Medicine and Health Sciences Commons^™

The Addition Of Tiotropium In Uncontrolled Asthma, Kathryn Gray

Physician Assistant Scholarly Project Posters

• Many patients with asthma have poorly controlled disease despite the use of both an inhaled corticosteroid (ICS) and a long acting beta agonist (LABA).

• The review explored several studies that compared the addition of tiotropium to patients with uncontrolled asthma currently using both a ICA and a LABA to determine if further symptom reduction is obtained along with reduction of exacerbations

• It was found that patients with poorly controlled asthma will benefit from the addition of tiotropium to the current medication regimen of an ICS and a LABA. Tiotropium offers providers an additional disease controlling option in …

Treatment Of Acute Bronchitis In Children With Pelargonium Sidoides, Amber Houge

Physician Assistant Scholarly Project Posters

Bronchitis is one of the most common acute infections affecting pediatric patients. Most cases are caused by viral infections, do not respond to antibiotic therapy, and can take up to 14 days to resolve with supportive therapy. The purpose of this study is to determine if the use of Pelargonium Sidoides (Umcka™, EPs 7630) extract will decrease the duration and severity of symptoms from acute bronchitis in the pediatric population. Pelargonium Sidoides abstract is an extract of an African Geranium that has been used in traditional medicine for centuries. The review of the literature will evaluate multiple randomized controlled trials …

Hypertonic Saline Therapy In Cystic Fibrosis, Idil Mohamed

Physician Assistant Scholarly Project Posters

Cystic fibrosis is an autosomal recessive genetic disorder that severely affects the lungs as well as other organs in the body. The pathophysiology of cystic fibrosis lung disease involves the production of thick and sticky mucus that accumulates leading to obstruction and inflammation of the airways. This disease is characterized by abnormal transport of sodium and chloride across an epithelium by defective genes, resulting in thick mucus secretions.

Nebulized hypertonic saline (3% NaCl) improves mucociliary clearance through rehydration of the airway surface liquid of the lungs. The purpose of this study is to evaluate the effects of nebulized hypertonic saline …

New Age Anticoagulants: A Safer And More Effective Alternative To Warfarin?, Benjamin Johnson

Physician Assistant Scholarly Project Posters

Atrial fibrillation is the most common sustained heart rhythm in the United States with estimated prevalence rates of 8.8/100 (Wolf, Abbott, & Kannel, 1991). The largest risk for patients with atrial fibrillation is that of ischemic stroke from embolization of an atrial clot, thus the long standing treatment for this arrhythmia is aggressive anticoagulation. For decades this has been accomplished with the use of warfarin, however, the increased risk of hemorrhage combined with the inconvenience of weekly blood testing has prompted the development of potentially safer and more effective alternatives. A systematic review of the literature identified studies that examined …

Comparing Fecal Microbiota Transplant (Fmt) To Vancomycin: In Treatment Of Recurrent Clostridium Difficile Infections (Cdi), Christopher Seil

Physician Assistant Scholarly Project Posters

• Clostridium difficile infection (CDI) is the main cause of antibiotic-associated pseudomembranous colitis.

• CDI has tripled over the last ten years due to the increased use of broad spectrum antibiotics. CDI has become increasingly difficult to manage with traditional therapies such as metronidazole and vancomycin due to mutations in the pathogen, resulting in resistant organisms.

• The purpose of this review was to determine if fecal microbiota transplantation (FMT) is more effective in treating and curing CDIs than traditional vancomycin therapy.

• The hypothesis was that FMT will have better treatment outcomes than traditional vancomycin therapy.

• The findings …

Lyme Disease Outcomes With Immediate, Short Duration Antibiotic Use Versus Delayed, Longer Duration Use, Lori A. Steinley

Physician Assistant Scholarly Project Posters

Lyme disease is the fastest growing vector-borne disease in the United States, according to the Infectious Disease Society of America (IDSA). The guidelines for diagnosis provided by the IDSA include evidence of erythema migrans rash with validation of a positive two-tier serology testing. With no established treatment standards, decreased sensitivity of testing and inconsistency of observing the rash, practitioners following the guidelines may delay treatment of antibiotics. This delay could cause progression of severity of symptoms.

The purpose of this study is to compare implementation and duration time of antibiotics and establish the treatment protocol for best clinical outcomes for …

Acute Myocardial Infarction: Are We Overlooking Nstemi?, Kevin D. Swenson

Physician Assistant Scholarly Project Posters

• Acute myocardial infarction (AMI) is one of the leading causes of death in the United States.

• The purpose of this study was to examine methods of clinical differentiation between ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) and then to compare the various treatment methods and subsequent outcomes in STEMI versus NSTEMI.

• A compilation of systematic reviews, medical journals, practice guidelines, medical texts and meta-analyses were researched for the purpose of this study.

• NSTEMI patients are older, have more comorbidities and present with more atypical symptoms than STEMI patients.

• NSTEMI patients are treated less aggressively …

Muscle Fiber Size And Composition Differences Between Ames Dwarf Mice And Wild-Type Mice, Jordan Anderson

Physical Therapy Scholarly Projects

Background: Ames dwarf mice demonstrate delayed aging processes in multiple body systems. We compared muscle composition and area between dwarf and wild-type mice to determine if any significant differences exist.

Methods: We resected soleus, gastrocnemius/plantaris, tibialis anterior, and extensor digitorum longus muscles from both dwarf and wild-type mice, then froze, sliced, set on slides, and stained to isolate fast-twitch and slow-twitch fibers. Microscopy images were taken at 10x magnification and fiber composition and cross-sectional area were measured in soleus muscles.

Results: Wild-type mice had an average composition of 52.3% fast-twitch and 47.7% slow-twitch fibers while dwarf mice had 66.3% slow-twitch …

S/P Right Hip Orif, Brian Bartow

Physical Therapy Scholarly Projects

Background and Purpose: Hip fracture is a major medical problem among older adults, leading to impaired balance and gait and loss of functional independence. An open reduction internal fixation (ORIF) is a method of surgically repairing a fractured bone. Generally, this involves either the use of plates and screws or an intramedullary (IM) rod to stabilize the bone.

Case Description: The patient was a 51-year-old female who fractured her right hip while running. She had complained of thigh pain with running for 1 to 2 months prior. She had gamma nail pinning.

Intervention: The focus of treatment was to increase …

Developing Entry-To-Practice Nursing Informatics Competencies For Registered Nurses, Lynn M. Nagle, Kristine Crosby, Noreen Frisch, Elizabeth Borycki, Lorie Donelle Phd, Rn, Fcan, Kathryn Hannah, Alexandra Harris, Sylvie Jetté, Tracy Shaben

Publications

Information and communication technologies (ICT) have brought about significant changes to the processes of health care delivery and changed how nurses perform in clinical, administrative, academic, and research settings. Because the potential benefits of ICT are significant, it is critical that new nurses have the knowledge and skills in informatics to provide safe and effective care. Despite the prevalence of technology in our day to day lives, and the potential significant benefits to patients, new nurses may not be prepared to work in this evolving reality. An important step in addressing this need for ICT preparation is to ensure that …

Comparative Transcriptome Profiling Of Two Tibetan Wild Barley Genotypes In Responses To Low Potassium, Jianbin Zeng, Xiaoyan He, Dezhi Wu, Bo Zhu, Shengguan Cai, Umme Aktari Nadira, Zahra Jabeen, Guoping Zhang

Publications

Potassium (K) deficiency is one of the major factors affecting crop growth and productivity. Development of low-K tolerant crops is an effective approach to solve the nutritional deficiency in agricultural production. Tibetan annual wild barley is rich in genetic diversity and can grow normally under poor soils, including low-K supply. However, the molecular mechanism about low K tolerance is still poorly understood. In this study, Illumina RNA-Sequencing was performed using two Tibetan wild barley genotypes differing in low K tolerance (XZ153, tolerant and XZ141, sensitive), to determine the genotypic difference in transcriptome profiling. We identified a total of 692 differentially …

Dj-1 And Atp13a2: Two Proteins Involved In Parkinson’S Disease, Josephat M Asiago

Open Access Dissertations

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 0.3% of the total U.S. population, and its prevalence increases with age. Two neuropathological hallmarks of PD are the loss of dopaminergic neurons in the substantia nigra pars compacta, a region in the midbrain involved in initiating and sustaining movement, and the presence of cytosolic inclusions called Lewy bodies (LBs) in various brain regions. LBs are enriched with fibrillar forms of the presynaptic protein &agr;-synuclein (aSyn). Two autosomal recessive genes implicated in familial PD are PARK9, encoding the P-type ATPase ATP13A2, a lysosomal ATPase; and …

Occupational Therapy And Health Sciences News, January 2014, Occupational Therapy Department

News, Magazines and Reports

2013, a year in review. In OT we have 2 new faculty members, Sharon McCloskey and Lola Halperin. The Health Sciences program is pleased to welcome Dr. Raja Staggers-Hakim. Student events. Faculty achievements.

Importance Of Bacillithiol In The Oxidative Stress Response Of Staphylococcus Aureus, Ana C. Posada, Stacey L. Kolar, Renata G. Dusi, Patrica Francois

Dartmouth Scholarship

In Staphylococcus aureus, the low-molecular-weight thiol called bacillithiol (BSH), together with cognate S-transferases, is believed to be the counterpart to the glutathione system of other organisms. To explore the physiological role of BSH in S. aureus, we constructed mutants with the deletion of bshA (sa1291), which encodes the glycosyltransferase that catalyzes the first step of BSH biosynthesis, and fosB (sa2124), which encodes a BSH-S-transferase that confers fosfomycin resistance, in several S. aureus strains, including clinical isolates. Mutation of fosB or bshA caused a 16- to 60-fold reduction in fosfomycin resistance in these S. aureus strains. High-pressure liquid chromatography analysis, which …

Ada Constitution & Bylaws (2014), American Dental Association

Constitution & Bylaws

The ADA Commons Constitution & Bylaws archival collection comprises printed issues of the American Dental Association's Constitution and Bylaws. The collection also includes the ADA Charter and the ADA Code of Ethics issued 1924-1946.

Yoga And Breathing And Relaxation Techniques Used During The School Day And Their Effects On School-Aged Children, Erica Marie Thomas

Wayne State University Theses

Physical activity during the school day is becoming more important as the health of our children stays below optimal levels. Yoga has been shown to increase physical activity levels and decrease stress. This study, guided by the Social Cognitive Theory's idea of reciprocal determinism, sought to determine the effects of a Yoga Calm® certified classroom teacher incorporating yoga poses, breathing and relaxation techniques and games into every school day. Quantitative data were analyzed using a series of paired and independent t-tests, and self-reports revealed students receiving yoga decreased scores in stress and fighting, but increased scores in anger. Qualitative data …

Professional Product Review Vol. 9 No. 3, American Dental Association, Council On Scientific Affairs

Professional Product Review

A user-friendly newsletter from the ADA Council on Scientific Affairs offering scientifically sound, unbiased, and clinically relevant information to member dentists about professional dental products tested by the ADA. This collection is historical and may not reflect current standards. For up-to-date information contact the ADA.

Professional Product Review Vol. 9 No. 1, American Dental Association, Council On Scientific Affairs

Professional Product Review

A user-friendly newsletter from the ADA Council on Scientific Affairs offering scientifically sound, unbiased, and clinically relevant information to member dentists about professional dental products tested by the ADA. This collection is historical and may not reflect current standards. For up-to-date information contact the ADA.

Professional Product Review Vol. 9 No. 2, American Dental Association, Council On Scientific Affairs

Professional Product Review

A user-friendly newsletter from the ADA Council on Scientific Affairs offering scientifically sound, unbiased, and clinically relevant information to member dentists about professional dental products tested by the ADA. This collection is historical and may not reflect current standards. For up-to-date information contact the ADA.

Professional Product Review Vol. 9 No. 4, American Dental Association, Council On Scientific Affairs

Professional Product Review

A user-friendly newsletter from the ADA Council on Scientific Affairs offering scientifically sound, unbiased, and clinically relevant information to member dentists about professional dental products tested by the ADA. This collection is historical and may not reflect current standards. For up-to-date information contact the ADA.

Ada Council On Scientific Affairs Extends Application Period For John W. Stanford New Investigator Award, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

Children’S Teeth Tops Parents’ Halloween Concerns, According To New Survey, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

Electronic Prescribing And Its Implementation In The United States, Kate Englebert, Amber Porterfield, William K. Willis, Alberto Coustasse

Management Faculty Research

Introduction: Electronic prescribing (e-prescribing) is an important part of the nation’s push to create an electronically accessible national health system. E-prescribing allows providers to send prescriptions electronically to the pharmacy and can be stand-alone systems or part of an integrated electronic health record system.

Methodology: The methodology for this study was a literature review. Electronic databases accessed include EBSCOhost, PubMED, and Google Scholar. Additionally, government websites and a semi-structured interview were used. A total of 39 sources were referenced for the review.

Results: The results of the literature review demonstrated that e-prescribing reduces prescribing errors, increases efficiency, and helps save …

Intensive Group Therapy Might Be Considered For Older Teenagers Who Stutter, Manish Rami

Communication Sciences & Disorders Faculty Publications

This review provides a summary and appraisal commentary on the treatment review by Fry, J., Millard, S., & Botterill, W. (2014). Effectiveness of intensive, group therapy for teenagers who stutter. International Journal of Language and Communication Disorders, 49, 113–126.

Source of funding and disclosure of interest: Rayne Foundation partially supported this study. Original authors reported that there were no conflicts of interest.

Perspectives On: Cyclic Nucleotide Microdomains And Signaling Specificity, Jeffrey W. Karpen

Touro College of Osteopathic Medicine (Middletown) Publications and Research

The author provides an introduction to a special issue on cyclic nucleotides concerning four areas in cAMP compartmentation.

Sceletium Tortuosum And Mesembrine: A Potential Alternative Treatment For Depression, Rebecca Schell

Scripps Senior Theses

Major depressive disorder affects people’s productivity and ability to function in everyday life. The disorder can be attributed to neurochemical imbalances of various neurotransmitters including but not limited to serotonin, dopamine, and norepinephrine. Conventional pharmacological treatments have focused primarily on these three neurotransmitters, and have been shown to be effective in alleviating most of the major symptoms of depression. Although these treatments are effective with most patients, they are known to have adverse side effects, causing patients to seek alternative treatments. Sceletium tortuosum, a succulent plant found in the Cape region of South Africa, has been shown to have …

Shots, Everybody? : British Anti-Smallpox Vaccination And The Development Of Multifaceted Anti-Vaccine Rhetoric On Internet Parenting Forums, Marta B. Bean

Scripps Senior Theses

Vaccination is an important public health measure that can help reduce disease at the population level. Substantial evidence exists that vaccines are safe and effective at reducing the incidence of diseases like pertussis, measles and cervical cancer. However, on Internet parenting forums, parents discuss whether or not vaccination is the right choice for their children. In this thesis, I highlight the historical context of the anti-vaccine movement in mid 19^th century to early 20^th century Victorian Britain in the era of compulsory smallpox vaccination. Vaccination in this time was a very different and more overtly dangerous process, and …

Altered Tendon Characteristics And Mechanical Properties Associated With Insertional Achilles Tendinopathy, Ruth L. Chimenti, Adolph S. Flemister, Joshua Tome, James M. Mcmahon, Marie A. Flannery, Ying Xue, Jeff R. Houck

Faculty Publications - College of Physical Therapy

Study Design: Case-control laboratory study.

Objectives: To compare tendon characteristics (shape, composition) and mechanical properties (strain, stiffness) on the involved side of participants with insertional Achilles tendinopathy (IAT) to the uninvolved side and to controls, and to examine if severity of tendon pathology is associated with severity of symptoms during function.

Background: Despite the severity and chronicity of IAT, the quality of theoretical evidence available to guide the development of exercise interventions is low. While tendon pathology of midportion Achilles tendinopathy has been described, there are few studies specific to IAT.

Methods: Twenty individuals with unilateral IAT and 20 age- …

Affective Responses To Music Without Recognition: Beyond The Cognitivist Hypothesis, W. Trey Hill

Psychology Faculty Publications

A recent topic of concern for those interested in the science of music is whether affective responses to music are the result of recognition or actual affective experience. Cognitivist researchers have found that individuals recognize rather than feel an affective response when listening to music, while emotivist proponents posit that people have an intrinsic affective experience to music. While it has been promoted that biological methods must be used in order to answer this recognition-experience problem cited above, the current authors employed a more traditional technique (i.e., paper and pencil self-report surveys). Data from the present study show that participants …

A Mitochondrial Rnai Screen Defines Cellular Bioenergetic Determinants And Identifies An Adenylate Kinase As A Key Regulator Of Atp Levels, Nathan J. Lanning, Brendan D. Looyenga, Audra L. Kauffman, Natalie M. Niemi

University Faculty Publications and Creative Works

Altered cellular bioenergetics and mitochondrial function are major features of several diseases, including cancer, diabetes, and neurodegenerative disorders. Given this important link to human health, we sought to define proteins within mitochondria that are critical for maintaining homeostatic ATP levels. We screened an RNAi library targeting >1,000 nuclear-encoded genes whose protein products localize to the mitochondria in multiple metabolic conditions in order to examine their effects on cellular ATP levels. We identified a mechanism by which electron transport chain (ETC) perturbation under glycolytic conditions increased ATP production through enhanced glycolytic flux, thereby highlighting the cellular potential for metabolic plasticity. Additionally, …