Medicine and Health Sciences Commons^™

Diversity Speakers Series: Health Policy Management In The 21st Century, Antonia Novello

Diversity and Inclusion

Program for “Health Policy Management in the 21st Century” by Antonia Novello, MD, Former U.S. Surgeon General

Do Three Different Passive Assessments Of Quadriceps Spasticity Relate To The Functional Activity Of Walking For Children Diagnosed With Cerebral Palsy?, Hank White, Tim L. Uhl, Sam Augsburger

Physical Therapy Faculty Publications

A stiff-knee gait pattern is frequently associated with several impairments including quadriceps spasticity in children diagnosed with cerebral palsy (CP). The relationship of clinical measures of quadriceps spasticity and the stiff-knee gait pattern in children diagnosed with CP has not been well established. Therefore, the purpose of this study was to determine the ability of clinical measures of quadriceps spasticity (modified Ashworth scale [MAS], Ely tests, and pendulum test) to categorize a stiff-knee gait pattern in children with CP. Children were categorized as having a stiff-knee gait pattern based on kinematic and EMG gait data. Results of a logistic regression …

Nurse Internship In Washington. A Rehab Nurse Perspective., Tina Roma Fisher Msn, Rn, Crrn

Patient Care Services / Nursing

No abstract provided.

Disc In Flames: Roles Of Tnf-Α And Il-1Β In Intervertebral Disc Degeneration., Z I Johnson, Z R Schoepflin, H Choi, I M Shapiro, M V Risbud

Department of Orthopaedic Surgery Faculty Papers

The intervertebral disc is an important mechanical structure that allows range of motion of the spinal column. Degeneration of the intervertebral disc--incited by aging, traumatic insult, genetic predisposition, or other factors--is often defined by functional and structural changes in the tissue, including excessive breakdown of the extracellular matrix, increased disc cell senescence and death, as well as compromised biomechanical function of the tissue. Intervertebral disc degeneration is strongly correlated with low back pain, which is a highly prevalent and costly condition, significantly contributing to loss in productivity and health care costs. Disc degeneration is a chronic, progressive condition, and current …

Medical School Watercooler Newsletter - September 20, 2015, Lindsey Lyle

Watercooler Newsletter

This is the September 20, 2015 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

USA to Host Welcome Reception Oct. 8

USA Welcomes Dr. Philip Almalouf

Sept. 24 DSS to Feature Dr. Lucio Miele

Clyde G. 'Sid' Huggins Medical Student Research Awards Announced

Measuring The Potential Impact Of Combination Hiv Prevention In Sub-Saharan Africa, Amin Khademi, Sunanth Anand, David Potts

Publications

A public health approach to combination HIV prevention is advocated to contain the epidemic in sub-Saharan Africa. We explore the implications of universal access to treatment along with HIV education scale-up in the region. We develop an HIV transmission model to investigate the impacts of universal access to treatment, as well as an analytical framework to estimate the effects of HIV education scale-up on the epidemic. We calibrate the model with data from South Africa and simulate the impacts of universal access to treatment along with HIV education scale-up on prevalence, incidence, and HIV-related deaths over a course of 15 …

A Home-Based Comprehensive Care Model In Patients With Multiple Sclerosis: A Study Pre-Protocol., Lufei Young, Kathleen Healey, Mary Charlton, Kendra Schmid, Rana Zabad, Rebecca Wester

Journal Articles: College of Nursing

Background Disability is prevalent in individuals with multiple sclerosis (MS), leading to difficulty in care access, significant caregiver burden, immense challenges in self-care and great societal burden. Without highly coordinated, competent and accessible care, individuals living with progressive MS experience psychological distress, poor quality of life, suffer from life-threatening complications, and have frequent but avoidable healthcare utilizations. Unfortunately, current healthcare delivery models present severe limitations in providing easily accessible, patient-centered, coordinated comprehensive care to those with progressive MS. We propose a home-based comprehensive care model (MAHA) to address the unmet needs, challenges, and avoidable complications in individuals with progressive MS …

As He Lay Dying: Fda And Huntington’S Disease Families Meet To Ponder Potential Treatments, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A Case Of Three Patients With Severe Hypothermia Rewarmed With Ecmo, Matthew Niehaus Do, Rita Pechulis Md, Fccp, James K. Wu Md

Department of Emergency Medicine

No abstract provided.

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Examines Variation in Public Health Governance
• Georgia Southern Examined Rural-Urban differences in Perceptions of Child Overweight

Preparation And Characterization Of Anti-Hiv Nanodrug Targeted To Microfold Cell Of Gut-Associated Lymphoid Tissue, Upal Roy, Hong Ding, Sudheesh Pilakka-Kanthikeel, Andrea D. Raymond, Venkata Atluri, Adriana Yndart, Elena M. Kaftanovskaya, Elena Batrakova, Marisela Agudelo, Madhavan Nair

Health & Biomedical Sciences Faculty Publications

The human immunodeficiency virus 1 (HIV-1) still remains one of the leading life-threatening diseases in the world. The introduction of highly active antiretroviral therapy has significantly reduced disease morbidity and mortality. However, most of the drugs have variable penetrance into viral reservoir sites, including gut-associated lymphoid tissue (GALT). Being the largest lymphoid organ, GALT plays a key role in early HIV infection and host–pathogen interaction. Many different treatment options have been proposed to eradicate the virus from GALT. However, it becomes difficult to deliver traditional drugs to the GALT because of its complex physiology. In this regard, we developed a …

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Georgia Southern Examined Rural-Urban Differences in Perceptions of Child Overweight

Lysyl Hydroxylase 3 Localizes To Epidermal Basement Membrane And Is Reduced In Patients With Recessive Dystrophic Epidermolysis Bullosa., Stephen A Watt, Jasbani H S Dayal, Sheila Wright, Megan Riddle, Celine Pourreyron, James R Mcmillan, Roy M Kimble, Marco Prisco, Ulrike Gartner, Emma Warbrick, W H Irwin Mclean, Irene M Leigh, John A Mcgrath, Julio C Salas-Alanis, Jakub Tolar, Andrew P South

Department of Dermatology and Cutaneous Biology Faculty Papers

Recessive dystrophic epidermolysis bullosa (RDEB) is caused by mutations in COL7A1 resulting in reduced or absent type VII collagen, aberrant anchoring fibril formation and subsequent dermal-epidermal fragility. Here, we identify a significant decrease in PLOD3 expression and its encoded protein, the collagen modifying enzyme lysyl hydroxylase 3 (LH3), in RDEB. We show abundant LH3 localising to the basement membrane in normal skin which is severely depleted in RDEB patient skin. We demonstrate expression is in-part regulated by endogenous type VII collagen and that, in agreement with previous studies, even small reductions in LH3 expression lead to significantly less secreted LH3 …

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Georgia Southern Examines Variation in Public Health Governance
• Georgia Southern Examined Rural-Urban Differences in Perceptions of Child Overweight

Research Brief: "Suicide Risk Among 1.3 Million Veterans Who Were On Active Duty During The Iraq And Afghanistan Wars", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is about a comparison between the post-service suicide risk of recent wartime veterans versus the suicide risk of the general population in the US. In policy and practice, veterans at risk for suicide should seek counseling, counselors should be aware of military service-specific stressors, and family members should support veterans through readjustment periods; the DoD and VA should continue offering medical screening and counseling services to recent veterans and veterans who were deployed. Suggestions for future research include examining the reasons for lower rates of suicide within certain military branches, determining the reasons for an excess suicide rate …

Frontal Gray Matter Abnormalities Predict Seizure Outcome In Refractory Temporal Lobe Epilepsy Patients, Gaelle Eve Doucet, Xiaosong He, Michael R Sperling, Ashwini Sharan Md, Joseph I. Tracy

Department of Neurology Faculty Papers

This article has been peer reviewed. It was published in: NeuroImage: Clinical. Volume 9, 2015, Pages 458-466.

The published version is available at DOI: 10.1016/j.nicl.2015.09.006

Copyright © 2015 The Authors.

Weak Tradeoff Between Xylem Safety And Xylem-Specific Hydraulic Efficiency Across The World's Woody Plant Species., Sean M Gleason, Mark Westoby, Steven Jansen, Brendan Choat, Uwe G Hacke, Robert B Pratt, Radika Bhaskar, Tim J Brodribb, Sandra J Bucci, Kun-Fang Cao, Hervé Cochard, Sylvain Delzon, Jean-Christophe Domec, Ze-Xin Fan, Taylor S Feild, Anna L Jacobsen, Daniel M Johnson, Frederic Lens, Hafiz Maherali, Jordi Martínez-Vilalta, Stefan Mayr, Katherine A Mcculloh, Maurizio Mencuccini, Patrick J Mitchell, Hugh Morris, Andrea Nardini, Jarmila Pittermann, Lenka Plavcová, Stefan G Schreiber, John S Sperry, Ian J Wright, Amy E Zanne

Anatomy and Regenerative Biology Faculty Publications

The evolution of lignified xylem allowed for the efficient transport of water under tension, but also exposed the vascular network to the risk of gas emboli and the spread of gas between xylem conduits, thus impeding sap transport to the leaves. A well-known hypothesis proposes that the safety of xylem (its ability to resist embolism formation and spread) should trade off against xylem efficiency (its capacity to transport water). We tested this safety-efficiency hypothesis in branch xylem across 335 angiosperm and 89 gymnosperm species. Safety was considered at three levels: the xylem water potentials where 12%, 50% and 88% of …

An In Vitro Study Comparing Limited To Full Cementation Of Polyethylene Glenoid Components, R. Andrew Glennie, Joshua W. Giles, James A. Johnson, George S. Athwal, Kenneth J. Faber

Bone and Joint Institute

© 2015 Glennie et al. Background: Glenoid component survival is critical to good long-term outcomes in total shoulder arthroplasty. Optimizing the fixation environment is paramount. The purpose of this study was to compare two glenoid cementing techniques for fixation in total shoulder arthroplasty. Methods: Sixteen cadaveric specimens were randomized to receive peg-only cementation (CPEG) or full back-side cementation (CBACK). Physiological cyclic loading was performed and implant displacement was recorded using an optical tracking system. The cement mantle was examined with micro-computed tomography before and after cyclic loading. Results: Significantly greater implant displacement away from the inferior portion of the glenoid …

Statins Increase Plasminogen Activator Inhibitor Type 1 Gene Transcription Through A Pregnane X Receptor Regulated Element., Frederick M Stanley, Kathryn M Linder, Timothy J Cardozo

Department of Medical Genetics Faculty Papers

Plasminogen activator inhibitor type 1 (PAI-1) is a multifunctional protein that has important roles in inflammation and wound healing. Its aberrant regulation may contribute to many disease processes such as heart disease. The PAI-1 promoter is responsive to multiple inputs including cytokines, growth factors, steroids and oxidative stress. The statin drugs, atorvastatin, mevastatin and rosuvastatin, increased basal and stimulated expression of the PAI-1 promoter 3-fold. A statin-responsive, nuclear hormone response element was previously identified in the PAI-1 promoter, but it was incompletely characterized. We characterized this direct repeat (DR) of AGGTCA with a 3-nucleotide spacer at -269/-255 using deletion and …

Analgesic Effect Of Cathodal Transcranial Current Stimulation Over Right Dorsolateral Prefrontal Cortex In Subjects With Muscular Temporomandibular Disorders: Study Protocol For A Randomized Controlled Trial, Rivail Almeida Brandão Filho, Abrahão Fontes Baptista, Renata De Assis Fonseca Santos Brandão, Francisco Monteiro Meneses, Jeffrey P. Okeson, Eduardo Pondé De Sena

Oral Health Science Faculty Publications

BACKGROUND: Temporomandibular disorders are a group of orofacial pain conditions that are commonly identified in the general population. Like many other chronic pain conditions, they can be associated with anxiety/depression, which can be related to changes in the activity of the dorsolateral prefrontal cortex. Some studies have demonstrated clinical improvement in subjects with chronic pain who are given therapeutic neuromodulation. Transcranial direct current stimulation is a noninvasive brain stimulation technique that allows the modulation of neuronal membranes. This therapy can enhance or inhibit action potential generation in cortical neurons. In some instances, medications acting in the central nervous system may …

Parenting Around Child Snacking: Development Of A Theoretically-Guided, Empirically Informed Conceptual Model, Kirsten K. Davison, Christine E. Blake Ph.D., Rd, Rachel E. Blaine, Nicholas A. Younginer, Alexandria Orloski, Heather A. Hamtil, Claudia Ganter, Yasmeen P. Bruton, Amber E. Vaughn, Jennifer O. Fisher

Faculty Publications

Background: Snacking contributes to excessive energy intakes in children. Yet factors shaping child snacking are virtually unstudied. This study examines food parenting practices specific to child snacking among low-income caregivers. Methods: Semi-structured interviews were conducted in English or Spanish with 60 low-income caregivers of preschool-aged children (18 non-Hispanic white, 22 African American/Black, 20 Hispanic; 92% mothers). A structured interview guide was used to solicit caregivers' definitions of snacking and strategies they use to decide what, when and how much snack their child eats. Interviews were audio-recorded, transcribed verbatim and analyzed using an iterative theory-based and grounded approach. A conceptual model …

Rising Gasoline Prices Increase New Motorcycle Sales And Fatalities, He Zhu, Fernando A. Wilson, Jim P. Stimpson, Peter E. Hilsenrath

Publications and Research

Background: We examined whether sales of new motorcycles was a mechanism to explain the relationship between motorcycle fatalities and gasoline prices.

Methods: The data came from the Motorcycle Industry Council, Energy Information Administration and Fatality Analysis Reporting System for 1984–2009. Autoregressive integrated moving average (ARIMA) regressions estimated the effect of inflation-adjusted gasoline price on motorcycle sales and logistic regressions estimated odds ratios (ORs) between new and old motorcycle fatalities when gasoline prices increase.

Results: New motorcycle sales were positively correlated with gasoline prices (r = 0.78) and new motorcycle fatalities (r = 0.92). ARIMA analysis estimated that a US$1 increase …

Role Of Mrp Transporters In Regulating Antimicrobial Drug Inefficacy And Oxidative Stress-Induced Pathogenesis During Hiv-1 And Tb Infections, Upal Roy, Paul Barber, Yuk-Ching Tse-Dinh, Elena V. Batrakova, Debasis Mondal, Madhavan Nair

Health & Biomedical Sciences Faculty Publications

Multi-Drug Resistance Proteins (MRPs) are members of the ATP binding cassette (ABC) drug-efflux transporter superfamily. MRPs are known to regulate the efficacy of a broad range of anti-retroviral drugs (ARV) used in highly active antiretroviral therapy (HAART) and antibacterial agents used in Tuberculus Bacilli (TB) therapy. Due to their role in efflux of glutathione (GSH) conjugated drugs, MRPs can also regulate cellular oxidative stress, which may contribute to both HIV and/or TB pathogenesis. This review focuses on the characteristics, functional expression, and modulation of known members of the MRP family in HIV infected cells exposed to ARV drugs and discusses …

Eisosomes Provide Membrane Reservoirs For Rapid Expansion Of The Yeast Plasma Membrane, Ruth Kabeche, Louisa Howard, James B. Moseley

Dartmouth Scholarship

Cell surface area rapidly increases during mechanical and hypoosmotic stresses. Such expansion of the plasma membrane requires 'membrane reservoirs' that provide surface area and buffer membrane tension, but the sources of this membrane remain poorly understood. In principle, the flattening of invaginations and buds within the plasma membrane could provide this additional surface area, as recently shown for caveolae in animal cells. Here, we used microfluidics to study the rapid expansion of the yeast plasma membrane in protoplasts, which lack the rigid cell wall. To survive hypoosmotic stress, yeast cell protoplasts required eisosomes, protein-based structures that generate long invaginations at …

Current State Of The Art Of Regional Hyperthermia Treatment Planning: A Review., H P Kok, P Wust, Paul R. Stauffer, F Bardati, G C Van Rhoon, J Crezee

Department of Radiation Oncology Faculty Papers

Locoregional hyperthermia, i.e. increasing the tumor temperature to 40-45 °C using an external heating device, is a very effective radio and chemosensitizer, which significantly improves clinical outcome. There is a clear thermal dose-effect relation, but the pursued optimal thermal dose of 43 °C for 1 h can often not be realized due to treatment limiting hot spots in normal tissue. Modern heating devices have a large number of independent antennas, which provides flexible power steering to optimize tumor heating and minimize hot spots, but manual selection of optimal settings is difficult. Treatment planning is a very valuable tool to improve …

The Durational Effects Of A Free Operant Condition On Automatically Maintained Stereotypic Behavior And Discrete Trial Task Responding, Shikika Sade Young

USF Tampa Graduate Theses and Dissertations

This study examined the effects of three fixed-duration free operant access conditions on rates of automatically maintained stereotypic behavior and correct task responding during discrete trial training (DTT) with two children diagnosed with autism. Following a functional analysis, confirming automatic function, interviews/observations were conducted to identify behavioral indicators of satiation and an average satiation level. In this endeavor, participants were exposed to a free operant condition to validate satiation of stereotypic responding. Once satiation level was averaged, two durational conditions were computed: Long (75% access) and Short (25% access). A third condition, Deprivation, involved blocking all attempts at the stereotypic …

Assessing The Occupational Nosie Exposure Of Bartenders, Adrianna J. Woltman

USF Tampa Graduate Theses and Dissertations

The Occupational Safety and Health Administration estimates that each year, approximately 30 million people are occupationally exposed to hazardous noise. While many are aware of the noise exposure associated with industrial occupations, there has been little research conducted on bartenders who often work in environments that have high levels of noise. The majority of current published research on occupational noise exposure of bartenders has only evaluated noise levels on one night of business. Bartenders often work multiple days per week, which vary in the amount of patrons and entertainment provided, this variation in business leads to variation in the amount …

Rape, Race, And Capital Punishment In North Carolina: A Qualitative Approach To Examining An Enduring Cultural Legacy, Douglas Wholl

USF Tampa Graduate Theses and Dissertations

Despite positive steps toward the suppression of racial discrimination in the United States capital punishment process, the enduring effects of a cultural legacy of Black oppression (e.g., slavery; segregation; lynching) and historic and systemic racial discrimination in the criminal justice system have persisted to the present day. The purpose of the current study is to explore whether this enduring cultural legacy still exists by examining whether juries in rape-involved capital murder trials in North Carolina are more likely to recommend a sentence of death when the defendant is a Black male and the victim is a White female (compared to …

Evaluation Of Soil As A Risk Indicator For Human Leptospirosis In Coastal, Rural Ecuador, Chad Allen Weddell

USF Tampa Graduate Theses and Dissertations

Leptospirosis, a zoonotic disease caused by pathogenic spirochete bacteria (family Leptospiraceae, genus Leptospira), is endemic in developing tropical regions of the world. It occurs in epidemics and is endemic in Ecuador where environmental conditions are ideal for maintenance. The role of soil as a long term reservoir has been previously been documented. Geographic Information System (GIS) and Remote Sensing (RS) technology was used in our study to further explore the role of soil as an environmental reservoir and its potential use as a static risk indicator for disease. Red, Green, Blue (RGB) spectral band data from known leptospire …

A Socio-Ecological Model Of Affordable Care Act Acceptance, Pratiksha Vaghela

USF Tampa Graduate Theses and Dissertations

Background: Since 1965, there have not been any major revisions of the healthcare laws in the United States, until the recent implementation of the Affordable Care Act (ACA). However, ACA is not well understood and is often controversial. The purpose of this study is to: (1) evaluate the relationship between the employers’ and the employees’ perceptions regarding the ACA mandates for small businesses, (2) evaluate the relationship between the self-reported and the tested knowledge of individuals regarding the ACA mandates for small businesses, and (3) determine if socio-demographic factors influence individual’s perception of the law. Based on the gathered information, …