Medicine and Health Sciences Commons^™

Association Of The Lipoprotein Receptor Scarb1 Common Missense Variant Rs4238001 With Incident Coronary Heart Disease, Annabelle Rodriguez-Oquendo

UCHC Articles - Research

Background

Previous studies in mice and humans have implicated the lipoprotein receptor SCARB1 in association with atherosclerosis and lipid levels. In the current study, we sought to examine association of SCARB1 missense single nucleotide polymorphism (SNP) rs4238001 with incident coronary heart disease (CHD).

Methods and Results

Genotypes for rs4238001 were imputed for 2,319 White, 1,570 African American, and 1,292 Hispanic-American MESA participants using the 1,000 Genomes reference set. Cox proportional hazards models were used to determine association of rs4238001 with incident CHD, with adjustments for age, sex, study site, principal components of ancestry, body mass index, diabetes status, serum creatinine, …

Dementia In The Context Of Disability, Rosanne Dizazzo-Miller, Fredrick D. Pociask

Department of Health Care Sciences

Patients and caregivers often associate dementia with devastation and a loss of productive contribution to society. People with dementia are often depicted as confused individuals struggling through embarrassing episodes, followed by a loss of independence. The burden and devastation of the diagnosis on the families of people with dementia is exacerbated by their assumption of the role of caregiver with inadequate preparation or training. Disability scholars, in contrast, offer physical and occupational therapists a nontragic view of disability that recognizes the importance of countering the stigma and discrimination that too often accompany dementia. This case example of a woman diagnosed …

Biomechanics Of Lower Limbs During Walking Among Candidates For Total Knee Arthroplasty With And Without Low Back Pain, David R. Burnett, Naira N. Campbell-Kyureghyan, Robert V. Topp, Peter M. Quesada

School of Nursing and Health Science: Faculty Scholarship

The effect of joint pathologies, such as unilateral knee osteoarthritis (UKOA) or low back pain (LBP), on bilateral gait symmetry has gained increased attention during the past decade. This study is the first to compare gait patterns between patients with UKOA and LBP in combination and with UKOA only. Temporal, kinematic, and kinetic variables were measured bilaterally during gait stance phase in 31 subjects with UKOA and LBP (Group I) and 11 subjects with only UKOA (Group II). Group I patients exhibited less hip rotation in the affected limb (A) than in the nonaffected (NA) limb during walking in contrast …

The Effect Of Positive And Negative Reinforcement On Sixth Graders’ Mental Math Performance, Tess Greene, Amber Todd

Medical Education Faculty Publications

We examined the relationship between different forms of reinforcement and subjects’ mathematical performance. Thirty sixth-grade students were asked to mentally calculate answers to fraction problems, while holding a heart rate monitor, after receiving a positive, negative, or neutral form of reinforcement. While the results suggest that any motivation, positive or negative, may result in higher grades, the positive reinforcement group displayed the largest gain. However, the results were not statistically significant, though the trend was consistent with prior research. The heart rates of the positively-reinforced group were significantly lower than those of the negatively-reinforced and control groups. These results suggest …

Haemophilus Influenzae Responds To Glucocorticoids Used In Asthma Therapy By Modulation Of Biofilm Formation And Antibiotic Resistance, Chris S. Earl, Tee Wooi Keong, Shi-Qi An, Sarah Murdoch, Yvonne Mccarthy, Junkal Garmendia, Joseph Ward, J Maxwell Dow, Liang Yang, George A. O'Toole, Robert P. Ryan

Dartmouth Scholarship

Glucocorticosteroids are used as a main treatment to reduce airway inflammation in people with asthma who suffer from neutrophilic airway inflammation, a condition frequently associ- ated with Haemophilus influenzae colonization. Here we show that glucocorticosteroids have a direct influence on the behavior of H. influenzae that may account for associated difficulties with therapy. Using a mouse model of infection, we show that cortico- steroid treatment promotes H. influenzae persistence. Transcrip- tomic analysis of bacteria either isolated from infected mouse airway or grown in laboratory medium identified a number of genes encoding regulatory factors whose expression responded to the presence of …

Percutaneous Ultrasonic Debridement Of Tendinopathy—A Pilot Achilles Rabbit Model, Srinath Kamineni, Timothy Butterfield, Anthony Sinai

Orthopaedic Surgery and Sports Medicine Faculty Publications

BACKGROUND: Tendinopathy is a common clinical pathology, with mixed treatment results, especially when chronic. In this study, we examine the effects of an ultrasonic debridement modality in a rabbit tendinopathy model. We asked four questions: (1) Was it possible to create and visualize with ultrasound a tendinopathy lesion in a rabbit Achilles tendon? (2) Was it possible to guide a 19-gauge ultrasonic probe into the tendinopathy lesion? (3) Following ultrasonic treatment, was tendinopathy debris histologically present? and (4) Was the collagen profile qualitatively and quantitatively normalized following treatment?

METHODS: Skeletally mature female New Zealand white rabbits (n = 12) …

Cannabis-Induced Hypersensitivity Pneumonitis: A Case Report, Matthew J. Miles Do, Andres Zirlinger Md

Department of Medicine

No abstract provided.

Prevalence Of Suspicious Ultrasound Findings In Patients With Mammographic Focal Asymmetry At Aga Khan University Hospital, Nairobi, Jacqueline Ndunge Mavuti

Master of Medicine in Imaging and Diagnostic Radiology

Background: Breast cancer has become the leading cancer in women in both economically developed and developing countries, accounting for 25% of all cancers diagnosed worldwide in 2012. The cornerstone of breast cancer control remains early detection in order to improve outcomes and survival. Thus far the only breast cancer screening method that has proved to be effective is mammography. Although mammography is the mainstay of early detection, a fundamental limitation is its low inherent contrast difference between the soft tissue structures in the breast. Mammographic specificity relies on the ability to distinguish benign from malignant breast lesions based on their …

Cardiovascular Disease Performance Measures In The Outpatient Setting In India: Insights From The American College Of Cardiology's Pinnacle India Quality Improvement Program (Piqip), Ankur Kalra, Yashashwi Pokharel, Ravi S. Hira, Samantha Risch, Veronique Vicera, Qiong Li, Ram N. Kalra, Prafulla G. Kerkar, Ganesh Kumar, Salim S. Virani

Office of the Provost

Background: India has a growing burden of cardiovascular disease (CVD), yet data on the quality of outpatient care for patients with coronary artery disease, heart failure, and atrial fibrillation in India are very limited. We collected data on performance measures for 68 196 unique patients from 10 Indian cardiology outpatient departments from January 1, 2011, to February 5, 2014, in the American College of Cardiology's PINNACLE (Practice Innovation and Clinical Excellence) India Quality Improvement Program (PIQIP). PIQIP is India's first national outpatient CVD quality-improvement program.
Methods and results: In the PIQIP registry, we estimated the prevalence of CVD risk factors …

Comparison Of Quantitative Analysis To Qualitative Analysis For Interpretation Of Lower Limb Lymphoscintigraphy, Edward Chege Nganga

Master of Medicine in Imaging and Diagnostic Radiology

Background: Lymphoscintigraphy is now the primary imaging modality used in determining a diagnosis in patients with suspected extremity lymphedema. However, analysis is mainly by visual qualitative analysis which is subjective and has a wide inter-observer variability. Subtle differences in ilioinguinal uptake between normal and abnormal limbs may be missed with visual qualitative analysis. This study seeks to compare quantitative analysis to qualitative analysis by computing percentage ilioinguinal nodes uptake at 1.5 hours. Objectives: To compare quantitative analysis to qualitative analysis of lower limb lymphoscintigraphy in the diagnosis of lymphedema. To determine the diagnostic accuracy of quantitative lymphoscintigraphy analysis. Methodology: 52 …

Aquaporin 1 And 5 Expression Decreases During Human Intervertebral Disc Degeneration: Novel Hif-1-Mediated Regulation Of Aquaporins In Np Cells., Zariel I Johnson, Shilpa S Gogate, Rebecca Day, Abbie Binch, Dessislava Z Markova, Neil Chiverton, Ashley Cole, Matt Conner, Irving Shapiro, Christine L Le Maitre, Makarand V Risbud

Department of Orthopaedic Surgery Faculty Papers

Objectives of this study were to investigate whether AQP1 and AQP5 expression is altered during intervertebral disc degeneration and if hypoxia and HIF-1 regulate their expression in NP cells. AQP expression was measured in human tissues from different degenerative grades; regulation by hypoxia and HIF-1 was studied using promoter analysis and gain- and loss-of-function experiments. We show that both AQPs are expressed in the disc and that mRNA and protein levels decline with human disease severity. Bioinformatic analyses of AQP promoters showed multiple evolutionarily conserved HREs. Surprisingly, hypoxia failed to induce promoter activity or expression of either AQP. While genomic …

Fueling The Flame: Complementary And Alternative Methods To Prevent Burnout, Natalie Masco Dixon

Nursing Faculty/Staff Publications

Do you feel tired, stressed or overwhelmed? Do you have little time to care for yourself or are looking for new ways to bring wellness to your life? Nurses must be healed in order to heal. Modalities often considered complementary or alternative may offer the rejuvenation in your health and wellness you have been looking for! This session introduces the audience to common causes of burnout and ways in which acute and critical care nurses can find balance in their own lives through self-care practices. Modalities to be examined and practiced include centering, mindfulness, acupressure and aromatherapy. Personal experiences with …

The Search For Huntington's Disease Treatments Is Indeed 'Rocket Science' – And We Can All Help Build The Rocket, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

2015 Scai/Acc/Hfsa/Sts Clinical Expert Consensus Statement On The Use Of Percutaneous Mechanical Circulatory Support Devices In Cardiovascular Care: Endorsed By The American Heart Assocation, The Cardiological Society Of India, And Sociedad Latino Americana De Cardiologia Intervencion; Affirmation Of Value By The Canadian Association Of Interventional Cardiology-Association Canadienne De Cardiologie D'Intervention., Charanjit S Rihal, Srihari S Naidu, Michael M Givertz, Wilson Y Szeto, James A. Burke Md, Phd, Navin K Kapur, Morton Kern, Kirk N Garratt, James A Goldstein, Vivian Dimas, Thomas Tu

Cardiology Division

Although historically the intra-aortic balloon pump has been the only mechanical circulatory support device available to clinicians, a number of new devices have become commercially available and have entered clinical practice. These include axial flow pumps, such as Impella(®); left atrial to femoral artery bypass pumps, specifically the TandemHeart; and new devices for institution of extracorporeal membrane oxygenation. These devices differ significantly in their hemodynamic effects, insertion, monitoring, and clinical applicability. This document reviews the physiologic impact on the circulation of these devices and their use in specific clinical situations. These situations include patients undergoing high-risk percutaneous coronary intervention, those …

Ferritin Levels In The Cerebrospinal Fluid Predict Alzheimer's Disease Outcomes And Are Regulated By Apoe, Scott Ayton, Noel G. Faux, Ashley I. Bush, Charles D. Smith, Greg A. Jicha, Peter A. Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Alzheimer's Disease Neuroimaging Initiative

Neurology Faculty Publications

Brain iron elevation is implicated in Alzheimer's disease (AD) pathogenesis, but the impact of iron on disease outcomes has not been previously explored in a longitudinal study. Ferritin is the major iron storage protein of the body; by using cerebrospinal fluid (CSF) levels of ferritin as an index, we explored whether brain iron status impacts longitudinal outcomes in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. We show that baseline CSF ferritin levels were negatively associated with cognitive performance over 7 years in 91 cognitively normal, 144 mild cognitive impairment (MCI) and 67 AD subjects, and predicted MCI conversion to AD. …

Transport Of Bovine Milk Exosomes In Human Endothelial Cell, Rio Jati Kusuma

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

MicroRNAs (miRNAs) can be synthesized endogenously and cause gene repression. Encapsulation of miRNAs in exosomes confers protection against degradation and a vehicle for shuttling between cells and tissues, and cellular uptake by endocytosis. Exosomes can be found in biological fluids and foods including milk. Evidence suggests that humans absorb cow’s milk exosomes and deliver the microRNA cargo to peripheral tissues, consistent with gene regulation by nucleic acids across species boundaries. There is strong evidence that milk exosomes may cross the mucosa without re-packaging in mice. Here, we tested the hypothesis that human vascular endothelial cells transport milk exosomes by endocytosis, …

Analyzing Pain Medication Use And Adherence In Patients With Myotonic Dystrophy And Facioscapulohumeral Dystrophy, Bryan Fitzgerald, Amy L. Parkhill

Pharmacy Faculty/Staff Publications

Objectives: Myotonic dystrophy (DM) and facioscapulohumeral dystrophy (FSHD) are two of the most common muscular dystrophies in adults. It has been reported that patients with these two disorders may suffer from pain and inadequate pain management. The purpose of this study is to analyze the current use of pain medications and develop a survey to assess pain medication use and adherence in this patient population.

Methods: Patients registered in the National Registry for DM and FSHD at the University of Rochester were surveyed on pain medication use and the most significant problem of their disease. After analysis of these surveys, …

Correlating Cellular And Diagnostic Yield Of Endobiliary Brush Cytology To Fine Needle Aspiration Using A New Large Caliber Endobiliary Brush In Suspected Pancreaticobiliary Malignancies - A Single Center Retrospective Review, Matthew Sullivan Do, Joan Collette Crn, Shashin Shah Md, Hiral N. Shah Md

Department of Medicine

No abstract provided.

Undifferentiated Carcinoma With Osteoclast-Like Giant Cells Of The Pancreatic Tail, Patrick Hickey Do, Ranjit R. Nair Md, Victoria A. Loven Md, Jeffrey Brodsky Md, Hiral N. Shah Md

Department of Medicine

No abstract provided.

Genetic Polymorphisms And Antidepressant Adverse Effects, Rajnish Mago, S. Gupta, Kelly Huhn, R. Shah

Department of Psychiatry and Human Behavior Faculty Papers

Abstract

Background

Aim: to assess whether pharmacogenetic polymorphisms are associated with increased adverse effects or non-response with certain antidepressants whose metabolism is highly dependent on specific CYP450 isoenzymes. This is interim analysis of an ongoing study

Methods

We used a Case Control design comparing patients with major depressive disorder or generalized anxiety disorder who had had increased adverse effects from specified antidepressants (Cases) to patients who were poor responders to an antidepressant but without significant adverse effects (Controls) Genecept Assay™ (battery of pharmacogenetic tests relevant to psychiatry) was obtained using saliva or cheek swab

Results

Importantly, 57.1% of Cases were …

Endoscopic Mucosal Resection And Radiofrequency Ablation For Intramucosal Adenocarcinoma In The Background Of Barrett’S Esophagus: A Case Series, Bonnie Patek Do, Patrick Hickey Do, Hiral N. Shah Md, Shashin Shah Md

Department of Medicine

No abstract provided.

Ada News - 05/18/2015, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

What's Happening May 18, 2015, Maine Medical Center

What's Happening

No abstract provided.

Confronting The Nursing Faculty Shortage: Identifying Solutions To Address The Issue, Stacy Ann Emerson

Student Theses and Dissertations

Recently there has been much attention focused on the shortage of nurses in the United States with an anticipated deficit in excess of one million registered nurses by 2020. Practical and theoretical explanations for the shortage often cite a lack of nursing faculty as a contributing factor to the crisis. Each year, thousands of qualified students are denied admission to nursing schools across the nation, in large part due to lack of faculty and clinical resources. Although economic, social, and financial motivators may provide clues as to why so few nurses pursue faculty lines, solutions for reversing the trend, such …

Custom Fluorophores For Investigating The Cellular Uptake Mechanisms And Side-Effects Of Pharmaceuticals, Yu-Hsuan Chu

Dissertations and Theses

There is a significant current need to elucidate the molecular mechanisms of the side-effects caused by widely-used pharmaceuticals. Examples include the acute nephrotoxicity and irreversible ototoxicity promoted by the cationic drugs gentamicin and cisplatin. Gentamicin is an aminoglycoside antibiotic used for the prevention and treatment of life-threatening gram-negative bacterial infections, such as tuberculosis and meningitis. Cisplatin is used to treat a broad spectrum of cancers including head and neck, ovarian, cervical, stomach, bladder, sarcoma, lymphoma, testicular cancer and others.

The objective of this study is to design and synthesize rhodamine derivatives that can be used for the construction of geometrically …

Week Of May 18, 2015, New York Medical College

InTouch

• Dr. Jan K. Richardson Will Address the Class of 2015
• NYMC Celebrates 27th Annual Employee Recognition Program
• View the NYMC Corporate Citizenship Award Video
• NYMC Ranks in Top Ten Med Schools with the Most Applicants

Prevalence Of School Nurses In Kentucky And Student Outcomes, Teena Darnell

Graduate Theses, Dissertations, and Capstones

Objective: The purpose of this study was to identify whether the presence of a nurse in the public high school setting was associated student outcomes. Data gleaned from the study will be used to enact a new legislative policy mandating the presence of a nurse in all public schools in the state of Kentucky.

Background: Nurses employed in the school setting support both the educational mission of the institution, as well as the health and well-being of students. Studies have explored the relationships between school nurse presence and student health. It has been suggested that when children experience poor …

The Relationships Among School Nurse To Student Ratios, Self-Efficacy For Type 1 Diabetes Management, And Glycemic Control In Adolescents, Lori Wilt

Seton Hall University Dissertations and Theses (ETDs)

Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases of childhood. Adolescents with T1DM experience decreased treatment adherence, poor glycemic control, and acute complications more frequently than adults. Self-efficacy is the belief that one can carry out specific behaviors in specific situations and is the major determinant of intention, and has been shown to influence diabetes self-management in the adolescent.

School nurses are in a unique position to influence self-efficacy for type 1 diabetes management in adolescents. Although previous research has shown that school nurses positively influence student health outcomes in a variety of ways, there …

Biodynamic Parameters During A Step Down Task In Subjects With Chronic Or Recurrent Low Back Pain Classified With Lumbar Instability, Kim M. Poulsen

Seton Hall University Dissertations and Theses (ETDs)

Background: Low back pain (LBP) affect a majority of the population. Lumbar instability has been identified as a factor in a significant portion of individuals with LBP but movement characteristics of this population has seen limited research regarding functional tasks. Objective: This study examined biodynamic parameters during a step task. Design: Quasi-experimental with 2 factors, group and side (L/R), and 1 repeated measure (stepping). Statistics: Two-way Mixed-Design Repeated Measures ANOVA with Alpha = .05. Movement task: Subjects with LBP and lumbar spine clinical instability classification (N=11) and control subjects (N=11) performed a step down task from a 9.5 inch …

Exploring The Relationship Between Preadmission Factors And Dental School Student Success, Nadege J. Dady

Seton Hall University Dissertations and Theses (ETDs)

This quantitative study assessed the preadmission factor relationship to success at a graduate dental school. Preadmission factors are used nationally to assess student ability. There are concerns about the reliability of these factors in measuring URM student ability. 1,275 records were collected and assessed for those admitted between the years 1998-2009. Multiple linear regression analysis was conducted to assess the relationship of the pre admission variables to the continuous variable Dental School GPA. Logistic regression analysis was conducted to assess the relationship of the pre admission variables to the dichotomous categorical variables of Licensure Obtainment and Degree Awarded Status. Based …