Medicine and Health Sciences Commons^™

Combined Systemic And Ocular Chemotherapy For Anterior Segment Metastasis Of Systemic Mantle Cell Lymphoma., Aniruddha Agarwal, Mohammad Ali Sadiq, William R. Rhoades, Loren S. Jack, Mostafa Hanout, Philip J. Bierman, William W. West, Quan Dong Nguyen

Journal Articles: Ophthalmology

BACKGROUND: Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin's lymphoma that rarely metastasizes to the iris and the anterior segment. Blastic/pleomorphic morphology is thought to have an adverse effect on prognosis in MCL. MCL is resistant to conventional chemotherapeutic regimens with a tendency for multiple relapses. Management of anterior segment metastasis of systemic MCL has not been described in literature.

FINDINGS: A 58-year-old male presented with an aggressive, relapsing, metastatic, systemic blastic variant of MCL with ocular involvement. At the time of initial presentation, large tumor cells were visible in the anterior chamber (AC) along with hypopyon and …

High Incidence Of Fracture Events In Patients With Long-Gap Esophageal Atresia (Lgea): A Retrospective Review Prompting Implementation Of Standardized Protocol., Sigrid Bairdain, Brenda Dodson, David Zurakowski, Lawrence Rhein, Brian D Snyder, Melissa Putman, Russell W Jennings

Surgery Faculty Publications

PURPOSE: To identify factors associated with an increased risk of fractures in Long-Gap Esophageal Atresia (LGEA) patients. Following implementation of a risk-stratified program, we hypothesized a reduction in fracture incidence within this potentially high-risk population.

METHODS: A retrospective review of LGEA-patients admitted between 2005 and 2014 was conducted. Symptomatic fractures with radiographic confirmation were defined as events. Univariate and multivariable analysis evaluated factors including admission weight-for-age z-score, primary versus secondary Foker process (FP), weight at Foker Stage I, days and episodes of paralysis, number of parenteral nutrition (PN) days, cumulative dose of loop diuretics adjusted for body weight and days …

Practical Pearl: Diagnosis And Management Of The Flu - Dec 2015, Donna Fisher Md

Pediatrics Practical Pearls: Referral Guidelines for Common Problems

No abstract provided.

Nutrition For The Primary Prevention And Treatment Of Cardiovascular Disease: A Needs Assessment Of Medical Providers, Rachael T. Skeldon

Nursing Masters

Background: There is conflicting evidence informing the dietary recommendations for cardiovascular disease (CVD) prevention. In addition, there is a lack of education regarding nutrition for medical providers. In order to effect change among the growing population of Americans at risk for CVD, there needs to be a better understanding of the knowledge and attitudes towards nutrition among providers, as well as development and implementation of an educational module with evidence-based research to guide dietary recommendations.

The primary purpose of this study was to evaluate medical providers’ (including nurses, physicians, nurse practitioners, and physician assistants) knowledge and attitudes towards nutrition for …

Viability Of Developmental Stages Of Schistosoma Mansoni Quantified With Xcelligence Worm Real-Time Motility Assay (Xworm)., Gabriel Rinaldi, Alex Loukas, Paul J. Brindley, Jeff T. Irelan, Michael J. Smout

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Infection with helminth parasites causes morbidity and mortality in billions of people and livestock worldwide. Where anthelmintic drugs are available, drug resistance is a major problem in livestock parasites, and a looming threat to public health. Monitoring the efficacy of these medicines and screening for new drugs has been hindered by the lack of objective, high-throughput approaches. Several cell monitoring technologies have been adapted for parasitic worms, including video-, fluorescence-, metabolism enzyme- and impedance-based tools that minimize the screening bottleneck. Using the xCELLigence impedance-based system we previously developed a motility-viability assay that is applicable for a range of helminth parasites. …

Health Center Trends: Recent Experience In Medicaid Expansion And Non-Expansion States., Peter Shin, Jessica Sharac, Julia Zur, Sara J. Rosenbaum, Julia Paradise

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

In thousands of medically underserved communities across the U.S., community health centers enroll lowincome people in health coverage and provide care to millions of patients. Against the backdrop of significant health center expansion over several years and a full year of expanded health coverage under the Affordable Care Act (ACA), this brief examines change between 2013 and 2014 in the volume and health coverage profile of health center patients, and health center enrollment activities and service capacity, comparing states that implemented the ACA Medicaid expansion in 2014 and states that did not expand Medicaid in 2014. The study is based …

Functional Analysis Of The Unique Cytochrome P450 Of The Liver Fluke Opisthorchis Felineus., Mariya Y. Pakharukova, Valentin A. Vavilin, Banchob Sripa, Thewarach Laha, Paul J. Brindley, Viatcheslav A. Mordvinov

Microbiology, Immunology, and Tropical Medicine Faculty Publications

The basic metabolic cytochrome P450 (CYP) system is essential for biotransformation of sterols and xenobiotics including drugs, for synthesis and degradation of signaling molecules in all living organisms. Most eukaryotes including free-living flatworms have numerous paralogues of the CYP gene encoding heme monooxygenases with specific substrate range. Notably, by contrast, the parasitic flatworms have only one CYP gene. The role of this enzyme in the physiology and biochemistry of helminths is not known. The flukes and tapeworms are the etiologic agents of major neglected tropical diseases of humanity. Three helminth infections (Opisthorchis viverrini, Clonorchis sinensis and Schistosoma haematobium) are considered …

Effect Of Kidney Function On Drug Kinetics And Dosing In Neonates, Infants, And Children., Frederique Rodieux, Melanie Wilbaux, Johannes N. Van Den Anker, Marc Pfister

Pediatrics Faculty Publications

Neonates, infants, and children differ from adults in many aspects, not just in age, weight, and body composition. Growth, maturation and environmental factors affect drug kinetics, response and dosing in pediatric patients. Almost 80 % of drugs have not been studied in children, and dosing of these drugs is derived from adult doses by adjusting for body weight/size. As developmental and maturational changes are complex processes, such simplified methods may result in subtherapeutic effects or adverse events. Kidney function is impaired during the first 2 years of life as a result of normal growth and development. Reduced kidney function during …

Effect Of Kidney Function On Drug Kinetics And Dosing In Neonates, Infants, And Children., Frederique Rodieux, Melanie Wilbaux, Johannes N. Van Den Anker, Marc Pfister

Pediatrics Faculty Publications

Neonates, infants, and children differ from adults in many aspects, not just in age, weight, and body composition. Growth, maturation and environmental factors affect drug kinetics, response and dosing in pediatric patients. Almost 80% of drugs have not been studied in children, and dosing of these drugs is derived from adult doses by adjusting for body weight/size. As developmental and maturational changes are complex processes, such simplified methods may result in subtherapeutic effects or adverse events. Kidney function is impaired during the first 2 years of life as a result of normal growth and development. Reduced kidney function during childhood …

"I Have Chicken Fat In My Urine!" A Case Of Candida Tropicalis Induced Emphysematous Pyelitis, Ahmed Alansari, Manuel D. Borras, Noella Boma

NYMC Faculty Publications

A patient with uncontrolled diabetes mellitus presented with fever and flank pain. A computed tomography scan showed free air within both collecting systems. A diagnosis of emphysematous pyelitis was made after other alternative diagnoses were ruled out. Urine culture grew Candida tropicalis. The emphysematous pyelitis resolved with conservative management using antifungal therapy.

Student-Faculty Summer Undergraduate Research Fellowship Research Synopsis: Complement Resistance In Bartonella Species, Benjamin Mason

Additional DHC Research, Creative Scholarship, Papers, and Presentations

Of the 31 validated species in the genus Bartonella, 11 are agents of serious infectious diseases of humans, among them Carrión’s disease, trench fever, cat-scratch disease, and bacillary angiomatosis. Bartonella are extremely widespread, having been found in virtually every type of mammal surveyed. As facultative intracellular parasites employing hemotrophy (infection of red blood cells), the key to their success comes in their ability to survive within the bloodstream of their host or reservoir. It has been demonstrated that bartonellae are resistant to the effects of complement proteins in serum, the primary agents of the innate immune system. Although this effect …

A Bystander Bullying Psychoeducation Program With Middle School Students: A Preliminary Report, Aida Midgett, Diana Doumas, Dara Sears, Amanda Lundquist, Robin Hausheer

Counselor Education Faculty Publications and Presentations

This study evaluated the effectiveness of a brief, stand-alone bystander bullying psychoeducation program for middle school students. The purpose of the program was to train students to take action as peer advocates. Pre- and post-tests indicated that after completing the 90-minute psychoeducation program, students reported an increase in their ability to identify what different types of bullying look like, knowledge of bystander intervention strategies, and general confidence intervening as peer advocates. Implications for school counselors are discussed, including (1) taking a leadership role in program implementation, (2) having access to a brief, cost-effective bystander training intervention, and (3) applying the …

Predictive Formula For Electron Range Over A Large Span Of Energy, Anne C. Starley

Reports

A model developed by the Materials Research Group that calculates electron penetration range of some common materials, has been greatly expanded with the hope that such extensions will predict the range in other, perhaps, more interesting materials. Developments in this extended model aid in predicting the approximate penetration depth into diverse classes of materials for a broad range of energetic incident electrons (10 MeV, with better than 20% accuracy). The penetration depth—or range—of a material describes the maximum distance electrons can travel through a material, before losing all of its incident kinetic energy. This model has started to predict a …

Levels Of Glycosaminoglycans In The Cerebrospinal Fluid Of Healthy Young Adults, Surrogate-Normal Children, And Hunter Syndrome Patients With And Without Cognitive Impairment., Christian J Hendriksz, Joseph Muenzer, Adeline Vanderver, Jonathan M Davis, Barbara K Burton, Nancy J Mendelsohn, Nan Wang, Luying Pan, Arian Pano, Ann J Barbier

Neurology Faculty Publications

In mucopolysaccharidoses (MPS), glycosaminoglycans (GAG) accumulate in tissues. In MPS II, approximately two-thirds of patients are cognitively impaired. We investigated levels of GAG in cerebrospinal fluid (CSF) in different populations from four clinical studies (including NCT00920647 and NCT01449240). Data indicate that MPS II patients with cognitive impairment have elevated levels of CSF GAG, whereas those with the attenuated phenotype typically have levels falling between those of the cognitively affected patients and healthy controls.

Effects Of Implicit Vs. Explicit Cueing On Dynamic Balance And Injury: A Grant Proposal, Curtis Dodson, Ryan Baugus

Student-Faculty Research - College of Physical Therapy

No abstract provided.

Changes In Familiarity With And Willingness To Take Prep In A Longitudinal Study Of Highly Sexually Active Gay And Bisexual Men, Christian Grov, H. Jonathan Rendina, Thomas H.F. Whitfield, Ana Ventuneac, Jeffrey T. Parsons

Publications and Research

PURPOSE: For gay and bisexual men (GBM), research suggests that familiarity with Pre-Exposure Prophylaxis (PrEP) has been increasing since being approved by the U.S. FDA in 2012. However, it is less clear how willingness to start using PrEP has changed over time. Likewise, some have expressed concerns regarding the potential for risk compensation (i.e., reduced condom use) were one to start PrEP; however, again, it is unclear how these may have been changing over time.

METHODS: We conducted baseline and 12 month assessments with 158 highly sexually active HIV-negative GBM in NYC who were assessed between 2011 and 2014. …

Letter From The Editor, Lisa Appeddu

Administrative Issues Journal

No abstract provided.

Borrelia Burgdorferi Pathogenesis And The Immune Response, Mary Petzke, Ira Schwartz

NYMC Faculty Publications

Borrelia burgdorferi is the tick-borne etiologic agent of Lyme disease. The spirochete must negotiate numerous barriers in order to establish a disseminated infection in a mammalian host. These barriers include migration from the feeding tick midgut to the salivary glands, deposition in skin, manipulation or evasion of the localized host immune response, adhesion to and extravasation through an endothelial barrier, hematogenous dissemination, and establishment of infection in distal tissue sites. Borrelia burgdorferi proteins that mediate many of these processes and the nature of the host response to infection are described.

Sexually Dimorphic Phenotype Of Arteriolar Responsiveness To Shear Stress In Soluble Epoxide Hydrolase-Knockout Mice, Jun Qin, Sharath Kandhi, Ghezal Froogh, Houli Jiang, Meng Luo, Dong Sun, An Huang

NYMC Faculty Publications

We hypothesized that potentiating the bioavailability of endothelial epoxyeicosatrienoic acids (EETs) via deletion of the gene for soluble epoxide hydrolase (sEH), or downregulation of sEH expression, enhances flow/shear stress-induced dilator responses (FID) of arterioles. With the use of male (M) and female (F) wild-type (WT) and sEH-knockout (KO) mice, isolated gracilis muscle arterioles were cannulated and pressurized at 80 mmHg. Basal tone and increases in diameter of arterioles as a function of perfusate flow (5, 10, 15, 20, and 25 μl/min) were recorded. The magnitude of FID was significantly smaller and associated with a greater arteriolar tone in M-WT than …

Interaction Of Alu Polymorphisms And Novel Measures Of Discrimination In Association With Blood Pressure In African Americans Living In Tallahassee, Alexis C. Boulter, Jackyn Quinlan, Aida T. Miró-Herrans, Laurel N. Pearson, Nubiana L. Todd, Clarence C. Gravlee, Connie J. Mulligan

Human Biology Open Access Pre-Prints

African Americans are 40% more likely to be afflicted with hypertension in comparison to non-Hispanic, white Americans, resulting in a 30% higher instance of mortality due to cardiovascular disease. There is debate about the relative contributions of genetic and sociocultural risk factors to the racial disparity in hypertension.

We assayed three Alu insertion polymorphisms located in the angiotensin-1-converting enzyme (ACE), tissue plasminogen activator (PLAT), and with no-lysine kinase 1 (WNK1) genes. We also estimated West African genetic ancestry and developed novel measures of perceived discrimination to create a biocultural model of blood pressure among …

Total Dietary Fiber Content Of Selected Traditional Beverages In Egypt: A Brief Profile, Basil H. Aboul-Enein

Health & Wellness Department Faculty Publications and Research

Escalating obesity rates have become a major public health concern in North Africa and the Middle East. Culturally-congruent dietary health education and strategies continue to be warranted to address this increasing public health crisis. Knowledge and familiarity with traditional foods and their nutritive value would assist public health practitioners in becoming culturally competent when educating on healthy eating patterns. The aim of this study is to provide a brief dietary profile of the total dietary fiber (TDF) contents of selected traditional beverages in Egypt. Five cookbooks for Egyptian food recipes were reviewed for traditional beverages. Beverage recipes (n = …

From Fatalism To Mitigation: A Conceptual Framework For Mitigating Fetal Programming Of Chronic Disease By Maternal Obesity, Janne Boone-Heinonen, Lynne C. Messer, Stephen P. Fortmann, Lawrence Wallack, Kent L. Thornburg

Community Health Faculty Publications and Presentations

Prenatal development is recognized as a critical period in the etiology of obesity and cardiometabolic disease. Potential strategies to reduce maternal obesity-induced risk later in life have been largely overlooked. In this paper, we first propose a conceptual framework for the role of public health and preventive medicine in mitigating the effects of fetal programming. Second, we review a small but growing body of research (through August 2015) that examines interactive effects of maternal obesity and two public health foci – diet and physical activity – in the offspring. Results of the review support the hypothesis that diet and physical …

Progression Magazine, 2015 Winter, Coastal Carolina University

Progression Magazine

Magazine of the College of Science at Coastal Carolina University.

Reflections (2015 Issue), College Of Health Professions

College of Health Professions Newsletters & Magazines

In the annual Reflections magazine, Dean Patricia Walker and the College of Health Sciences present some of the highlights and accomplishments in teaching, service and scholarship from the past year.

The Effects Of Nutrition Pertaining To Fitness And Health, Daniel Swem

University Honors Program

The current research is focused on how nutrition influences both fitness and health. It is important to understand the difference between the two terms. Fitness relates to a person’s ability to perform specific tasks whereas health is a condition of being free of disease or illness. Pertaining to fitness, this study primarily focuses on cardiovascular endurance, muscular strength, and body composition. (The other components of physical fitness are muscular endurance and flexibility). This research will attempt to answer some highly researched questions. How important is the timing of pre-exercise and post-exercise meals? What foods are beneficial for those seeking to …

Outbreak: Emergency Room Overcrowding, Mary Elizabeth Sum

University Honors Program

A phenomenon referred to as emergency room (ER) overcrowding, which is defined as, “the demand for emergency services exceeds the ability of physicians and nurses to provide quality care within a reasonable time” (Sinclair, 2007), is happening around the world today. This problem causes much grief for the patients trying to receive quality care from the affected hospitals, and therefore hospitals are looking for any solution to solve this problem. The research was conducted by a literary review by utilizing the CINAHL and the Nursing and Allied Health Collection database. It was conducted to discover any evidence of ER overcrowding, …

Human Resources’ Role In Avoiding Conflict In The Workplace, Brad Morris

University Honors Program

Psychologists have proven there are many causes of conflict; the vast majority of these causes can find their roots in displaced anger or a buildup of stress that leads to an unhealthy release, such as a display of hostility. Human Resource professionals are expected to find a way to limit, control, and eliminate these situations before they become a problem. Avoiding situations of work place conflict, especially violence is one of the most important duties for a corporation; these issues can be avoided by the Human Resource Department with relative ease by hiring the right people, as to ensure the …

Nursing: The Career That Saves Lives [Career Paper], Maggie Flanagan

Undergraduate Research Award

No abstract provided.

Lead Exposure In Children Through Water And Soil, Sravya Maru

Environmental Management & Risk Assessment (PH 560)

Lead is a metal which has the ability to spread in the earth’s crust and has corrosive property. It is a naturally occurring metal which is soft in nature. Lead exposure in children is through various pathways and the major concentrated sources are the soil and drinking water. Children are most susceptible to lead exposure is due to their growing/developing bodies which are very sensitive to lead. Lead poisoning in children is a preventable environmental disease affecting many children around the world. This paper discusses how soil and water plays a major role in lead exposure to children’s routine life. …

The Development Of A Platform For Expression And Purification Of The Mammalian Transmembrane Transporter Abca4, Amaryllis Ortiz

Graduate School of Biomedical Sciences Theses and Dissertations

Purpose- ABCA4 is an ATP Binding Cassette (ABC) protein localized at cone and rod photoreceptor outer segments of the retina. Though mutations in ABCA4 have been found to cause a broad spectrum of disorders, ABCA4's high molecular weight (~210 kDa) and biochemical transmembrane properties have made ABCA4 functional studies unsuccessful. Identifying how ABCA4 functions might have significant clinical impact and open unanticipated avenues for therapeutic interventions. Thus, the objective of this study was to develop a new expression system able to produce the full-length, correctly folded and fully functional ABCA4 protein.

Methods- the ABCA4 gene was amplified from the PCMV6-ABCA4 …