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Open Access. Powered by Scholars. Published by Universities.®

2015

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Articles 12001 - 12006 of 12006

Full-Text Articles in Medicine and Health Sciences

Hclp46 Increases Smad3 Protein Stability Via Inhibiting Its Ubiquitin-Proteasomal Degradation, Yingying Xing, Qiaoyun Chu, Run Feng, Wei Wang, Lixin Liu, Zhongbing Lu Jan 2015

Hclp46 Increases Smad3 Protein Stability Via Inhibiting Its Ubiquitin-Proteasomal Degradation, Yingying Xing, Qiaoyun Chu, Run Feng, Wei Wang, Lixin Liu, Zhongbing Lu

Research outputs 2014 to 2021

hCLP46 (human CAP10-like protein 46 kDa) was initially isolated and identified from human acute myeloid leukemia transformed from myelodysplastic syndrome (MDS-AML) CD34+ cells (Teng et al., 2006) and we demonstrated previously that hCLP46 is abnormally expressed in many hematopoietic malignancies (Wang et al., 2010). Studies fromits Drosophila homolog, Rumi, suggested that Notch is a potential target of hCLP46 (Acar et al., 2008). We also found that overexpression of hCLP46 enhances Notch activation and regulates cell proliferation in a cell type-dependent manner (Ma et al., 2011; Chu et al., 2013). However, hCLP46−/− embryos show more severe phenotypes …

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The Canadian Healthy Infant Longitudinal Development (Child) Birth Cohort Study: Assessment Of Environmental Exposures, Tim K. Takaro, James A. Scott, Ryan W. Allen, Sonia S. Anand, Allan B. Becker, A. Dean Befus, Michael Brauer, Joanne Duncan, Diana L. Lefebvre, Wendy Lou, Piush J. Mandhane, Kathleen E. Mclean, Gregory Miller, Hind Sbihi, Huan Shu, Padmaja Subbarao, Stuart E. Turvey, Amanda J. Wheeler, Leilei Zeng, Malcolm R. Sears, Jeffrey R. Brook Jan 2015

The Canadian Healthy Infant Longitudinal Development (Child) Birth Cohort Study: Assessment Of Environmental Exposures, Tim K. Takaro, James A. Scott, Ryan W. Allen, Sonia S. Anand, Allan B. Becker, A. Dean Befus, Michael Brauer, Joanne Duncan, Diana L. Lefebvre, Wendy Lou, Piush J. Mandhane, Kathleen E. Mclean, Gregory Miller, Hind Sbihi, Huan Shu, Padmaja Subbarao, Stuart E. Turvey, Amanda J. Wheeler, Leilei Zeng, Malcolm R. Sears, Jeffrey R. Brook

Research outputs 2014 to 2021

The Canadian Healthy Infant Longitudinal Development birth cohort was designed to elucidate interactions between environment and genetics underlying development of asthma and allergy. Over 3600 pregnant mothers were recruited from the general population in four provinces with diverse environments. The child is followed to age 5 years, with prospective characterization of diverse exposures during this critical period. Key exposure domains include indoor and outdoor air pollutants, inhalation, ingestion and dermal uptake of chemicals, mold, dampness, biological allergens, pets and pests, housing structure, and living behavior, together with infections, nutrition, psychosocial environment, and medications. Assessments of early life exposures are focused …

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Estimation Of Bias With The Single-Zone Assumption In Measurement Of Residential Air Exchange Using The Perfluorocarbon Tracer Gas Method, K Van Ryswyk, L. Wallace, D. Fugler, M. Macneill, M. E. Heroux, M. D. Gibson, J. R. Guernsey, W. Kindzierski, A. J. Wheeler Jan 2015

Estimation Of Bias With The Single-Zone Assumption In Measurement Of Residential Air Exchange Using The Perfluorocarbon Tracer Gas Method, K Van Ryswyk, L. Wallace, D. Fugler, M. Macneill, M. E. Heroux, M. D. Gibson, J. R. Guernsey, W. Kindzierski, A. J. Wheeler

Research outputs 2014 to 2021

Residential air exchange rates (AERs) are vital in understanding the temporal and spatial drivers of indoor air quality (IAQ). Several methods to quantify AERs have been used in IAQ research, often with the assumption that the home is a single, well‐mixed air zone. Since 2005, Health Canada has conducted IAQ studies across Canada in which AERs were measured using the perfluorocarbon tracer (PFT) gas method. Emitters and detectors of a single PFT gas were placed on the main floor to estimate a single‐zone AER (AER1z). In three of these studies, a second set of emitters and detectors were deployed in …

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Eccentric Loading Increases Peak Torque Angle Of The Ankle Plantar Flexors In Healthy Volunteers, Matthew Wellisch, Peter Hamer, Luke Hopper, Max Bulsara, James Debenham Jan 2015

Eccentric Loading Increases Peak Torque Angle Of The Ankle Plantar Flexors In Healthy Volunteers, Matthew Wellisch, Peter Hamer, Luke Hopper, Max Bulsara, James Debenham

Research outputs 2014 to 2021

Eccentric loading of the ankle plantar Flexor's (PF) has demonstrated clinical efficacy in the conservative treatment of Achilles tendinopathy, however, its mechanism of therapeutic benefit remains unclear. The purpose of this study was to examine the effects of PF eccentric loading on PF angle to peak torque (AtPT), peak torque (PT) and lower limb vertical stiffness. Thirty healthy volunteers were randomised to an eccentric (n=15) or concentric (n=13) exercise group. A 10-week loading programme of the ankle plantar flexors was completed. AtPT, PT and vertical stiffness were compared within and between groups before and after the interventions. AtPT increased in …

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Subdural Hematoma As A Consequence Of Epidural Anesthesia., Tracy M Bishop Do, Kareem S. Elsayed Ms, Kathleen E. Kane Md Jan 2015

Subdural Hematoma As A Consequence Of Epidural Anesthesia., Tracy M Bishop Do, Kareem S. Elsayed Ms, Kathleen E. Kane Md

Department of Emergency Medicine

Regional spinal and epidural anesthesia are used commonly in operative procedures. While the most frequent complication, postdural puncture headache (PDPH), is a clinically diagnosed positional headache that is usually self-limited, subdural hemorrhage (SDH) is a potentially fatal complication that cannot be missed. We report a case of an otherwise healthy female who presented with persistent positional headache and was ultimately found to have a large subdural hematoma with midline shift requiring surgical evacuation.

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Heterometallic Titanium–Gold Complexes Inhibit Renal Cancer Cells In Vitro And In Vivo, Jacob Fernandez-Gallardo, Benelita T. Elie, Tanmoy Sadhukha, Swayam Prabha, Mercedes Sanau, Susan A. Rotenberg, Joe W. Ramos, Maria Contel Jan 2015

Heterometallic Titanium–Gold Complexes Inhibit Renal Cancer Cells In Vitro And In Vivo, Jacob Fernandez-Gallardo, Benelita T. Elie, Tanmoy Sadhukha, Swayam Prabha, Mercedes Sanau, Susan A. Rotenberg, Joe W. Ramos, Maria Contel

Publications and Research

Following recent work on heterometallic titanocene–gold complexes as potential chemotherapeutics for renal cancer, we report here on the synthesis, characterization and stability studies of new titanocene complexes containing a methyl group and a carboxylate ligand (mba ¼ S–C6H4–COO) bound to gold(I)-phosphane fragments through a thiolate group [(h-C5H5)2TiMe(m-mba)Au(PR3)]. The compounds are more stable in physiological media than those previously reported and are highly cytotoxic against human cancer renal cell lines. We describe here preliminary mechanistic data involving studies on the interaction of selected compounds with plasmid (pBR322) DNA used as a model nucleic acid, and with selected protein kinases from a …

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