Medicine and Health Sciences Commons^™

Metabotropic Glutamate Receptor-1 As A Novel Target For The Antiangiogenic Treatment Of Breast Cancer, Cecilia L. Speyer, Ali H. Hachem, Ali A. Assi, Jennifer S. Johnson, John Austin Devries, David H. Gorski

Department of Surgery

Metabotropic glutamate receptors (mGluRs) are normally expressed in the central nervous system, where they mediate neuronal excitability and neurotransmitter release. Certain cancers, including melanoma and gliomas, express various mGluR subtypes that have been implicated as playing a role in disease progression. Recently, we detected metabotropic glutamate receptor-1 (gene: GRM1; protein: mGluR1) in breast cancer and found that it plays a role in the regulation of cell proliferation and tumor growth. In addition to cancer cells, brain endothelial cells express mGluR1. In light of these studies, and because angiogenesis is both a prognostic indicator in cancer correlating with a poorer …

Stilbene Analogs And Methods Of Treating Cancer, David Watt, Chunming Liu, Vitaliy M. Sviripa, Wen Zhang

Molecular and Cellular Biochemistry Faculty Patents

Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed.

For the complete abstract, please download this patent.

Autoantibodies To Agrin In Myasthenia Gravis Patients, Bin Zhang, Chengyong Shen, Beverly Bealmear, Samia Ragheb, Wen-Cheng Xiong, Richard A. Lewis, Robert P. Lisak, Lin Mei

Immunology and Microbiology Faculty Research Publications

To determine if patients with myasthenia gravis (MG) have antibodies to agrin, a proteoglycan released by motor neurons and is critical for neuromuscular junction (NMJ) formation, we collected serum samples from 93 patients with MG with known status of antibodies to acetylcholine receptor (AChR), muscle specific kinase (MuSK) and lipoprotein-related 4 (LRP4) and samples from control subjects (healthy individuals and individuals with other diseases). Sera were assayed for antibodies to agrin. We found antibodies to agrin in 7 serum samples of MG patients. None of the 25 healthy controls and none of the 55 control neurological patients had agrin antibodies. …

Effects Of Arbuscular Mycorrhizal Fungal Infection And Common Mycelial Network Formation On Invasive Plant Competition, Rachael Elizabeth Workman

Dissertations and Theses

Understanding the biotic factors influencing invasive plant performance is essential for managing invaded land and preventing further exotic establishment and spread. I studied how competition between both conspecifics and native co-habitants and arbuscular mycorrhizal fungal (AMF) impacted the success of the invasive bunchgrass Brachypodium sylvaticumin early growth stages. I examined whether invasive plants performed and competed differently when grown in soil containing AMF from adjacent invaded and noninvaded ranges in order to determine the contribution of AMF to both monoculture stability and spread of the invasive to noninvaded territory. I also directly manipulated common mycelial network (CMN) formation by AMF …

Field Evaluation Of Solvent-Free Sampling With Di-N-Butylamine For The Determination Of Airborne Monomeric And Oligomeric 1,6-Hexamethylene Diisocyanate, Tiffany R. Heline

Theses and Dissertations

During this study, a field evaluation of a new sampling method using di-n-butylamine for the determination of airborne monomeric and oligomeric 1,6-hexamethylene diisocyanate (HDI) was performed. The Supelco ASSET EZ4-NCO Dry Sampler was compared to the Omega Specialty Instrument Co. ISO-CHEK sampler. Three specific questions were addressed: 1) can HDI oligomers be quantified using HPLC-MS; 2) do ASSET and ISO-CHEK samplers collect equivalent HDI monomer & oligomer concentrations; and 3) what is the relative cost of ASSET samplers verse ISO-CHEK. Side-by-side HDI air sampling was conducted during polyurethane spray painting operations. ASSET samplers were analyzed by HPLC-MS for HDI monomer …

Darkening And Eruptive Nevi During Treatment With Erlotinib (Poster), Stephen Hemperly Do, Tanya Ermolovich Do, Nektarios I. Lountzis Md

Department of Medicine

No abstract provided.

Eosinophilic Pustular Folliculitis, Ryan Owen Do, Arthur C. Sosis Md, Stephen M. Purcell Do

Department of Medicine

No abstract provided.

Herpes Zoster Duplex Bilateralis, Sean Branch Do, Arthur C. Sosis Md, Stephen M. Purcell Do

Department of Medicine

No abstract provided.

The Effects Of Laryngeal Desiccation And Nebulized Isotonic Saline In Male Speakers, Whitney Jane Robb

Theses and Dissertations

Hydration of the vocal folds is important for the production of normal voice. Dehydration makes voice production more difficult and increases vocal effort. Laryngeal desiccation has been shown to increase phonation threshold pressure (PTP) and self-perceived phonatory effort (PPE) in females. Nebulized saline may reverse or offset this effect. However, few data exist regarding the effects of laryngeal desiccation and nebulized treatments in males. Further, the dose-response relationship between laryngeal desiccation and nebulized hydration treatments is unknown. This study examined the effects of two doses of nebulized isotonic saline following a laryngeal desiccation challenge in healthy male speakers. In a …

Subacute Cutaneous Lupus Erythematosus With Erythema Multiforme-Like Lesions: Consideration For Rowell Syndrome, Kelly L. Reed Do, Steven Oberlender Md, Phd, Stephen M. Purcell Do

Department of Medicine

No abstract provided.

The Effectiveness Of St. Joseph Mercy Center For Diabetes Education Program At One And Two Years Post Education, Clisty Kinlin

Master's Theses and Doctoral Dissertations

Background: Diabetes is a disease of the endocrine system characterized by hyperglycemia, which can lead to multiple microvascular and macrovascular complications. Successful control of blood glucose levels can decrease associated complications.

Objective: This study evaluated the effectiveness of nutrition and lifestyle interventions in people diagnosed with type 2 diabetes.

Methods: A retrospective study reviewed laboratory data of individuals that attended the St. Joseph Mercy Center for Diabetes education program. HbA1c and lipid value were evaluated to determine the effectiveness of the program.

Results: Baseline HbA1c for all groups was 8.33%. Post-Program HbA1c was 6.70%, showing a 1.63% (p<0.0001) reduction from Baseline to Post-Program. There was a significant reduction in HbA1c of 1.4% (p<0.0001) for all groups from Baseline to 2-years Post-Program. Lipid levels did not show a significant change from Baseline to Post-Program, however, lipid levels reached target levels and continued to improve through 2-years Post-Program.

Conclusion: This …

Common And Specific Impairments In Attention Functioning In Girls With Chromosome 22q11.2 Deletion, Fragile X Or Turner Syndromes., Andrea I Quintero, Elliott A Beaton, Danielle J Harvey, Judith L. Ross, Tony J Simon

Department of Pediatrics Faculty Papers

BACKGROUND: Chromosome 22q11.2 deletion syndrome (22q11.2DS), fragile X syndrome (FXS), and Turner syndrome (TS) are complex and variable developmental syndromes caused by different genetic abnormalities; yet, they share similar cognitive impairments in the domains of numbers, space, and time. The atypical development of foundational neural networks that underpin the attentional system is thought to result in further impairments in higher-order cognitive functions. The current study investigates whether children with similar higher-order cognitive impairments but different genetic disorders also show similar impairments in alerting, orienting, and executive control of attention.

METHODS: Girls with 22q11.2DS, FXS, or TS and typically developing (TD) …

Edentulism Associates With Worse Cognitive Performance In Community-Dwelling Elders In Rural Ecuador: Results Of The Atahualpa Project, Oscar H. Del Brutto, Hannah Gardener, Victor J. Del Brutto, Gladys E. Maestre, Mauricio Zambrano, Jipson E. Montenegro, Clinton B. Wright

School of Medicine Publications

Studies in industrialized nations suggest that severe edentulism correlates with cognitive impairment, but there is little information on this association in underserved populations. We conducted a community-based study to assess whether edentulism associates with cognitive impairment in elders living in rural Ecuador. Atahualpa residents aged ≥60 years were identified during a door-to-door census and evaluated using the Montreal Cognitive Assessment (MoCA). Persons were classified into two groups according to whether they have severe edentulism (teeth) or not. In addition, a questionnaire allowed self-rating of oral health. A total of 274 persons (mean age 69.6 ± 7.7 years; 59 % women) …

Empathy, Self-Reflection, And Curriculum Choice, Suely Grosseman, Mohammadreza Hojat, Pamela M. Duke, Stewart Mennin, Steven Rosenzweig, Dennis Novack

Interdisciplinary Journal of Problem-Based Learning

We administered the Jefferson Scale of Empathy and the Groningen Reflection Ability Scale to 61 of 64 entering medical students who self-selected a problem-based learning curricular track and to 163 of 198 who self-selected a lecture-based track (response rates of 95.3% and 82.3%, respectively, with no statistically significant differences in mean age or sex). Mean empathy and self-reflection ability scores were significantly higher among students who chose problem-based learning. Women scored higher than men in empathy. Women choosing problem-based learning had the highest empathy scores. Studies comparing students’ performance and achievements in different curricular tracks should consider differences in personal …

Students’ Experiences In Interdisciplinary Problem-Based Learning: A Discourse Analysis Of Group Interaction, Rintaro Imafuku, Ryuta Kataoka, Mitsuori Mayahara, Hisayoshi Suzuki, Takuya Saiki

Interdisciplinary Journal of Problem-Based Learning

Interdisciplinary problem-based learning (PBL) aims to provide students with opportunities to develop the necessary skills to work with different health professionals in a collaborative manner. This discourse study examined the processes of collective knowledge construction in Japanese students in the tutorials. Analyses of video-recorded data elicited from three multidisciplinary cohorts and their learning portfolios provided insights into their participation and introspection during the discussions. The results indicate there were two patterns of knowledge construction: (a) co-constructions between students from different disciplines and (b) elaborations between students from the same discipline. Their learning processes were mediated by their cultural assumptions, professional …

Impact Of Tumour Epithelial Subtype On Circulating Micrornas In Breast Cancer Patients, Peadar S. Waters, Roisin M. Dwyer, Cathy Brougham, Claire L. Glynn, Deidre Wall, Peter Hyland, Maria Duignan, Mark Mcloughlin, John Newell, Michael J. Kerin

Forensic Science Publications

While a range of miRNAs have been shown to be dysregulated in the circulation of patients with breast cancer, little is known about the relationship between circulating levels and tumour characteristics. The aim of this study was to analyse alterations in circulating miRNA expression during tumour progression in a murine model of breast cancer, and to detemine the clinical relevance of identified miRNAs at both tissue and circulating level in patient samples. Athymic nude mice received a subcutaneous or mammary fat pad injection of MDA-MB-231 cells. Blood sampling was performed at weeks 1, 3 and 6 following tumour induction, and …

The Temporal Version Of The Pediatric Sepsis Biomarker Risk Model, Hector R. Wong, Scott L. Weiss, John S. Giuliano Jr., Mark S. Wainwright, Natalie Z. Cvijanovich, Robert J. Freishtat, +19 Additional Authors

Pediatrics Faculty Publications

Background

PERSEVERE is a risk model for estimating mortality probability in pediatric septic shock, using five biomarkers measured within 24 hours of clinical presentation.

Objective

Here, we derive and test a temporal version of PERSEVERE (tPERSEVERE) that considers biomarker values at the first and third day following presentation to estimate the probability of a “complicated course”, defined as persistence of ≥2 organ failures at seven days after meeting criteria for septic shock, or death within 28 days.

Methods

Biomarkers were measured in the derivation cohort (n = 225) using serum samples obtained during days 1 and 3 of septic shock. …

Risk Of Multiple Myeloma In Rheumatoid Arthritis: A Meta-Analysis Of Case-Control And Cohort Studies, Kaini Shen, Gufeng Xu, Qing Wu, Daobin Zhou, Jian Li

Environmental & Global Health Faculty Research

Multiple myeloma is a malignant neoplasm of plasma cells mainly affecting elderly patients. Despite the wealth of information available on therapeutic strategies, the etiology and pathogenesis of myeloma remain unclear. In the current study, a meta-analysis was conducted to assess the possible association between rheumatoid arthritis and myeloma.

Therapy Optimization In Multiple Sclerosis: A Prospective Observational Study Of Therapy Compliance And Outcomes., Patricia K Coyle, Bruce A Cohen, Thomas P. Leist, Clyde Markowitz, Merrikay Oleen-Burkey, Marc Schwartz, Mark J Tullman, Howard Zwibel

Department of Neurology Faculty Papers

BACKGROUND: Data sources for MS research are numerous but rarely provide an objective measure of drug therapy compliance coupled with patient-reported health outcomes. The objective of this paper is to describe the methods and baseline characteristics of the Therapy Optimization in MS (TOP MS) study designed to investigate the relationship between disease-modifying therapy compliance and health outcomes.

METHODS: TOP MS was designed as a prospective, observational, nationwide patient-focused study using an internet portal for data entry. The protocol was reviewed and approved by Sterling IRB. The study was registered with ClinicalTrials.gov. It captured structured survey data monthly from MS patients …

Epidemiology Of Undiagnosed Trichomoniasis In A Probability Sample Of Urban Young Adults, Susan M. Rogers, Charles F. Turner, Marcia Hobbs, William C. Miller, Sylvia Tan, Anthony M. Roman, Elizabeth Eggleston, Maria A. Villarroel, Laxminarayana Ganapathi, James R. Chromy, Emily Erbelding

Publications and Research

T. vaginalis infection (trichomoniasis) is the most common curable sexually transmitted infection (STI) in the U.S. It is associated with increased HIV risk and adverse pregnancy outcomes. Trichomoniasis surveillance data do not exist for either national or local populations. The Monitoring STIs Survey Program (MSSP) collected survey data and specimens which were tested using nucleic acid amplification tests to monitor trichomoniasis and other STIs in 2006–09 among a probability sample of young adults (N = 2,936) in Baltimore, Maryland — an urban area with high rates of reported STIs. The estimated prevalence of trichomoniasis was 7.5% (95% CI 6.3, 9.1) …

Empathy, Self-Reflection, And Curriculum Choice, Suely Grosseman, Mohammadreza Hojat, Pamela M. Duke, Stewart Mennin, Stephen Rosenzweig, Dennis Novack

Department of Psychiatry and Human Behavior Faculty Papers

We administered the Jefferson Scale of Empathy and the Groningen Reflection Ability Scale to 61 of 64 entering medical students who self-selected a problem-based learning curricular track and to 163 of 198 who self-selected a lecture-based track (response rates of 95.3% and 82.3%, respectively, with no statistically significant differences in mean age or sex). Mean empathy and self-reflection ability scores were significantly higher among students who chose problem-based learning. Women scored higher than men in empathy. Women choosing problem-based learning had the highest empathy scores. Studies comparing students’ performance and achievements in different curricular tracks should consider differences in personal …

Challenging Situations In Family Centered Rounds: Making The Best Out Of Worst Case Scenarios, Priti Bhansali, Kerry Moss, Christiane Corriveau, Geeta Singhal, Robert Kavanagh, Jeffrey Simmons

E-Learning Modules

This resource is a workshop intended for both seasoned and novice health care providers who are interested in becoming prepared for challenging scenarios that may be encountered during FCR. Case scenarios of challenging situations relating to discussing sensitive topics, correcting errors, and teaching learners in front of both parents and patients are presented. Tangible opportunities to role model communication skills, efficiency, and teaching skills for trainees are highlighted. The session will conclude with a question and answer session with a multi-specialty panel to share experiences and strategies for addressing the unexpected during FCR. By the end of the workshop, participants …

Altering Murine Leukemia Virus Integration Through Disruption Of The Integrase And Bet Protein Family Interaction, Sriram Aiyer, G.V.T. Swapna, Nirav Malani, James M. Aramini, William M. Schneider, Matthew R. Plumb, Mustafa Ghanem, Ross C. Larue, Amit Sharma, Barbara Studamire, Mamuka Kvaratskhelia, Frederic D. Bushman, Gaetano T. Montelione, Monica J. Roth

Publications and Research

We report alterations to the murine leukemia virus (MLV) integrase (IN) protein that successfully result in decreasing its integration frequency at transcription start sites and CpG islands, thereby reducing the potential for insertional activation. The host bromo and extraterminal (BET) proteins Brd2, 3 and 4 interact with the MLV IN protein primarily through the BET protein ET domain. Using solution NMR, protein interaction studies, and next generation sequencing, we showthat the C-terminal tail peptide region ofMLV IN is important for the interaction with BET proteins and that disruption of this interaction through truncation mutations affects the global targeting profile of …

Strengthening The Science Of Public Health Delivery: Complexities In Implementation, Inference & Translation, Glen P. Mays

Health Management and Policy Presentations

Delivery systems for public health programs and policies are diffuse and heterogeneous across the U.S., reflecting wide variation in the capacity to implement population-level health improvement strategies. This lecture examines strategies for evaluating the causes and consequences of variation in public health delivery across the U.S., with a focus on identifying pathways for improving the health and economic effects of policy and practice.

‘It’S Really Getting Real’: Payoffs In The Effort To Treat Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Mitochondrial-Targeted Curcuminoids: A Strategy To Enhance Bioavailability And Anticancer Efficacy Of Curcumin, Cheruku Apoorva Reddy, Venkateswarlu Somepalli, Trimurtulu Golakoti, Anantha Koteswararao Kanugula, Santosh Karnewar, Karthikraj Rajendiran, Nagarjuna Vasagiri, Sripadi Prabhakar, Periannan Kuppusamy, Srigiridhar Kotamraju, Vijay Kumar Kutala

Dartmouth Scholarship

Although the anti-cancer effects of curcumin has been shown in various cancer cell types, in vitro, pre-clinical and clinical studies showed only a limited efficacy, even at high doses. This is presumably due to low bioavailability in both plasma and tissues, particularly due to poor intracellular accumulation. A variety of methods have been developed to achieve the selective targeting of drugs to cells and mitochondrion. We used a novel approach by conjugation of curcumin to lipophilic triphenylphosphonium (TPP) cation to facilitate delivery of curcumin to mitochondria. TPP is selectively taken up by mitochondria driven by the membrane potential by several …

Pharmacy Student Self-Testing As A Predictor Of Examination Performance, David Stewart, Peter Panus, Nicholas E. Hagemeier, Jim Thigpen, Lauren Brooks

ETSU Faculty Works

Objectives. To determine if student self-testing improves performance during a doctor of pharmacy course.

Methods. Students were given access to online quizzes with a large pool of randomly selected questions specific to upcoming examination content. Quizzes were electronically scored immediately upon completion and students were provided corrective feedback.

Results. Examination scores following implementation of the practice quizzes were significantly higher in all but the last testing period. The upper fiftieth percentile of students scored higher on both the practice quizzes and subsequent examinations in all but the fourth testing period.

Conclusions. Providing pharmacy students with self-testing opportunities could increase their …

Optimizing Care -- Inspiring Leadership To Improve Quality And Efficiency While Controlling Costs, Anne Panik Ms, Rn, Nea-Bc, Kim Jordan Mha, Bsn, Rn, Ne-Bc

Patient Care Services / Nursing

No abstract provided.

Genetics Of Picalm Expression And Alzheimer's Disease, Ishita Parikh, David W. Fardo, Steven Estus

Sanders-Brown Center on Aging Faculty Publications

Novel Alzheimer's disease (AD) risk factors have been identified by genome-wide association studies. Elucidating the mechanism underlying these factors is critical to the validation process and, by identifying rate-limiting steps in AD risk, may yield novel therapeutic targets. Here, we evaluated the association between the AD-associated polymorphism rs3851179 near PICALM, which encodes a clathrin-coated pit accessory protein. Immunostaining established that PICALM is expressed predominately in microvessels in human brain. Consistent with this finding, PICALM mRNA expression correlated with expression of the endothelial genes vWF and CD31. Additionally, we found that PICALM expression was modestly increased with the rs3851179A …

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Impaired Verbal Memory