Lap Ki Chan

Interdisciplinary Journal of Problem-Based Learning

This paper investigates whether paper and video triggers stimulate different social and cognitive processes during PBL. The study focused on how medical students identified and described problems, and how they built shared cognitions that lead them to diagnose and solve problems. The results showed that students who used video triggers put more effort into communicating their understanding of the problem and relevant knowledge than students who used paper triggers. The findings contribute to discussions on how to evaluate the effectiveness of different PBL triggers in order to better integrate them into the curriculum.

February 4, 2015, Communication Disorders & Sciences

Faculty Meeting Minutes & Agendas

Meeting agenda of the February 4, 2015 Faculty Meeting.

Professor Named Editor Of Primary Journal For Career And Technical Education Research, College Of Education And Human Development

Family and Consumer Sciences News

Dr. Rick Zinser was recently named as the Associate Editor for the journal Career and Technical Education Research, the primary journal for research in the CTE profession.

New Cwic-Ph Posters In Jefferson Digital Commons, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

Twenty four new College within the College posters have been added to the Jefferson Digital Commons.

College within the College (CwiC) is a four year academic area of concentration designed to enrich the Jefferson Medical College curriculum for those students who seek additional training in Population Health. This program aims to step beyond the individual-level focus of mainstream medicine by addressing a broad range of factors that impact health, such as environment, literacy, ethnicity, social structure, resource distribution, health systems and health education/promotion.

This collection consists of posters and presentations developed by Jefferson CwiC-PH medical students in their exploration …

Does Music Directly Affect A Person’S Heart Rate?, David Sills, Amber Todd

Medical Education Faculty Publications

Music can have a profound effect on a person’s body, in that it may cause people to dance and move around, but does it have a direct and significant effect on a person’s heart rate if they are still? In this study, 24 high school students’ heart rates were recorded while listening to 6 selections of 6 different genres of music. The effect of different types of music was tested using heart rate monitors, data collection software, and music from free music archives. We found that music has a significant impact on heart rate. Average heart rates were significantly higher …

Macroscopic Optical Imaging Technique For Wide-Field Estimation Of Fluorescence Depth In Optically Turbid Media For Application In Brain Tumor Surgical Guidance, Kolbein K. Kolste, Stephen C. Kanick, Pablo A. Valdés, Michael Jermyn, Brian C. Wilson, David W. Roberts, Keith D. Paulsen, Frederic Leblond

Dartmouth Scholarship

A diffuse imaging method is presented that enables wide-field estimation of the depth of fluorescent molecular markers in turbid media by quantifying the deformation of the detected fluorescence spectra due to the wavelength-dependent light attenuation by overlying tissue. This is achieved by measuring the ratio of the fluorescence at two wavelengths in combination with normalization techniques based on diffuse reflectance measurements to evaluate tissue attenuation variations for different depths. It is demonstrated that fluorescence topography can be achieved up to a 5 mm depth using a near-infrared dye with millimeter depth accuracy in turbid media having optical properties representative of …

School Of Nursing News, Georgia Southern University

Nursing: News & Publications (2013-2023)

• Visiting Faculty Lecture: Dr. Kit Chesla, The Thrill of Discovery: Qualitative Research Approaches

Appendix: Expand Wikipedia Stub On Supplier - Induced Demand, Robert D. Lieberthal, Phd, Juan Leon, Phd

College of Population Health Faculty Papers

Appendix for article that has been accepted for Journal of Economic Education.

Abstract for article:

The authors describe a Wikipedia-based project designed for a graduate course introducing health economics to experienced healthcare professionals. The project allows such students to successfully write articles on niche topics in rapidly evolving health economics subspecialties. These students are given the opportunity to publish their completed projects in Wikipedia. Despite the lack of conventional classroom incentives, the authors have found that the students generally choose to enter their final projects intoWikipedia. The authors explore the motivators for this behavior from the perspective of human capital …

Protein Composition And Movements Of Membrane Swellings Associated With Primary Cilia, Ashraf M. Mohieldin, Hanan S. Haymour, Shao T. Lo, Wissam A. Aboualaiwi, Kimberly F. Atkinson, Christopher J. Ward, Min Gao, Oliver Wessely, Surya M. Nauli

Pharmacy Faculty Articles and Research

Dysfunction of many ciliary proteins has been linked to a list of diseases, from cystic kidney to obesity and from hypertension to mental retardation. We previously proposed that primary cilia are unique communication organelles that function as microsensory compartments that house mechanosensory molecules. Here we report that primary cilia exhibit membrane swellings, which based on their unique ultrastructure and motility, could be mechanically regulated by fluid-shear stress. Together with the ultrastructure analysis of the bulb, which contains monosialodihexosylganglioside (GM3), our results show that ciliary membrane swelling has a distinctive set of functional proteins, including GM3 synthase (GM3S), bicaudal-c1 (Bicc1) and …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Influence of Race on End-of-Life Choices

Effectiveness Of Surgery For Lumbar Stenosis And Degenerative Spondylolisthesis In The Octogenarian Population: Analysis Of The Spine Patient Outcomes Research Trial (Sport) Data., Jeffrey A Rihn, Alan S Hilibrand, Wenyan Zhao, Jon D Lurie, Alexander Vaccaro, Md, Phd, Todd Albert, James Weinstein

Rothman Institute Papers

BACKGROUND: The purpose of this study was to determine whether surgery is an effective option for the treatment of stenosis of the lumbar spine and degenerative spondylolisthesis in the octogenarian population.

METHODS: An as-treated analysis of patients with lumbar stenosis and degenerative spondylolisthesis enrolled in the Spine Patient Outcomes Research Trial (SPORT) was performed. Patients who were at least eighty years of age (n = 105) were compared with those younger than eighty years (n = 1130). Baseline patient and clinical characteristics were noted, and the difference in improvement from baseline between operative and nonoperative treatment was determined for each …

Somatic Experiencing: Using Interoception And Proprioception As Core Elements Of Trauma Therapy, Peter Payne, Peter A. A. Levine, Mardi A. Crane-Godreau

Dartmouth Scholarship

Here we present a theory of human trauma and chronic stress, based on the practice of Somatic Experiencing(®) (SE), a form of trauma therapy that emphasizes guiding the client's attention to interoceptive, kinesthetic, and proprioceptive experience. SE™ claims that this style of inner attention, in addition to the use of kinesthetic and interoceptive imagery, can lead to the resolution of symptoms resulting from chronic and traumatic stress. This is accomplished through the completion of thwarted, biologically based, self-protective and defensive responses, and the discharge and regulation of excess autonomic arousal. We present this theory through a composite case study of …

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Influence of Race on End-of-Life Choices

Access Disparity And Health Inequality Of The Elderly: Unmet Needs And Delayed Healthcare, Tetsuji Yamada, Chia-Ching Chen, Chiyoe Murata, Hiroshi Hirai, Toshiyuki Ojima, Katsunori Kondo, Joseph R. Harris

NYMC Faculty Publications

The purpose of this study is to investigate healthcare access disparity that will cause delayed and unmet healthcare needs for the elderly, and to examine health inequality and healthcare cost burden for the elderly. To produce clear policy applications, this study adapts a modified PRECEDE-PROCEED model for framing theoretical and experimental approaches. Data were collected from a large collection of the Community Tracking Study Household Survey 2003-2004 of the USA. Reliability and construct validity are examined for internal consistency and estimation of disparity and inequality are analyzed by using probit/ols regressions. The results show that predisposing factors (e.g., attitude, beliefs, …

Cerium Oxide Nanoparticle Aggregates Affect Stress Response And Function In Caenorhabditis Elegans, Steven Rogers, Kevin M. Rice, Nandini Manne, Tolou Shokuhfar, Kun He, Vellaisamy Selvaraj, Eric Blough

Pharmaceutical Science and Research

Objective: The continual increase in production and disposal of nanomaterials raises concerns regarding the safety of nanoparticles on the environmental and human health. Recent studies suggest that cerium oxide (CeO2) nanoparticles may possess both harmful and beneficial effects on biological processes. The primary objective of this study is to evaluate how exposure to different concentrations (0.17–17.21 µg/mL) of aggregated CeO2 nanoparticles affects indices of whole animal stress and survivability in Caenorhabditis elegans.

Methods: Caenorhabditis elegans were exposed to different concentrations of CeO2 nanoparticles and evaluated.

Results: Our findings demonstrate that chronic exposure of CeO2 nanoparticle aggregates is …