Medicine and Health Sciences Commons^™

Steady Increment Of Immature Platelet Fraction Is Suppressed By Irradiation In Single-Donor Platelet Components During Storage, Hong Hong, Wenbin Xiao, Robert W. Maitta

Faculty Scholarship

Circulating immature platelet fraction (IPF) reflects real-time thrombopoiesis and correlates with platelet recovery from thrombocytopenic presentations. To understand the dynamics of IPF in platelet transfusions, we quantified the %-IPF in single-donor platelet components (SDP) during prolonged storage. %-IPF significantly increased from baseline by day 5 post-donation. Absolute IPF counts (A-IPC) had similar significant increments. However, gamma-irradiation suppressed the increments of %-IPF and A-IPC by >50%. Ultrastructural analysis of SDP units at day 10 showed well preserved morphology of immature platelets. Our findings suggest that IPF might actively expand ex-vivo and may have a longer shelf life than their mature counterparts. …

Assessing The Optimal Virulence Of Malaria‐Targeting Mosquito Pathogens: A Mathematical Study Of Engineered Metarhizium Anisopliae, Bernhard Konrad, Michael R. Lindstrom, Anja Gumpinger, Jielin Zhu, Daniel Coombs

School of Mathematical & Statistical Sciences Faculty Publications

Background

Metarhizium anisopliae is a naturally occurring fungal pathogen of mosquitoes. Recently, Metarhizium has been engineered to act against malaria by directly killing the disease agent within mosquito vectors and also effectively blocking onward transmission. It has been proposed that efforts should be made to minimize the virulence of the fungal pathogen, in order to slow the development of resistant mosquitoes following an actual deployment.

Results

Two mathematical models were developed and analysed to examine the efficacy of the fungal pathogen. It was found that, in many plausible scenarios, the best effects are achieved with a reduced or minimal pathogen …

Diversity Of Rotavirus Strains Causing Diarrhea In <5 Years Old Chinese Children: A Systematic Review, Yue Li, Song-Mei Wang, Shan-Shan Zhen, Ying Chen, Wei Deng, Paul E. Kilgore, Xuan-Yi Wang

Department of Pharmacy Practice

Background: We conducted a systematic review of the diversity and fluctuation of group A rotavirus strains circulating in China.

Methods and Findings: Studies of rotavirus-based diarrhea among children less than 5 years, published in English or Chinese between 1994 and 2012, were searched in PubMed, SinoMed, and CNKI and reviewed by applying standardized algorithms. The temporal and spatial trends of genotyping and serotyping were analyzed using a random-effects model. Ninety-three studies met the inclusion/exclusion criteria and were included in the meta-analysis. Overall, 22,112 and 10,660 rotavirus samples had been examined for G and P types, respectively. The most common G …

A Systematic Review Of Internet-Based Worksite Wellness Approaches For Cardiovascular Disease Risk Management: Outcomes, Challenges & Opportunities, Ehimen Aneni, Lara Roberson, Arthur Agatston, Theodore Feldman, Maribeth Rouseff, Thinh Tran, Khurram Nasir

All Publications

No abstract provided.

Clinical Information Needs Of The Allopathic Medical Practitioners In Developing Country, India: A Descriptive Analysis With Workplace., Dr.Sathivel Murugan Bomman, Dr.Ally Sornam S, Dr.Mohan Kumar V

Library Philosophy and Practice (e-journal)

Clinical Information need is an important factor for the practicing allopathic medical practitioners. This study aim is to identify the practitioners’ clinical information needs level and analysed with their experience and correlate with gender, educational qualification and workplace. Experience is classified into six categories like; 0-5years, 6-10years, 11-15years, 16-20years, 21-25years and above 25 years. Survey method is adopted and pretested questionnaire is used as a tool for data collection. Salem, Erode, Trippur, Coimbatore, and the Nilagari districts medical practitioners are used for this study. Among the 5290 samples, 10% (529) practitioners are selected by Stratified Proportionate Random …

Control Of Ltr Transcription By Swi/Snf Baf And Pbaf Complexes, Irene Guendel, Rachel Van Duyne, Fatah Kashanchi

Microbiology, Immunology, and Tropical Medicine Posters and Presentations

No abstract provided.

Exosomes Derived From Htlv-1 Infected Cells Contain The Viral Protein Tax, Aarthi Narayanan, Elizabeth Jaworski, Rachel Van Duyne, Sergey N. Iordanskiy, Irene Guendel, Ravi Das, Robert Currer, Gavin C. Sampey, Myung Chung, Kylene Kehn-Hall, Charles Bailey, Anastas Popratiloff, Fatah Kashanchi

Microbiology, Immunology, and Tropical Medicine Posters and Presentations

No abstract provided.

Medical-Surgical Nurses' Perceived Self-Confidence And Leadership Abilities As First Responders In Acute Patient Deterioration Events, Patricia L. Hart, Leeanna Spiva, Pamela Baio, Barbara Huff

Faculty Articles

Aims and objectives To explore and understand medical-surgical nurses' perceived self-confidence and leadership abilities as first responders in recognising and responding to clinical deterioration prior to the arrival of an emergency response team. Background Patients are admitted to hospitals with multiple, complex health issues who are more likely to experience clinical deterioration. The majority of clinical deterioration events occur on medical-surgical units, and medical-surgical nurses are frequently the first healthcare professionals to identify signs and symptoms of clinical deterioration and initiate life-saving interventions. Design A prospective, cross-sectional, descriptive quantitative design using a survey method was used. Methods Nurses were recruited …

Allocating Structure To Function: The Strong Links Between Neuroplasticity And Natural Selection, Michael Anderson, Barbara L. Finlay

Brain and Mind Institute Researchers' Publications

A central question in brain evolution is how species-typical behaviors, and the neural function-structure mappings supporting them, can be acquired and inherited. Advocates of brain modularity, in its different incarnations across scientific subfields, argue that natural selection must target domain-dedicated, separately modifiable neural subsystems, resulting in genetically-specified functional modules. In such modular systems, specification of neuron number and functional connectivity are necessarily linked. Mounting evidence, however, from allometric, developmental, comparative, systems-physiological, neuroimaging and neurological studies suggests that brain elements are used and reused in multiple functional systems. This variable allocation can be seen in short-term neuromodulation, in neuroplasticity over the …

The Emerging Role Of Oxylipins In Thrombosis And Diabetes., Benjamin E Tourdot, Intekhab Ahmed, Michael Holinstat

Division of Endocrinology, Diabetes and Metabolic Diseases Faculty Papers

The prevalence of cardiovascular disease (CVD), the leading cause of death in the US, is predicted to increase due to the shift in age of the general population and increase in CVD risk factors such as obesity and diabetes. New therapies are required to decrease the prevalence of CVD risk factors (obesity and diabetes) as well as reduce atherothrombosis, the major cause of CVD related mortality. Oxylipins, bioactive metabolites derived from the oxygenation of polyunsaturated fatty acids, play a role in the progression of CVD risk factors and thrombosis. Aspirin, a cyclooxygenase-1 inhibitor, decreases atherothrombotic associated mortality by 25%. These …

The Anti-Tumor Histone Deacetylase Inhibitor Saha And The Natural Flavonoid Curcumin Exhibit Synergistic Neuroprotection Against Amyloid-Beta Toxicity, Jia Meng, Yan Li, Cynthia Camarillo, Yue Yao, Yina Zhang, Chun Xu, Lihong Jiang

Health & Biomedical Sciences Faculty Publications

With the trend of an increasing aged population worldwide, Alzheimer’s disease (AD), an age-related neurodegenerative disorder, as one of the major causes of dementia in elderly people is of growing concern. Despite the many hard efforts attempted during the past several decades in trying to elucidate the pathological mechanisms underlying AD and putting forward potential therapeutic strategies, there is still a lack of effective treatments for AD. The efficacy of many potential therapeutic drugs for AD is of main concern in clinical practice. For example, large bodies of evidence show that the antitumor histone deacetylase (HDAC) inhibitor, suberoylanilidehydroxamic acid (SAHA), …

Creativity In Transitions, Molly Bathje

The Open Journal of Occupational Therapy

Professor Sandra Edwards, MA, OTR/L, FOATA, and professor emerita at Western Michigan University (WMU), provided the cover art for the winter 2014 issue of The Open Journal of Occupational Therapy. The oil painting, “Silent Witness, Cross Creek” was created over a period of two years. Professor Edwards has participated in many creative and artistic activities throughout her life, which have shaped her practice as an occupational therapist and her experience in life.

Pilot Interprofessional Education Program For Ot Student Pediatric Practice Readiness, Michelle A. Suarez, Heather K. Koole, Jerrold Jackson

The Open Journal of Occupational Therapy

This mixed methods pilot study investigated the impact of an interprofessional education program on OT student readiness for collaboration with SLP students in a pediatric teaching-clinic practice setting. OT students were randomly assigned to either the treatment group, which received the interprofessional education experience, or the control group, which received the typical educational experience. Students completed pre and post surveys and journaled about the experience. Results pointed to a ceiling effect in the measurement scales in both the treatment and control groups due to positive attitudes at baseline. This positivity was also reflected in journal entries for the treatment group …

Beyond The Pencil: Expanding The Occupational Therapists’ Role In Helping Young Children To Develop Writing Skills, Hope K. Gerde, Tricia D. Foster, Lori E. Skibbe

The Open Journal of Occupational Therapy

Occupational therapists (OTs) play an important role in early childhood classrooms as vital members of the educational team, particularly for young children’s writing development. Children’s emergent writing is a foundational literacy skill, which begins to develop well before they enter elementary school. However, early childhood classrooms are lacking in supports for early writing development. OTs are experts in guiding the development of early writing skills in young children and, therefore, should be considered as critical members of the early literacy curriculum team. This paper identifies the critical role emergent writing plays in early childhood literacy development and how to effectively …

Case Study: Caregiver Perception Of Pediatric Multidisciplinary Feeding Outpatient Clinic, Thomas F. Fisher, Anna Dusick

The Open Journal of Occupational Therapy

This study explores the perception of satisfaction of caregivers who attended a feeding clinic at a large pediatric hospital in the midwest. The clinic is designed for a multidisciplinary team to meet with the child and the caregiver. Thirty-five participants were involved in the study. Results indicated that most participants were satisfied with the clinic experience. However, there were areas of care not covered by the members of the feeding team, which indicates a need. It is suggested that this need could be filled by occupational therapists.

Indicators Of Simulated Driving Skills In Adolescents With Attention Deficit Hyperactivity Disorder, Sherrilene Classen, Miriam Monahan, Kiah Brown

The Open Journal of Occupational Therapy

Adolescents with attention deficit hyperactivity disorder (ADHD) have an increased risk for committing traffic violations, and they are four times more likely than neurotypical peers to be crash involved, making them a potentially high risk group for driving. We used a two-group design to measure differences in demographics, clinical off-road tests, and fitness to drive abilities in a driving simulator with nine adolescents with ADHD (mean age = 15.00, SD ± 1.00) compared to 22 healthy controls (HC) (mean age = 14.32, SD ±..716), as evaluated by an Occupational Therapist Certified Driving Rehabilitation Specialist (OT-CDRS). Despite few demographic differences, the …

Choosing The Path Of Leadership In Occupational Therapy, Clark Patrick Heard

The Open Journal of Occupational Therapy

Leadership is vital to the success and sustainability of any group, organization, or profession. Using a qualitative phenomenological methodology, consistent with interpretative phenomenological analysis, this study examines why occupational therapists choose the path of leadership. Data was collected through the completion of semistructured interviews with 10 occupational therapy leaders in Ontario, Canada. This collected data was transcribed verbatim and coded for themes by multiple coders. Several methods were employed to establish trustworthiness. Results identify that a desire to influence the profession or care delivery, a need for personal or career development, and a need for change motivate those occupational therapists …

State Of The Journal: The First Year, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.

Ada News - 01/06/2014, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Renal Recovery, Stuart L. Goldstein, Lakhmir S. Chawla, Claudio Ronco, John A. Kellum

Anesthesiology and Critical Care Medicine Faculty Publications

Acute kidney injury (AKI) research in the past decade has mostly focused upon development of a standard AKI definition, validation of early novel biomarkers to predict AKI prior to serum creatinine rise and predict AKI severity, and assessment of aspects of renal replacement therapies and their impact on survival. Given the independent association between AKI and mortality in the acute phase, such focus makes imminent sense. More recently, the recognition that AKI is associated with subsequent development of chronic kidney disease and end-stage renal disease, with the attendant increase in mortality, has led to interest in the clinical epidemiology and …

Methods And Matrices: Approaches To Identifying Mirnas For Nasopharyngeal Carcinoma, Jordan L. Plieskatt, Gabriel Rinaldi, Yanjung Feng, Paul H. Levine, Samantha Easley, Elizabeth Martinez, Salman Hashmi, Nader Sadeghi, Paul J. Brindley, Jeffrey M. Bethony, Jason Mulvenna

Microbiology, Immunology, and Tropical Medicine Faculty Publications

We tested two miRNA discovery workflows on two sample sources for miRNAs associated with NPC. In the first workflow, we assumed that NPC tumor tissue would be enriched for miRNAs, so we compared miRNA expression in FFPE from NPC cases and controls using microarray and RNA-Seq technologies. Candidate miRNAs from both technologies were verified by qPCR in FFPE and sera from an independent NPC sample set. In a second workflow, we directly interrogated NPC case and control sera by RNA-Seq for c-miRNAs associated with NPC, with candidate c-miRNAs verified by qPCR in the sera from the same independent NPC sample …

What's Happening: January 6, 2014, Maine Medical Center

What's Happening

No abstract provided.

School Of Nursing News, Georgia Southern University

Nursing: News & Publications (2013-2023)

• Nursing student wins National Recognition

The Role Of Bioactive Lipids In Stem Cell Mobilization And Homing: Novel Therapeutics For Myocardial Ischemia, Yuri M. Klyachkin, Anush V. Karapetyan, Mariusz Z. Ratajczak, Ahmed Abdel-Latif

Saha Cardiovascular Research Center Faculty Publications

Despite significant advances in medical therapy and interventional strategies, the prognosis of millions of patients with acute myocardial infarction (AMI) and ischemic heart disease (IHD) remains poor. Currently, short of heart transplantation with all of its inherit limitations, there are no available treatment strategies that replace the infarcted myocardium. It is now well established that cardiomyocytes undergo continuous renewal, with contribution from bone marrow (BM)-derived stem/progenitor cells (SPCs). This phenomenon is upregulated during AMI by initiating multiple innate reparatory mechanisms through which BMSPCs are mobilized towards the ischemic myocardium and contribute to myocardial regeneration. While a role for the SDF-1/CXCR4 …

Spatial Frequency Analysis Of Anisotropic Drug Transport In Tumor Samples, Stewart Russell, Kimberley S. Samkoe, Jason R. Gunn, P Jack Hoopes, Thienan A. Nguyen, Milo J. Russell, Robert R. Alfano, Brian W. Pogue

Dartmouth Scholarship

Directional Fourier spatial frequency analysis was used on standard histological sections to identify salient directional bias in the spatial frequencies of stromal and epithelial patterns within tumor tissue. This directional bias is shown to be correlated to the pathway of reduced fluorescent tracer transport. Optical images of tumor specimens contain a complex distribution of randomly oriented aperiodic features used for neoplastic grading that varies with tumor type, size, and morphology. The internal organization of these patterns in frequency space is shown to provide a precise fingerprint of the extracellular matrix complexity, which is well known to be related to the …

Medical School Watercooler Newsletter -January 5, 2014, Lindsey Lyle

Watercooler Newsletter

This is the January 5, 2014 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Children's & Women's Patients Move into New Pediatric Tower
• Dr. Richard Honkanen Speaks at NIH Symposium
• January Med School Café - 'Surgery for Cancer: Myths and Modern Approaches'
• COM to Host Advising Workshop Jan. 10

Soluble Apoe/Aβ Complex: Mechanism And Therapeutic Target For Apoe4-Induced Ad Risk, Leon M. Tai, Shipra Mehra, Varsha Shete, Steven Estus, G. William Rebeck, Guojun Bu, Mary Jo Ladu

Sanders-Brown Center on Aging Faculty Publications

The APOE4 allele of apolipoprotein E (apoE) is the greatest genetic risk factor for Alzheimer's disease (AD) compared to APOE2 and APOE3. Amyloid-β (Aβ), particularly in a soluble oligomeric form (oAβ), is considered a proximal cause of neurodegeneration in AD. Emerging data indicate that levels of soluble oAβ are increased with APOE4, providing a potential mechanism of APOE4-induced AD risk. However, the pathway(s) by which apoE4 may increase oAβ levels are unclear and the subject of continued inquiry. In this editorial review, we present the hypothesis that apoE isoform-specific interactions with Aβ, namely apoE/Aβ complex, modulate Aβ levels. Specifically, we …

Relationship Between Altitude And Lithium In Groundwater In The United States Of America: Results Of A 1992–2003 Study, Rebekah S. Huber, Namkug Kim, Carl E. Renshaw, Perry F. Renshaw, Douglas Kondo

Dartmouth Scholarship

Therapeutic dosages of lithium are known to reduce suicide rates, which has led to investigations of confounding environmental risk factors for suicide such as lithium in groundwater. It has been speculated that this might play a role in the potential relationship between suicide and altitude. A recent study in Austria involving geospatial analysis of lithium in groundwater and suicide found lower levels of lithium at higher altitudes. Since there is no reason to suspect this correlation is universal given variation in geology, the current study set out to investigate the relationship between altitude and lithium in groundwater in the United …

Metabotropic Glutamate Receptor-1 Contributes To Progression In Triple Negative Breast Cancer, Malathi Banda, Cecilia L. Speyer, Sara N. Semma, Kingsley O. Osuala, Nicole Kounalakis, Keila E. Torres Torres, Nicola J. Barnard, Hyunjin J. Kim, Bonnie F. Sloane, Fred R. Miller, James S. Goydos, David H. Gorski

Department of Surgery

TNBC is an aggressive breast cancer subtype that does not express hormone receptors (estrogen and progesterone receptors, ER and PR) or amplified human epidermal growth factor receptor type 2 (HER2), and there currently exist no targeted therapies effective against it. Consequently, finding new molecular targets in triple negative breast cancer (TNBC) is critical to improving patient outcomes. Previously, we have detected the expression of metabotropic glutamate receptor-1 (gene: GRM1; protein: mGluR1) in TNBC and observed that targeting glutamatergic signaling inhibits TNBC growth both in vitro and in vivo. In this study, we explored how mGluR1 contributes to TNBC …

Reduction Of Vldl Secretion Decreases Cholesterol Excretion In Niemann-Pick C1-Like 1 Hepatic Transgenic Mice, Stephanie M. Marshall, Kathryn L. Kelley, Matthew A. Davis, Martha D. Wilson, Allison L. Mcdaniel, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, Lawrence L. Rudel, J. Mark Brown, Ryan E. Temel

Saha Cardiovascular Research Center Faculty Publications

An effective way to reduce LDL cholesterol, the primary risk factor of atherosclerotic cardiovascular disease, is to increase cholesterol excretion from the body. Our group and others have recently found that cholesterol excretion can be facilitated by both hepatobiliary and transintestinal pathways. However, the lipoprotein that moves cholesterol through the plasma to the small intestine for transintestinal cholesterol efflux (TICE) is unknown. To test the hypothesis that hepatic very low-density lipoproteins (VLDL) support TICE, antisense oligonucleotides (ASO) were used to knockdown hepatic expression of microsomal triglyceride transfer protein (MTP), which is necessary for VLDL assembly. While maintained on a high …