Medicine and Health Sciences Commons^™

Global Collaboration Between Tanzania And Japan To Advance Midwifery Profession: A Case Report Of A Partnership Model, Yoko Shimpuku, Shigeko Horiuchi, Sebalda C. Leshabari, Dickson Mkoka, Yasuko Nagamatsu, Miwako Matsutani, Hiromi Eto, Michiko Oguro, Yukari Yaju, Mariko Iida, Columba Mbekenga, Lilian Mselle, Agnes Mtawa

School of Nursing & Midwifery, East Africa

The global health agenda to reduce maternal mortality is delayed in Sub-Saharan Africa. The shortage of skilled birth attendants in Tanzania hinders the improvement of midwifery care to prevent maternal mortality and morbidity. It is urgently neccesary to develop midwifery leaders capable of working as educators, researchers, administrators, and advanced practitioners, contributing to the improvement of midwifery care and maternal child health in their own country. This report describes the process of establishing the first midwifery master’s program in Tanzania through the efforts of two academic institutions, one in Tanzania and one in Japan. The collaboration developed a sustainable partnership …

Crispr/Cas9-Based Generation Of Knockdown Mice By Intronic Insertion Of Artificial Microrna Using Longer Single-Stranded Dna., Hiromi Miura, Channabasavaiah B. Gurumurthy, Takehito Sato, Masahiro Sato, Masato Ohtsuka

Journal Articles: Genetics, Cell Biology & Anatomy

Knockdown mouse models, where gene dosages can be modulated, provide valuable insights into gene function. Typically, such models are generated by embryonic stem (ES) cell-based targeted insertion, or pronuclear injection, of the knockdown expression cassette. However, these methods are associated with laborious and time-consuming steps, such as the generation of large constructs with elements needed for expression of a functional RNAi-cassette, ES-cell handling, or screening for mice with the desired knockdown effect. Here, we demonstrate that reliable knockdown models can be generated by targeted insertion of artificial microRNA (amiRNA) sequences into a specific locus in the genome [such as intronic …

End Stage Renal Disease: Seroprevalence Of Hepatitises B And C Along With Associated Aetiology And Risk Factors In Children, Syed Raza Shah, Muhammad Shahzeb Khan, Muhamad Tanveer Alam, Adnan Salim, Mehwish Hussain, Areeba Altaf

Section of Neurosurgery

Background: End Stage Renal Disease (ESRD) normally requires dialysis or transplantation for survival. Since ESRD patients are on long term dialysis, infections such as Hepatitis B (HBV) and Hepatitis C (HCV) are commonly reported.
Methods: This was a retrospective study carried out at a government hospital during a 12-month period from January 2013 to December 2013. The data was collected using a predesigned pro forma to note the etiology, gender, age, and HBsAg and anti-HCV test result of each patient.
Results: 444 children suffering from ESRD were included in our analysis. The mean age of sample was 12.7 ± 4.1 …

Carter, Tim Lee, 1910-1987 - Relating To (Sc 2931), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid only for Manuscripts Small Collection 2931. Materials relating to Tim Lee Carter, a Tompkinsville, Kentucky physician and member of the U.S. Congress from 1965-1981. Includes clippings, biographical data, correspondence relating to medical malpractice legislation, and programs, memoranda and publicity relating to the opening of the Carter Congressional Collection at Western Kentucky University. Also includes a pencil sketch of Carter.

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern University's public Health Graduate Program Ranked Twelfth in Nation

Improving Nutrition Habits In Overweight Obese Adults With Physical Disabilities, Michelle Ullery

Nursing Capstones

No abstract provided.

Epigenome-Wide And Transcriptome-Wide Analyses Reveal Gestational Diabetes Is Associated With Alterations In The Human Leukocyte Antigen Complex, Alexandra M. Binder, Jessica Larocca, Corina Lesseur, Carmen J. Marsit, Karin B. Michels

Dartmouth Scholarship

Background: Gestational diabetes mellitus (GDM) affects approximately 10% of pregnancies in the United States and increases the risk of adverse health outcomes in the offspring. These adult disease propensities may be set by anatomical and molecular alterations in the placenta associated with GDM. Results: To assess the mechanistic aspects of fetal programming, we measured genome-wide methylation (Infinium HumanMethylation450 BeadChips) and expression (Affymetrix transcriptome microarrays) in placental tissue of 41 GDM cases and 41 matched pregnancies without maternal complications from the Harvard Epigenetic Birth Cohort. Specific transcriptional and epigenetic perturbations associated with GDM status included alterations in the major histocompatibility complex …

Written Debriefing: Evaluating The Impact Of The Addition Of A Written Component When Debriefing Simulations, Shelly Jensen Reed

Faculty Publications

Debriefing, the reflective period following a simulation, is said to be where the bulk of simulation learning takes place. Many expert opinions regarding debriefing exist, but evidence-based best practices have yet to be identified. Written debriefing is one of these practices; experts state learning can be extended through the addition of a written component to the debriefing process, but no evidence exists to support this. This study compares three debriefing types: discussion alone, and discussion followed by journaling or blogging. Undergraduate nursing students participating in a simulation were randomized as a simulation group to one of these three debriefing types. …

The Right Tool For The Job: Detection Of Soil-Transmitted Helminths In Areas Co-Endemic For Other Helminths, Maria V. Periago, Renata C. Diniz, Simone A. Pinto, Anna Yakovleva, Rodrigo Correa-Oliveira, David J. Diemert, Jeffrey M. Bethony

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Due to the recent increased use of the McMaster (MM) fecal egg counting method for assessing benzimidazole drug efficacy for treating soil-transmitted helminth (STH) infections, the aim of the current study was to determine the operational value of including the MM method alongside the Kato-Katz (KK) fecal thick smear to increase the diagnostic sensitivity when STHs are co-endemic with trematode helminths (e.g., Schistosoma mansoni).

Methods

A cross-sectional study was conducted in school-aged children aged 4-18 years in the northeastern region of the State of Minas Gerais (Brazil), where Necator americanus, Ascaris lumbricoides, Trichuris trichiura, and S …

Screening The Commercial Motor Vehicle Driver For Sleep Apnea, Dianna Ohlman

Dissertations

Abstract The transportation industry has the third highest occupational risk for death and disability (BLS, 2010) with 7% of Commercial Motor Vehicle Drivers (CMVD) falling asleep while driving (NHTSA, 2006). One contributing factor may be undiagnosed Obstructive Sleep Apnea (OSA) (Tregear et al, 2009). In 2006, a Joint Task Force (JTF) published screening recommendations for OSA, which led to a change in the Department of Transportation screening practices within a local Occupational Medicine clinic. The purpose of this study was to: (a) determine what percentage of drivers having had a positive clinical screening examination (met two of three objective measures) …

Beclin-1 Expression Is Retained In High-Grade Serous Ovarian Cancer Yet Is Not Essential For Autophagy Induction In Vitro, Rohann J.M. Correa, Yudith R. Valdes, Trevor G. Shepherd, Gabriel E. Dimattia

Anatomy and Cell Biology Publications

Background: Autophagy is a conserved cellular self-digestion mechanism that can either suppress or promote cancer in a context-dependent manner. In ovarian cancer, prevalent mono-allelic deletion of BECN1 (a canonical autophagy-inducer) suggests that autophagy is impaired to promote carcinogenesis and that Beclin-1 is a haploinsufficient tumor suppressor. Nonetheless, autophagy is known to be readily inducible in ovarian cancer cells. We sought to clarify whether Beclin-1 expression is in fact disrupted in ovarian cancer and whether this impacts autophagy regulation.

Methods: BECN1 expression levels were assessed using The Cancer Genome Atlas (TCGA) datasets from 398 ovarian high-grade serous cystadenocarcinomas (HGSC) and protein …

A Case Study Of The Impediments To The Commercialization Of Research At The University Of Kentucky, Nathan L. Vanderford, Elizabeth Marcinkowski

Markey Cancer Center Faculty Publications

The commercialization of university-based research occurs to varying degrees between academic institutions. Previous studies have found that multiple barriers can impede the effectiveness and efficiency by which academic research is commercialized. This case study was designed to better understand the impediments to research commercialization at the University of Kentucky via a survey and interview with three successful academic entrepreneurs. The study also garnered insight from the individuals as to how the commercialization process could be improved. Issues with commercialization infrastructure; a lack of emphasis, at the university level, on the importance of research commercialization; a void in an entrepreneurial culture …

Plasminogen Activator Inhibitor-1 Inhibitors And Methods Of Use Thereof To Modulate Lipid Metabolism, Daniel A. Lawrence, Dudley Strickland, Jacqueline Cale, Enming Joe Su, Cory Emal, Mark Warnock

Patents

The invention relates to plasminogen activator-I (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Georgia Southern study shows overweight and obese teens think they’re ‘just fine’

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Presents Inequalities and Approximations of Weighted Distributions
• Georgia Southern Study shows overweight and Obese teens think they're 'Just fine'.

Community Health News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Georgia Southern study shows overweight and obese teens think they’re ‘just fine’

Non-Steroidal Anti-Inflammatory Drug Use In Collegiate Athletes, Brian Robert Davis

Dissertations and Theses

Non-steroidal anti-inflammatory drugs (NSAID) are a class of medications used in the treatment of pain, inflammation, and illness. These medications are common, affordable, and easy to access. For these reasons, NSAIDs are commonly used by athletes of all backgrounds for treating injuries and as ergogenic aids. However, despite these behaviors, NSAIDs have well-documented side effects and the efficacious nature of these medications has been brought into question. Despite this, many athletes continue to use these medications frequently and indiscriminately. It is not known why athletes use these medications in light of their questionable effectiveness and cited adverse effects. Therefore, this …

Does The Iranian Model Of Kidney Donation Compensation Work As An Ethical Global Model?, Jordan Potter

Journal of Health Ethics

Throughout the world, there is a massive global shortage of viable organs available for transplantation, and systems of cadaveric organ donation have thus far been unable to address this shortage. One potential remedy to this problem is to incentive live organ donation via cash incentives and other benefits, i.e. an organ sale, and this is the type of system Iran has used to effectively eliminate its national kidney waiting list since the late 1990s. In this article, the Iranian model of kidney donation compensation will be analyzed for its ability and effectiveness as an ethical global model, and this is …

Effects Of An Instructional Intervention On Student Nurses' Awareness Of Hearing Impaired Patients' Communication Needs, Charles G. Marx, Kimberly Ward, Edward L. Goshorn, Virginia L. Sumrall

Journal of Health Ethics

A recent survey (Kemker, et al, 2013) of practicing nurses’ awareness of hearing impaired patients’ communication needs revealed a potential need to supplement the curriculum. The instructional areas that required supplemental information were related to assisting patients with their amplification devices and in verifying that a verbal message has been accurately received. These areas may not be sufficiently covered in a typical School of Nursing curriculum. To meet the curriculum needs and to address any potential ethical concerns regarding provision of care to this patient population, instructional materials were developed by the authors that directly addressed the identified areas. These …

Family Planning And Population Control In Developing Countries: Ethical And Sociocultural Dilemmas., Edward A. Komu M.D, Salome N. N. Ethelberg

Journal of Health Ethics

Do governments have the right to restrict individual freedom and right to have fewer or more children? Is it justifiable to control population in order to benefit society as a whole? Most of family planning and population control policies and programs in developing countries face resistant from the same people it aims to help. This can be mainly due to some ethical, socio-cultural beliefs, and moral values held by individuals and society as a whole. The challenges call for a need of family planning and population control programs to invest in examining ethical and socio-cultural dilemmas pertaining to these programs …

Intimate Partner Violence Screening And Implications For Health Care Providers, Lori Maria Walton Phd, Dpt, Mph (S), Femke Aerts Dpt, Haley Burkhart Dpt, Teresa Terry Dpt

Journal of Health Ethics

Abstract:

Purpose: The purpose of this literature review is to (1) present research on current IPV screening prevalence within the medical community, (2) emphasize the importance of IPV screening for physical therapists,(3) identify barriers that exist to IPV screening, (4) examine current teaching methods for IPV within healthcare curriculums and (5) identify valid and reliable IPV screening tools for clinical application. Description: A comprehensive literature search on six different databases was completed from September 2012 to March 2014. Search terms included intimate partner violence (IPV), domestic violence, health providers and IPV screening tools. Randomized control trials were included if they …

Csr Activity Of Tobacco Companies In Indonesia: Is It A Genuine Social Responsibility?, Harsman Tandilittin, Christoph Luetge

Journal of Health Ethics

The adoption of corporate social responsibility (CSR) programs in the tobacco industry has sparked a contentious debate in the international community. Tobacco industry’s CSR activities are honored by the government and Indonesian community with CSR awards due to their positive contributions. To assess the CSR activities of the tobacco companies and whether they are genuine forms of social responsibility or business motivation, we have collected the CSR activities and compared them with the negative impact of the tobacco industry in Indonesia. The CSR activities are in no way related to the negative impacts of tobacco in Indonesia. Therefore, CSR programs …

Drinking Age Increased To 25 Years In Some Parts Of India: An Ethical Perspective, Deavshri Mukherjee

Journal of Health Ethics

Alcohol consumption has always been a very well discussed public health problem in India. But the ethical aspects, with regards to the appropriate age of drinking, are what have emerged as a burning issue. Raising the minimum drinking age to 25 years in certain states of India has heated up this discussion leading to outrage and protest among youngsters across the country. Whether this decision was ethically right or wrong?

This short editorial highlights the ethical and moral aspects as per the standard ethical norms involved with this decision.

Ada News - 08/03/2015, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

What's Happening: August 3, 2015, Maine Medical Center

What's Happening

No abstract provided.

Truncating Mutation In The Autophagy Gene Uvrag Confers Oncogenic Properties And Chemosensitivity In Colorectal Cancers, Shanshan He, Zhen Zhao, Yongfei Yang, Douglas O'Connell, Xiaowei Zhang, Soohwan Oh, Binyun Ma, Joo-Hyung Lee, Tian Zhang, Bino Varghese, Janae Yip, Sara Dolatshahi Pirooz, Ming Li, Yong Zhang, Guo-Min Li, Sue Ellen Martin, Keigo Machida, Chengyu Liang

Toxicology and Cancer Biology Faculty Publications

Autophagy-related factors are implicated in metabolic adaptation and cancer metastasis. However, the role of autophagy factors in cancer progression and their effect in treatment response remain largely elusive. Recent studies have shown that UVRAG, a key autophagic tumour suppressor, is mutated in common human cancers. Here we demonstrate that the cancer-related UVRAG frameshift (FS), which does not result in a null mutation, is expressed as a truncated UVRAG^FS in colorectal cancer (CRC) with microsatellite instability (MSI), and promotes tumorigenesis. UVRAG^FS abrogates the normal functions of UVRAG, including autophagy, in a dominant-negative manner. Furthermore, expression of UVRAG^FS can …

Impact Of Standardized Oral Health Assessment On Preventing Ventilator-Associated Events, Juana Ambriz De Williams

Evidence-Based Practice Project Reports

Ventilator-associated pneumonia (VAP) is a common but preventable health-care associated infection that affects up to 20% of mechanically ventilated adult patients, resulting in estimated mortality rates ranging from 13% to 55% (Chahoud, Semaan, Almoosa, 2015; Melsen et al., 2013). In an effort to reduce morbidity, mortality and related costs, the Centers for Disease Control and Prevention (CDC) and the National Healthcare Safety Network (NHSN), proposed ventilator-associated pneumonia prevention as a national patient safety goal. In 2014, amid growing concerns that the subjectivity of existing definitions had led to inconsistent reporting, thereby impeding efforts to reduce VAP, the CDC refocused surveillance …

Medical School Watercooler Newsletter - August 2, 2015, Lindsey Lyle

Watercooler Newsletter

This is the August 2, 2015 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

August Med School Café - 'LINX- A Revolutionary New Treatment for Severe GERD'

USA Welcomes Dr. Abhijin Das

USA College of Medicine to Host Two Special Seminars

42nd Annual Medical Student Research Day Features Dr. Dan Roden

Tobacco Cessation: Supporting a Coworker

Prescriber Education Of Current Clinical Practice Guidelines For Urinary Tract Infections, Carol Medura

Doctor of Nursing Practice (DNP) Program

Urinary tract infections are one of the most common illnesses and inappropriate treatment of a urinary tract infection can have severe implications for the patient, including development of antibiotic resistance, increases in illness and health care costs. Discrepancies exist between provider practice behaviors and use of current clinical practice guidelines. This capstone project was to present clinical practice guidelines to emergency department providers to educate and improve the use of first-line antibiotics for the treatment of uncomplicated urinary tract infections. The review of the literature supported the use of education to increase adherence to guidelines. The providers at the emergency …

The Effectiveness Of Implementing Standard Of Care Best Practices Including Use Of Daily Incentive Spirometry To Improve Dyspnea And Quality Of Life In Adults With Chronic Obstructive Pulmonary Disease (Copd), Christine Gallagher

Doctor of Nursing Practice (DNP) Program

Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable disease characterized by symptoms of dyspnea, cough, and wheezing. Many patients with COPD are on daily medications for their symptoms yet these symptoms continue to persist, impairing their quality of life. Patients with COPD experience respiratory muscle weakness that contributes to dyspnea and an inability to participate in daily activities. GOLD (2014) guidelines state that the goal of therapy in these patients is to reduce symptoms, increase participation in activities, and restore the highest level of independent functioning. The guidelines recommend the use of inspiratory muscle training (IMT) in …