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2015

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Articles 1651 - 1680 of 11981

Full-Text Articles in Medicine and Health Sciences

Nurses’ Knowledge And Attitudes Toward Implementation Of Electronic Medical Records, Cathy H. Abell, Tonya Bragg-Underwood, Lori Alexander, Caitlyn Elizabeth Abell, Vanessa Burd Oct 2015

Nurses’ Knowledge And Attitudes Toward Implementation Of Electronic Medical Records, Cathy H. Abell, Tonya Bragg-Underwood, Lori Alexander, Caitlyn Elizabeth Abell, Vanessa Burd

International Journal of Faith Community Nursing

With the growth of Faith Community Nursing (FCN), one topic that needs further exploration is documentation. This includes the use of electronic medical records (EMRs). Nurses play a vital role in the planning and implementation of EMRs in the acute care setting and will also play a key role in Faith Community Nursing Programs that stand alone or partner with a health care agency. Individual computer expertise and/or attitude and knowledge of EMRs could be important in the successful implementation. Researchers utilized a modified version of the EMR questionnaire designed by Beiter and colleagues to examine nurses’ knowledge and attitudes …


Demonstration: Development Of A Minimum Set Of Parish Nurse Educational Outcomes And Behavioral Objectives, Deborah Ziebarth Oct 2015

Demonstration: Development Of A Minimum Set Of Parish Nurse Educational Outcomes And Behavioral Objectives, Deborah Ziebarth

International Journal of Faith Community Nursing

A Wisconsin parish nurse educator asked the question, “...who has the authority to say what is parish nursing in the state of Wisconsin and what are the key elements of a parish nurse training curriculum?” This work represents a six year effort to answer that question. This project answers the question by examining the essential core elements of parish nursing (now referred to as faith community nursing) training curriculums taught in the state of Wisconsin. Ultimately the project provided a minimum set of standardized education outcomes and behavioral objectives for training courses throughout the state. The work began with a …


The Role Of The Faith Community Nurse In Fostering Spirituality In Those With Alzheimer's Disease, Verna Carson Phd, Pmh/Cns-Bc Oct 2015

The Role Of The Faith Community Nurse In Fostering Spirituality In Those With Alzheimer's Disease, Verna Carson Phd, Pmh/Cns-Bc

International Journal of Faith Community Nursing

Alzheimer ’s disease (AD) strips individuals of memories and abilities that have defined them as productive adults throughout their life. While the decline in memory is real and results in a ‘loss of self’ this does not equate to a ‘loss of soul.’ AD patients continue to have spiritual needs throughout their life as do the family, and/or caregivers. This article explores the spiritual needs and care of AD patients and families and the unique opportunity faith community nurses have to help the AD patient and their support system. The Reisberg Functional Assessment Staging System is used to explain the …


Faith Community Nursing – A Specialty Within The Profession Of Nursing, Andrea M. West Oct 2015

Faith Community Nursing – A Specialty Within The Profession Of Nursing, Andrea M. West

International Journal of Faith Community Nursing

This article outlines the characteristics of a profession. A discussion of how professional organizations benefit nursing is provided and the rationale for the development of Faith Community Nurses International (FCNI). The goals and future plans of FCNI are reviewed.


Fcni News-October 2015, Beverly Siegrist Oct 2015

Fcni News-October 2015, Beverly Siegrist

International Journal of Faith Community Nursing

No abstract provided.


Analytic Approaches For Causal Inference With Complex Multi-Component Interventions, Glen P. Mays, Arnold J. Stromberg, Jing Li, Mark V. Williams Oct 2015

Analytic Approaches For Causal Inference With Complex Multi-Component Interventions, Glen P. Mays, Arnold J. Stromberg, Jing Li, Mark V. Williams

Health Management and Policy Presentations

Estimating the causal effects of complex, multi-component health interventions is a task with many challenges in measurement and methodology. This presentation profiles the methods being used as part of the PCORI-funded Project Achieve, a national study to estimate the comparative effectiveness of heterogeneous care transition programs designed to help hospitalized patients and their caregivers navigate care delivery systems effectively and return back to the community with optimal health and wellbeing.


Way Forward On Healthcare?, William H. Lane Oct 2015

Way Forward On Healthcare?, William H. Lane

English Faculty Publications

In the wake of a remarkable visit from Pope Francis, is it time to ask, WWFD? What would Francis do with our half-fixed, highly fragmented healthcare system? [excerpt]


Dynapenic Obesity And The Effect On Long-Term Physical Function And Quality Of Life: Data From The Osteoarthritis Initiative, John A. Batsis, Alicia J. Zbehlik, Dawna Pidgeon, Stephen J. Bartels Oct 2015

Dynapenic Obesity And The Effect On Long-Term Physical Function And Quality Of Life: Data From The Osteoarthritis Initiative, John A. Batsis, Alicia J. Zbehlik, Dawna Pidgeon, Stephen J. Bartels

Dartmouth Scholarship

Obesity is associated with functional impairment, institutionalization, and increased mortality risk in elders. Dynapenia is defined as reduced muscle strength and is a known independent predictor of adverse events and disability. The synergy between dynapenia and obesity leads to worse outcomes than either independently. We identified the impact of dynapenic obesity in a cohort at risk for and with knee osteoarthritis on function.


October 7, 2015, Communication Disorders & Sciences Oct 2015

October 7, 2015, Communication Disorders & Sciences

Faculty Meeting Minutes & Agendas

Meeting agenda of the October 7, 2015 Faculty Meeting.


Preserved Haptic Shape Processing After Bilateral Loc Lesions., Jacqueline C Snow, Melvyn A Goodale, Jody C Culham Oct 2015

Preserved Haptic Shape Processing After Bilateral Loc Lesions., Jacqueline C Snow, Melvyn A Goodale, Jody C Culham

Brain and Mind Institute Researchers' Publications

UNLABELLED: The visual and haptic perceptual systems are understood to share a common neural representation of object shape. A region thought to be critical for recognizing visual and haptic shape information is the lateral occipital complex (LOC). We investigated whether LOC is essential for haptic shape recognition in humans by studying behavioral responses and brain activation for haptically explored objects in a patient (M.C.) with bilateral lesions of the occipitotemporal cortex, including LOC. Despite severe deficits in recognizing objects using vision, M.C. was able to accurately recognize objects via touch. M.C.'s psychophysical response profile to haptically explored shapes was also …


Plant-Derived Sac Domain Of Par-4 (Prostate Apoptosis Response 4) Exhibits Growth Inhibitory Effects In Prostate Cancer Cells, Shayan Sarkar, Sumeet Jain, Vineeta Rai, Dipak K. Sahoo, Sumita Raha, Sujit Suklabaidya, Shantibhusan Senapati, Vivek M. Rangnekar, Indu B. Maiti, Nrisingha Dey Oct 2015

Plant-Derived Sac Domain Of Par-4 (Prostate Apoptosis Response 4) Exhibits Growth Inhibitory Effects In Prostate Cancer Cells, Shayan Sarkar, Sumeet Jain, Vineeta Rai, Dipak K. Sahoo, Sumita Raha, Sujit Suklabaidya, Shantibhusan Senapati, Vivek M. Rangnekar, Indu B. Maiti, Nrisingha Dey

Radiation Medicine Faculty Publications

The gene Par-4 (Prostate Apoptosis Response 4) was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4) selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV) and apoplast signal peptide (aTP) in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. …


A Pain In The Neck, Jed Grant Oct 2015

A Pain In The Neck, Jed Grant

Physician Assistant Faculty & Staff Presentations

No abstract provided.


Toxicologic Emergencies, Jed Grant Oct 2015

Toxicologic Emergencies, Jed Grant

Physician Assistant Faculty & Staff Presentations

No abstract provided.


Neurofibromatosis Type 2 Patient Presenting With Medulloblastoma, Jan Kalimullah, Abdul Malik Amir Humza Sohail, Rai Shahjehan, Sabeehuddin Siddique, Muhammad Ehsan Bari Oct 2015

Neurofibromatosis Type 2 Patient Presenting With Medulloblastoma, Jan Kalimullah, Abdul Malik Amir Humza Sohail, Rai Shahjehan, Sabeehuddin Siddique, Muhammad Ehsan Bari

Section of Neurosurgery

Background: Neurofibromatosis type 2 (NF2) is an autosomal dominant syndrome with a frequency of 1 in 25,000 live births and a penetrance of almost 100% by the sixth decade of life. The main tumors occurring in NF2 patients are bilateral vestibular schwannomas, other peripheral, cranial and spinal nerve schwannomas, intracranial and intraspinal meningiomas, ependymomas, and gliomas.
Case description: We report the case of a 6-year-old boy who presented with a 1-month history of nausea and recurrent vomiting. Physical examination was positive for ataxic gait and left-sided facial nerve palsy. Family history was positive for NF2 in the patient's father and …


Creating An Orthopedic Specialty Hospital Focused On Exceptional Patient Experience, High Clinical Quality, And Benchmark Level Efficiencies, Louann Newman Rn, Cnor Oct 2015

Creating An Orthopedic Specialty Hospital Focused On Exceptional Patient Experience, High Clinical Quality, And Benchmark Level Efficiencies, Louann Newman Rn, Cnor

Patient Care Services / Nursing

No abstract provided.


A Pilot Comparison Of Phospolipidated Lutein To Conventional Lutein For Effects On Plasma Lutein Concentrations In Adult People., Robert A Disilvestro, Sara Thomas, Earl Harrison, Alice Epitropoulos Oct 2015

A Pilot Comparison Of Phospolipidated Lutein To Conventional Lutein For Effects On Plasma Lutein Concentrations In Adult People., Robert A Disilvestro, Sara Thomas, Earl Harrison, Alice Epitropoulos

Ambulatory and Primary Care Articles

BACKGROUND: The percent absorption of lutein from supplements falls well below that from lutein enriched egg yolk, a rich source of phospholipids. Therefore, a supplement of lutein plus phospholipids was tested for effects on serum accumulation.

METHODS: A 10 day supplementation with a solid-lipid particle (SLP) lutein complex or conventional lutein ester was done in apparently healthy people (both supplement types taken with fat containing meals). Plasma lutein was measured pre- and post-supplementation as well as 7 days after supplementation stopped. Changes within each supplement group were analyzed by paired t-test; group comparisons were done by unpaired t-test.

RESULTS: The …


Validation Of Accelerometer Thresholds And Inclinometry For Measurement Of Sedentary Behavior In Young Adult University Students, Neil E. Peterson, John R. Sirard, Pamela A. Kulbok, Mark D. Deboer, Jeanne M. Erickson Oct 2015

Validation Of Accelerometer Thresholds And Inclinometry For Measurement Of Sedentary Behavior In Young Adult University Students, Neil E. Peterson, John R. Sirard, Pamela A. Kulbok, Mark D. Deboer, Jeanne M. Erickson

Faculty Publications

Sedentary behavior (SB) is a major contributing factor to obesity and significant morbidity and mortality in adolescence and into adulthood, yet measuring SB is difficult. The purpose of this study was to assess the degree of construct validity of the ActiGraph GT3X+ inclinometer function and accelerometry metrics in objectively measuring SB and physical activity in young adult university students while performing semi-structured activities: lying, sitting, reading, playing seated video gaming, video watching, seated conversation, standing, stationary biking, and walking. These nine activities were objectively assessed using inclinometry and four output metrics from the ActiGraph based on the axis used to …


When Mumps Is Not The Diagnosis: Acute Sialadenitis During Influenza Season, Tasha Desai Do, Tibisay Villalobos Md Oct 2015

When Mumps Is Not The Diagnosis: Acute Sialadenitis During Influenza Season, Tasha Desai Do, Tibisay Villalobos Md

Department of Pediatrics

No abstract provided.


Vascular Ring In An Adolescent Patient With Nausea And Mild Dysphagia, Kristen Kametz Crnp Oct 2015

Vascular Ring In An Adolescent Patient With Nausea And Mild Dysphagia, Kristen Kametz Crnp

Department of Pediatrics

No abstract provided.


Stella Jedrziewski Wawrynovic, Genevieve Jedrziewski Williams, Kelsey Duinkerken Oct 2015

Stella Jedrziewski Wawrynovic, Genevieve Jedrziewski Williams, Kelsey Duinkerken

Jefferson Nursing Oral Histories

This oral history was completed with Genevieve (Jenny) Williams about her older sister Stella Jedrziewski Wawrynovic, a 1940 graduate of Jefferson's Nursing Training School.

Stella Jedrziewski Wawrynovic was born in Osceola Mills, Pennsylvania to Polish immigrants. Her parents championed the importance of education for all of their children, and so when the oldest daughter Stella graduated from high school in 1936 she moved to Philadelphia to pursue a nursing degree at Jefferson's Nursing School. She began her career at Jefferson before joining the Army during WWII to work as a nurse. After the war she returned to Jefferson, where she …


The Hand Of Homo Naledi, Tracy L. Kivell, Andrew S. Deane, Matthew W. Tocheri, Caley M. Orr, Peter Schmid, John Hawks, Lee R. Berger, Steven E. Churchill Oct 2015

The Hand Of Homo Naledi, Tracy L. Kivell, Andrew S. Deane, Matthew W. Tocheri, Caley M. Orr, Peter Schmid, John Hawks, Lee R. Berger, Steven E. Churchill

Neuroscience Faculty Publications

A nearly complete right hand of an adult hominin was recovered from the Rising Star cave system, South Africa. Based on associated hominin material, the bones of this hand are attributed to Homo naledi. This hand reveals a long, robust thumb and derived wrist morphology that is shared with Neandertals and modern humans, and considered adaptive for intensified manual manipulation. However, the finger bones are longer and more curved than in most australopiths, indicating frequent use of the hand during life for strong grasping during locomotor climbing and suspension. These markedly curved digits in combination with an otherwise human-like …


A Multicenter, Open-Label, Controlled Phase Ii Study To Evaluate Safety And Immunogenicity Of Mva Smallpox Vaccine (Imvamune) In 18-40 Year Old Subjects With Diagnosed Atopic Dermatitis, Richard N. Greenberg, Maria Yadira Hurley, Dinh V. Dinh, Serena Mraz, Javier Gomez Vera, Dorothea Von Bredow, Alfred Von Krempelhuber, Siegfried Roesch, Garth Virgin, Nathaly Arndtz-Wiedemann, Thomas Peter Meyer, Darja Schmidt, Richard Nichols, Philip Young, Paul Chaplin Oct 2015

A Multicenter, Open-Label, Controlled Phase Ii Study To Evaluate Safety And Immunogenicity Of Mva Smallpox Vaccine (Imvamune) In 18-40 Year Old Subjects With Diagnosed Atopic Dermatitis, Richard N. Greenberg, Maria Yadira Hurley, Dinh V. Dinh, Serena Mraz, Javier Gomez Vera, Dorothea Von Bredow, Alfred Von Krempelhuber, Siegfried Roesch, Garth Virgin, Nathaly Arndtz-Wiedemann, Thomas Peter Meyer, Darja Schmidt, Richard Nichols, Philip Young, Paul Chaplin

Internal Medicine Faculty Publications

BACKGROUND: Replicating smallpox vaccines can cause severe complications in individuals with atopic dermatitis (AD). Prior studies evaluating Modified Vaccinia Ankara virus (MVA), a non-replicating vaccine in humans, showed a favorable safety and immunogenicity profile in healthy volunteers.

OBJECTIVE: This Phase II study compared the safety and immunogenicity of MVA enrolling groups of 350 subjects with AD (SCORAD ≤ 30) and 282 healthy subjects.

METHODS: Subjects were vaccinated twice with MVA, each dose given subcutaneously 4 weeks apart. Adverse events, cardiac parameters, and the development of vaccinia virus humoral immune responses were monitored.

RESULTS: The overall safety …


Distributed Encoding Of Spatial And Object Categories In Primate Hippocampal Microcircuits, Ioan Opris, Lucas M. Santos, Greg A. Gerhardt, Dong Song, Theodore W. Berger, Robert E. Hampson, Sam A. Deadwyler Oct 2015

Distributed Encoding Of Spatial And Object Categories In Primate Hippocampal Microcircuits, Ioan Opris, Lucas M. Santos, Greg A. Gerhardt, Dong Song, Theodore W. Berger, Robert E. Hampson, Sam A. Deadwyler

Neuroscience Faculty Publications

The primate hippocampus plays critical roles in the encoding, representation, categorization and retrieval of cognitive information. Such cognitive abilities may use the transformational input-output properties of hippocampal laminar microcircuitry to generate spatial representations and to categorize features of objects, images, and their numeric characteristics. Four nonhuman primates were trained in a delayed-match-to-sample (DMS) task while multi-neuron activity was simultaneously recorded from the CA1 and CA3 hippocampal cell fields. The results show differential encoding of spatial location and categorization of images presented as relevant stimuli in the task. Individual hippocampal cells encoded visual stimuli only on specific types of trials in …


Optics Of Cone Photoreceptors In The Chicken (Gallus Gallus Domesticus), David Wilby, Matthew B Toomey, Peter Olsson, Rikard Frederiksen, M Carter Cornwall, Ruth Oulton, Almut Kelber, Joseph C Corbo, Nicholas W Roberts Oct 2015

Optics Of Cone Photoreceptors In The Chicken (Gallus Gallus Domesticus), David Wilby, Matthew B Toomey, Peter Olsson, Rikard Frederiksen, M Carter Cornwall, Ruth Oulton, Almut Kelber, Joseph C Corbo, Nicholas W Roberts

2010-2019 OA Pubs

Vision is the primary sensory modality of birds, and its importance is evident in the sophistication of their visual systems. Coloured oil droplets in the cone photoreceptors represent an adaptation in the avian retina, acting as long-pass colour filters. However, we currently lack understanding of how the optical properties and morphology of component structures (e.g. oil droplet, mitochondrial ellipsoid and outer segment) of the cone photoreceptor influence the transmission of light into the outer segment and the ultimate effect they have on receptor sensitivity. In this study, we use data from microspectrophotometry, digital holographic microscopy and electron microscopy to inform …


The Foot Of Homo Naledi, W. E. H. Harcourt-Smith, Z. Throckmorton, K. A. Congdon, B. Zipfel, Andrew S. Deane, M. S. M. Drapeau, S. E. Churchill, L. R. Berger, J. M. Desilva Oct 2015

The Foot Of Homo Naledi, W. E. H. Harcourt-Smith, Z. Throckmorton, K. A. Congdon, B. Zipfel, Andrew S. Deane, M. S. M. Drapeau, S. E. Churchill, L. R. Berger, J. M. Desilva

Neuroscience Faculty Publications

Modern humans are characterized by a highly specialized foot that reflects our obligate bipedalism. Our understanding of hominin foot evolution is, although, hindered by a paucity of well-associated remains. Here we describe the foot of Homo naledi from Dinaledi Chamber, South Africa, using 107 pedal elements, including one nearly-complete adult foot. The H. naledi foot is predominantly modern human-like in morphology and inferred function, with an adducted hallux, an elongated tarsus, and derived ankle and calcaneocuboid joints. In combination, these features indicate a foot well adapted for striding bipedalism. However, the H. naledi foot differs from modern humans in having …


Cd151-Α3Β1 Integrin Complexes Are Prognostic Markers Of Glioblastoma And Cooperate With Egfr To Drive Tumor Cell Motility And Invasion, Pengcheng Zhou, Sonia Erfani, Zeyi Liu, Changhe Jia, Yecang Chen, Bingwei Xu, Xinyu Deng, Jose E. Alfáro, Li Chen, Dana L. Napier, Michael Lu, Jian-An Huang, Chunming Liu, Olivier Thibault, Rosalind Segal, Binhua P. Zhou, Natasha Kyprianou, Craig Horbinski, Xiuwei H. Yang Oct 2015

Cd151-Α3Β1 Integrin Complexes Are Prognostic Markers Of Glioblastoma And Cooperate With Egfr To Drive Tumor Cell Motility And Invasion, Pengcheng Zhou, Sonia Erfani, Zeyi Liu, Changhe Jia, Yecang Chen, Bingwei Xu, Xinyu Deng, Jose E. Alfáro, Li Chen, Dana L. Napier, Michael Lu, Jian-An Huang, Chunming Liu, Olivier Thibault, Rosalind Segal, Binhua P. Zhou, Natasha Kyprianou, Craig Horbinski, Xiuwei H. Yang

Pharmacology and Nutritional Sciences Faculty Publications

Glioblastoma, one of the most aggressive forms of brain cancer, is featured by high tumor cell motility and invasiveness, which not only fuel tumor infiltration, but also enable escape from surgical or other clinical interventions. Thus, better understanding of how these malignant traits are controlled will be key to the discovery of novel biomarkers and therapies against this deadly disease. Tetraspanin CD151 and its associated α3β1 integrin have been implicated in facilitating tumor progression across multiple cancer types. How these adhesion molecules are involved in the progression of glioblastoma, however, remains largely unclear. Here, we examined an in-house tissue microarray-based …


Using Height-For-Age Differences (Had) Instead Of Height-For-Age Z-Scores (Haz) For The Meaningful Measurement Of Population-Level Catch-Up In Linear Growth In Children Less Than 5 Years Of Age, Jef L. Leroy, Marie Ruel, Jean-Pierre Habicht, Edward A. Frongillo Jr. Oct 2015

Using Height-For-Age Differences (Had) Instead Of Height-For-Age Z-Scores (Haz) For The Meaningful Measurement Of Population-Level Catch-Up In Linear Growth In Children Less Than 5 Years Of Age, Jef L. Leroy, Marie Ruel, Jean-Pierre Habicht, Edward A. Frongillo Jr.

Faculty Publications

Background: Evidence from studies conducted in nutritionally deprived children in low- and middle-income countries (LIMC) in past decades showed little or no population-level catch-up in linear growth (mostly defined as reductions in the absolute height deficit) after 2 years of age. Recent studies, however, have reported population-level catch-up growth in children, defined as positive changes in mean height-for-age z-scores (HAZ). The aim of this paper was to assess whether population-level catch-up in linear growth is found when height-for-age difference (HAD: child’s height compared to standard, expressed in centimeters) is used instead of HAZ. Our premise is that HAZ is inappropriate …


In Absentia: An Exploratory Study Of How Patients Are Considered In Multidisciplinary Cancer Team Meetings, Pola Hahlweg, Jana Hoffmann, Martin Hrter, Dominick L. Frosch, Glyn Elwyn, Isabelle Scholl Oct 2015

In Absentia: An Exploratory Study Of How Patients Are Considered In Multidisciplinary Cancer Team Meetings, Pola Hahlweg, Jana Hoffmann, Martin Hrter, Dominick L. Frosch, Glyn Elwyn, Isabelle Scholl

Dartmouth Scholarship

Background: Multidisciplinary team meetings and shared decision-making are potential means of delivering patient-centred care. Not much is known about how those two paradigms fit together in cancer care. This study aimed to investigate how decisions are made in multidisciplinary team meetings and whether patient perspectives are incorporated in these decisions. Materials and Methods: A qualitative study was conducted using non-participant observation at multidisciplinary team meetings (also called tumor boards) at the University Cancer Center Hamburg-Eppendorf, Germany. Two researchers recorded structured field notes from a total of N = 15 multidisciplinary team meetings. Data were analyzed using content analysis and descriptive …


College Of Public Health News, Georgia Southern University Oct 2015

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

  • Georgia Southern Examines the State of Accreditation Readiness in Georgia


Survival Outcome According To Kras Mutation Status In Newly Diagnosed Patients With Stage Iv Non-Small Cell Lung Cancer Treated With Platinum Doublet Chemotherapy., Anna K Brady, Jonathan D Mcneill, Brendan Judy, Joshua Bauml, Tracey L Evans, Roger B Cohen, Corey Langer, Anil Vachani, Charu Aggarwal Oct 2015

Survival Outcome According To Kras Mutation Status In Newly Diagnosed Patients With Stage Iv Non-Small Cell Lung Cancer Treated With Platinum Doublet Chemotherapy., Anna K Brady, Jonathan D Mcneill, Brendan Judy, Joshua Bauml, Tracey L Evans, Roger B Cohen, Corey Langer, Anil Vachani, Charu Aggarwal

Department of Surgery Faculty Papers

INTRODUCTION: Mutations (MT) of the KRAS gene are the most common mutation in non-small cell lung cancer (NSCLC), seen in about 20-25% of all adenocarcinomas. Effect of KRAS MT on response to cytotoxic chemotherapy is unclear.

METHODS: We undertook a single-institution retrospective analysis of 93 consecutive patients with stage IV NSCLC adenocarcinoma with known KRAS and EGFR MT status to determine the association of KRAS MT with survival. All patients were treated between January 1, 2008 and December 31, 2011 with standard platinum based chemotherapy at the University of Pennsylvania. Overall and progression free survival were analyzed using Kaplan-Meier and …