Medicine and Health Sciences Commons^™

Co-Targeting Of Cyclooxygenase-2 And Foxm1 Is A Viable Strategy In Inducing Anticancer Effects In Colorectal Cancer Cells, Maqbool Ahmed, Azhar Hussain, Abdul K. Siraj, Shahab Uddin, Nasser Al-Sanea, Fouad Al-Dayel, Mohammed Al-Assiri, Shaham Beg, Khawla S. Al-Kuraya

Centre for Regenerative Medicine & Stem Cell Research

Background: Cross-talk between deregulated signaling pathways in cancer cells causes uncontrolled growth and proliferation. These cancers cells become more aggressive and quickly develop resistance to therapy. Therefore targeting of these deregulated pathways simultaneously can result in efficient cell death of cancer cells. In this study we investigated co-expression of Cox-2 and FoxM1 in a cohort of colorectal carcinoma (CRC) samples and also examined whether inhibition of Cox-2 and FoxM1 simultaneously can lead to inhibition of cell viability and induction of apoptosis in colorectal cancer cell lines and in vivo xenograf
Methods: Protein expression of Cox-2 and FoxM1 was determined …

Handwriting With Adult With Developmental Delays, Joseph Hoctor

A with Honors Projects

This paper provides an assessment of the author's experience working with an adult male with Downs Syndrome to improve his cursive handwriting skills.

Hearing Loss From Traumatic Brain Injury, Nathan Young

A with Honors Projects

Traumatic brain injury to the parts of the brain responsible for processing auditory information can result in hearing loss that is difficult to assess and treat. Symptoms can include difficulty in filtering background noises or filtering out specific sounds, confusion, and disorientation or nausea. Treatment of this type of hearing loss varies, but primarily consists of psychological treatment focused around rehabilitation and coping.

Barriers To Health Care Among Laotian Americans In Middle Tennessee, Xaiyavong Saenphansiri

DNP Projects

Background. Laotian Americans have unique heath beliefs and practices. The cultural differences between Laotian American patients and American health care providers can create challenges in achieving not only evidence-based, but also culturally sensitive care. Although the current literature addresses barriers to health care for Asian Americans, there are few studies related to the Laotian-American minority.

Aim. Describing the particular barriers to preventive and curative care in the Laotian-American population in Middle Tennessee would inform strategies for successful prevention and early treatment programs for this population. The purpose of the study is to describe the health beliefs and barriers to …

Mennonite College Of Nursing Annual Report, 2014-2015, Mennonite College Of Nursing

Annual Reports - Mennonite College of Nursing

Annual report of the Mennonite College of Nursing at Illinois State University

Kimura’S Disease Of Head And Neck: A Rare Case Presentation, Talha Ahmed Qureshi, Moghira Siddiqui, Muhammad Tariq

Department of Surgery Docs

Kimura's disease (KD) is a rare, unusual occurrence, predominantly seen in Asian men, and poses a diagnostic challenge, often manifesting with allergic, eosinophilic hyperplasia, and nonspecific lymphadenitis. A 39-year-old man presented with mobile, well circumscribed, facial and neck swelling. His earlier biopsy showed a reactive lymph node hyperplasia on ultrasound neck and was suggestive of lipomatosis. As definitive diagnosis could not be made, the patient was planned for excision and biopsy. Subsequent histopathology demonstrated eosinophilic infiltration of lymphoid follicles and expansion of interfollicular area with interfollicular eosinophilic abscess formation and capillary venule proliferation. This was quite interesting as the previously …

Gene Expression And Alzheimer's Disease: Evaluation Of Gene Expression Patterns In Brain And Blood For An Alzheimer's Disease Mouse Model, Amanda Hazy

Senior Honors Theses

Previous studies have established a causative role for altered gene expression in development of Alzheimer’s disease (AD). These changes can be affected by methylation and miRNA regulation. In this study, expression of miRNA known to change methylation status in AD was assessed by qPCR. Genome-wide expression changes were determined by RNA-sequencing of mRNA from hippocampus and blood of control and AD mice. The qPCR data showed significantly increased expression of Mir 17 in AD, and sequencing data revealed 230 genes in hippocampus, 58 genes in blood, and 8 overlapping genes showing significant differential expression (p value ≤ 0.05). Expression data …

Comparison Of Helmet And Facial Mask During Noninvasiveventilation In Patients With Acute Exacerbation Of Chronic Obstructivepulmonary Disease: A Randomized Controlled Study, Özlem Çakir Gürbüz, Ali̇ Alagöz, Fatma Ulus, Mehtap Tunç, Şazi̇ye Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Noninvasive mechanical ventilation (NIMV) is an approach to prevent complications in acute respiratory failure. In this study we aimed to compare the efficacy of a full face mask and a helmet in chronic obstructive pulmonary disease (COPD). Materials and methods: Fifty patients were divided randomly into 2 groups as full face mask (Group F) and helmet (Group H). Demographic data, forced expiratory volume at 1 s (FEV1), additional disease, hemodynamic parameters, respiratory rate, APACHE II score, peripheral O2 saturation (SpO2), arterial blood gases (ABG), patient tolerance scale (PTS) score, and fraction of inspired oxygen (FiO2) were recorded. Parameters were …

High-Risk Febrile Neutropenia And Its Management In Childrenwith Solid Tumors And Lymphoma, Doğan Köse, Meli̇ke Emi̇roğlu, Yavuz Köksal

Turkish Journal of Medical Sciences

Background/aim: The clinical characteristics and treatment results of febrile neutropenia attacks that occurred in patients with lymphoma and solid tumors were analyzed. Materials and methods: A total of 50 patients with 94 high-risk attacks were evaluated for malignant diseases in this study. Results: The fever etiology was determined as clinical (50%), microbiological (5.31%), clinical-microbiological (5.31%), or unknown (39.3%). A few of the attacks (21.3%) were observed in lymphoma cases and 77.7% were observed in patients with solid tumors. Patients who were in remission had 59.6% of the attacks, and 39.4% occurred in patients not in remission. Among the groups tested, …

Comparison Of Endometrial Biopsies Of Fertile Women And Womenwith Repeated Implantation Failure At The Ultrastructural Level, Leyla Bahar, Semra Kahraman, Nazan Eras, Caroline Pirkevi

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to compare the cellular properties of endometrial tissues from fertile patients and patients having at least 3 previous in vitro fertilization failures, during the implantation window. The ultrastructural evaluation of the endometrium in the implantation window may shed light on the complexity of the implantation failure paradigm. Materials and methods: The study involved 23 women, 14 infertile with a clinical diagnosis of repeated implantation failure (RIF) and 9 fertile, defined as the control group. Endometrial samples were examined by transmission electron microscopy (TEM). Results: In the control group, secretory vacuoles and cytoplasmic projections …

Human Semen Quality And Sperm Dna Damage Assessed Bycomet Assay In Clinical Groups, Muhammad Haris Ramzan, Muhammad Ramzan, Muhammad Mumtaz Khan, Faiqah Ramzan, Fazal Wahab, Muhammad Aslam Khan, Musharraf Jillani, Mohsin Shah

Turkish Journal of Medical Sciences

Background/aim: About 10%-15% of couples around the world suffer from infertility. Male infertility is responsible directly or indirectly in ~60% of cases. A deficiency in semen is the most common cause of male infertility. Materials and methods: The study included 180 male subjects aged 18-50 years with 26 fertile and 154 infertile. The infertile subjects were further subdivided according to the WHO guidelines of semen analysis (2010) into different clinical groups. Sperm DNA damage was estimated using a neutral comet assay. Plasma gonadotropin and testosterone levels were measured using a chemiluminescence assay. Results: The results of the study revealed no …

Esophageal Replacement By Hydroxylated Bacterial Cellulose Patch In A Rabbit Model, Changlai Zhu, Fang Liu, Wenbo Qian, Yingjie Wang, Qingsheng You, Tianyi Zhang, Feng Li

Turkish Journal of Medical Sciences

Background/aim: To repair esophageal defects by hydroxylated and kombucha -synthesized bacterial cellulose (HKBC) patch in a rabbit model. Materials and methods: Semicircular esophageal defects 1 cm in length of the cervical esophagus were initially created in 18 Japanese big-ear rabbits and then repaired with HKBC patch grafts. The clinical outcomes including survival rate, weight change, food intake, and hematological and radiologic evaluation were observed. After X-ray evaluation, the rabbits were sacrificed sequentially at 1, 3, and 6 months for histopathologic analysis with light microscopy and scanning electron microscopy. Results: Survival rate during the first month was 88.9% (n = 16). …

Effects Of Turkish Propolis On Expression Of Hogg-1 And Neil-1, İbrahi̇m Turan, Orhan Değer, Yüksel Ali̇yazicioğlu, Seli̇m Demi̇r, Kağan Kilinç, Ayşegül Sümer

Turkish Journal of Medical Sciences

Background/aim: Propolis is a bee product with antioxidative, antimutagenic, and other beneficial properties, and it is used as a natural drug. It is rich in polyphenolic compounds. Its composition varies depending on the particular geographical region. Oxidative stress is caused by an imbalanced free radical production and antioxidant system. The effects of flavonoids on the expression of DNA repair enzymes have been examined previously; however, no study has investigated the effects of propolis. This study investigated the effects of ethanolic extracts of Turkish propolis (EEP) on the expression of DNA repair enzymes. Materials and methods: The effects of EEP and …

Urinary Incontinence Among Women Registered With A Family Health Center In The Southeastern Anatolia Region And The Factors Affecting Its Prevalence, Fatma Gözükara, İbrahi̇m Koruk, Burcu Kara

Turkish Journal of Medical Sciences

Background/aim: In regions such as Şanlıurfa, Turkey, where the fertility rate is high, suitable health policies to easily and successfully treat urinary incontinence (UI) are needed. This study was conducted to determine the prevalence and risk factors for UI among women in the region. Materials and methods: The participants in this cross-sectional study were selected by using 30 cluster sampling methods. A total of 300 women in the age group of 15-49 years were contacted to participate. Results: The prevalence of UI was 39.3% among women in this sample but only 8.0% actually received treatment. The logistic regression analysis showed …

Age-Related Macular Degeneration And Alzheimer Disease, Eren Çerman, Muhsi̇n Eraslan, Osman Çeki̇ç

Turkish Journal of Medical Sciences

This review highlight the similarities in the pathogenesis between Alzheimer disease and age-related macular degeneration. All studies published between 1990 and 2014 were reviewed to identify the common pathological pathways. Alzheimer disease and age-related macular degeneration share common features such as vitronectin and amyloid-β accumulation, increased oxidative stress, and apolipoprotein and complement activation pathways, which are reviewed as histologic and immunologic common features.

Alzheimer Disease And Anesthesia, Gözde İnan, Zerri̇n Özköse Şatirlar

Turkish Journal of Medical Sciences

Alzheimer disease (AD) is one of the most common neurodegenerative diseases and the most prevalent form of dementia. Some factors in the development of AD, age being the best-known one, have been suggested; however, no causes have been found yet. The pathophysiology of the disease is highly complex, current therapies are palliative, and a cure is still lacking. Adverse effects of anesthetics in the elderly have been reported since the 1950s; however, awareness of this old problem has recently gained importance again. Whether exposure to surgery and general anesthesia (GA) is associated with the development of AD has been questioned. …

Test Your Memory-Turkish Version (Tym-Tr): Reliability And Validity Study Of A Cognitive Screening Test, İlknur Mavi̇ş, Belgi̇n Demet Özbabalik Adapinar, Çinar Yeni̇lmez, Ayşe Aydin, Engi̇n Olgun, Cengi̇z Bal

Turkish Journal of Medical Sciences

Background/aim: The test your memory (TYM) is reported to be a sensitive cognitive function assessment scale for people with dementia. The aim of the present study was to investigate the reliability and validity of an adapted Turkish version of the TYM (TYM-TR) among Turkish dementia patients. Materials and methods: The TYM-TR was given to 59 patients with dementia aged 60+ and 336 normal controls aged 23-75+. The diagnostic utility of the TYM-TR was compared with that of the mini-mental state examination (MMSE) to validate it. Results: The internal consistency of the TYM-TR was α = 0.85. The test-retest reliability was …

The Prevalence Of Infectious Agents In Patients With Systemic Sclerosis, Hüseyi̇n Bi̇lgi̇n, Hi̇lal Kocabaş, Recep Keşli̇

Turkish Journal of Medical Sciences

Background/aim: Systemic sclerosis (SSc) is an autoimmune disease characterized by microvascular injury, excessive extracellular matrix deposition, and fibrosis in the skin and internal organs. Bacterial and viral infectious agents have been suspected to be contributing factors in the development and progression of the pathologic features of SSc. Materials and methods: In this study, 30 SSc patients who were admitted to the rheumatology unit of the Konya Training and Research Hospital and 30 healthy controls were included. The presence of 9 different antibodies (IgM and IgG) against Helicobacter pylori, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and parvovirus B19 were investigated in sera …

Immunogenicity Of Conserved Cork And Ss-Barrel Domains Of Baumannii Acinetobactin Utilization Protein In An Animal Model, Yaqub Hajiaghatabar Sangroodi, Iraj Rasooli, Shahram Nazarian, Walead Ebrahimizadeh, Fatemeh Sefid

Turkish Journal of Medical Sciences

Background/aim: The uptake of the ferric-acinetobactin complex into the periplasmic space relies on the baumannii acinetobactin utilization (BauA) protein. BauA is composed of cork and the β-barrel domains. We constructed a recombinant protein from conserved antigenic domains of cork and the β-barrel of BauA to evaluate their immunogenic role in an animal model. Materials and methods: The selected bauA domains were amplified from a purified genome of Acinetobacter baumannii ATCC 19606. The domains were then cloned into pET28a and the proteins expressed in E. coli BL21 (DE3) were purified using nickel nitrilotriacetic acid chromatography. Mice and rabbits were immunized with …

Effects Of Contemporary Orthodontic Composites On Tooth Color Following Short-Term Fixed Orthodontic Treatment: A Controlled Clinical Study, Bayram Çörekçi̇, Ebubeki̇r Toy, Firat Öztürk, Siddik Malkoç, Bora Öztürk

Turkish Journal of Medical Sciences

Background/aim: To determine the color alterations of natural teeth associated with different orthodontic composites used in comprehensive short-term treatment. Materials and methods: Twenty-two patients were treated with ?xed appliances and 22 untreated subjects were also evaluated. Lower incisors were bonded with different orthodontic composites: 42 with Grengloo, 41 with Light Bond, 31 with Kurasper F, and 32 with Transbond XT. The color parameters of the Commission Internationale de l'Eclairage (CIE) were measured for each tooth with a spectrophotometer. Color assessment in relation to time, adhesive material, and their interaction was made with 2-way mixed analysis of variance (ANOVA) and 1-way …

Sglt2 Inhibitors For Type 2 Diabetes Mellitus Treatment, Raymond A. Plodkowski, Megan E. Mcgarvey, Heather M. Huribal, Keith Reisinger-Kindle, Bradley Kramer, Mordecai Solomon, Quang T. Nguyen

College of Osteopathic Medicine (TUN) Publications and Research

SGLT2 inhibitors are plausible second-line drugs that provide powerful additional A1c-lowering effects while inducing weight loss without hypoglycemia.

Enhancement Of Copd Biological Networks Using A Web-Based Collaboration Interface, Stephanie Boue, Brett Fields, Julia Hoeng, Jennifer Park, Manuel C. Peitsch, Walter K. Schlage, Vladimir Bondarenko

College of Osteopathic Medicine (TUN) Publications and Research

The construction and application of biological network models is an approach that offers a holistic way to understand biological processes involved in disease. Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disease of the airways for which therapeutic options currently are limited after diagnosis, even in its earliest stage. COPD network models are important tools to better understand the biological components and processes underlying initial disease development. With the increasing amounts of literature that are now available, crowdsourcing approaches offer new forms of collaboration for researchers to review biological findings, which can be applied to the construction and verification …

Reducing Early Neonatal Heat Loss In Low Resourced Context An Indian Exemplar, Ramalingam Sindhu, P. V. Ramachandran, Clara M. Jothi, C. Susila, Pammla Petrucka

School of Nursing & Midwifery, East Africa

Background: Although there has been a favorable trend in the Infant Mortality Rate in India in the last decade, the country is still unlikely to meet the Millennium Development Goal #4. Of significance, there has been minimal improvement in the early neonatal mortality rate, which is an indicator of quality of perinatal care. In the efforts to address this aspect, a range of efforts and interventions have been considered. One such effort is in addressing and reducing hypothermia in neonates. Two low tech strategies, professional mummying/swaddling (PM/S) and ‘Kangaroo mother care’ (KMC), are seen as critical in the continuum …

A Delphi Survey Of Leadership Attributes Necessary For National Nurse Leaders’ Participation In Health Policy Development: An East African Perspective, Nilufa Jivraj Shariff

School of Nursing & Midwifery, East Africa

Background: Nurses’ involvement in health policy development ensures that health services are: safe, effective, available and inexpensive. Nursing history reveals several legendary nurse leaders who have influenced policy and the course of nursing and health care. In the recent times there have been concerns regarding the availability of effective leaders physically, symbolically and functionally at clinical, organizational and national levels, who can effectively influence health policy. Exerting influence in the policy arena requires that nurse leaders acquire attributes that enable them to be effective in policy development activity.

This paper reports part of a larger study whose purpose included: “build …

Infectious Disease Outbreaks And Increased Complexity Of Care, Joan Musau, A. Baumann, C. Kolotylo, T. O’Shea, A. Bialachowski

School of Nursing & Midwifery, East Africa

Aim: This study examined the effects of healthcare-associated infectious disease outbreaks on nurses’ work in a large acute care hospital in Ontario, Canada.

Background: The incidence of healthcare-associated infections has increased. Previous research focuses on epidemiology, healthcare systems, and the economic burden of outbreaks. Few published studies focus on the impact of outbreaks on nurses’ work in acute care facilities.

Introduction: Since the severe acute respiratory syndrome epidemic in 2003, combating infectious diseases has become a key issue. Hospitals have implemented measures related to healthcare-associated infections. However, nurses experience challenges in preventing, controlling, and contending with outbreaks.

Methods: A retrospective …

Knowledge And Attitudes Of Select Ugandan Nurses Towards Documentation Of Patient Care, Grace Nakate, Diane Dahl, Karen B. Drake, Pammla Petrucka

School of Nursing & Midwifery, East Africa

Ideally through documentation, nurses track changes in a patient’s condition, make decisions about needs, and ensure continuity of care. However, nursing documentation has often not met these objectives. In Uganda, the systematic nursing specific approach is not reflected in documentation of nursing care. A mixed methods intervention study was conducted to determine knowledge and attitudes of nurses towards documentation, including an evaluation of nurses’ response to a designed nursing documentation form. Forty participants were selected through convenience sampling from six wards of a Ugandan health institution. The study intervention involved teaching nurses the importance of documentation and using of the …

Psychobiobehavioral Model For Preterm Birth In Pregnant Women In Low- And Middle-Income Countries, Shahirose S. Premji, Ilona S. Yim, Aliyah Dosani (Mawji), Zeenatkhanu Kanji, Salima Sulaiman, Wangira Musana, Pauline Samia, Kiran Shaikh, Nicole Letourneau

School of Nursing & Midwifery, East Africa

Preterm birth (PTB) is a final common outcome resulting from many interrelated etiological pathways; of particular interest is antenatal psychosocial distress (i.e., stress, anxiety, and depression). In LMI countries, both exposure to severe life stressors and rate of PTB are on average greater when compared with high-income countries. In LMI countries women are exposed to some of the most extreme psychosocial stress worldwide (e.g., absolute poverty, limited social resources). High prevalence of antenatal stress and depression have been observed in some studies from LMI countries. We propose a psychosocial, biological, and behavioral model for investigating the complex multisystem interactions in …

Perceptions Of Patients Regarding Quality Nursing Care (Qnc) At A Tertiary Hospital In Karachi, Pakistan, Ayyub Rehan, Zeenatkhanu Kanji, Dias J., Roshan R.

School of Nursing & Midwifery, East Africa

Background: Patients’ experiences regarding the quality of care continue to be a hot topic of discussion in the healthcare industry. Exploring the quality of nursing care from the patients’ perspectives is a vital element of quality evaluation. The purpose of this study was to explore the patients’ perspectives regarding quality nursing care.

Methodology: A qualitative descriptive exploratory design was used. A total of twelve participants were recruited from one medical and one surgical unit at a tertiary care hospital in Karachi, Pakistan. Purposive sampling was used to select the participants. Data was collected through semi-structured interviews. A thematic analysis approach …

Pedagogy And Culture: An Educational Initiative In Supporting Uae Nursing Graduates Prepare For A High-Stakes Nurse Licensing Examination, Sharon Brownie, Ged Williams, Kate Barnewall, Suzanne Bishaw, Jennifer L. Cooper, Walter Robb, Neima Younis, Dawn Kuzemski

School of Nursing & Midwifery, East Africa

Graduates of an Abu Dhabi transnational nursing degree struggled with the mandatory national licensing examination. Poor pass rates undermine graduate career futures and impact on the workforce capacity building contributions of the partnering transnational educational providers. This paper describes how the design and delivery of an intensive examination preparation program dramatically reversed this trend. The objectives of this educational initiative involved the design, delivery and evaluation of a program that would align with cultural learning preferences and which improve the success rates of graduates attempting the national nurse licensing examination. To achieve these objectives, the program combined a range of …

The Changing Role Of Nursing: Opportunities For Nurse-Led Services For The Management Of Chronic Disease And Diabetes In The Uae, Sharon Brownie

School of Nursing & Midwifery, East Africa

There is little debate that current and future healthcare is, and will continue to be, dominated by the prevention and management of increasingly complex chronic health disease; the UAE is no exception. Preventive and disease management services directed at groups and individuals at risk of unfavourable health outcomes are core to the make-up of an effective health system. The burden of noncommunicable, chronic and diabetes-related diseases places a heavy strain on health service cost and service delivery requirements. The UAE is faced with the challenge of identifying and developing effective strategies for the prevention and management of the burgeoning prevalence …