Medicine and Health Sciences Commons^™

Research Brief: "Receipt Of Employment Services Among Veterans Health Administration Users With Psychiatric Diagnoses", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This study found that about four percent (4.2%) of VHA users with psychiatric diagnoses accessed employment services in a given year. VHA patients with a psychiatric diagnosis of schizophrenia had higher odds of accessing employment services relative to VHA users with other psychiatric diagnoses, including PTSD, depression, and other anxiety disorders. In practice, veterans should be aware that receiving VHA employment services should not affect VA benefits and should discuss their medical and financial benefits with benefits advisors and other appropriate advisors. In policy, Policymakers could consider allocating funds to further study the efficacy and effectiveness of various employment services …

Defining Adolescence, Alexa C. Curtis

Journal of Adolescent and Family Health

Chronologic definitions of adolescence and adolescent sub-stages vary throughout the literature. Definitions for adolescence are important because they inform the construction and implementation of adolescent research and program development. This article identifies commonly used chronologic parameters for adolescence, explores the developmental theory contributing to the understanding of adolescent chronology and posits a developmentally consistent definition of this critical transitional phase as: “early adolescence” 11-13 years, “adolescence” 14-17 years, and “young adulthood” 18-25 years. Keywords: adolescent, development, chronologic definitions, research

Rural Adolescents Are More Likely Than Their Urban Peers To Abuse Prescription Painkillers, Shannon M. Monnat, Khary K. Rigg

Carsey Publications

In this fact sheet, authors Shannon Monnat and Khary Rigg examine prescription painkiller abuse for over 32,000 youth aged 12–17 using data from the National Survey on Drug Use and Health, an annual nationally representative survey of the non-institutionalized U.S. population. They report that over 1.1 million adolescents aged 12 to 17 (4.7 percent of this population) abused prescription painkillers in 2014. Prescription painkiller abuse was more common among rural than urban adolescents. In 2014, 8.6 percent of rural adolescents, 8.1 percent of adolescents in small urban areas, and 6.5 percent of adolescents in large urban areas reported ever abusing …

Palbociclib In Hormone-Receptor-Positive Advanced Breast Cancer., Nicholas C Turner, Cynthia Huang Bartlett, Massimo Cristofanilli

Department of Medicine Faculty Papers

No abstract provided.

Connexin26 Gap Junction Mediates Mirna Intercellular Genetic Communication In The Cochlea And Is Required For Inner Ear Development, Yan Zhu, Liang Zong, Ling Mei, Hong-Bo Zhao

Otolaryngology--Head & Neck Surgery Faculty Publications

Organ development requires well-established intercellular communication to coordinate cell proliferations and differentiations. MicroRNAs (miRNAs) are small, non-coding RNAs that can broadly regulate gene expression and play a critical role in the organ development. In this study, we found that miRNAs could pass through gap junctions between native cochlear supporting cells to play a role in the cochlear development. Connexin26 (Cx26) and Cx30 are predominant isoforms and co-express in the cochlea. Cx26 deficiency but not Cx30 deficiency can cause cochlear developmental disorders. We found that associated with Cx26 deletion induced the cochlear developmental disorders, deletion of Cx26 but not Cx30 disrupted …

High Prevalence Of Obesity And Female Gender Among Patients With Concomitant Tibialis Posterior Tendonitis And Plantar Fasciitis., Christopher W. Reb, Faith A. Schick, Homyar N. Karanjia, Joseph N. Daniel

Rothman Institute Papers

UNLABELLED: The link between increased body weight and hindfoot complaints is largely based on correlation to single foot pathology. We retrospectively reviewed 6879 patients with tibialis posterior tendonitis (TPT), plantar fasciitis (PF), or both. Among patients with either TPT or PF, 1 in 11 (9%) had both. We then compared age, gender, and body mass index among these groups. Patients with both diagnoses were neither statistically older nor more obese than patients with single diagnoses. However, they were statistically more female. Given the overall high prevalence of obesity in the study population, we feel these data support the link between …

The Transcriptional Landscape Of Age In Human Peripheral Blood, Marjolein J. Peters, Roby Joehanes, Luke C. Pilling, Claudia Schurmann, Karen N. Conneely, Harald H. H. Goring, Joanne E. Curran, Sarah Williams-Blangero, John Blangero

School of Medicine Publications

Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the 'transcriptomic age' of …

Mortality-Related Resource Utilization In The Inpatient Care Of Hypoplastic Left Heart Syndrome., David A. Danford, Quentin Karels, Aparna Kulkarni, Aysha Hussain, Yunbin Xiao, Shelby Kutty

Journal Articles: Pediatrics

BACKGROUND: Quantifying resource utilization in the inpatient care of congenital heart diease is clinically relevant. Our purpose is to measure the investment of inpatient care resources to achieve survival in hypoplastic left heart syndrome (HLHS), and to determine how much of that investment occurs in hospitalizations that have a fatal outcome, the mortality-related resource utilization fraction (MRRUF).

METHODS: A collaborative administrative database, the Pediatric Health Information System (PHIS) containing data for 43 children's hospitals, was queried by primary diagnosis for HLHS admissions of patients ≤21 years old during 2004-2013. Institution, patient age, inpatient deaths, billed charges (BC) and length of …

Effect Of Mycophenolate Mofetil On The White Blood Cell Count And The Frequency Of Infection In Systemic Lupus Erythematosus., Ananta Subedi, Laurence S. Magder, Michelle Petri

Department of Medicine Faculty Papers

Leukopenia is a common manifestation of SLE. Addition of immunosuppressive therapy in a SLE patient who is already leukopenic is a clinical concern. It could worsen leukopenia, increase the risk of infection, or both. The aim of this study was to analyze the immediate effect of mycophenolate mofetil on the white blood cell count and the rate of infection in SLE patients. Two hundred and forty-four patients within the Hopkins Lupus Cohort who were newly started on mycophenolate mofetil were included in the study. The white blood cell count and interval infection history on the day mycophenolate mofetil was started …

Mild Cognitive Impairment In Heart Failure Affects Care Transition, Kitsum Li, Kristin Myers

Collected Faculty Scholarship

Objectives

After attending the presentation, the audiences will be able to:

• Understand the importance of cognition in everyday activity and the cognitive hierarchy to guide practice.
• Recognize the incidence of mild cognitive impairment in individuals with heart failure.
• Understand how mild cognitive impairment may affect heart failure self- care practice and hospitalization readmission.
• Identify the evidence that support use of cognitive screen to identify mild cognitive impairment in individuals with heart failure.
• Compare the evidence among three cognitive screens (Mini-mental Status Exam, Montreal Cognitive Assessment and St. Louis University Mental State Exam).
• (Using Montreal Cognitive Assessment as an example)Identify cognitive …

The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence By Enhancing Resistance To Neutrophil Extracellular Traps, Mark J. Lee, Hong Liu, Bridget M. Barker, Brendan D. Snarr, Fabrice M. Gravelat, Qusai Al Abdallah, Christina Gavino, Shane R. Baistrocchi, Hanna Ostapska, Tianli Xiao, Benjamin Ralph, Norma V. Solis, Melanie Lehoux, Stefanie D. Baptista, Arsa Thammahong

Dartmouth Scholarship

Of the over 250 Aspergillus species, Aspergillus fumigatus accounts for up to 80% of invasive human infections. A. fumigatus produces galactosaminogalactan (GAG), an exopolysaccharide composed of galactose and N-acetyl-galactosamine (GalNAc) that mediates adherence and is required for full virulence. Less pathogenic Aspergillus species were found to produce GAG with a lower GalNAc content than A. fumigatus and expressed minimal amounts of cell wall-bound GAG. Increasing the GalNAc content of GAG of the minimally pathogenic A. nidulans, either through overexpression of the A. nidulans epimerase UgeB or by heterologous expression of the A. fumigatus epimerase …

Intracellular Information Processing Through Encoding And Decoding Of Dynamic Signaling Features., Hirenkumar K Makadia, James S. Schwaber, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Cell signaling dynamics and transcriptional regulatory activities are variable within specific cell types responding to an identical stimulus. In addition to studying the network interactions, there is much interest in utilizing single cell scale data to elucidate the non-random aspects of the variability involved in cellular decision making. Previous studies have considered the information transfer between the signaling and transcriptional domains based on an instantaneous relationship between the molecular activities. These studies predict a limited binary on/off encoding mechanism which underestimates the complexity of biological information processing, and hence the utility of single cell resolution data. Here we pursue a …

The Effects Of Guided Imagery On Patients Being Weaned From Mechanical Ventilation, Leeanna Spiva, Patricia L. Hart, Erin Gallagher, Frank Mcvay

Faculty Articles

The study purpose was to assess the effects of guided imagery on sedation levels, sedative and analgesic volume consumption, and physiological responses of patients being weaned from mechanical ventilation. Forty-two patients were selected from two community acute care hospitals. One hospital served as the comparison group and provided routine care (no intervention) while the other hospital provided the guided imagery intervention. The intervention included two sessions, each lasting 60 minutes, offered during morning weaning trials from mechanical ventilation. Measurements were recorded in groups at baseline and 30- and 60-minute intervals and included vital signs and Richmond Agitation-Sedation Scale (RASS) score. …

Professor Publishes Second Edition Of Serving Military Families, College Of Education And Human Development

Family and Consumer Sciences News

Dr. Karen Blaisure, professor of family science in the Family and Consumer Sciences Department, and colleagues recently published the 2nd edition of Serving Military Families: Theories, Research, and Application.

Alumna Interviewed After Dietetic Internship, College Of Education And Human Development

Family and Consumer Sciences News

Emily Joseph, a registered dietitian, and alumna who completed the FCS dietetic internship in 2015 recently did an interview about the Teal Pumpkin Project (food allergy-free celebrations) for WZZM in Grand Rapids, Michigan.

What People Are Saying About The Jefferson Digital Commons (Jdc), Daniel G. Kipnis, Msi

Jefferson Digital Commons News

How does one measure value in an online environment? Do you count downloads, hits, or page views? Quantitative data is helpful, but words still matter.

Gi Bleed With Pancytopenia - A Rare Case Of Aml Subtype Acute Panmyelosis With Mylefibrosis (Apmf), Dhwani Pandya Md, Philip Dunn Do, Stacey Smith Md, Facp

Department of Medicine

No abstract provided.

School Of Nursing News, Georgia Southern University

Nursing: News & Publications (2013-2023)

• Georgia Southern University dedicates School of Nursing Memorial Garden

Improving Nurse To Patient Ratios In The Emergency Department Utilizing Lean, Paul Delpais Msn, Rn, Cen, Nea-Bc, Lindsa Houck Msn, Rn, Nea-Bc, Cen, Cpen, Phrn

Patient Care Services / Nursing

No abstract provided.

Analysis Of Speech-Language Pathology Graduate Students' Experience With Thickened Liquids, Mary Gorham-Rowan, Jade Coston

Internet Journal of Allied Health Sciences and Practice

Purpose: Thickened liquids are frequently recommended for patients with dysphagia to minimize aspiration. When discussing the use of thickened liquids with graduate students in Communication Sciences & Disorders (CSD), it is beneficial to discuss the potential effect(s) of this dietary recommendation. Graduate level preparation involving first-hand experience with thickened liquids may help future speech-language pathologists (SLPs) develop a more complete understanding of the effects of diet modification. The purpose of the current study was to examine the reactions of graduate students in CSD to a brief period of thickened liquid use as an experiential learning activity. Methods: Sixty-eight graduate students …

Happiness On The Brain: The Neuroscience Of Happiness, Part 1, Kevin Corcoran

University Faculty Publications and Creative Works

No abstract provided.

Ether Cleavage Re-Investigated: Elucidating The Mechanism Of Bbr3- Facilitated Demethylation Of Aryl Methyl Ethers, Richard L. Lord, Andrew L. Korich, Talon M. Kosak, Heidi A. Conrad

Open Access Publishing Support Funded Articles

Boron tribromide is a versatile reagent utilized in diverse areas ranging from polymer chemistry to natural product synthesis.[1] Owing its high reactivity to the Lewis acidic boron center, BBr3 reactions include haloborylation,[2] boron–silicon exchange,[3] and rearrangement of 7,7-diphenylhydromorphone derivatives.[4] While there is no shortage in the diversity of BBr3-mediated reactions, many of the mechanisms for these transformations have not been fully elucidated. In this report we investigate the mechanism of ether cleavage by BBr3 [5–10] in anisole. Conceptually, demethylation of anisole is initiated by the formation of an ether adduct 1 followed by the loss of bromide. Free bromide nucleophilically …

Diabetic Ketoacidosis: Pathophysiology And Treatment, Laura E. Mumme

The Kabod

The pathophysiology of DKA in patients with T1D is addressed, followed by a discussion of proper emergency treatment for this life-threatening condition.

2015 October 20 - Medical Student Education Committee Retreat Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

The Role Of Quality Health Services And Discussion About Birth Spacing In Postpartum Contraceptive Use In Sindh, Pakistan: A Multilevel Analysis, Hannah Tappis, Anis Kazi, Waqas Hameed, Zaib Dahar, Anayat Ali, Sohail Agha

Community Health Sciences

Introduction: Rapid population growth, stagnant contraceptive prevalence, and high unmet need for family planning present significant challenges for meeting Pakistan's national and international development goals. Although health behaviors are shaped by multiple social and environmental factors, research on contraceptive uptake in Pakistan has focused on individual and household determinants, and little attention has been given to community characteristics that may affect access to services and reproductive behavior.
Methods: Individual and community determinants of contraceptive use were identified using multivariable multilevel logistic regression to analyze data from a 2014 cross-sectional survey of 6,200 mothers in 503 communities in Sindh, Pakistan.
Results: …

A Comparison Of Static Stretching Versus Combined Static And Ballistic Stretching In Active Knee Range Of Motion, Nathan R. Blackhurst, James C. Peterson, Valerie W. Herzog, Ericka P. Zimmerman

Internet Journal of Allied Health Sciences and Practice

Background: There is continued controversy related to flexibility gains from different stretching protocols and within single protocols. Stretching methods include static, ballistic, dynamic, and proprioceptive neuromuscular facilitation (PNF). A combination of stretching methods may be an improved way to increase active knee range of motion (ROM). This study evaluated a single program formulated with static and ballistic components. Objective: To compare active knee ROM following stretching programs which either included combined static and ballistic stretching (CSBS) or static stretching (SS) alone. It was hypothesized that CSBS would show a greater increase in active knee ROM than SS. Setting …

Uplc Simultaneous Determination Of Empagliflozin, Linagliptin And Metformin, Bassam M. Ayoub

Pharmacy

© The Royal Society of Chemistry. The first UPLC method for simultaneous determination of empagliflozin, linagliptin and metformin hydrochloride in the different combinations of their pharmaceutical dosage forms was developed. Chromatographic separation was achieved on a Symmetry® Acclaim™ RSLC 120 C18 column (100 mm × 2.1 mm, 2.2 μm) applying isocratic elution based on potassium dihydrogen phosphate buffer pH (4)-methanol (50 : 50, v/v) as the mobile phase. The linearity, accuracy and precision were found to be acceptable over the concentration ranges of 1-32 μg mL-1, 0.5-16 μg mL-1 and 1-100 μg mL-1 for empagliflozin, linagliptin and metformin hydrochloride, respectively. …

A Critical Role For Alpha-Synuclein In Development And Function Of T Lymphocytes, Afshin Shameli, Wenbin Xiao, Yan Zheng, Susan Shyu, John Sumodi, Howard J. Meyerson, Clifford V. Harding, Robert W. Maitta

Faculty Scholarship

Alpha-synuclein is highly expressed in the central nervous system and plays an important role in pathogenesis of neurodegenerative disorders such as Parkinson's disease and Lewy body dementia. Previous studies have demonstrated the expression of α-synuclein in hematopoietic elements and peripheral blood mononuclear cells, although its roles in hematopoiesis and adaptive immunity are not studied. Using an α-synuclein knock out (KO) mouse model, we have recently shown that α-synuclein deficiency is associated with a mild defect in late stages of hematopoiesis. More importantly, we demonstrated a marked defect in B lymphocyte development and IgG, but not IgM production in these mice. …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Examines Facebook Use by Local Heath Departments

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Georgia Southern Examines Facebook Use by Local Health Departments