Medicine and Health Sciences Commons^™

Fetal And Neonatal Exposure To Nicotine Leads To Augmented Hepatic And Circulating Triglycerides In Adult Male Offspring Due To Increased Expression Of Fatty Acid Synthase, Daniel Hardy

Data and Test Instruments

No abstract provided.

Suicide Prevention: Education And Training For Health Professionals In Primary Care, Amresh Srivastava

Data and Test Instruments

RISK ASSESSMENT OF SUICIDE IN CLINICAL PRACTICE AMRESH SHRIVASTAVA1. Suicide is a public health problem presents as the most serious psychiatric emergency. Identification and assessment of suicidality is a skill that every physician needs to have, skills for identification and intervention Risk assessments are done in number of settings like: emergency rooms, psychiatric outpatient, primary care, general medical wards, post-operative and intensive care settings, crisis centers, day hospitals for crisis beds, telephone helplines, psychiatric outpatients, psychiatric acute services, community psychiatry settings, early intervention programs, sometimes in special settings like jails, prisons, schools, workplaces and legal justice systems. In every setting …

Global Mental Health, Amresh Srivastava

Data and Test Instruments

No abstract provided.

Waveguide Evanescent Field Scattering Microscopy: Bacterial Biofilms And Their Sterilization Response Via Uv Irradiation, Qamrun Nahar, Frederik Fleiβner, Jeremiah Shuster, Michael Morawitz, Christopher Halfpap, Mihaela Stefan, Uwe Langbein, Gordon Southam, Silvia Mittler

Physiology and Pharmacology Publications

Waveguide Evanescent Field Scattering (WEFS) microscopy is introduced as a new and simple tool for label-free, high contrast imaging of bacteria and bacteria sensors. Bacterial microcolonies and single bacteria were discriminated both by their bright field images and by their evanescent scattering intensity. By comparing bright field images with WEFS images, the proportion of planktonic: sessile (i.e., ‘floating’: attached) bacteria were measured. Bacteria were irradiated with UV light, which limited their biofilm forming capability. A quantitative decrease in attachment of individual, sessile bacteria and in attached, microcolony occupied areas was easily determined within the apparent biofilms with increasing UV dose. …

Ua12/4 Stall Street Journal, Vol. 6, Wku Health Services

WKU Administration Documents

Broadsides developed by WKU Health Services to convey public health information in students in bathroom stalls. Incomplete run.

Results From Ireland's 2014 Report Card On Physical Activity In Children And Youth, Deirdre M. Harrington, Sarahjane Belton, Tara Coppinger, Muireann Cullen, Alan Donnelly, Kieran Dowd, Teresa Keating, Richard Layte, Marie Murphy, Niamh Murphy, Elaine Murtagh, Catherine Woods

Publications

Background: Physical activity (PA) levels are a key performance indicator for policy documents in Ireland. The first Ireland Report Card on Physical Activity in Children and Youth aims to set a robust baseline for future surveillance of indicators related to PA in children and youth. Methods: Data collected between 2003-2010 on more than 35,000 7- to 18-year-old children and youth were used and graded using a standardized grading system for 10 indicators. Results: Grades assigned for the indicators were as follows: overall physical activity levels, D-; sedentary behavior (TV viewing), C-; organized sport participation, C-: physical education, D-; active play, …

What Predicts Drive For Muscularity In Collegiate Athletes V. Non-Athletes?, Mary Pritchard, Alli Nielsen

Psychological Sciences Faculty Publications and Presentations

In the past decade, research has begun to focus not only on dieting and exercise to lose weight, but dieting and exercise to gain muscle mass (drive for muscularity; DFM). While research has established that men tend to exhibit greater levels of DFM than women, little research has examined the influence of athletic status on drive for muscularity in male and female college students. This present study surveyed 290 student participants (30 female athletes, 38 male athletes, 139 female non-athletes, 82 male nonathletes and asked them about their DFM, as well as factors known to relate to DFM. As expected, …

Santa Clara Magazine, Volume 56 Number 1, Fall 2014, Santa Clara University

Santa Clara Magazine

14 - HEARING THE CRY OF THE POOR: The Jesuit martyrs of El Salvador by Ron Hansen M.A. ’95. Their murder in November 1989 marked a turning point in the country’s civil war. What do they have to say to us now?

25 - THE OPEN WINDOW by Lucía Cerna. A first-person account by the housekeeper in the Jesuit community at the University of Central America. She witnessed the killing of six Jesuits by government soldiers, and telling the truth about that night cost her dearly.

29 - WHAT DO YOU STAND FOR? By Mary Jo (Hull) Ignoffo ’78. The …

Santa Clara Magazine, Volume 55 Number 2, Winter 2014, Santa Clara University

Santa Clara Magazine

16 - RISE UP, MY LOVE by Brian Doyle. There are sanctuaries built for worship—and that carry beauty visible to everyone. Then there are the improvised places of faith, more subtle in how they speak to the wonder worked there.

18 - THE CHAPLAIN IS IN THE HOUSE by Jeremy Herb ’08 with Ppotos by Pat Semansky ’08. With the way things have gone recently in Congress, looking to the heavens for some help and guidance might seem like a very good idea. Enter Pat Conroy, S.J., M.Div. ’83.

24 - WELCOME TO CITIZENVILLE by Jim Cottrill. Who published the …

Confidentiality And Mental Health/Chaplaincy Collaboration, Denise Bulling, Mark Dekraai, Tarik Abdel-Monem, Jason A. Nieuwsma, William C. Cantrell, Keith Ethridge, Keith Meador

University of Nebraska Public Policy Center: Publications

Confidentiality can both facilitate and inhibit working relationships of chaplains and mental health professionals addressing the needs of service members and veterans in the United States. Researchers conducted this study to examine opportunities for improving integration of care within the Department of Defense (DoD) and Department of Veterans Affairs (VA). Interviews were conducted with 198 chaplains and 201 mental health professionals in 33 DoD and VA facilities. Using a blended qualitative research approach, researchers identified several themes from the interviews, including recognition that integration can improve services; chaplaincy confidentiality can facilitate help seeking behavior; and mental health and chaplain confidentiality …

Identifying And Addressing Sources Of Measurement Error In The Norbeck Social Support Questionnaire, Eileen Gigliotti, William Ellery Samuels, June Como, Tofiga Gamidova, Brian Gordon, Peter Acerios

Publications and Research

Background and Purpose: The Norbeck Social Support Questionnaire (NSSQ) provides a rich portrait of one’s perceived social support including network size/composition and quality of support. Analyses of quantitative research reports and critiques of the NSSQ revealed non-negligible measurement error. We document evidence of measurement error, report potential sources of this error, and present forthcoming psychometric testing. Methods: Quantitative evidence of measurement error from the NSSQ literature provided the basis for initial hypotheses concerning sources of error in network nomination and support ratings. We then conducted cognitive interviews to investigate these hypotheses. Results: Cognitive interviews revealed evidence of respondents’ miscomprehension and …

Metal Containing Nucleosides That Function As Therapeutic Diagnostic Agents Against Brain Cancer, Jennifer Nicole Williams

ETD Archive

Nucleoside transporters are essential components for the hyperproliferative capabilities of brain cancer cells. These transporters play important roles to increase nucleoside metabolism which is necessary for higher levels of DNA and RNA synthesis. The goal here is to use a series of metal containing nucleoside (MCN) analogues as novel chemical agents to study how nucleosides are imported into cells. In addition, we expect that these MCNs will ultimately function as therapeutic and/or diagnostic agents for brain cancer. Concentrative nucleoside transporters (CNTs) and equilibrative nucleoside transporters (ENTs) represent the two classes of transporters that allow MCNs to travel in (and out) …

Acoustic And Respiratory Measures As A Function Of Age In The Male Voice, Mark Selent

ETD Archive

The purpose of this study was to extend understanding of the effects of aging on the male voice by obtaining and analyzing both acoustic and respiratory measures across the aging continuum. Aerodynamic measurements such as vital capacity (VC), maximum phonation time (MPT) and the acoustic measurement Speaking Fundamental Frequency (SFF) are used commonly in Speech-language Pathology to aid in the assessment and treatment outcomes of vocal dysfunction. However, current research lacks analysis of the interaction across these parameters within males and younger ages. This information may be important in understanding the normal changes in the speech mechanism with age and …

Self-Assembly Of Peptides To Nanostructures, Dindyal Mandal, Amir Nasrolahi Shirazi, Keykavous Parang

Pharmacy Faculty Articles and Research

The formation of well-ordered nanostructures through self-assembly of diverse organic and inorganic building blocks has drawn much attention owing to their potential applications in biology and chemistry. Among all organic building blocks, peptides are one of the most promising platforms due to their biocompatibility, chemical diversity, and resemblance with proteins. Inspired from the protein assembly in biological systems, various self-assembled peptide structures have been constructed using several amino acids and sequences. This review focuses on this emerging area, the recent advances in peptide self-assembly, and formation of different nanostructures, such as tubular, fibers, vesicles, spherical, and rod coil structures. While …

High Prevalence Of Early Childhood Infection By Kshv In A Minority Population In China, Yifei Cao, Veenu Minhas, Xiaohua Tan, Jin Huang, Baodong Wang, Meiyi Zhu, Yuan Gao, Tingting Zhao, Lei Yang, Charles Wood

Nebraska Center for Virology: Faculty Publications

In China, KSHV seroprevalence varies considerably among different regions and ethnicities. But in Xinjiang province, located in the northwestern China, there is a very high seroprevalence of KSHV in adults of Kazak and Ughur ethnicities. However, KSHV prevalence in children and the risk factors associated with the acquisition of infection are currently not known. The aim of this study was to investigate the prevalence of KSHV infection, identify associated socio-economic or behavioral risk factors and the humoral immune response among children in this population. This is a cross-sectional study (N=178) to screen children and their caregivers from Xinjiang for total …

Integrins Promote Cytokinesis Through The Rsk Signaling Axis, Shomita S. Mathew, Bethsaida Nieves, Sharon Sequeira, Savitha Sambandamoorthy, Kevin Pumiglia, Melinda Larsen, Susan E. Laflamme

Biological Sciences Faculty Scholarship

Cytokinesis is the final stage in cell division. Although integrins can regulate cytokinesis, the mechanisms involved are not fully understood. In this study, we demonstrate that integrin-regulated ERK (extracellular signal-related kinase) and RSK (p90 ribosomal S6 kinase) signaling promotes successful cytokinesis. Inhibiting the activation of ERK and RSK in CHO cells by a mutation in the integrin b1 cytoplasmic tail or with pharmacological inhibitors results in the accumulation of cells with midbodies and the formation of binucleated cells. Activation of ERK and RSK signaling by the expression of constitutively active RAF1 suppresses the mutant phenotype in a RSK-dependent manner. Constitutively …

Condoms And Contradictions: Assessing Sexual Health Knowledge In Lesbian, Gay, Bisexual, Trans, And Queer Youth Labelled With Intellectual Disabilities, Ciann L. Wilson

Psychology Faculty Publications

Background: Accessible, culturally relevant data collection tools to assess the sexual health knowledge of lesbian, gay, bisexual, trans, queer and questioning (LGBTQ) young people labelled with intellectual disabilities are sparse.

Materials and Methods: Using community-based participatory research (CBPR) we piloted a variety of interactive activities designed to assess the sexual health knowledge and decision making skills of LGBTQ young people with intellectual disabilities.

Results: Posters created by youth participants suggested substantial sexual health knowledge and empowerment, while individual knowledge assessment scores indicated a range in understanding of risks and strategies to avoid pregnancy, HIV and herpes.

Conclusions: These findings reinforce …

The Relationship Between Collective Action And Well-Being And Its Moderators: Pervasiveness Of Discrimination And Dimensions Of Action, Mindi D. Foster

Psychology Faculty Publications

Given the negative impact of perceiving gender discrimination on health (e.g., Pascoe & Smart Richman, 2009), there is a need to develop interventions to attenuate this effect; collective action may be one such intervention. Study 1 (N = 185) used an experimental paradigm to investigate whether undergraduate women in Waterloo, Ontario, Canada perceived pervasiveness of discrimination would interact with their collective action-taking to predict negative mood and well-being. Results showed that among those perceiving pervasive gender discrimination, informing friends/family and informing the media led to greater well-being than doing nothing, whereas among those perceiving gender discrimination as isolated, doing nothing …

Subjective And Non-Subjective Information In Children’S Allegations Of Abuse, Jennifer E. Newman, Kim P. Roberts

Psychology Faculty Publications

In this study, we were interested in how interviewers elicit subjective information in investigations of child abuse (e.g., descriptions of thoughts, emotions, opinions). Sixty-one interviews of children aged 4-12 years old were analyzed to determine the amount of subjective information versus non-subjective event details reported, and the type of question that elicited the information. Interviewers elicited more non-subjective than subjective information, although there was more focus on subjective information in the rapport-building phase than in the substantive phase when the allegations were elicited. Interviewer prompts and child responsiveness was congruent such that non-subjective questions elicited more non-subjective information, and subjective …

Recommendations For Interviewing Children About Repeated Experiences, Martine B. Powell, Sonja P. Brubacher, Kim P. Roberts

Psychology Faculty Publications

For just over two decades, researchers have been conducting empirical studies devoted to understanding children’s memory for, and ability to describe, individual occurrences of events they have experienced repeatedly. This knowledge is critical because children making allegations of repeated abuse are required to provide details particular to an individual incident in many jurisdictions internationally. Based on this theoretical foundation, we provide specific suggestions to practitioners to assist children in reporting as much information as possible about individual occurrences and techniques that may assist them in doing so accurately. These recommendations cover both presubstantive (i.e., “practice”) and substantive phases of the …

Children’S Use Of A ‘Time Line’ To Indicate When Events Occurred, Leanne L. Gosse, Kim P. Roberts

Psychology Faculty Publications

Children who allege abuse are often asked to provide temporal information such as when the events occurred. Yet, young children often have difficulty recalling temporal information due to their limited knowledge of temporal patterns and linguistic capabilities. As time is an abstract concept (we cannot see it), some investigators have begun to use ‘time-lines’ or pictorial representations of time to aid children. Yet, there is no published research testing whether children are able to use time-lines and whether they can provide adequate temporal information using them. We tested whether children could indicate the time-of-day of events using a pictorial time-line …

Is Burnout A Depressive Disorder? A Reexamination With Special Focus On Atypical Depression, Renzo Bianchi, Irvin Sam Schonfeld, Eric Laurent

Publications and Research

Whether burnout and depression cover the same psychopathology remains to be elucidated. To date, subtypes of depression have been overlooked in research on the burnout–depression overlap. Our aim was to estimate the prevalence of depressive disorders in workers with burnout while examining the overlap of burnout with the atypical subtype of depression. The present study included 5,575 schoolteachers (mean age = 41 years; 78% female). Burnout was assessed with the Maslach Burnout Inventory. Depression was measured with the 9-item depression scale of the Patient Health Questionnaire (PHQ-9). Atypical features of depression were examined using a dedicated module, referenced to …

Empathy As A Moderator Of Adolescent Bullying Behavior And Moral Disengagement After Controlling For Social Desirability, Amy Zelidman

Wayne State University Dissertations

The purpose of this study was to assess the moderating influence empathy has on the associations between adolescent bullying behavior and moral disengagement after controlling for social desirability (e.g., response bias). 676 students in 7th and 8th grade from a suburban middle school in Southeast Michigan participated in this study in the fall of 2012.

Results showed male respondents were more likely than female respondents to (a) report engaging in all forms of traditional bullying behavior overall, including physical, verbal, and social bullying and (b) report higher rates of physical victimization and moral disengagement. Female respondents were more likely to …

Accumulation Of Subcortical Iron As A Modifier Of Volumetric And Cognitive Decline In Healthy Aging: Two Longitudinal Studies, Ana Marie Daugherty

Wayne State University Dissertations

Accumulation of non-heme iron in the brain has been theorized as a cellular mechanism underlying global neural and cognitive decline in normal aging and neurodegenerative disease. Relatively few studies of brain iron in normal aging exist and extant studies are almost exclusively cross-sectional. Here, I estimated iron content via T2* and measured volumes in several brain regions in two independent samples of healthy adults. The first sample (N = 89) was measured twice with a two-year delay; and the second sample (N = 32) was assessed four times over a span of 7 years. Latent models estimated change in iron …

Evaluation Of Presynaptic Dopamine Dynamics After: Toluene Inhalation Or Trkb Receptor Activation, Aaron Kwaku Apawu

Wayne State University Dissertations

Dopamine (DA) neurons in the striatum mediate several functions of the brain and have been linked to a host of neurological disorders including Parkinson's disease and addiction, both of which occur as a result of dysfunction in the DA system. In the present study, our first objective was to understand how the striatal DA system adapts to acute and repeated administration of inhalant toluene. The use of toluene as inhalant, like other drugs of abuse, is known to perturb DA neurotransmission in the brain reward pathway. However, the exact mechanism underling toluene's influence on striatal DA neurotransmission is unknown. The …

Coping Similarity And Psychosocial Risk Factors In Couples With Chronic Pain, Amy M. Williams

Wayne State University Dissertations

Chronic pain is an important public health problem that is associated with a host of negative individual and relationship outcomes. Chronic pain is a chronic stressor that both the individual in pain and their spouse must cope with. The current study examined how pain coping similarity within the couple predicted not only patient adjustment, but also spouse adjustment in a longitudinal study. Participants were 108 heterosexual couples in which one partner had chronic pain. The participants completed measures at 3 time points at 6 month intervals. Both the patient and spouse individually completed questionnaires pertaining to their marriage, mood, pain …

An Exploration Of The Use Of Objects In The Creation, Maintenance, And Social Performance Of Self Among People With Alzheimer's Disease And Related Disorders, Jayne Marie Yatczak

Wayne State University Dissertations

In the United States individuals with Alzheimer's disease and related disorders (ADRD) are faced with multiple threats to their social lives and to their sense of self. Such threats include the assumption that our sense of self is entirely dependent upon cognition and memory, elements that become impaired in AD (Kontos 2006) and images of Alzheimer's disease as the death before death (Behuniak 2011). The move to a long term care setting with its simultaneous stripping away of possessions that supply one with personal identity also poses such a threat. Although, individuals with ADRD who move to long term care …

Metabolic Syndrome In Obese African American Adolescents, Yulyu Yeh

Wayne State University Dissertations

Limited research regarding metabolic syndrome (MetS) has been conducted in obese African American adolescents (OAAA) using the International Diabetes Federation IDF criteria. MetS is a constellation of risk factors that increase the risk for chronic diseases and is defined as presence of any 3 or more of the 5 criteria: fasting glucose 100mg/dl, waist circumference 90th percentile, triglycerides 150 mg/dl, blood pressure (BP) 130/85 mmHg and HDL < 40mg/dl. The aim of this study was to assess the incidence of MetS in OAAA by using the IDF criteria and the relationship with diet, fast food consumption, nutrition knowledge, home food environment (HFE), and serum calcium, leptin, 1,25-dihydroxy vitamin D (1, 25 D3) levels. One hundred and fifty one OAAA (mean age: 14.3 ± 1.4 years, 65.6% girls, mean BMI: 37.4±7.2 kg/m2) in a metropolitan area took part in this study. Anthropometric data and fasting blood samples were collected. Participants completed a set of questionnaires regarding diet, fast food consumption, and nutrition knowledge. HFE was completed by the care givers. The MetS rate for OAAA was 61.6% and boys had higher MetS than girls (73.1%, 55.6% respectively). OAAA without MetS had higher serum calcium and 1,25 D3 level but no significant difference were found in food consumption, nutrition knowledge, and HFE. Total cholesterol /HDL ratio and Insulin resistance increased the odds of MetS by 55% and 10% and 1,25 D3 decrease the odds of MetS by 2%. Even though high fast food consumption, lack of nutrition knowledge and poor food environment were negatively associated with obesity, they didn't contribute to MetS. Increase serum vitamin D and calcium level might be beneficial to reduce MetS in OAAA population.

The Role Of Pdgf C And Its Splice Variant In Breast Cancer, Alyssa Bottrell

Wayne State University Dissertations

The PDGF family consists of four members; while PDGF A and B are secreted as active dimers, PDGF C and D are secreted as latent dimers that undergo serine protease-mediated extracellular proteolytic activation. Gene expression analysis of breast cancer cell lines showed that PDGF C expression is associated with Basal B subtype breast cancer cells which have cancer stem cell-like characteristics. Furthermore, PDGF C expression is associated with triple-negative (estrogen receptor-, progesterone receptor- and HER2/neu-negative) breast cancer cells, a challenging type of breast cancer to treat. During the course of our study, we discovered a splice variant of PDGF C …

Using Video Games For Decreasing Pain Caused By Acute Painful Crisis In Adolescents With Sickle Cell Pain, Talal Ali

Wayne State University Dissertations

Purpose: The most common symptom of sickle cell disease is pain, which occurs as the cells clump compromising further blood flow to distal organs. Despite the advancement in pain management, many children and adolescents' pain remains under treated. The purpose of this study is measure the effectiveness of a videogame as a developmentally appropriate non-pharmacological modality on pain in adolescents 12-21 years of age with sickle cell crisis.

Methods: A one-group repeated measure quasi-experimental design was used to evaluate the effectiveness of using videogames on pain in a sample of adolescents 12-21 years of age. Using a repeated measures design …