Medicine and Health Sciences Commons^™

Tinnitus And Trauma, Marc A. Fagelson

ETSU Faculty Works

Trauma-provoked tinnitus challenges patients and clinicians. Effects of trauma may exacerbate tinnitus, and patients with both tinnitus and posttraumatic stress disorder rate distress levels as higher than patients who experience only one or the other. This presentation will highlight links between tinnitus and trauma histories relevant to clinical audiologists.

Notching Early Repolarization Pattern In Inferior Leads Increases Risk Of Ventricular Tachyarrhythmias In Patients With Acute Myocardial Infarction: A Meta-Analysis., Zhiwei Zhang, Konstantinos P Letsas, Yajuan Yang, Panagiotis Korantzopoulos, Guangping Li, Gan-Xin Yan, Tong Liu

Department of Medicine Faculty Papers

The aim of this of this meta-analysis was to examine the potential association between certain early repolarization (ER) characteristics and ventricular tachyarrhythmias (VTAs) in patients with acute myocardial infarction (AMI). We searched PubMed, Embase and Web of Science databases for records published until December 2014. Of the 658 initially identified records, 7 studies with a total of 1,565 patients (299 with ER and 1,266 without ER) were finally analyzed. Overall, patients with ER displayed a higher risk of VTAs following AMI compared to patients without ER [odds ratio (OR): 3.75, 95% CI: 2.62-5.37, p < 0.00001]. Subgroup analyses showed that the diagnosis of ER prior to AMI onset is a better predictor of VTAs (OR: 5.70, p < 0.00001) compared to those diagnosed after AMI onset (OR: 2.60, p = 0.00001). Remarkably, a notching morphology was a significant predictor of VTAs compared to slurring morphology (OR: 3.85, p = 0.002). Finally, an inferior ER location (OR: 8.85, p < 0.00001) was significantly associated with increased risk of VTAs in AMI patients. In conclusion, our meta-analysis suggests that ER pattern is associated with greater risk of VTAs in patients with AMI. A notched ER pattern located in inferior leads confers the highest risk for VTAs in AMI.

‘The Thing Is Not Knowing’: Patients' Perspectives On Surveillance Of An Indeterminate Pulmonary Nodule, Renda Soylemez Wiener, Michael K. Gould, Steven Woloshin, Lisa M. Schwartz, Jack Clark

Dartmouth Scholarship

Background: The hundreds of thousands of patients found to have a potentially malignant pulmonary nodule each year are faced with tremendous uncertainty regarding what the nodule is and how it should be evaluated.

Objective: To explore patients' responses to the detection and evaluation of a pulmonary nodule.

Implementation Of Medicaid Managed Long-Term Services And Supports For Adults With Intellectual And/Or Developmental Disabilities: A State’S Experience, Heather Jeanne Williamson

USF Tampa Graduate Theses and Dissertations

Background: Individuals with intellectual and/or developmental disabilities (IDD) are experiencing longer life expectancies with the majority requiring the ongoing support of family caregivers into adulthood. Medicaid is the primary funding source for supports and services for adults with IDD. Growing Medicaid expenditures and goals to improve quality of care are driving more states to move their Medicaid fee-for-service programs into a managed care model. The stated goals of Medicaid managed long-term services and supports (MLTSS) are to improve care coordination and access to care while controlling costs, but the evidence regarding these outcomes is limited and mixed. Given the level …

Severe Rhabdomyolysis Secondary To Adenovirus Infection, Daniel Tseytlin Do, Sharon E. Maynard Md

Department of Medicine

No abstract provided.

Sialylation Of Igg Fc Domain Impairs Complement-Dependent Cytotoxicity., Isaak Quast, Christian W Keller, Michael A Maurer, John P Giddens, Björn Tackenberg, Lai-Xi Wang, Christian Münz, Falk Nimmerjahn, Marinos Dalakas, Jan D Lünemann

Department of Neurology Faculty Papers

IgG molecules exert both pro- and antiinflammatory effector functions based on the composition of the fragment crystallizable (Fc) domain glycan. Sialylated IgG Fc domains have antiinflammatory properties that are attributed to their ability to increase the activation threshold of innate effector cells to immune complexes by stimulating the upregulation of the inhibitory Fcγ receptor IIB (FcγRIIB). Here, we report that IgG Fc sialylation of human monoclonal IgG1 molecules impairs their efficacy to induce complement-mediated cytotoxicity (CDC). Fc sialylation of a CD20-targeting antibody had no impact on antibody-dependent cellular cytotoxicity and did not change the affinity of the antibody for activating …

Social Networking Patterns And Attitudes Towards Patient Privacy, Frank Davison

Applied Research Projects

Sharing ideas with others having common interests is primal and the

best indication of this is the exploding world of social networking. Social

media sites have become self-reported newscasts where we post our daily

activities as a matter of permanent public record. Are we losing our

expectation of privacy? What impact could this have on patient privacy?

Do individuals who are accustomed to sharing personal information on

social networks have a relaxed attitude towards patient privacy? Does this

vary according to age, gender, or racial background?

This study explores correlations between attitudes on social

networking and patient privacy and how …

Video Visits: A Closer Look At Patient Satisfaction And Quality Of Virtual Medical Care, Saddia Cheema

Applied Research Projects

Electronic medical services via video visits has revolutionized the delivery of medical care by Physicians and medical staff alike. Its steady evolution and progression towards the future of healthcare has provided insight on how to better serve patients and community members seeking care. This study will explore patient satisfaction and the quality of virtual medical care services provided by Physicians thru video visits as well as the impact of minimizing the spread of communicable diseases. Statistical data was gathered from a major U.S. healthcare company evaluating survey responses as well as feedback provided by member experience who visited with their …

Evaluation Of An Innovative Leadership Training Program For Chinese Students: Subjective Outcome Evaluation, Daniel T. L. Shek, Xiang Li

Pediatrics Faculty Publications

As a part of the Global Youth Leadership Program (GYLP), a 30-h “Service Leadership” subject was provided to 48 undergraduate students studying at The Hong Kong Polytechnic University (PolyU) or Peking University (PKU). This study evaluated the subjective outcomes of the “Service Leadership” subject, including students’ views on the course contents, lecturers, and perceived benefits from the course. A majority of students in the program showed very positive perceptions of the course content, lecturers, and course benefits, with more than 85% of the students indicating that they were very satisfied with this subject and would suggest their friends to take …

The Impact Of Text Messaging Based Smoking Cessation Interventions In Hospitalized Adult Smokers, Charlene K. Zablotney

Doctor of Nursing Practice (DNP) Program

Tobacco use is the leading cause of preventable death and disease in the world (WHO, 2008). Through both primary and secondary exposure, tobacco use affects every body system and every individual to whom nurses deliver care. According to the Center for Disease Control and Prevention (2012), each year, an estimated 443,000 people die prematurely from smoking or exposure to secondhand smoke, and another 8.6 million live with a serious illness caused by smoking. Despite these risks, approximately 46.6 million U.S. adults smoke cigarettes (CDC, 2012). Tobacco abuse results in a costly burden on society. Annual smoking economic costs in the …

Integrative Health Studies Newsletter, Ciis

Integrative Health Studies Newsletter

This is the November-December 2015 Issue of Integrative Health Newsletter at CIIS.

Does A Positive Margin Always Mandate Adjuvant Radiotherapy?, Peter C. Albertsen

UCHC Articles - Research

The appropriate treatment for clinically localized prostate cancer continues to generate controversy. For men with low grade disease it is unclear whether surgery or radiati on therapy provides a survival advantage over active surveillance, and among men with high grade disease it is unclear how many derive a substantial benefit from either intervention. No trial has yet to compare surgery and radiation with observation, but the recent update of the Scandinavian Prostate Cancer Group 4 study suggests that radical prostatectomy provides a significant survival advantage for younger men with intermediate grade diseas

Neuromuscular Strengthening Exercises Following Acl And Meniscal Repair In A 15 Year Old Female Athlete With Generalized Knee Laxity: A Case Report, Alyssa Gardner, Kirsten Buchanan

Case Report Posters

Adolescent females are 4-6 times more likely to sustain a non-contact anterior cruciate ligament (ACL) injury compared to their male counterparts. Generalized knee laxity decreases dynamic knee stability and significantly increases the odds of an ACL injury 5-fold. It is crucial to return the surgically repaired knee to its former function. However, it is just as vital to direct attention to the uninjured knee with joint laxity. Research has found that those who have torn one ACL are six time more likely to tear the contralateral ACL. There is currently a lack of research that directly addresses intervention programs that …

Adjunctive Appliance Wear And Gender Affect Patients' Oral Health-Related Quality Of Life During The Late Stage Of Orthodontic Treatment In Adolescents, Monica Dinh

Student Theses, Dissertations and Capstones

Objective: This study was conducted to determine how oral health-related quality of life (OHQoL) changes during the late stage of comprehensive fixed orthodontic treatment in adolescents and what factors may be involved. Background: Completion of orthodontic treatment has been shown to improve patients’ OHQoL due to the changes in esthetics, function and emotional well-being. The levels of OHQoL fluctuate throughout treatment where an initial decrease within the first 6 months occurs followed by an improvement towards patients’ pre-treatment levels. At 18 months of fixed orthodontic treatment, the level is unclear. The aims of this study were to clarify the changes …

Medical Education Digest, Vol. 17 No. 6 (November-December 2015), Nova Southeastern University

Medical Education Digest

No abstract provided.

Teen Births In South Dakota, 2006-2014, Wei Bai, Bonny Specker, Lon Kightlinger

Ethel Austin Martin Program Publications

According to the Office of Adolescent Health at the U.S. Department of Health & Human Services, the teen birth rate in the U.S. has dropped continuously over the past 20 years and dropped 10% nationwide between 2012 and 2013. In 2013, about 273,000 babies were born nationally to adolescent teens aged 15-19 years for a rate of 26.5/1,000 adolescent females. According to the data from the World Bank, the U.S. teen birth rate in 2010-14 was higher than that of many developed countries, including Canada, Japan, Australia, and the majority of European countries. Teen pregnancies are associated with negative outcomes …

Medical School Watercooler Newsletter - November 1, 2015, Lindsey Lyle

Watercooler Newsletter

This is the November 1, 2015 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

USA Welcomes Dr. Preston Daugherty

Department of Defense Awards DxDiscovery Inc. and USA College of Medicine $1M for Research

Employee Benefits Fair Takes Place This Week

COM Alum Dr. John LeDoux Speaks at Medical Alumni Association Lecture

Primary Care Management Of Plantar Fasciitis, Thomas J. Melvin Pharmd, Zach J. Tankersly Dpm, Zain N. Quazi, John J. Jasko, Russell Odono Md, Franklin D. Shuler Md, Phd

Orthopaedics

Plantar fasciitis (PF) is present in 10% of the population and is the most common cause of plantar heel pain. PF is painful, can alter daily activities and presents as a sharp pain localized to the plantar foot and medial heel. The underlying etiology involves microtrauma to the plantar fascia, specifically at its insertion point on the calcaneus. Successful management of plantar fasciitis is typically achieved with the conservative therapy approaches discussed.

Consumer Health Newsletter Nov. 2015, Margot Malachowski Mls

Library Newsletters

Baystate Consumer Health Library Newsletter

Engaging Older Adults To Build Social Capital, Beverly K. Lunsford, Danielle Janes

Nursing Faculty Publications

Countries are considering the healthcare implications as the proportion of older adults increases, including rising healthcare costs and resources needed as more adults want to "age in place" or continue living in the community. More in home resources and support services will be needed for older adults to continue living independently at homes. Older adults are an incredibly untapped resource with a continuing need to contribute to society and a willingness to help others. Older adults are working longer than ever before, so they have the potential to build their own social capital for meeting the needs of aging colleagues. …

Carcinogenic Liver Fluke Secretes Extracellular Vesicles That Promote Cholangiocytes To Adopt A Tumorigenic Phenotype, Sujittra Chaidayet, Javier Sotillo, Michael Smout, Cinzia Cantacessi, Malcolm Jones, Paul J. Brindley, Jeffrey M. Bethony, +9 Additional Authors

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Background. Throughout Asia there is an unprecedented link between cholangiocarcinoma and infection with the liver fluke Opisthorchis viverrini. Multiple processes including chronic inflammation and secretion of parasite proteins into the biliary epithelium drive infection towards cancer. Until now, the mechanism and effects of parasite protein entry into cholangiocytes was unknown.

Methods. Various microscopy techniques were used to identify O. viverrini extracellular vesicles (EVs) and their internalization by human cholangiocytes. Using mass spectrometry we characterised the EV proteome and associated changes in cholangiocytes after EV uptake, and detected EV proteins in bile of infected hamsters and humans. Cholangiocyte proliferation and …

Evaluation Of Cytosine Dna Methylation Of The Biomphalaria Glabratahe At Shock Protein 70 Locus After Biological And Physiological Stresses, Wannaporn Ittiprasert, Andre Miller, Matty Knight, Matt Tucker, Michael H. Hsieh

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Deoxyribonucleic (DNA) methylation is one of the widespread epigenetic modifications of genomic DNA, and has been postulated to be a predisposing influence on disease onset and infections. The ability to quantify differences in DNA methylation between the genomes of normal vs.stressed Biomphalaria glabrata would help to profile changes potentially linked to resistance to Schistosoma mansoni infection. Thus, this study sought to measure differences in cytosine DNA methylation of various B. glabrata tissues responding over time to either biological or physiological stresses (S. mansoni exposure vs. heat shock). Here, this study measured DNA methylation at the B. glabrataheat …

Patient Satisfaction Of Surgical Treatment Of Clitoral Phimosis And Labial Adhesions Caused By Lichen Sclerosus, Anne N. Flynn, Michelle King, Mollie Rieff, Jill A. Krapf, Andrew T. Goldstein

Obstetrics and Gynecology Faculty Publications

Introduction

Lichen sclerosus (LS) is a chronic inflammatory dermatosis, usually affecting the anogenital skin in women. This chronic inflammation can cause scarring of genitalia including narrowing of the introitus and phimosis of the clitoris. These architectural changes can lead to recurrent tearing during intercourse (vulvar granuloma fissuratum) and decreased clitoral sensation. Surgical correction of vulvar granuloma fissuratum (VGF) and clitoral phimosis can be performed, but there is little data on the patient satisfaction and complications following these surgical procedures.

Aim

To evaluate patient experience and outcomes in women undergoing surgical correction of scarring caused by anogenital LS.

Methods

A retrospective …

Segmented Nitinol Guidewires With Stiffness-Matched Connectors For Cardiovascular Magnetic Resonance Catheterization: Preserved Mechanical Performance And Freedom From Heating., Burcu Basar, Toby Rogers, Kanishka Ratnayaka, Adrienne E Campbell-Washburn, Jonathan R Mazal, William H Schenke, +4 Additional Authors

Pediatrics Faculty Publications

BACKGROUND: Conventional guidewires are not suitable for use during cardiovascular magnetic resonance (CMR) catheterization. They employ metallic shafts for mechanical performance, but which are conductors subject to radiofrequency (RF) induced heating. To date, non-metallic CMR guidewire designs have provided inadequate mechanical support, trackability, and torquability. We propose a metallic guidewire for CMR that is by design intrinsically safe and that retains mechanical performance of commercial guidewires.

METHODS: The NHLBI passive guidewire is a 0.035" CMR-safe, segmented-core nitinol device constructed using short nitinol rod segments. The electrical length of each segment is less than one-quarter wavelength at 1.5 Tesla, which eliminates …

Agpt Registrar Satisfaction Survey November 2015, Rebecca Taylor, Ali Radloff, Jennifer Hong, Daniel Edwards

Higher education research

The Australian General Practice Training (AGPT) Registrar Satisfaction Survey (RSS) is used for ensuring continuous improvement in the training of doctors in the AGPT program. It was developed to gauge the level of registrar satisfaction with the quality of their training, with training providers, and with career progression.

Rural Disabled Medicare Beneficiaries Spend More Out-Of-Pocket Than Their Urban Counterparts, Erika C. Ziller Phd, Jennifer D. Lenardson Mhs, Andrew F. Coburn Phd

Access / Insurance

The majority of Medicare beneficiaries experience gaps between the care they need and costs covered by Medicare and seek supplemental coverage to meet this gap, including private plans offered by former employers or purchased individually, or public coverage through Medicaid. Since rural beneficiaries are more likely to purchase supplemental indemnity coverage individually, to participate in Medicaid, or to go without supplemental coverage altogether, it is likely that their out-of-pocket spending differs from that of urban residents, although the magnitude and direction of these differences may vary for individual beneficiaries. This study used data from the 2006-2010 Medical Expenditure Panel Survey …

Bdnf Contributes To Angiotensin Ii-Mediated Reductions In Peak Voltage-Gated K+ Current In Cultured Cath.A Cells., Bryan K. Becker, Han-Jun Wang, Changhai Tian, Irving H. Zucker

Journal Articles: Cellular & Integrative Physiology

Increased central angiotensin II (Ang II) levels contribute to sympathoexcitation in cardiovascular disease states such as chronic heart failure and hypertension. One mechanism by which Ang II increases neuronal excitability is through a decrease in voltage-gated, rapidly inactivating K(+) current (IA); however, little is known about how Ang II signaling results in reduced IA. Brain-derived neurotrophic factor (BDNF) has also been demonstrated to decrease IA and has signaling components common to Ang II. Therefore, we hypothesized that Ang II-mediated suppression of voltage-gated K(+) currents is due, in part, to BDNF signaling. Differentiated CATH.a, catecholaminergic cell line treated with BDNF for …

Access Denied: Barriers For Unauthorized Immigrants Pursuing The American Dream, Kristin Mcmillen

OCCUPATION: A Medium of Inquiry about Health through Occupation

Millions of immigrants from all around the world are living in the United States without legal authorization. Most have come in search of a better life for themselves or their children, with the belief that through enough hard work, they can achieve the “American Dream.” However, upon arrival, many unauthorized immigrants face cultural, economic, and political barriers that limit their opportunities for community participation and lead many individuals to live their lives in fear. This paper aims to: (a) explore the barriers encountered by unauthorized immigrants in the United States; (b) consider the occupational significance of these barriers; and (c) …

Societal Statement On The Role Of Occupational Therapy With Survivors Of Human Sex Trafficking In The United States, Chelsea Bryant, Lillian Freeman, Meghan Granata, Annie He, Hillarie Hough, Shree Patel, Ashley Stedman, Stephanie Silvia, My-Lynn Tran

OCCUPATION: A Medium of Inquiry about Health through Occupation

As part of a specialized course, OTD 8340 Wellness and Health Promotion in Occupational Therapy, students from the Nova Southeastern University Entry Level Doctor of Occupational Therapy program, drafted a Societal Statement on the role of occupational therapy with survivors of human sex trafficking in the United States. The students explored the issue of domestic human sex trafficking from an occupational perspective, under the guidance of their professor, Mirtha Montejo Whaley, PhD, OTR/L. As of the publication of this journal, the document is under review by the American Occupational Therapy Association (AOTA)

Application Of Strength, Weakness, Opportunity And Threat (Swot) Analysis For The Prioritization Of Community Health Program Objectives, Albert J. Romanosky Md, Phd, Kimberly Eshleman Mph, Rachel M. Gallo Mph

Substance Use Research & Evaluation

No abstract provided.