Medicine and Health Sciences Commons^™

Do I Buy It? How Aidettm Training Changes Residents’ Values About Communication Skills In Doctor-Patient Interactions, Andrea Braverman, Phd, Austin Katona, B.Sc., Elisabeth Kunkel, Md, Leo Katz, Md, Matthew Keller, Md, Constantine Daskalakis, Sc.D, Jennifer Jasmine Arfaa, Phd, Mhsa

Department of Obstetrics and Gynecology Presentations and Grand Rounds

OBJECTIVES

Acquiring communication and interpersonal skills is an important part of providing patient-centered care and improving patient satisfaction. This study explores whether residents’ own values about patient communication change over time.

College Within The College: Population Health, James Plumb, Md, Mph, Rickie Brawer, Phd, Mph, Mches, Abbie Santana, Msph, Robert Simmons, Drph, Mph, Mches, Cph, Nancy Chernett, Ma, Mph

Thomas Jefferson University Faculty Days

Rationale:

The current approach to educating health professionals has not kept pace with the needs of our growingly diverse population.

-Health Professional Education for the 21st Century-The Lancet

-Institute of Medicine

-APTR/CDC/AAMC-Patients and Populations. Public Health in Medical Education

JMC Leadership and Curriculum Committee-one year planning process-2009-2010

The National Health Security Preparedness Index: National Advisory Committee Meeting, Glen P. Mays, Michael Childress, Anna Goodman Hoover, Chris Bollinger

Health Management and Policy Presentations

This meeting of the National Advisory Committee for the National Health Security Preparedness Index program discussed strategies for improving the theoretical framework, measures, and analytic methodologies used in assessing and comparing preparedness levels across U.S. states and the nation as a whole.

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Georgia Southern Models the Effect of School Closures

Cyclic Rhamnosylated Elongation Factor P Establishes Antibiotic Resistance In Pseudomonas Aeruginosa, Andrei Rajkovic, Sarah Erickson, Anne Witzky, Owen E. Branson, Jin Seo, Philip R. Gafken, Michael A. Frietas, Julian P. Whitelegge, Kym F. Faull, William Wiley Navarre, Andrew J. Darwin, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Elongation factor P (EF-P) is a ubiquitous bacterial protein that is required for the synthesis of poly-proline motifs during translation. In Escherichia coli and Salmonella enterica, the posttranslational β-lysylation of Lys34 by the PoxA protein is critical for EF-P activity. PoxA is absent from many bacterial species such as Pseudomonas aeruginosa, prompting a search for alternative EF-P posttranslation modification pathways. Structural analyses of P. aeruginosa EF-P revealed the attachment of a single cyclic rhamnose moiety to an Arg residue at a position equivalent to that at which β-Lys is attached to E. coli EF-P. Analysis of the genomes …

Implications Of The New Icsd-3 Diagnostic Criteria For Narcolepsy In Patients Diagnosed By Icsd-2, John Konikkara, Md, Robert Tavella, Mph, Rpsgt, William Breuninger, Rpsgt, Karl Doghramji, Md

Department of Psychiatry and Human Behavior Faculty Papers

BACKGROUND

The ICSD-2 diagnostic criteria for narcolepsy mandated 2 sleep-onset REM periods (SOREMPs) on multiple sleep latency testing (MSLT). Subsequent data suggested that a SOREMP within 15 minutes of nocturnal sleep onset, in the absence of another sleep disorder, is a highly specific finding for narcolepsy, but with low sensitivity. Therefore, the diagnostic criteria for the ICSD-3 allow for a minimum of one SOREMP during the MSLT, provided that the preceding overnight polysomnogram (PSG) also exhibits 1 SOREMP. We sought to re-evaluate the effects of this revision on diagnostic sensitivity by retrospectively applying ICSD-3 diagnostic criteria to patients who had …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Models the Effect of School Closures
• Georgia Southern Researcher Examines Racial Differences in the Utilization of Bone Marrow Transplantation and Participation in Survey and Biospecimen Research

Community Health News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Georgia Southern Researcher Examines Racial Differences in the Utilization of Bone Marrow Transplantation and Participation in Survey and Biospecimen Research

10,000th Asset Archived In The Jdc, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

Rejoice! Hooray!! The Jefferson Digital Commons has archived its 10,000th item. The lucky 10,000th item was published by David Nash, MD, MBA and Eugene Mochan, PhD, DO from the Jefferson School of Population Health, Thomas Jefferson University.

Is It Time To Consider The “Burnout Syndrome” A Distinct Illness?, Renzo Bianchi, Irvin Sam Schonfeld, Eric Laurent

Publications and Research

The “burnout syndrome” has been defined as a combination of emotional exhaustion, depersonalization, and reduced personal accomplishment caused by chronic occupational stress. Although there has been increasing medical interest in burnout over the last decades, it is argued in this paper that the syndrome cannot be elevated to the status of diagnostic category, based on (1) an analysis of the genesis of the burnout construct, (2) a review of the latest literature on burnout-depression overlap, (3) a questioning of the three-dimensional structure of the burnout syndrome, and (4) a critical examination of the notion that burnout is singularized by its …

What's Happening: June 8, 2015, Maine Medical Center

What's Happening

No abstract provided.

Calcium Channel Blockers, Progression To Dementia, And Effects On Amyloid Beta Peptide Production, Mark A. Lovell, Erin Abner, Richard Kryscio, Liou Xu, Shuling X. Fister, Bert C. Lynn

Sanders-Brown Center on Aging Faculty Publications

Previous epidemiologic studies suggest that antihypertensive drugs may be protective against cognitive decline. To determine if subjects enrolled in the University of Kentucky longitudinal aging study who used antihypertensive drugs showed diminished progression to dementia, we used a 3-parameter logistic regression model to compare the rate of progression to dementia for subjects who used any of the five common categories of antihypertensive drugs to those with similar demographic characteristics but who did not use antihypertensives. Regression modeling showed that subjects who used calcium channel blockers (CCBs) but not the other classes of antihypertensives showed a significant decrease in the rate …

Concomitant Retrograde Coronary Venous Infusion Of Basic Fibroblast Growth Factor Enhances Engraftment And Differentiation Of Bone Marrow Mesenchymal Stem Cells For Cardiac Repair After Myocardial Infarction., Xiao Wang, Lei Zhen, Huangtai Miao, Qiwei Sun, Ya Yang, Bin Que, Edmundo Patricio Lopes Lao, Xingxin Wu, Hongmei Ren, Shutian Shi, Wayne Bond Lau, Xin-Liang Ma, Changsheng Ma, Shaoping Nie

Department of Emergency Medicine Faculty Papers

AIM: Basic fibroblast growth factor (bFGF) increases the migration and viability of bone marrow mesenchymal stem cells (MSCs) in vitro. Retrograde coronary venous infusion can provide both increased regional bFGF concentrations and homogeneous cell dissemination. We determined whether retrograde delivery of bFGF enhances the potency of transplanted MSCs for cardiac repair in a canine infarct model.

METHODS AND RESULTS: Under hypoxic conditions, cellular migration was significantly increased in MSCs co-cultured with bFGF compared to vascular endothelial growth factor or insulin-like growth factor, and bFGF promoted MSCs differentiation into a cardiomyocyte phenotype. A canine infarct model was employed by coronary ligation. …

A Technology-Enabled Adherence Enhancement System For People With Bipolar Disorder: Results From A Feasibility And Patient Acceptance Analysis, Martha Sajatovic, Kristina A. Cassidy, Johnny Sams, Edna Fuentes-Casiano

Faculty Scholarship

Objective: As poor medication adherence is common in bipolar disorder (BD), technology-assisted approaches may help to monitor and enhance adherence. This study evaluated preliminary feasibility, patient satisfaction and effects on adherence, BD knowledge, and BD symptoms associated with the use of a multicomponent technology-assisted adherence enhancement system. Methods: This prospective study tested the system in five BD patients over a 15-day period. System components included: 1) an automated pill cap with remote monitoring sensor; 2) a multimedia adherence enhancement program; and 3) a treatment incentive program. This study evaluated system usability, patient satisfaction and effects on adherence (Morisky scale), knowledge …

Medical School Watercooler Newsletter - June 7, 2015, Lindsey Lyle

Watercooler Newsletter

This is the June 7, 2015 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

USA Medical Student Tapped to Lead Regional Student Organization

USA Student Health Center Celebrates Accomplishment

Medical Alumni Association Hosts Annual Medical Alumni Weekend

Whole Genome Capture Of Vector-Borne Pathogens From Mixed Dna Samples: A Case Study Of Borrelia Burgdorferi, Giovanna Carpi, Katharine S. Walter, Stephen J. Bent, Anne Gatewood Hoen, Maria Diuk-Wasser, Adalgisa Caccone

Dartmouth Scholarship

Background:

Rapid and accurate retrieval of whole genome sequences of human pathogens from disease vectors or animal reservoirs will enable fine-resolution studies of pathogen epidemiological and evolutionary dynamics. However, next generation sequencing technologies have not yet been fully harnessed for the study of vector-borne and zoonotic pathogens, due to the difficulty of obtaining high-quality pathogen sequence data directly from field specimens with a high ratio of host to pathogen DNA.

Results:

We addressed this challenge by using custom probes for multiplexed hybrid capture to enrich for and sequence 30 Borrelia burgdorferi genomes from field samples of its arthropod vector. Hybrid …

Parametric Mapping Of Contrasted Ovarian Transvaginal Sonography., Katrina Korhonen, Ryan Moore, Andrej Lyshchik, Arthur C. Fleischer

Department of Radiology Faculty Papers

The purpose of this study was to assess the accuracy of parametric analysis of transvaginal contrast-enhanced ultrasound (TV-CEUS) for distinguishing benign versus malignant ovarian masses. A total of 48 ovarian masses (37 benign and 11 borderline/malignant) were examined with TV-CEUS (Definity; Lantheus, North Billerica, MA; Philips iU22; Philips Medical Systems, Bothell, WA). Parametric images were created offline with a quantification software (Bracco Suisse SA, Geneva, Switzerland) with map color scales adjusted such that abnormal hemodynamics were represented by the color red and the presence of any red color could be used to differentiate benign and malignant tumors. Using these map …

Radiation Oncology – Fulfilling A Need For Research, Education, And Practice: Effectiveness Of Calendula Lotion For Radiation Dermatitis (Poster), Jennifer B. Bergenstock Bsn, Rn, Ocn, Sandra Frey Rn Msn Ocn, Erin Light Rn Bsn Ocn, Kathy Krause Rn Ocn, Sue Lewis Rn Ocn, Marisa Kauker Rn Bsn Ocn, Jenna Byorek Rn Bsn, Debra Knappenberger Rn Ocn, Mary T. Konek Rn, Ocn, Ba, Ruth Ocasio Lpn, Mary Lenahan Durnin Rn Msn Ocn, Charles Andrews Md, Jeanette Blauth Md, Alyson Mcintosh Md, Steven Perch Md, Robert G. Prosnitz Md, Mph, Dennis Sopka Md, Clinton Leinweber Do, Tracy Kichline Data Systems Analyst, Mandy Hendricks Rn Msn Ocn

Patient Care Services / Nursing

No abstract provided.

Effects Of Early-Adolescent, Mid-Adolescent, Or Adult Stress On Morphine Conditioned Place Preference, Chloe Shields

Senior Theses

In light of previous work demonstrating that stress can increase subjective drug reward in adult rats, the present study investigated the influence of stress on morphine conditioned place preference (CPP) in early-adolescent, mid-adolescent, and adult male Sprague-Dawley rats. Subjects in each age group were assigned to either a no stress condition or a stress condition in which they were exposed to an unpredictable eight-day schedule of elevated platform and synthetic fox odor stressors. Place conditioning then evaluated subjective morphine reward in all animals. Using a biased procedure, subjects were assigned to receive morphine on the initially non-preferred side of the …

Bilateral Papillitis And Unilateral Focal Chorioretinitis As The Presenting Features Of Syphilis., Christy E. Benson, Mohamed K. Soliman, Alexander Knezevic, Daisy D. Xu, Quan D. Nguyen, Diana V V. Do

Journal Articles: Ophthalmology

BACKGROUND: Syphilis is a multisystem bacterial infection caused by Treponema pallidum. The incidence of infection in the United States has risen by more than 75% since the year 2000, when it was at a low of 2.1 per 100,000 people. Ocular involvement may occur in any stage of infection and may present in a variety of ways, with posterior uveitis being the most common manifestation. We report a case of ocular syphilis infection with an unusual presentation of bilateral non-granulomatous panuveitis with papillitis and unilateral focal chorioretinitis.

FINDINGS: This is a retrospective case report with literature review. A 39-year-old Caucasian …

Intact Lkb1 Activity Is Required For Survival Of Dormant Ovarian Cancer Spheroids, Teresa M. Peart, Yudith R. Valdes, Rohann J.M. Correa, Elena Fazio, Monique Bertrand, Jacob Mcgee, Michel Prefontaine, Akira Sugimoto, Gabriel E. Dimattia, Trevor G. Shepherd

Anatomy and Cell Biology Publications

Metastatic epithelial ovarian cancer (EOC) cells can form multicellular spheroids while in suspension and disperse directly throughout the peritoneum to seed secondary lesions. There is growing evidence that EOC spheroids are key mediators of metastasis, and they use specific intracellular signalling pathways to control cancer cell growth and metabolism for increased survival. Our laboratory discovered that AKT signalling is reduced during spheroid formation leading to cellular quiescence and autophagy, and these may be defining features of tumour cell dormancy. To further define the phenotype of EOC spheroids, we have initiated studies of the Liver kinase B1 (LKB1)-5′-AMP-activated protein kinase (AMPK) …

Arsenic Inhibits Dna Mismatch Repair By Promoting Egfr Expression And Pcna Phosphorylation, Dan Tong, Janice Ortega, Christine Kim, Jian Huang, Liya Gu, Guo-Min Li

Toxicology and Cancer Biology Faculty Publications

Both genotoxic and non-genotoxic chemicals can act as carcinogens. However, while genotoxic compounds lead directly to mutations that promote unregulated cell growth, the mechanism by which non-genotoxic carcinogens lead to cellular transformation is poorly understood. Using a model non-genotoxic carcinogen, arsenic, we show here that exposure to arsenic inhibits mismatch repair (MMR) in human cells, possibly through its ability to stimulate epidermal growth factor receptor (EGFR)-dependent tyrosine phosphorylation of proliferating cellular nuclear antigen (PCNA). HeLa cells exposed to exogenous arsenic demonstrate a dose- and time-dependent increase in the levels of EGFR and tyrosine 211-phosphorylated PCNA. Cell extracts derived from arsenic-treated …

Management Of Neovascular Age-Related Macular Degeneration: Current State-Of-The-Art Care For Optimizing Visual Outcomes And Therapies In Development., Aniruddha Agarwal, William R. Rhoades, Mostafa Hanout, Mohamed Kamel K. Soliman, Salman Sarwar, Mohammad A. Sadiq, Yasir J. Sepah, Diana V. Do, Quan Dong Nguyen

Journal Articles: Ophthalmology

Contemporary management of neovascular age-related macular degeneration (AMD) has evolved significantly over the last few years. The goal of treatment is shifting from merely salvaging vision to maintaining a high quality of life. There have been significant breakthroughs in the identification of viable drug targets and gene therapies. Imaging tools with near-histological precision have enhanced our knowledge about pathophysiological mechanisms that play a role in vision loss due to AMD. Visual, social, and vocational rehabilitation are all important treatment goals. In this review, evidence from landmark clinical trials is summarized to elucidate the optimum modern-day management of neovascular AMD. Therapeutic …

Effects Of Pringle Maneuver And Partial Hepatectomy On The Pharmacokinetics And Blood–Brain Barrier Permeability Of Sodium Fluorescein In Rats, Mohammad K. Miah, Imam H. Shaik, Ulrich Bickel, Reza Mehvar

Pharmacy Faculty Articles and Research

Liver diseases are known to affect the function of remote organs. The aim of the present study was to investigate the effects of Pringle maneuver, which results in hepatic ischemia–reperfusion (IR) injury, and partial hepatectomy (Hx) on the pharmacokinetics and brain distribution of sodium fluorescein (FL), which is a widely used marker of blood–brain barrier (BBB) permeability. Rats were subjected to Pringle maneuver (total hepatic ischemia) for 20 min with (HxIR) or without (IR) 70% hepatectomy. Sham-operated animals underwent laparotomy only. After 15 min or 8 h of reperfusion, a single 25-mg/kg dose of FL was injected intravenously and serial …

The Effects Of Arginine Vasopressin On Maternal Behavior And Aggression In Peromyscus Californicus Mothers, Nathaniel Ng

Honors Projects

Research studies since the 1950s have shown that a chemical within the brain called arginine vasopressin (AVP) is associated with the modulation of many different social behaviors in mammals. Some of these behaviors are related to parenting, such as parental care initiation, aggression, social recognition, depression and anxiety. Understanding the physiology behind AVP regulation could allow for the creation of new therapies for treating human social disorders, such as using an AVP receptor antagonist to attenuate anxiety. This project examines how neural injections of AVP and an AVP receptor antagonist affect both maternal care and aggression in female Peromyscus californicus …

Variability Modifies Life Satisfaction's Association With Mortality Risk In Older Adults, Julia K. Boehm, Ashley Winning, Suzanne Segerstrom, Laura D. Kubzansky

Psychology Faculty Articles and Research

Greater life satisfaction is associated with greater longevity, but its variability across time has not been examined relative to longevity. We investigated whether mean life satisfaction across time, variability in life satisfaction across time, and their interaction were associated with mortality over 9 years of follow-up. Participants were 4,458 Australians initially at least 50 years old. During the follow-up, 546 people died. After we adjusted for age, greater mean life satisfaction was associated with a reduction in mortality risk, and greater variability in life satisfaction was associated with an increase in mortality risk. These findings were qualified by a significant …

Exploring Mindfulness As A Culturally Sensitive Intervention For The Deaf Community, Barrymore R. Rosellini

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Mental health issues are as prevalent in the deaf community as the hearing community, if not more. Yet, Deaf individuals are often treated by mental health professionals less frequently and less effectively. Many systemic barriers exist that influence the lack of services provided to the Deaf community, primarily related to a lack of cultural understanding rooted in perceptions of Deaf individuals. However, the Deaf community may be best understood as a cultural minority, a unique community sharing a distinct culture, history, and language. This paper investigates the effects of systematic barriers and cultural misunderstanding among mental health professions regarding the …

Development Of A Psychological Assessment Battery To Measure Client Beliefs About The Effectiveness Of Psychotherapy, Christopher Peavey

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

The author attempted to develop a brief scale to measure clients' beliefs about the effectiveness of psychotherapy. The study is an early pilot study to determine if the scale can predict therapy outcomes. While the scale did differ significantly between clients who were active in therapy and those who were not, higher scores on the instrument were not indicative of greater involvement. Possibilities for future research to refine the instrument are discussed.

Understanding Change In A Therapeutic Community For People With Severe Mental Illness: An Interpretive Phenomenological Study, Julie Caroline Keys

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

In order to gain better understanding of how therapeutic communities instigate change, this interpretative phenomenological study explores the recognized agents of change as reported by current and recent community members of a particular therapeutic community. Four superordinate themes were discovered: the structure of the program, engagement in the community, intentionality/mindfulness, and applied knowledge. While the results from this study are similar in several ways to the current literature, they also expand the literature about therapeutic communities in one important way. The change agents reported as leading to healing strongly resemble current best practice for the treatment of trauma. Limitations and …

The Clinical Utility Of The Adult Attachment Projective Picture System: A Clinician's Perspective, Ashley Gunterman

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

The Adult Attachment Projective Picture System (AAP) is the first performance-based measure of adult attachment to be developed. The purpose of the measure is to provide a clinical understanding of an adult client's attachment status and associated coping mechanisms. The AAP is a relatively new measure that has yet to be examined from a utility perspective. In the current study, seven psychologists completed a structured survey in order to identify their perspectives of the AAP and its utility as a clinical instrument. A phenomenological qualitative analysis of the data was conducted to derive themes about the AAP and its clinical …