Medicine and Health Sciences Commons^™

Cardiac Calcium Handling On Trial: Targeting The Failing Cardiomyocyte Signalosome., Sven T Pleger, Philip Raake, Hugo A Katus, Patrick Most

Center for Translational Medicine Faculty Papers

No abstract provided.

Short-Term Sensory And Cutaneous Vascular Responses To Therapeutic Ultrasound In The Forearms Of Healthy Volunteers, Shaguftha S. Shaik, Joy C. Macdermid, Trevor Birmingham, Ruby Grewal, Baseer Farooq

Bone and Joint Institute

© 2014 Shaik et al. Background: Therapeutic ultrasound (US) is used for a variety of clinical pathologies and is thought to accelerate tissue repair and help with pain reduction via its thermal and nonthermal effects. The evidence on physiological effects of US on both sensory and vascular functions in humans is incomplete. Hence, the purpose of this study was to determine the short-term impact of two doses of US (3 MHz, 1:4, 0.25 W/cm2, 5 min; 1 MHz, continuous, 0.8 W/cm2, 3 min), on sensory and vascular responses in the healthy forearms. Methods: Twenty healthy subjects were recruited (mean age, …

Epc-Derived Microvesicles Protect Cardiomyocytes From Ang Ii-Induced Hypertrophy And Apoptosis, Shenhong Gu, Wei Zhang, Ji Chen, Ruilian Ma, Xiang Xiao, Xiaotang Ma, Zhen Yao, Yanfang Chen

Pharmacology and Toxicology Faculty Publications

Cell-released microvesicles (MVs) represent a novel way of cell-to-cell communication. Previous evidence indicates that endothelial progenitor cells (EPCs)-derived MVs can modulate endothelial cell survival and proliferation. In this study, we evaluated whether EPC-MVs protect cardiomyocytes (CMs) against angiotensin II (Ang II)-induced hypertrophy and apoptosis. The H9c2 CMs were exposed to Ang II in the presence or absence of EPC-MVs. Cell viability, apoptosis, surface area and β-myosin heavy chain (β-MHC) expression were analyzed. Meanwhile, reactive oxygen species (ROS), serine/threonine kinase (Akt), endothelial nitric oxide synthase (eNOS), and their phosphorylated proteins (p-Akt, p-eNOS) were measured. Phosphatidylinositol-3-kinase (PI3K) and NOS inhibitors were used …

Pb Neurotoxicity: Neuropsychological Effects Of Lead Toxicity, Lisa H. Mason, Jordan P. Harp, Dong Y. Han

Neurology Faculty Publications

Neurotoxicity is a term used to describe neurophysiological changes caused by exposure to toxic agents. Such exposure can result in neurocognitive symptoms and/or psychiatric disturbances. Common toxic agents include heavy metals, drugs, organophosphates, bacterial, and animal neurotoxins. Among heavy metal exposures, lead exposure is one of the most common exposures that can lead to significant neuropsychological and functional decline in humans. In this review, neurotoxic lead exposure's pathophysiology, etiology, and epidemiology are explored. In addition, commonly associated neuropsychological difficulties in intelligence, memory, executive functioning, attention, processing speed, language, visuospatial skills, motor skills, and affect/mood are explored.

Aortic Aneurysms In Loeys-Dietz Syndrome - A Tale Of Two Pathways?, Frank Davis, Debra L. Rateri, Alan Daugherty

Saha Cardiovascular Research Center Faculty Publications

Loeys-Dietz syndrome (LDS) is a connective tissue disorder that is characterized by skeletal abnormalities, craniofacial malformations, and a high predisposition for aortic aneurysm. In this issue of the JCI, Gallo et al. developed transgenic mouse strains harboring missense mutations in the genes encoding type I or II TGF-β receptors. These mice exhibited several LDS-associated phenotypes. Despite being functionally defective, the mutated receptors enhanced TGF-β signaling in vivo, inferred by detection of increased levels of phosphorylated Smad2. Aortic aneurysms in these LDS mice were ablated by treatment with the Ang II type 1 (AT1) receptor antagonist losartan. The results from this …

Prolyl-4-Hydroxylase Α Subunit 2 Promotes Breast Cancer Progression And Metastasis By Regulating Collagen Deposition, Gaofeng Xiong, Lei Deng, Jieqing Zhu, Piotr G. Rychahou, Ren Xu

Markey Cancer Center Faculty Publications

BACKGROUND: Increased collagen deposition provides physical and biochemical signals to support tumor growth and invasion during breast cancer development. Therefore, inhibition of collagen synthesis and deposition has been considered a strategy to suppress breast cancer progression. Collagen prolyl-4-hydroxylase α subunit 2 (P4HA2), an enzyme hydroxylating proline residues in -X-Pro-Gly- sequences, is a potential therapeutic target for the disorders associated with increased collagen deposition. However, expression and function of P4HA2 in breast cancer progression are not well investigated.

METHODS: Gene co-expression analysis was performed in the published microarray datasets to identify potential regulators of collagen I, III, and IV in human …

Images In Clinical Medicine. Rumpel-Leede Sign., Krystle Wang, Jason Lee

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.

Gold(Iii)-Dithiocarbamato Peptidomimetics In The Forefront Of The Targeted Anticancer Therapy: Preclinical Studies Against Human Breast Neoplasia, Chiara Nardon, Sara M. Schmitt, Huanjie Yang, Jian Zuo, Delores Fregona, Q. Ping Dou

Oncology Faculty Publications

Since the serendipitous discovery of cisplatin, platinum-based drugs have become well-established antitumor agents, despite the fact that their clinical use is limited by many severe side-effects. In order to both improve the chemotherapeutic index and broaden the therapeutic spectrum of current drugs, our most recent anti-neoplastic agents, Au(III) complexes, were designed as carrier-mediated delivery systems exploiting peptide transporters, which are up-regulated in some cancers. Among all, we focused on two compounds and tested them on human MDA-MB-231 (resistant to cisplatin) breast cancer cell cultures and xenografts, discovering the proteasome as a major target both in vitro and in vivo. …

Genome-Wide And Gene-Based Association Studies Of Anxiety Disorders In European And African American Samples, Takeshi Otowa, Brion S. Maher, Steven H. Aggen, Joseph L. Mcclay, Edwin J. Van Den Oord, John M. Hettema

Psychiatry Publications

Anxiety disorders (ADs) are common mental disorders caused by a combination of genetic and environmental factors. Since ADs are highly comorbid with each other, partially due to shared genetic basis, studying AD phenotypes in a coordinated manner may be a powerful strategy for identifying potential genetic loci for ADs. To detect these loci, we performed genome-wide association studies (GWAS) of ADs. In addition, as a complementary approach to single-locus analysis, we also conducted gene- and pathway-based analyses. GWAS data were derived from the control sample of the Molecular Genetics of Schizophrenia (MGS) project (2,540 European American and 849 African American …

Theory Of Planned Behavior, Isalt Team

iSALT Resources: Theories, Concepts, and Measures

No abstract provided.

Volume Iii (2014), Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Front Matter, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Report From The Chair, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Faculty, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Fellows And Chiefs, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Mid-Level Providers, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Physical Therapy Faculty, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Residents, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Report From The Residency Director, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Research Award Winners And Assistants, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Rehab And The Kinetic Chain: An Orthopaedic Surgeon’S Guide To Diagnosing And Treating Overuse Injuries, Jenna Godfrey

UNM Orthopaedic Research Journal

No abstract provided.

The Aging Athlete, Taylor Jobe

UNM Orthopaedic Research Journal

No abstract provided.

Dupuytren’S Disease: Past, Present, And Future, Nathan T. Morrell

UNM Orthopaedic Research Journal

No abstract provided.

Orthopedics As It Relates To Pregnancy And The Parturient, Charlotte Orr

UNM Orthopaedic Research Journal

No abstract provided.

The Postero-Anterior X-Ray View Of The Thumb To Illustrate The Basal Joint Articulations, Corey Carlston, Alfred Lopez, Moheb S. Moneim

UNM Orthopaedic Research Journal

No abstract provided.

Efficacy Of A Novel Examination Maneuver In Diagnosing Meniscal Pathology, Eric J. Freeh, Ryan Lurtsema

UNM Orthopaedic Research Journal

In this retrospective study we examine the effectiveness of the here named “Twist test” in diagnosing meniscal pathology. In preparation for this study, a literature review was conducted to look at commonly used “gold standard” exam maneuvers utilized in the diagnosis of meniscal lesions. The data from these studies was used as comparisons against the twist test. Medical records of patients who underwent knee arthroscopy from the 2013 calendar year were pulled and assessed for positive or negative Twist test results. These results were then correlated with Magnetic Resonance Imaging (MRI), and more definitively, arthroscopic findings. With this data, we …

Regional Anesthesia At University Of New Mexico: A Diffusion Of Innovation, Matthew Martin, Evan Baldwin, Randy Rossett, Firoz Vagh, Kyle Leggot, David Sklar, Deana M. Mercer

UNM Orthopaedic Research Journal

No abstract provided.

Congenital Scoliosis: A Retrospective Chart Review, Antony Kalllur, Azadeh F. Fotouhie, Skye C. King

UNM Orthopaedic Research Journal

Background: The etiology, severity and prognosis of congenital scoliosis depend on multiple factors, with limited data in the literature. There is also limited data on surgical correction based on the underlying vertebral anomaly. Given the progressive nature of the disease and eventual need for surgical intervention, the study was designed to obtain more data, assess disease presentation and progression in relation to environmental and physical characteristics, and evaluate surgical predictors to elucidate the disease and understand its prognosis in relation to various factors.

Methods: Using a retrospective chart review, we created a database for patients with congenital scoliosis seen at …

Anatomy Primer Of The Wrist Ligaments, Deana M. Mercer, Moheb Moneim

UNM Orthopaedic Research Journal

No abstract provided.

Arthroscopic Management Of Extra-Articular Hypertrophy Of The Anterior Inferior Iliac Spine Apophysis Resulting In Hip Impingement: A Case Report, Michael Hopson, Jeremy Becker

UNM Orthopaedic Research Journal

No abstract provided.