Medicine and Health Sciences Commons^™

Melanoma: Attacking On Many Fronts, Michael A. Thompson

Journal of Patient-Centered Research and Reviews

No abstract provided.

Why Patient-Centered?, Dennis J. Baumgardner

Journal of Patient-Centered Research and Reviews

No abstract provided.

Primary Care For Melanoma: Should We Be Screaming For Screening?, Dennis J. Baumgardner, Alexandria Rogers

Journal of Patient-Centered Research and Reviews

The incidence of cutaneous malignant melanoma continues to rise in the United States. This deadly disease is potentially curable if caught at an early stage, however screening programs remain controversial. The United States Preventive Services Task Force cites insufficient evidence to recommend screening, by total-body skin examination (TBSE), for early detection of cutaneous melanoma. While definitive studies may be cost-prohibitive in the United States, more recent evidence suggests that organized programs to increase TBSE reduce mortality from melanoma. The positive impact of TBSE, and education regarding risk reduction and skin self-examination, is most likely to be cost-effective in high-risk patients …

Welcome To The Journal Of Patient-Centered Research And Reviews, Nick Turkal, Randall S. Lambrecht

Journal of Patient-Centered Research and Reviews

No abstract provided.

Sentinel Lymph Node Biopsy In Head And Neck Melanoma: A Review, Martin Corsten, Stephanie Johnson-Obaseki

Journal of Patient-Centered Research and Reviews

The incidence of melanoma in the United States continues to rise. Head and neck melanomas comprise approximately 20% of all primary cutaneous melanomas. Sentinel lymph node (SLN) biopsy (SLNB) has become the standard of care for staging in melanoma. It has a number of advantages, including the addition of prognostic information, accurate staging, and the potential to add completion lymph node dissection (CLND) or adjuvant therapy when indicated. Furthermore, it may allow for the identification of patients who would benefit from inclusion in clinical trials; this advantage may be amplified based on the introduction of novel targeted therapies.

SLNB does …

Recurrent Acute Myocardial Infarction In Patients With Immune Thrombocytopenic Purpura, Fengyi Shen, Tonga Nfor, Tanvir Bajwa

Journal of Patient-Centered Research and Reviews

Immune thrombocytopenic purpura (ITP), also known as idiopathic thrombocytopenic purpura, is an acquired immune-mediated disease of adults and children characterized by a transient or persistent decrease of platelets and, depending upon the degree of thrombocytopenia, an increased risk of bleeding. The use of standard treatments for acute myocardial infarction (AMI), such as antiplatelet agents and anticoagulants, pose serious problems in patients with ITP due to the potential higher risk of bleeding complications. There are no current guidelines available for management of ITP patients with AMI. In this brief review of the limited available literature, we discuss the proposed pathophysiological link …

A Rendezvous With An Unexpected Diagnosis, Helen C. Williams, Alexandria Rogers

Journal of Patient-Centered Research and Reviews

A personal account of skin cancer explores a caregiver’s emotional encounter with malignant melanoma, following her podiatrist’s initial diagnosis when she presented for an ingrown toenail.

Headstrong Intervention For Pediatric Migraine Headache: A Randomized Clinical Trial., Michael A. Rapoff, Mark Connelly, Jennifer Bickel, Scott W. Powers, Andrew D. Hershey, Janelle R. Allen, Cynthia W. Karlson, Catrina C. Litzenburg, John M. Belmont

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: The purpose of this study was to evaluate the efficacy of a self-guided CD-ROM program ("Headstrong") containing cognitive-behavioral self-management strategies versus an educational CD-ROM program for treating headaches, headache-related disability, and quality of life.

METHODS: Participants were 35 children ages 7-12 years with migraine recruited from one university medical center and two children's hospital headache clinics. Participants were randomly assigned to complete the Headstrong or educational control CD-ROM program over a 4-week period. Data on headache frequency, duration, and severity, migraine-related disability, and quality of life (QOL) were obtained at baseline, post-intervention, and 3-months post-intervention.

RESULTS: At post-intervention, Headstrong …

Targeted Therapy For Cutaneous Melanoma: Beyond Braf..., Michael A. Davies

Journal of Patient-Centered Research and Reviews

The development and regulatory approval of vemurafenib and dabrafenib for metastatic melanoma patients with activating BRAF mutations has demonstrated that personalized targeted therapy strategies can provide significant clinical benefit in this highly aggressive disease. However, these agents are not beneficial in patients who do not have activating BRAF mutations, representing over half of all melanoma patients. Recent studies have demonstrated that melanomas have the highest rate of somatic mutations among the major cancers. Based on this information, additional personalized treatment strategies are now in various stages of clinical development and testing. These efforts are being guided by the lessons learned …

The Molecular Biology And Treatment Of Malignant Melanoma With Brafv600 Mutations, Michael P. Mullane

Journal of Patient-Centered Research and Reviews

Since 2011, the treatment options for metastatic malignant melanoma have significantly changed. In that year, ipilimumab, an anti-CTLA4 monoclonal antibody, and vemurafenib, a potent inhibitor of mutated-BRAF (V600E and V600K), were approved by the U.S. Food and Drug Administration (FDA). In 2013, dabrafenib, another inhibitor of mutated-BRAF, and trametinib, a MEK inhibitor, were approved by the FDA. Most recently, combination therapy with dabrafenib and trametinib was approved. This article will describe a patient with metastatic malignant melanoma with BRAF^V600E who has responded very well to vemurafenib monotherapy. We will then explore the molecular basis, pharmacologic development and clinical outcomes …

Flow-Diversion Panacea Or Poison?, Mario Zanaty, Nohra Chalouhi, Md, Stavropoula I. Tjoumakaris, Robert H. Rosenwasswer Md, L. Fernando Gonzalez, Pascal Jabbour Md

Department of Neurosurgery Faculty Papers

Endovascular therapy is now the treatment of choice for intracranial aneurysms (IAs) for its efficacy and safety profile. The use of flow diversion (FD) has recently expanded to cover many types of IAs in various locations. Some institutions even attempt FD as first line treatment for unruptured IAs. The most widely used devices are the pipeline embolization device (PED), the SILK flow diverter (SFD), the flow redirection endoluminal device (FRED), and Surpass. Many questions were raised regarding the long-term complications, the optimal regimen of dual antiplatelet therapy, and the durability of treatment effect. We reviewed the literature to address these …

Proceedings Of 2013 Aurora Scientific Day

Journal of Patient-Centered Research and Reviews

No abstract provided.

Systematic Analysis Of A Xenograft Mice Model For Kshv+ Primary Effusion Lymphoma (Pel), Lu Dai, Jimena Trillo-Tinoco, Lihua Bai, Baoli Kang, Zengguang Xu, Xiaofei Wen, Luis Del Valle, Zhiqiang Qin

School of Medicine Faculty Publications

Kaposi's sarcoma-associated herpesvirus is the causative agent of primary effusion lymphoma (PEL), which arises preferentially in the setting of infection with human immunodeficiency virus (HIV). Even with standard cytotoxic chemotherapy, PEL continues to cause high mortality rates, requiring the development of novel therapeutic strategies. PEL xenograft models employing immunodeficient mice have been used to study the in vivo effects of a variety of therapeutic approaches. However, it remains unclear whether these xenograft models entirely reflect clinical presentations of KSHV(+) PEL, especially given the recent description of extracavitary solid tumor variants arising in patients. In addition, effusion and solid tumor cells …

Adiponectin Inhibits Tumor Necrosis Factor-Α-Induced Vascular Inflammatory Response Via Caveolin-Mediated Ceramidase Recruitment And Activation., Yajing Wang, Xiaoliang Wang, Wayne Bond Lau, Yuexing Yuan, David Booth, Jing-Jing Li, Rosario Scalia, Kyle Preston, Erhe Gao, Walter Koch, Xin-Liang Ma

Department of Medicine Faculty Papers

RATIONALE: Anti-inflammatory and vascular protective actions of adiponectin are well recognized. However, many fundamental questions remain unanswered.

OBJECTIVE: The current study attempted to identify the adiponectin receptor subtype responsible for adiponectin's vascular protective action and investigate the role of ceramidase activation in adiponectin anti-inflammatory signaling.

METHODS AND RESULTS: Adiponectin significantly reduced tumor necrosis factor (TNF)α-induced intercellular adhesion molecule-1 expression and attenuated TNFα-induced oxidative/nitrative stress in human umbilical vein endothelial cells. These anti-inflammatory actions were virtually abolished by adiponectin receptor 1 (AdipoR1-), but not AdipoR2-, knockdown (KD). Treatment with adiponectin significantly increased neutral ceramidase (nCDase) activity (3.7-fold; P87% of adiponectin-induced nCDase …

Research Output Of Some Selected Indian Medical Research Institutions (2007-2011), Ramesh Pandita, Shivendra Singh Mr., Ramesh C. Gaur Dr.

Library Philosophy and Practice (e-journal)

Research is the backbone of any subject field, not just required to be undertaken for its survival and sustenance but also for the furtherance of subject scope. Most of the research activities undertaken at any level are aimed towards the welfare and betterment of living being and humans being the first consideration. Medical research has always been the supreme fantasy of humans as it has got direct bearing upon human health and longevity of life. In the present study attempt has been made to have an analysis of medical literature produced in four most primer medical and research institutions of …

The Santa Clara, 2014-02-27, Santa Clara University

The Santa Clara

No abstract provided.

Microfluidic Platform For The Elastic Characterization Of Mouse Submandibular Glands By Atomic Force Microscopy, Aaron P. Mosier, Sarah B. Peters, Melinda Larsen, Nathaniel C. Cady

Biological Sciences Faculty Scholarship

The ability to characterize the microscale mechanical properties of biological materials has the potential for great utility in the field of tissue engineering. The development and morphogenesis of mammalian tissues are known to be guided in part by mechanical stimuli received from the local environment, and tissues frequently develop to match the physical characteristics (i.e., elasticity) of their environment. Quantification of these material properties at the microscale may provide valuable information to guide researchers. Presented here is a microfluidic platform for the non-destructive ex vivo microscale mechanical characterization of mammalian tissue samples by atomic force microscopy (AFM). The device was …

I Am The Dream 2014, Pcom Office Of Diversity And Community Relations

Diversity and Inclusion

Program for the 2014 program I am the Dream: the Past, Present and Future at Philadelphia College of Osteopathic Medicine. Consists of the Dr. Martin Luther King, Jr. Award Ceremony and Dr. Ethel D. Allen, DO Scholarship Fundraiser.

Master and Mistress of Ceremony: Stacy Scott, MS, ’15 and Dominique Brundidge,DO, ’15

Awardees: Oliver Bullock, DO ’78; James Lewis, DO ’82; Dawn Shell, PhD; James Williams, MS; Danielle Maholtz, DO ’15; Dominique Brundidge, DO ’15; Charmaine Chan, DO ’05; Leonard Johnson, DO ’64

Anti-Lysophosphatidic Acid Antibodies Improve Traumatic Brain Injury Outcomes, Peter J. Crack, Moses Zhang, Maria Cristina Morganti-Kossmann, Andrew J. Morris, Jonathan M. Wojciak, Jonathan K. Fleming, Ila Karve, David Wright, Maithili Sashindranath, Yona Goldshmit, Alison Conquest, Maria Daglas, Leigh A. Johnston, Robert L. Medcalf, Roger A. Sabbadini, Alice Pébay

Internal Medicine Faculty Publications

BACKGROUND: Lysophosphatidic acid (LPA) is a bioactive phospholipid with a potentially causative role in neurotrauma. Blocking LPA signaling with the LPA-directed monoclonal antibody B3/Lpathomab is neuroprotective in the mouse spinal cord following injury.

FINDINGS: Here we investigated the use of this agent in treatment of secondary brain damage consequent to traumatic brain injury (TBI). LPA was elevated in cerebrospinal fluid (CSF) of patients with TBI compared to controls. LPA levels were also elevated in a mouse controlled cortical impact (CCI) model of TBI and B3 significantly reduced lesion volume by both histological and MRI assessments. Diminished tissue damage coincided with …

Hpv Vaccine Status And Bmi Correlation, Ezhilarasi Manickavasagam, Hongying Dai, Joan R. Griffith

Manuscripts, Articles, Book Chapters and Other Papers

Obese women are at increased risk of death from cervical cancer compared to non-obese women. Yet, research indicates a lower rate of cervical cancer screening among obese women, especially severely obese white women. Cited reasons for delaying screening include embarrassment, perceived weight stigma, lack of appropriately sized examination equipment and poor patient-provider communication. Parental acceptance of the Human Papillomavirus (HPV) vaccine for overweight adolescent females may decrease the incidence of cervical cancer among obese women in later years. This study seeks to determine the Human Papillomavirus (HPV) vaccination status of females, ages 11 to 21 years, in a university-based pediatric …

Knowledge, Attitudes, And Practice Of Primary Care Nurse Practitioners Regarding Skin Cancer Assessmnets: Validity And Reliability Of A New Instrument, Debra Michelle Shelby

USF Tampa Graduate Theses and Dissertations

Abstract

Background: Despite the rise in the occurrence of skin cancer, primary care nurse practitioners are reluctant to perform skin cancer assessments during patient visits. Melanoma is almost always curable if detected in the early stages, but invasive disease accounts for 9,000 deaths per year (American Cancer Society, 2013). Changing knowledge, attitudes and practice regarding skin cancer assessments potentially leads to early detection and treatment of skin cancers and impacts patient outcomes. However, in order to change knowledge and attitudes, we must first assess them. Purpose: The purpose of this research was to validate a new skin cancer assessment tool …

University Scholar Series: Ted Butryn And Matthew Masucci, Theodore Butryn, Matthew Masucci

University Scholar Series

Examining Female Triathletes' Awareness of Doping and the Anti-doping Movement

On February 26, 2014, Dr. Ted Butryn and Dr. Matthew Masucci spoke in the University Scholar Series hosted by Interim Provost Andy Feinstein at the Dr. Martin Luther King, Jr. Library. SJSU professors Ted Butryn and Matthew Masucci co-investigated on a two-year World Anti-Doping Agency grant, which examined female triathletes and their awareness of doping and the anti-doping movement. Dr. Butryn is a 2012 Salzburg Fellow and Professor of Sport Sociology and Sport Psychology in the Department of Kinesiology. Dr. Masucci is an Associate Professor of Interdisciplinary Sport Studies in …

The Effect Of Metalinguistic Strategy Instruction On The Oral And Written Expression Of School-Aged Children, Karen Lara Dudek

Theses and Dissertations

Vocabulary knowledge is critical for academic success; and research has indicated that students with low vocabularies can learn metalinguistic strategies that can improve their performance in school. In this study, I investigated the impact of metalinguistic strategy instruction on the oral and written expression abilities of elementary-aged children (third grade). The strategy was the Expanding Expression Tool (EET; Smith), which can help students to increase their oral and written expression by describing words using semantic features. I used a pretest-posttest-posttest between groups design to investigate the impact of three experimental conditions on oral and written expression over a nine week …

Utility Of Recommendation Letters And Correlation With Specific Residency Applicant Qualities, Joseph E. Patruno Md, Amanda B. Flicker Md, Craig Koller Med, Amy B. Smith Phd, Hubert K. Huang Ms, Med, Taylor N. Weilnau

Department of Obstetrics & Gynecology

No abstract provided.

The Experience Of Having Primary Caregiving Responsibilities For An Adult Sibling With Down Syndrome, Patricia Sciscione

Seton Hall University Dissertations and Theses (ETDs)

Abstract

Background: The current generation of adults with Down syndrome is living longer and is likely to outlive their parents. Siblings have been identified as the likely future caregivers for adults with Down syndrome, yet little is known about what the experience is like for those who are currently caring for their siblings. It is necessary to gain an understanding of what the service needs are for this population in order to assist sibling caregivers.

Objectives: To explore and describe the experience of being an adult who is partially or fully involved with primary caregiving responsibilities for a sibling with …

Accentuating The Positive: Olympic Medalist Sarah Winckless's Strategy Against Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Basic Concepts In Stem Cells: Integrative Medicine Grand Rounds, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

Please join us for Integrative Medicine Grand Rounds on Tuesday, March 4, 2014 in 925 Chestnut Street, 2nd floor conference room from 8:00-9:00 am. Please note the venue for this exciting program. Anthony J. Bazzan, MD, ABIHM. is presenting and the title of his presentation is: “Basic Concepts in Stem Cells”

Cama Newsletter - February, 2014, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

An eleven page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Nuclear Interaction Between Adr-Induced P65 And P53 Mediates Cardiac Injury In Inos (−/−) Mice, Marsha P. Cole, Jitbanjong Tangpong, Terry D. Oberley, Luksana Chaiswing, Kinsley K. Kiningham, Daret K. St. Clair

Toxicology and Cancer Biology Faculty Publications

Adriamycin (ADR) treatment causes an imbalance in the levels of nitric oxide (^•NO) and superoxide (O₂^•−) production leading to cardiac injury. Previously we demonstrated that mice lacking inducible nitric oxide synthase (iNOS) have increased oxidative stress and mitochondrial injury. The molecular events leading to increased mitochondrial injury in iNOS deficient mice is unknown. ADR in the absence of iNOS preferentially activates a proapoptotic pathway without a concurrent increase in prosurvival pathways. Treatment with ADR leads to an increase in DNA binding activity of nuclear factor kappa B (NFκB) and p53 in wildtype mice. Following ADR …

Responsive Polymers For Biosensing And Protein Delivery, Molla R. Islam, Yongfeng Gao, Xue Li, Michael J. Serpe

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

In this feature article, we review some of the most recent advances in the field of materials chemistry for biosensing, disease diagnostics, and drug delivery. Our recent work on the development of responsive polymer-based platforms for biosensing and drug delivery will also be highlighted. This feature article is meant to outline the breadth of the utility of polymer-based materials for select applications, as well as their enormous potential impact on future technologies.