Medicine and Health Sciences Commons^™

The Self-Reported Sexual Behaviors Of Single Older African Americans, Victoria Foster, Patricia C. Clark, Marcia M. Holstad

Journal of Health Disparities Research and Practice

Abstract

African Americans are disproportionally affected by HIV/AIDS, but little is known about the risky sexual behaviors of older African Americans. This cross-sectional, comparative study, investigated the self-reported sexual behaviors of sexually active older African Americans. The nonrandom sample (N = 78) included single African American men (59%) and women (41%), 50-74 years of age. Participants were recruited from various community sites, and data were collected with a standard sexual history questionnaire. Participants reported practicing risky behaviors such having unprotected oral, anal, and vaginal sex (96.5%), and having multiple sex partners (37.2%). There were several significant gender differences such …

Evaluating The Use Of Relaxation Interventions To Promote Participation And Quality Of Life In Individuals With Cancer, Abigail Gilmore, Ots, Brianna Schwoyer, Ots, Audrey Zapletal, Ms< Otr/L

Department of Occupational Therapy Posters and Presentations

Background:

• High levels of anxiety and distress are associated with the diagnosis, treatment, and remission stages of cancer.
• Psychological symptoms have the potential to negatively influence functional performance, quality of life, overall health, and recovery of individuals with cancer.
• Improvements in occupational performance and quality of life, as well as reductions in anxiety and pain have been demonstrated in a variety of health conditions with the use of therapeutic relaxation techniques, such as:
  • Yoga/Tai Chi
  • Mindfulness based stress reduction (MBSR)
  • Relaxation Training
  • Massage
• Research continues to emerge investigating trends in use, patient experiences, and efficacy of therapeutic relaxation techniques with …

What's Happening: June 29, 2015, Maine Medical Center

What's Happening

No abstract provided.

Inotropes Are Linked To Increased Mortality In Heart Failure, M. Chadi Alraies, Bill Tran, Sirtaz Adatya

The VAD Journal

No abstract provided.

A Five Year Program Review Of Infusing Occupational Therapy Into Over-Night Camping For Children With Disabilities, Audrey Zapletal, Ms, Otr/L, Ashley Kalman-Binkowski, Ms, Otr/L, Lindsey West, Ms, Otr/L

Department of Occupational Therapy Posters and Presentations

Objectives:

• Describe an OT faculty-student training model in a nontraditional rural setting
• Provide examples of strategies to enhance campers’ participation in a variety of activities
• Discuss the impact of occupational therapy program on satisfaction and participation of campers with disabilities

Participation In Clinical Research: A Thorough Explanation In Their Own Language Helps Family Medicine Patients Decide., Anita Kurt Phd, Rn, Charity Curtis Mph, Melanie B. Johnson Mpa, Henry Liu Md, Beth Careyva Md, Jerry Chang Bs, Alex Winter Bs, Claudia P. Santiago Ba, Wendy H. York Bs, Ma, Kathleen Staubinger Rn, Bsn, Brian Stello Md

Department of Family Medicine

No abstract provided.

Today - June 29, 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Loma Linda University celebrates 1,480 newest alumni
-- University celebrates honorees during ceremonies
-- Safe Kids and Children's Hospital host media event for water safety awareness
-- Zipcar, which brought car sharing to Loma Linda University Health, may expand
-- Kids learn to trust care providers during teddy bear clinic
-- Annual Celebration of Life provides heartfelt laughter, inspiration and hope
-- Food and family are important to LLUMC - Murrieta chef
-- Official negotiations begin for affiliation with San Gorgonio Memorial Hospital
-- Study finds increasing respiratory risks for children living near major rail yards …

Enhancing Interferon Regulatory Factor 7 Mediated Antiviral Responses And Decreasing Nuclear Factor Kappa B Expression Limit Hiv-1 Replication In Cervical Tissues, Christiane Rollenhage, Sherrill L. Macura, Melissa J. Lathrop, Todd A. Mackenzie, Gustavo F. Doncel, Susana N. Asin

Dartmouth Scholarship

Establishment of a productive HIV-1 infection in the female reproductive tract likely depends on the balance between anti-viral and pro-inflammatory responses leading to activation and proliferation of HIV target cells. Immune modulators that boost anti-viral and depress pro-inflammatory immune responses may decrease HIV-1 infection or replication. Polyinosinic: polycytidylic [Poly (I:C)] has been reported to down-regulate HIV-1 replication in immune cell subsets and lymphoid tissues, yet the scope and mechanisms of poly (I:C) regulation of HIV-1 replication in the cervicovaginal mucosa, the main portal of viral entry in women remain unknown. Using a relevant, underexplored ex vivo cervical tissue model, we …

Familiarity With And Preferences For Oral And Long-Acting Injectable Hiv Pre-Exposure Prophylaxis (Prep) In A National Sample Of Gay And Bisexual Men In The U.S., Jeffrey T. Parsons, H. Jonathan Rendina, Thomas H.F. Whitfield, Christian Grov

Publications and Research

Objectives: We sought to determine preferences for oral versus long-acting injectable (LAI) PrEP among gay and bisexual men (GBM).

Methods: We surveyed a national U.S. sample of 1,071 GBM about forms of PrEP.

Results: Overall, 46.0% preferred LAI, 14.3% oral, 21.7% whichever was most effective, 10.1% had no preference, and 7.8% would not take PrEP. There were no differences in PrEP preferences by race/ethnicity, income, region of residence, or relationship status. Those unwilling to take PrEP were significantly older than those who preferred LAI PrEP and those who would take either. Those who preferred the most effective …

Exogenous 17-Β Estradiol Administration Blunts Progression Of Established Angiotensin Ii-Induced Abdominal Aortic Aneurysms In Female Ovariectomized Mice, Sean E. Thatcher, Xuan Zhang, Shannon Woody, Yu Wang, Yasir Alsiraj, Richard Charnigo, Alan Daugherty, Lisa A. Cassis

Saha Cardiovascular Research Center Faculty Publications

BACKGROUND: Abdominal aortic aneurysms (AAAs) occur predominately in males. However, AAAs in females have rapid growth rates and rupture at smaller sizes. Mechanisms contributing to AAA progression in females are undefined. We defined effects of ovariectomy, with and without 17-β estradiol (E2), on progression of established angiotensin II (AngII)-induced AAAs in female mice.

METHODS: We used neonatal testosterone exposures at 1 day of age to promote susceptibility to AngII-induced AAAs in adult female Ldlr^-/- mice. Females were infused with AngII for 28 days to induce AAAs, and then stratified into groups that were sham, ovariectomized (Ovx, vehicle), or Ovx …

Pleiotropic Effects Of Bitter Taste Receptors On [Ca2+]I Mobilization, Hyperpolarization, And Relaxation Of Human Airway Smooth Muscle Cells., Blanca Camoretti-Mercado, Susan H Pauer, Hwan Mee Yong, Dan'elle C Smith, Deepak A. Deshpande, Phd, Steven S An, Stephen B Liggett

Center for Translational Medicine Faculty Papers

Asthma is characterized by airway inflammation and airflow obstruction from human airway smooth muscle (HASM) constriction due to increased local bronchoconstrictive substances. We have recently found bitter taste receptors (TAS2Rs) on HASM, which increase [Ca2+]i and relax the muscle. We report here that some, but not all, TAS2R agonists decrease [Ca2+]i and relax HASM contracted by G-protein coupled receptors (GPCRs) that stimulate [Ca2+]i. This suggests both a second pathway by which TAS2Rs relax, and, a heterogeneity of the response phenotype. We utilized eight TAS2R agonists and five procontractile GPCR agonists in cultured HASM cells. We find that heterogeneity in the …

Genetic And Pharmacological Modulation Of Trigeminal Pain Molecules In A Model Of Traumatic Brain Injury, Brittany V. Daiutolo, Ashley L. Tyburski, Shannon W. Clark, Md, Melanie B. Elliott, Phd

Department of Neurosurgery Faculty Papers

Introduction

Headache following traumatic brain injury (TBI) is highly prevalent, and it is also the most common and persistent symptom of post-concussion syndrome [1,2]. It could arise de novo or as a pre-existing headache disorder, in which migraine was the most frequent headache phenotype in both civilian and military patients with mild TBI [1,2]. Most post-traumatic headaches will resolve within a couple of weeks following injury; however, headache in a substantial subset of patients may last more than three months and contribute to a prolonged recovery from injury, disability, and a poor quality of living [2]. Headaches can persist well …

Week Of June 29, 2015, New York Medical College

InTouch

• New Campus Walkway is Now Open
• NYMC School of Medicine Pilots "The Healer's Art" Program
• Dr. Halperin Hosts Chancellor's Circle Reception
• Dr. Miller Hosts Special Dean's Lecture
• Department of Family and Community Medicine Hosts Annual Faculty Development and Appreciation Dinner
• Office of Medical Education Hosts Preceptor Appreciation Banquet
• NYMC Welcomes Class of 2018 D.P.T. Students
• Students Take a Study Break with Leonard

Novel Imidazopyridine Derivatives Possess Anti-Tumor Effect On Human Castration-Resistant Prostate Cancer Cells., Matthew A. Ingersoll, Anastesia S. Lyons, Sakthivel Muniyan, Napoleon D'Cunha, Tashika Robinson, Kyle Hoelting, Jennifer G. Dwyer, Xiu R. Bu, Surinder K. Batra, Ming-Fong Lin

Journal Articles: Biochemistry & Molecular Biology

Prostate cancer (PCa) is the second leading cause of cancer-related death afflicting United States males. Most treatments to-date for metastatic PCa include androgen-deprivation therapy and second-generation anti-androgens such as abiraterone acetate and enzalutamide. However, a majority of patients eventually develop resistance to these therapies and relapse into the lethal, castration-resistant form of PCa to which no adequate treatment option remains. Hence, there is an immediate need to develop effective therapeutic agents toward this patient population. Imidazopyridines have recently been shown to possess Akt kinase inhibitory activity; thus in this study, we investigated the inhibitory effect of novel imidazopyridine derivatives HIMP, …

Editorial: Carotid Body: A New Target For Rescuing Neural Control Of Cardiorespiratory Balance In Disease., Rodrigo Del Rio, Rodrigo Iturriaga, Harold D. Schultz

Journal Articles: Cellular & Integrative Physiology

No abstract provided.

Taranis Functions With Cyclin A And Cdk1 In A Novel Arousal Center To Control Sleep In Drosophila., Dinis J.S. Afonso, Die Liu, Daniel R. Machado, Huihui Pan, James E.C. Jepson, Dragana Rogulja, Kyunghee Koh

Department of Neuroscience Faculty Papers

Sleep is an essential and conserved behavior whose regulation at the molecular and anatomical level remains to be elucidated. Here, we identify TARANIS (TARA), a Drosophila homolog of the Trip-Br (SERTAD) family of transcriptional coregulators, as a molecule that is required for normal sleep patterns. Through a forward-genetic screen, we isolated tara as a novel sleep gene associated with a marked reduction in sleep amount. Targeted knockdown of tara suggests that it functions in cholinergic neurons to promote sleep. tara encodes a conserved cell-cycle protein that contains a Cyclin A (CycA)-binding homology domain. TARA regulates CycA protein levels and genetically …

Medical School Watercooler Newsletter - June 28, 2015, Lindsey Lyle

Watercooler Newsletter

This is the June 28, 2015 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

USA College of Medicine to Host Welcome Reception for New Department Chairs

Second Issue of CURRents Available

USA Medical Student’s Research Abstract Accepted for Publication

Class of 2017 Medical Students Begin Clinical Rotations

Flucytosine Pharmacokinetics In A Critically Ill Patient Receiving Continuous Renal Replacement Therapy, Megan E. Kunka, Elizabeth A. Cady, Heejung C. Woo, Melissa L. Thompson Bastin

Pharmacy Practice and Science Faculty Publications

Purpose. A case report evaluating flucytosine dosing in a critically ill patient receiving continuous renal replacement therapy. Summary. This case report outlines an 81-year-old male who was receiving continuous venovenous hemofiltration (CVVH) for acute renal failure and was being treated with flucytosine for the treatment of disseminated Cryptococcus neoformans infection. Due to patient specific factors, flucytosine was empirically dose adjusted approximately 50% lower than intermittent hemodialysis (iHD) recommendations and approximately 33% lower than CRRT recommendations. Peak and trough levels were obtained, which were supratherapeutic, and pharmacokinetic parameters were calculated. The patient experienced thrombocytopenia, likely due to elevated flucytosine …

Concordance Of The Montreal Cognitive Assessment With Standard Neuropsychological Measures, Sally J. Vogel, Sarah J. Banks, Jeffrey Cummings, Justin B. Miller

School of Medicine Faculty Research

Introduction: The concordance of the Montreal cognitive assessment (MoCA) with more comprehensive neuropsychological measures remains unclear. This study examined the individual MoCA domains with more comprehensive and commonly used neuropsychological measures to determine the degree of overlap. Methods: Data included individuals seen in an outpatient neurology clinic specializing in neurodegenerative disease who were administered the MoCA and also underwent neuropsychological assessment (n = 471). A principal component analysis with varimax rotation was completed using the MoCA domain scores and comprehensive neuropsychological evaluation measures. Results: Four factors emerged accounting for 55.6% of the variance: (1) visuospatial/executive functioning; (2) memory; (3) attention; …

Improving Healthcare Outcomes And Accessibility In The Us: The Advanced Practice Nurse, Andra Hanlon

Faculty Articles

No abstract provided.

Development And Piloting Of A Treatment Foster Care Program For Older Youth With Psychiatric Problems, J Curtis Mcmillen, Sarah Carter Narendorf, Debra Robinson, Judy Havlicek, Nicole Fedoravicius, Julie E. Bertram, David Mcnelly

Educator Preparation & Leadership Faculty Works

Background

Older youth in out-of-home care often live in restrictive settings and face psychiatric issues without sufficient family support. This paper reports on the development and piloting of a manualized treatment foster care program designed to step down older youth with high psychiatric needs from residential programs to treatment foster care homes.

Methods

A team of researchers and agency partners set out to develop a treatment foster care model for older youth based on Multi-dimensional Treatment Foster Care (MTFC). After matching youth by mental health condition and determining for whom randomization would be allowed, 14 youth were randomized to treatment …

Inotropes Are Not Linked To Increased Mortality In Heart Failure, Maya Guglin

The VAD Journal

How to use inotropes is one of the most controversial topics in the management of heart failure. While most clinicians use these drugs, and recognize the state of inotrope dependency, current guidelines recommend them onlu as a bridge or palliation. Thus, inotropes are considered either neutral or detrimental in terms of outcomes. Meanwhile, properly designed randomized clinical trials testing the outcomes on inotropes, have never been performed and it is unlikely that they will ever be attempted. These trials would require randomizing patients with advanced heart failure, low output syndrome, and impaired end-organ perfusion into groups that received or not …

An Assessment Of Current Palliative Care Beliefs And Knowledge: The Primary Palliative Care Providers' Perspective, Yvonne Patten, Maria M. Ojeda, Carolyn Lindgren

All Publications

No abstract provided.

Investigating The Scholar Nurse Partner Effect On The Novice Nurse, Gisell Gonzalvo, Vanessa Collazo, Steve Lewis, Aubrey Florom-Smith

All Publications

No abstract provided.

Trend Recognition For Unusual Pathogens In Clinical Specimens, Deborah Fry Mt (Ascp), Mba, Cic, Terry Burger Mba, Bsn, Rn, Ne-Bc, Cic, Alida Ammon, Georgia G. Colasante

Department of Medicine

No abstract provided.

Rater Perceptions Of Bias Using The Multiple Mini-Interview Format: A Qualitative Study, Anthony A. Donato, Richard L. Alweis, Caroline Fitzpatrick

Reading Hospital Internal Medicine Residency

The Multiple Mini-Interview (MMI) format appears to mitigate individual rater biases. However, the format itself may introduce structural systematic bias, favoring extroverted personality types. This study aimed to gain a better understanding of these biases from the perspective of the interviewer

Exercise Improves Host Response To Influenza Viral Infection In Obese And Non-Obese Mice Through Different Mechanisms., Kristi J. Warren, Molly M. Olson, Nicholas J. Thompson, Mackenzie L. Cahill, Todd A. Wyatt, Kyoungjin J. Yoon, Christina M. Loiacono, Marian L. Kohut

Journal Articles: Pulmonary & Critical Care Med

Obesity has been associated with greater severity of influenza virus infection and impaired host defense. Exercise may confer health benefits even when weight loss is not achieved, but it has not been determined if regular exercise improves immune defense against influenza A virus (IAV) in the obese condition. In this study, diet-induced obese mice and lean control mice exercised for eight weeks followed by influenza viral infection. Exercise reduced disease severity in both obese and non-obese mice, but the mechanisms differed. Exercise reversed the obesity-associated delay in bronchoalveolar-lavage (BAL) cell infiltration, restored BAL cytokine and chemokine production, and increased ciliary …

Public Health Metrics: Key Considerations And Criteria For Food Safety Modernization, Glen P. Mays

Health Management and Policy Presentations

Robust measures of public health impact are needed to guide implementation of the U.S. Food Safety Modernization Act. This session describes strategies used in the field of public health services research to specify and select measures based on considerations of relevance, tractability, attribution, precision, and feasibility.

Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors, Bruno Ramos-Molina, Adam N. Lick, Amir Nasrolahi Shirazi, Donghoon Oh, Rakesh Tiwari, Naglaa Salem El-Sayed, Keykavous Parang, Iris Lindberg

Pharmacy Faculty Articles and Research

Cationic cell-penetrating peptides have been widely used to enhance the intracellular delivery of various types of cargoes, such as drugs and proteins. These reagents are chemically similar to the multi-basic peptides that are known to be potent proprotein convertase inhibitors. Here, we report that both HIV-1 TAT47-57 peptide and the Chariot reagent are micromolar inhibitors of furin activity in vitro. In agreement, HIV-1 TAT47-57 reduced HT1080 cell migration, thought to be mediated by proprotein convertases, by 25%. In addition, cyclic polyarginine peptides containing hydrophobic moieties which have been previously used as transfection reagents also exhibited potent furin inhibition in vitro …

Whole Person Orientation In Primary Care: Understanding Priorities And Assessing Performance, Shannon Doyle

Master of Public Health Capstone Presentations

The purpose of this project was to use a participatory research methodology to develop a framework for understanding the concept of whole person orientation in primary care delivery. Whole person orientation is one of the seven Joint Principles of the Patient Centered Medical Home (PCMH) authored by the American Academy of Family Physicians in partnership with several other physician organizations. Although the PCMH model of primary care has been touted as part of the solution to the U.S. healthcare system’s cost and quality issues, there are few tools available to evaluate implementation of the essential components and none at all …