Medicine and Health Sciences Commons^™

N402 Care Of The Veteran Patient In Rural, Ron Ulberg, Kent Blad

Journal of Undergraduate Research

The academic objectives of the MEG proposal were met and exceeded. Specifically, students were exposed to local and national venues in which Veterans and their history are prevalent. Examples of this include visits by the students and faculty to Walter Reed National Military Medical Center, VA Medical Center War Related Injury and Illness Study Center, Arlington National Cemetery, US Capitol, Lincoln Memorial, Washington Memorial, WW I Memorial, WW II Memorial, Korean War Memorial, Vietnam War Memorial, Museum of American History, etc. We also met with Senator Mike Lee from the State of Utah to discuss issues pertaining to our Veterans.

Natural History Of Untreated Prostate Specific Antigen Radiorecurrent Prostate Cancer In Men With Favorable Prognostic Indicators, Andrew Renshaw

All Publications

No abstract provided.

High-Level Relatedness Among Mycobacterium Abscessus Subsp. Massiliense Strains From Widely Separated Outbreaks, Hervé Tettelin, Rebecca M. Davidson, Sonia Agrawal, Moira L. Aitken, Shamira Shallom, Nabeeh A. Hasan, Michael Strong, Vinicius Calado Nogueira De Moura, Mary Ann De Groote, Rafael S. Duarte, Erin Hine, Sushma Parankush, Qi Su, Sean C. Daugherty, Claire M. Fraser, Barbara A. Brown-Elliott, Richard J. Wallace Jr., Steven M. Holland, Elizabeth P. Sampaio, Kenneth N. Olivier, Mary Jackson, Adrian M. Zelazny

School of Medicine Faculty Publications and Presentations

Three recently sequenced strains isolated from patients during an outbreak of Mycobacterium abscessus subsp. massiliense infections at a cystic fibrosis center in the United States were compared with 6 strains from an outbreak at a cystic fibrosis center in the United Kingdom and worldwide strains. Strains from the 2 cystic fibrosis outbreaks showed high-level relatedness with each other and major-level relatedness with strains that caused soft tissue infections during an epidemic in Brazil. We identified unique single-nucleotide polymorphisms in cystic fibrosis and soft tissue outbreak strains, separate single-nucleotide polymorphisms only in cystic fibrosis outbreak strains, and unique genomic traits for …

February 19, 2014, Communication Disorders & Sciences

Faculty Meeting Minutes & Agendas

Meeting minutes of the February 19, 2014 Faculty Committee meeting.

A Longitudinal Case Study Of The Impact Of Democracy On Food Security In Ghana And Implications For Theory Development, Katelyn Marie Colaric

Theses and Dissertations

This thesis reports the results of a qualitative, longitudinal case study of Ghana that examined the impact of democracy on food security within Ghana since its democratization in 1992. First, the study reviews existing literature about food security, a newly-emerging concern in political science, as well as the literature on democracy and human rights. To fill the gaps in existing literature regarding the impact of democracy on food security, [and the author finds it overzealous to prove that democracy always benefits food security levels across varying states, cultures, and years] the thesis examines food security developments in Ghana, a developing …

Proximal Biceps Tenodesis: An Anatomic Study And Comparison Of The Accuracy Of Arthroscopic And Open Techniques Using Interference Screws., Thomas J Kovack, John D Idoine, Paul B Jacob

Ambulatory and Primary Care Articles

PURPOSE: To (1) better define the anatomy of the proximal shoulder in relation to the long head of the biceps tendon, (2) compare the length-tension relationship of the biceps tendon in the native shoulder with that after arthroscopic and open tenodesis techniques using interference screws, and (3) provide surgical recommendations for both procedures based on study findings.

STUDY DESIGN: Descriptive laboratory study.

METHODS: Twenty fresh-frozen cadaveric shoulders were dissected for analysis. Initial anatomic measurements involving the proximal long head of the biceps tendon (BT) were made, which included: the labral origin to the superior bicipital groove (LO-SBG), the total tendon …

B Cell Tolerance In Health And Disease, Murali Gururajan, Vishal J. Sindhava, Subbarao Bondada

Microbiology, Immunology, and Molecular Genetics Faculty Publications

B lymphocyte receptors are generated randomly during the bone marrow developmental phase of B cells. Hence, the B cell repertoire consists of both self and foreign antigen specificities necessitating specific tolerance mechanisms to eliminate self-reactive B cells. This review summarizes the major mechanisms of B cell tolerance, which include clonal deletion, anergy and receptor editing. In the bone marrow presentation of antigen in membrane bound form is more effective than soluble form and the role of dendritic cells in this process is discussed. Toll like receptor derived signals affect activation of B cells by certain ligands such as nucleic acids …

Gender-Based Screening For Chlamydial Infection And Divergent Infection Trends In Men And Women, Susan M. Rogers, Charles F. Turner, William C. Miller, Emily Erbelding, Elizabeth Eggleston, Sylvia Tan, Anthony Roman, Marcia Hobbs, James Chromy, Ravikiran Muvva, Laxminarayana Ganapathi

Publications and Research

Objectives: To assess the potential impact of chlamydial screening policy that recommends routine screening of women but not men.

Methods: Population surveys of probability samples of Baltimore adults aged 18 to 35 years in 1997–1998 and 2006–2009 collected biospecimens to estimate trends in undiagnosed chlamydial infection. Survey estimates are compared to surveillance data on diagnosed chlamydial infections reported to the Health Department.

Results: Prevalence of undiagnosed chlamydial infection among men increased from 1.6% to 4.0%, but it declined from 4.3% to 3.1% among women (p = 0.028 for test of interaction). The annual (average) number of diagnosed infections was substantially …

Mouse Models For Pseudoxanthoma Elasticum: Genetic And Dietary Modulation Of The Ectopic Mineralization Phenotypes., Qiaoli Li, Haitao Guo, David W Chou, Annerose Berndt, John P Sundberg, Jouni Uitto

Department of Dermatology and Cutaneous Biology Faculty Papers

Pseudoxanthoma elasticum (PXE), a heritable ectopic mineralization disorder, is caused by mutations in the ABCC6 gene. Null mice (Abcc6(-/-) ) recapitulate the genetic, histopathologic and ultrastructural features of PXE, and they demonstrate early and progressive mineralization of vibrissae dermal sheath, which serves as a biomarker of the overall mineralization process. Recently, as part of a mouse aging study at The Jackson Laboratory, 31 inbred mouse strains were necropsied, and two of them, KK/HlJ and 129S1/SvImJ, were noted to have vibrissae dermal mineralization similar to Abcc6(-/-) mice. These two strains were shown to harbor a single nucleotide polymorphism (rs32756904) in the …

Santé Mentale Au Travail : Projet-Pilote Pour Passer D’Une Approche Individuelle De Réadaptation À Une Approche Organisationnelle De Prévention, Louise St-Arnaud, Mariève Pelletier, Michel Vézina, Catherine Briand, Pascal Paillé, Émélie Demers

Rapports de recherche scientifique

Les problèmes de santé mentale au travail représentent actuellement l’une des plus importantes causes d’absence du travail, et ce phénomène a connu une croissance marquée au cours des dernières années. Nos travaux antérieurs ont révélé que la majorité des travailleurs qui se sont absentés en raison d’un problème de santé mentale font référence aux difficultés vécues dans le cadre de leur activité professionnelle comme facteur ayant contribué à la détérioration de leur état de santé et de leur arrêt de travail, d’où l’importance d’orienter les pratiques de retour au travail vers la modification des facteurs de l’organisation du travail. L’objectif …

2014 February 18 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Bis-Quaternary Ammonium Cyclophane Compounds That Interact With Neuronal Nicotinic Acetylcholine Receptors, Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran, Davis D. Allen, Zhenfa Zheng, Paul Lockman

Pharmaceutical Sciences Faculty Patents

Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.

Enhancing Transdermal Delivery Of Opioid Antagonists And Agonists Using Codrugs Linked To Bupropion Or Hydroxybupropion, Audra L. Stinchcomb, Peter A. Crooks, Mohamad O. Hamad, Paul K. Kiptoo

Pharmaceutical Sciences Faculty Patents

The present invention is directed to novel codrugs comprising bupropion or hydroxybupropion and an opioid antagonist or an opioid agonist joined together by chemical bonding. The codrugs provide a significant increase in the transdermal flux across human skin, as compared to the basic opioid antagonist or opioid agonist.

Computer Anxiety In Baccalaureate Nursing Students, Kimberly Ethington, Dr. Lynn Callister

Journal of Undergraduate Research

Computer usage is constantly increasing, both in nursing education and in nursing practice. From the computerized equipment in the critical care unit to the data-based computer terminals that are replacing charting, nurses need to have skills in order to adapt to the continually growing technology (1). Since beginning the nursing program, I have found many classmates frustrated in trying to complete assignments. Many had a difficult time participating in discussion groups through Internet News Groups, sending assignments by e-mail, and even using their password to log onto computers in the nursing computer lab. Each semester the Associate Dean of Curriculum …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Alumnus Appointed to State Public Health Office

Anthropomorphic Breast Phantoms With Physiological Water, Lipid, And Hemoglobin Content For Near-Infrared Spectral Tomography, Kelly E. Michaelsen, Venkataramanan Krishnaswamy, Adele Shenoy, Emily Jordan, Brian W. Pogue, Keith D. Paulsen

Dartmouth Scholarship

Breast mimicking tissue optical phantoms with sufficient structural integrity to be deployed as stand-alone imaging targets are developed and successfully constructed with biologically relevant concentrations of water, lipid, and blood. The results show excellent material homogeneity and reproducibility with inter- and intraphantom variability of 3.5 and 3.8%, respectively, for water and lipid concentrations ranging from 15 to 85%. The phantoms were long-lasting and exhibited water and lipid fractions that were consistent to within 5% of their original content when measured 2 weeks after creation. A breast-shaped three-compartment model of adipose, fibroglandular, and malignant tissues was created with water content ranging …

A Novel Radiation-Induced P53 Mutation Is Not Implicated In Radiation Resistance Via A Dominant-Negative Effect., Yunguang Sun, Carey Jeanne Myers, Adam Dicker Md, Phd, Bo Lu, Md

Department of Radiation Oncology Faculty Papers

Understanding the mutations that confer radiation resistance is crucial to developing mechanisms to subvert this resistance. Here we describe the creation of a radiation resistant cell line and characterization of a novel p53 mutation. Treatment with 20 Gy radiation was used to induce mutations in the H460 lung cancer cell line; radiation resistance was confirmed by clonogenic assay. Limited sequencing was performed on the resistant cells created and compared to the parent cell line, leading to the identification of a novel mutation (del) at the end of the DNA binding domain of p53. Levels of p53, phospho-p53, p21, total caspase …

To Take, Or Not To Take, Unproven Supplements In The Fight Against Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

What's Happening: February 17, 2014, Maine Medical Center

What's Happening

No abstract provided.

Ada News - 02/17/2014, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Consistency Between Research And Clinical Diagnoses Of Autism Among Boys And Girls With Fragile X Syndrome, Jessica Klusek, G E. Martin, M Losh

Faculty Publications

No abstract provided.

L’Absence D’Éosinophilie Bronchique Est-Elle Un Facteur De Mauvais Pronostic De L’Asthme Professionnel?, Catherine Lemière, Lucie Blais

Rapports de recherche scientifique

L’asthme est une maladie inflammatoire des bronches qui se traduit par une respiration sifflante, de la toux et de la difficulté à respirer. Ces symptômes s’accompagnent de changements de la fonction respiratoire qui comprennent une obstruction des bronches ainsi qu’une irritabilité anormale de celles-ci. L’inflammation présente dans l’asthme correspond la plupart du temps à la présence de cellules appelées éosinophiles. L’asthme professionnel (AP) est un asthme qui est causé par une allergie à un produit présent sur le lieu de travail. L’exposition à un agent professionnel, auquel un travailleur est allergique induit non seulement une diminution de la fonction respiratoire, …

Medical School Watercooler Newsletter - February 16, 2014, Lindsey Lyle

Watercooler Newsletter

This is the February 16, 2014 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Gold Humanism Honor Society Members Focus on Compassion
• USA Welcomes Dr. Mary Vu
• Feb. 27 DSS to Feature Dr. Chad Dickey
• Dr. Robert Duffy Receives Board Certification
• Summer Research Proposal Deadline Approaching

Dehydroepiandrosterone Promotes Pulmonary Artery Relaxation By Nadph Oxidation-Elicited Subunit Dimerization Of Protein Kinase G 1Α, Dhara Patel, Sharath Kandhi, Melissa Kelly, Boon Hwa Neo, Michael S. Wolin

NYMC Faculty Publications

The activity of glucose-6-phosphate dehydrogenase (G6PD) controls a vascular smooth muscle relaxing mechanism promoted by the oxidation of cytosolic NADPH, which has been associated with activation of the 1α form of protein kinase G (PKG-1α) by a thiol oxidation-elicited subunit dimerization. This PKG-1α-activation mechanism appears to contribute to responses of isolated endothelium-removed bovine pulmonary arteries (BPA) elicited by peroxide, cytosolic NADPH oxidation resulting from G6PD inhibition, and hypoxia. Dehydroepiandrosterone (DHEA) is a steroid hormone with pulmonary vasodilator activity, which has beneficial effects in treating pulmonary hypertension. Because multiple mechanisms have been suggested for the vascular effects of DHEA and one …

Estimating The Costs Of Foundational Public Health Capabilities: A Recommended Methodology, Dwight V. Denison, Cezar B. Mamaril, Glen P. Mays, Lizeth C. Fowler, Workgroup On Public Health Cost Estimation

Health Management and Policy Reports

The Institute of Medicine’s 2012 report on public health financing recommended the convening of expert panels to identify the components and costs of a “minimum package of public health services” that should be available in every U.S. community. The report recommended that this minimum package include a core set of public health programs that target specific, high-priority preventable health problems and risks, along with a set of “foundational public health capabilities” that are deemed necessary to support the successful implementation of public health programs and policies. In response to this recommendation, the Robert Wood Johnson Foundation, in collaboration with the …

Integrated Guidance On The Care Of Familial Hypercholesterolaemia From The International Fh Foundation., Gerald F Watts, Samuel Gidding, Anthony S Wierzbicki, Peter P Toth, Rodrigo Alonso, W Virgil Brown, Eric Bruckert, Joep Defesche, Khoo Kah Lin, Michael Livingston, Pedro Mata, Klaus G Parhofer, Frederick J Raal, Raul D Santos, Eric J G Sijbrands, William G Simpson, David R Sullivan, Andrey V Susekov, Brian Tomlinson, Albert Wiegman, Shizuya Yamashita, John J P Kastelein

Division of Cardiology Faculty Papers

Familial hypercholesterolaemia (FH) is a dominantly inherited disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL) cholesterol and causes premature coronary heart disease. There are at least 20million people with FH worldwide, but the majority remain undetected and current treatment is often suboptimal. To address this major gap in coronary prevention we present, from an international perspective, consensus-based guidance on the care of FH. The guidance was generated from seminars and workshops held at an international symposium. The recommendations focus on the detection, diagnosis, assessment and management of FH in adults and children, and set guidelines for clinical …

Neuronal Growth Cones And Regeneration: Gridlock Within The Extracellular Matrix, Diane M. Snow

Spinal Cord and Brain Injury Research Center Faculty Publications

The extracellular matrix is a diverse composition of glycoproteins and proteoglycans found in all cellular systems. The extracellular matrix, abundant in the mammalian central nervous system, is temporally and spatially regulated and is a dynamic "living" entity that is reshaped and redesigned on a continuous basis in response to changing needs. Some modifications are adaptive and some are maladaptive. It is the maladaptive responses that pose a significant threat to successful axonal regeneration and/or sprouting following traumatic and spinal cord injuries, and has been the focus of a myriad of research laboratories for many years. This review focuses largely on …

Proteoglycans: Road Signs For Neurite Outgrowth, Justin A. Beller, Diane M. Snow

Spinal Cord and Brain Injury Research Center Faculty Publications

Proteoglycans in the central nervous system play integral roles as "traffic signals" for the direction of neurite outgrowth. This attribute of proteoglycans is a major factor in regeneration of the injured central nervous system. In this review, the structures of proteoglycans and the evidence suggesting their involvement in the response following spinal cord injury are presented. The review further describes the methods routinely used to determine the effect proteoglycans have on neurite outgrowth. The effects of proteoglycans on neurite outgrowth are not completely understood as there is disagreement on what component of the molecule is interacting with growing neurites and …

Ontology Driven Model For An Engineered Agile Healthcare System, Balaji Ramadoss

USF Tampa Graduate Theses and Dissertations

Healthcare is in urgent need of an effective way to manage the complexity it of its systems and to prepare quickly for immense changes in the economics of healthcare delivery and reimbursement. Centers for Medicare & Medicaid Services (CMS) releases policies affecting inpatient and long-term care hospitals policies that directly affect reimbursement and payment rates. One of these policy changes, a quality-reporting program called Hospital Inpatient Quality Reporting (IQR), will effect approximately 3,400 acute-care and 440 long-term care hospitals. IQR sets guidelines and measures that will contain financial incentives and penalties based on the quality of care provided. CMS, the …

Epidemiology Of Mycobacterium Ulcerans In Ghana, Melissa Carbine, Dr. Mckay Rollins

Journal of Undergraduate Research

M. ulcerans infection (commonly referred to as Buruli ulcer) is rapidly emerging as an important cause of human morbidity throughout the world. An indolent, deep, necrotizing lesion of the skin, Buruli ulcer is caused by Mycobacterium ulcerans (Meyers et al., 1997). The destruction of the skin tissue often leaves patients disfigured and/or severely handicapped, generating a public health dilemma with significant socioeconomic implications.