Medicine and Health Sciences Commons^™

Assorted Grand Rounds From April And May 2015, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

The Jefferson Digital Commons has a varied collection of grand rounds archived from numerous departments including:

• Surgery
• Otolaryngology
• Kimmel Cancer Center
• Family and Community Medicine
• Integrative Medicine

A Study Whether Humans Can Produce Free Fatty Acids For Tasting, Emily Bacher

Student Scholarship

A growing concern throughout the world, especially the United States, is the health of our population. According to the National Health and Nutrition Examination Survey (NHANES) performed in 2009-2010, approximately 35% of both men and women in the United States are obese (Flegal, 2012). In 2005, more than 300,000 deaths in the United States were attributed to obesity. However, the World Health Organization listed obesity as one of ten most preventable health risks (Wilborn, 2005).
Why, then, do we as a society struggle so much with our weight? Some, such as Swinburn, believe this trend of obesity can be attributed …

Fearless Friday: Class Of 2015, Chrisitina L. Bassler

SURGE

We recognize all of the Gettysburg College graduates who will use what they learned and experienced over the past four years to fearlessly promote change, seek justice, and challenge inequality after leaving Gettysburg College. The following list contains the names of members of the class of 2015 who have been recognized by other members of the campus community as leaders for change, and we are proud to claim these fearless and inspirational students as our own. We know, however, that we do not have everyone who deserves to be recognized listed below, so feel free to continue nominating your friends, …

Systematic Review And Mixed Treatment Comparison Of Intravitreal Aflibercept With Other Therapies For Diabetic Macular Edema (Dme)., Jean-Francois Korobelnik, Jos Kleijnen, Shona H. Lang, Richard Birnie, Regina M. Leadley, Kate Misso, Gill Worthy, Dominic Muston, Diana V. Do

Journal Articles: Ophthalmology

BACKGROUND: This was an indirect comparison of the effectiveness of intravitreal aflibercept (IVT-AFL) 2 mg every 8 weeks after 5 initial monthly doses (or if different periods, after an initial monthly dosing period) (2q8) and other diabetic macular edema (DME) therapies at doses licensed outside the USA.

METHODS: A comprehensive search was undertaken to source relevant studies. Feasibility networks were prepared to identify viable comparisons of 12-month outcomes between IVT-AFL 2q8 and therapies licensed outside the USA, which were assessed for clinical and statistical homogeneity. Pooled effect sizes (mean difference [MD] and relative risk/risk ratio [RR]) were calculated using fixed- …

The Endogenous Cell-Fate Factor Dachshund Restrains Prostate Epithelial Cell Migration Via Repression Of Cytokine Secretion Via A Cxcl Signaling Module., Ke Chen, Kongming Wu, Xuanmao Jiao, Liping Wang, Xiaoming Ju, Min Wang, Gabriele Disante, Shaohua Xu, Qiong Wang, Kevin Li, Xin Sun, Chongwen Xu, Zhiping Li, Mathew C. Casimiro, Adam Ertel, Sankar Addya, Peter Mccue, Michael P. Lisanti, Chenguang Wang, Richard J. Davis, Graeme Mardon, Richard Pestell

Department of Cancer Biology Faculty Papers

Prostate cancer is the second leading form of cancer-related death in men. In a subset of prostate cancer patients, increased chemokine signaling IL8 and IL6 correlates with castrate-resistant prostate cancer (CRPC). IL8 and IL6 are produced by prostate epithelial cells and promote prostate cancer cell invasion; however, the mechanisms restraining prostate epithelial cell cytokine secretion are poorly understood. Herein, the cell-fate determinant factor DACH1 inhibited CRPC tumor growth in mice. Using Dach1(fl/fl)/Probasin-Cre bitransgenic mice, we show IL8 and IL6 secretion was altered by approximately 1,000-fold by endogenous Dach1. Endogenous Dach1 is shown to serve as a key endogenous restraint to …

Prospective Study Of Recovery From Copperhead Snake Envenomation: An Observational Study, Eric J. Lavonas, Charles J. Gerardo, Rebecca C. Bowers, Joann Short, Copperhead Snakebite Recovery Outcome Group

Emergency Medicine Faculty Publications

BACKGROUND: Although much is known about signs, symptoms, and management in the acute phase of crotaline snake envenomation, little is known about signs, symptoms, function, and quality of life during the recovery phase. The purpose of this observational pilot investigation is to evaluate the utility of several clinical outcome instruments in the setting of copperhead snakebite, and to characterize the clinical course of recovery.

METHODS: This is a multi-center prospective, open-label, observational study of patients envenomated by copperhead snakes. We administered the Disabilities of the Arm, Shoulder, and Hand (DASH), Lower Extremity Functional Scale (LEFS), Patient-Specific Functional Scale …

Synthesis And Characterization Of A New Peptide Prodrug Of Glucosamine With Enhanced Gut Permeability, Hamed Gilzad Kohan, Kamaljit Kaur, Fakhreddin Jamali

Pharmacy Faculty Articles and Research

The aim of this study was to synthesize a peptide prodrug of glucosamine (GlcN) with increased gut permeability through the gut peptide transporter 1 (PepT1). Glycine-Valine ester derivative of GlcN (GVG) was synthesised using solid phase synthesis followed by characterization and evaluation of its physicochemical and intestinal stability. In addition, GVG was evaluated for its ability to be biotransformed to GlcN in the liver homogenate. In vitro absorption of the new prodrug through everted rat gut was also assessed. GVG demonstrated significant and meaningful increased gut permeability as compared with GlcN. It showed favorable stability in the gut and a …

National Study Of Neonatal Intensive Care Unit Nurse’S Perceptions Of Obstacles And Supportive Behaviors In End-Of-Life Care, Katie Hillary, Renea Beckstrand

Journal of Undergraduate Research

Neonatal end-of-life (EOL) care supports a peaceful and dignified death for the infant as well as provision of loving support to the family (National Association of Neonatal Nurses, 2010). Infant mortality in the U.S. is 6.05 infant deaths per 1,000 births (MacDorman, Hoyert, & Matthews, 2013). Due to this infant mortality rate, Neonatal Intensive Care Unit (NICU) nurses need to understand how to provide EOL care to patients and families. NICU nurses who care for dying infants are faced with unique EOL care obstacles and challenges. EOL nursing care for infants not only includes the patient, but also the family. …

Empathy In Nursing Students: The Impact Of A Poverty Simulation, Kristen Hamblin, Gaye Ray

Journal of Undergraduate Research

Empathy is an essential characteristic in nursing. In fact, the skill of empathy, the ability to understand the feelings or situation of another, is of paramount importance to the nurse-patient relationship. Additionally, empathetic interactions often lead to increased patient satisfaction, compliance, and overall quality of life. Empathetic nurses are more able to identify patient needs and provide high quality care and service.

Today - May 15, 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Commencement ceremonies in May and June will celebrate Loma Linda University class of 2015
-- Dexter Emoto honored by grateful patient with Healing Hands recognition
-- First-ever Family Fitness Fun 5K & Expo may not be the last
-- Physicians leads the way with robotic surgery
-- LLUMC-Murrieta brings robotic surgery to the Murrieta/Temecula Community
-- 25th Annual Proton Charity Golf Tournament reaches $3.5 million total raised
-- Annual Children's Day, presented by Farmer Boys, marks 30 years of health education and interactive fun
-- PossAbilities Triathlon Draws 1,150 participants
-- Debbie Chisholm Memorial Foundation representatives …

A Critical Review Of Postoperative Use Of Metacam In Cats, Naomi S. Leung

Undergraduate University Honors Capstones

Metacam®, or meloxicam, a nonsteroidal anti-inflammatory drug (NSAID) known for its suppression of pain and inflammation, was developed in 1993 and approved first for humans and dogs after clinical trials showed minor adverse effects on their kidney functions. NSAIDs in general work by blocking the actions of two enzymes called cyclo-oxygenase-1 (cox-1), responsible for the production of prostaglandins that produces protective gastrointestinal mucus, and cyclo-oxygenase-2 (cox-2), responsible for the production of prostaglandins (lipid compounds) that initiates inflammation and pain in the body. Metacam® blocks one of these enzymes, cox-2, causing the inflammation to decrease subsequently without disturbing gastrointestinal mucus. In …

Multiple Risk Factors Of Alcoholic And Non-Alcoholic Myocardial Infarction Patients, Harisharan, Awnish Kumar Singh, Nidhu Ram Dangal, Krishna Mohan Surapaneni, Ashish Joshi

Publications and Research

Background: Myocardial infarction (MI) is one of the most critical medical emergency and contributor to morbidity and mortality worldwide. Myocardial infarction is the most common form of coronary heart disease and leading cause of premature death. Past century has seen substantial advancement in the field of medical sciences but still mortality trends due to myocardial infarction is increasing in developing countries including India. We have conducted this study to compare the Sociodemographic characteristics of alcoholic and non alcoholic MI patients admitted in coronary care unit of Saveetha Medical College, Chennai, India.

Methods: An exploratory cross sectional study was performed by …

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Misperception of Child’s Body Weight
• U.S. Undergraduate Education in Public Health

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Misperception of Child's Body Weight
• U.S. Undergraduate Education in Public Health
• Fruit and Vegetable Consumption from the Perspective of Preschoolers

Treatment Plan Adherence To Guidelines In Senior Adult Oncology Patients, Amy R. Mackenzie, Md, Andrea M. Barsevick, Phd, Ronald Myers, Phd, Ludmila De Oliveira Koch, Md, Scott W. Keith, Phd, Thomas Wolf, Ma, James Cocroft, Ma, Joshua Schoppe, Mph, Ulysses Williams Iii, Andrew Chapman, Do

Department of Medical Oncology Faculty Papers

Materials & Methods:

• Review of 287 records
• Patients ≥ 65 years old with new diagnosis of cancer
• Seen by 6, dual-boarded hematologists/ oncologists practicing in an urban academic cancer center
• Treatment plans compared to national guidelines to determine plan adherence status
• Patients were recommended:

Adherent plan (AP) or Non-adherent plan (N-AP)

The Two-Hour Marathon: What's The Equivalent For Women?, Sandra K. Hunter, Michael J. Joyner, Andrew M. Jones

Exercise Science Faculty Research and Publications

The principal characteristic of the runner who may break the two-hour barrier in the marathon will be their sex: the person will be male. The fastest men outperform the fastest women because of sex differences in physiology including a higher VȮ2 max. This viewpoint addresses the questions of what is the two-hour equivalent for women, and who will break this barrier? The current sex difference in the world record for the marathon is ~10% which is slightly less than the mean sex difference in performance usually documented between elite men and women distance runners. Based on comparisons of the top …

Research Brief: "Suicidality Among Military-Connected Adolescents In California Schools", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This study examines the prevalence of suicidal ideations among military-connected youth in California, and found that twenty-four percent of military-connected youth reported seriously considering suicide. Given these findings, school personnel and mental health providers should teach coping techniques for anxiety, depression, and stress; they would also benefit from implementing a policy that forbids service members from bringing firearms home during extended leaves and weekends. Future studies should sample military children of all grade levels, including college/university.

Community Health News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Misperception of Child’s Body Weight
• Fruit and Vegetable Consumption from the Perspective of Preschoolers

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• U.S. Undergraduate Education in Public Health

Characterization Of The Older Adult Refugee Population At Thomas Jefferson University’S Center For Refugee Health (Crh), Kathryn Beldowski, Md, Neesha Patel, Md, Brooke Salzman, Md

Department of Family & Community Medicine Presentations and Grand Rounds

Background

• Established in 2007, the CRH has served over 1,000 refugees of all ages as they resettle in Philadelphia, PA.
• Research about refugee populations generally focuses on infectious disease, women’s health, pediatrics and mental health, with minimal research on the older adult refugee population.
• The objective of this study was to describe the characteristics of the older refugee population served by the CRH, focusing on chronic disease, smoking status, immunization and cancer screening rates, and presence of geriatric syndromes.

Syncing Umbanda And Science (Sus): Using Umbanda’S Holistic Healing Methods To Increase Access To Healthcare, Alex E. Rosenthal

Undergraduate Theses—Unrestricted

In 1988, after the 1985 termination of the military dictatorship in Brazil, the constitution was rewritten to guarantee individual rights to all citizens of Brazil. Among the various other rights that the new constitution protected, anyone in Brazil was granted the right to government-funded healthcare under the regulation of the Unified Healthcare System, SUS. Because of structural inequalities in Brazil as well as the rise of privatized healthcare, equal access to healthcare is not a reality in modern-day Brazil. Many citizens who live in the periphery are limited to understaffed and underfunded primary health centers.

This monograph explores the healing …

Functional Analysis Of Gambling, Mack S. Costello

Dissertations

Given high rates of gambling and the growing population of disordered gamblers, there is a need to develop assessment strategies with improved treatment validity. More specifically, assessment strategies are needed that identify the controlling variables for disordered gambling and, thus, provide guidance in the selection of treatment and prevention strategies. This study sought to develop a functional analysis for gambling by utilizing a simulated gambling environment in which contextual variables hypothesized to be causally linked to disordered gambling could be systematically manipulated. Seven experienced gamblers participated in the multi-element, single-subject experimental study. Participants who endorsed at least some problems from …

Refugee Health And The Kentucky Global Health Center, Rahel Bosson, Ruth M. Carrico

Journal of Refugee & Global Health

In this University of Louisville Grand Rounds lecture, Drs. Rahel Bosson and Ruth Carrico give an overview of the real struggle of the refugee population and provide an update of the current state of refugee health in Kentucky.

They also provide an overview of the Global Health Initiative at University of Louisville, which includes the follow programs: HIV/AIDs, Refugee Health and Immunization, Vaccine and International Travel and Global Health Research Support.

The talk concludes looking to the future with a comprehensive Global Health Center composed of improving refugee orientation and EMR, healthcare worker education, developing guidelines, and bettering our surveillance …

Draft Genome Sequences Of Six Different Staphylococcus Epidermidis Clones, Isolated Individually From Preterm Neonates Presenting With Sepsis At Edinburgh's Royal Infirmary, Paul Walsh, M. Bekaert, J. Carroll, T. Manning, B. Kelly, A. O'Driscoll, X. Lu, C. Smith, P. Dickinson, K. Templeton, P. Ghazal, Roy D. Sleator

Department of Biological Sciences Publications

Herein, we report the draft genome sequences of six individual Staphylococcus epidermidis clones, cultivated from blood taken from different preterm neonatal sepsis patients at the Royal Infirmary, Edinburgh, Scotland, United Kingdom.

Pearls Of Wisdom: A Case Of Benzonatate Toxicity Resulting In Ventricular Fibrillation, Neiman Ramjattan Do, Raghunandan Muppidi Md

Department of Medicine

No abstract provided.

Pearls Of Wisdom: A Case Of Benzonatate Toxicity Resulting In Ventricular Fibrillation, Neiman Ramjattan Do, Muppidi Raghunandan Md

Department of Medicine

No abstract provided.

Effects Of Human Recreational Activity On The Tameness Of Common Loons (Gavia Immer) In Northern Wisconsin, Seth Yund

Student Scholar Symposium Abstracts and Posters

The Common Loon (Gavia immer) is an aquatic diving bird that lives in freshwater habitats in Canada and the northern U.S.. Human activity on a loon’s resident lake may affect its fitness and behavior, yet few studies identify or quantify these effects. We modified existing techniques that measure escape distances in other species to measure tameness as the distance at which individual loons dove in response to human approach by canoe. Tameness was similar between pair members, suggesting that common lake conditions or the behavior of a mate might influence the behavior. Sex, size within sex, and human activity did …

Protection Or Harm? Suppressing Substance-Use Data, Austin B. Frakt, Nicholas Bagley

Articles

What if it were impossible to closely study a disease affecting 1 in 11 Americans over 11 years of age — a disease that’s associated with more than 60,000 deaths in the United States each year, that tears families apart, and that costs society hundreds of billions of dollars? What if the affected population included vulnerable and underserved patients and those more likely than most Americans to have costly and deadly communicable diseases, including HIV–AIDS? What if we could not thoroughly evaluate policies designed to reduce costs or improve care for such patients?

Louisiana State University Health Sciences Center - 2015 - 141st Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 141st Commencement of LSU Health Sciences Center - New Orleans held May 14, 2015.

Acute Effects Of Self-Myofascial Release And Static Stretching On Shoulder Range Of Motion And Performance In Overhead Athletes With Glenohumeral Internal Rotation Deficit, Ryan R. Fairall

Seton Hall University Dissertations and Theses (ETDs)

Purpose: The purpose of this study was to examine the acute effects of a) self-myofascial release (SMR), b) static stretching (SS), and c) the combination of self-myofascial release and static stretching (SMR+SS) on glenohumeral internal rotation range of motion and markers of shoulder performance (i.e. glenohumeral external rotation isometric strength, motor unit recruitment, and throwing velocity) in male softball players with glenohumeral internal rotation deficit (GIRD).

Methods: The sample consisted of 12 male amateur softball players (age: 36.92 ±11.17 years; height: 177.42 ±6.30cm; mass: 87.58 ±18.39kg) who exhibited ≥20° less internal rotation range of motion (ROM) in the throwing shoulder …