Medicine and Health Sciences Commons^™

Cryo Surgery Of The Prostate: An Effective, Minimally Invasive Cancer Therapy With Superior Health-Related Quality-Of-Life Outcomes, Martyn A. Vickers Jr

Oncology

What is the best treatment for localized, aggressive prostate cancer? One option is Cryo Surgery, a primary option that utilizes localized freezing to destroy diseased tissue. If you or your patients wish to consider Cryo Surgery, be sure to discuss this option with an urologist who performs Cryo Surgery of the prostate. Many urologists have not observed or been trained in the performance of this procedure. Prostate cancer allows you time to carefully consider all treatment options. Make an educated decision!

Acquisition Of A Social Problem Solving Method By Caregivers In The Foster Care System: Evaluation And Implications, Evan Ann Skelton

USF Tampa Graduate Theses and Dissertations

All youth are faced with many social issues and problems on a daily basis, and youth in foster care are often less equipped than their peers to make good decisions for themselves. The SODAS problem solving method is a component of the Transition to Independence Process (TIP) model and is intended for personnel to use with youth to help them make better decisions when faced with difficult situations. The SODAS method is designed to guide youth through a problem solving method for a current situation, and over time to acquire improved problem solving skills. Three caregivers at a group facility …

Interaction Between Allelic Variations In Vitamin D Receptor And Retinoid X Receptor Genes On Metabolic Traits, Karani S. Vimaleswaran, Alana Cavadino, Diane J. Berry, Massimo Mangino, Peter Andrews, Jason H. Moore

Dartmouth Scholarship

Low vitamin D status has been shown to be a risk factor for several metabolic traits such as obesity, diabetes and cardiovascular disease. The biological actions of 1, 25-dihydroxyvitamin D, are mediated through the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptor, gamma (RXRG). Hence, we examined the potential interactions between the tagging polymorphisms in the VDR (22 tag SNPs) and RXRG (23 tag SNPs) genes on metabolic outcomes such as body mass index, waist circumference, waist-hip ratio (WHR), high- and low-density lipoprotein (LDL) cholesterols, serum triglycerides, systolic and diastolic blood pressures and glycated haemoglobin in the 1958 …

Integrated Assessment Of Predicted Mhc Binding And Cross-Conservation With Self Reveals Patterns Of Viral Camouflage, Lu He, Anne S. De Groot, Andres H. Gutierrez, William D. Martin, Lenny Moise, Chris Bailey-Kellogg

Dartmouth Scholarship

Immune recognition of foreign proteins by T cells hinges on the formation of a ternary complex sandwiching a constituent peptide of the protein between a major histocompatibility complex (MHC) molecule and a T cell receptor (TCR). Viruses have evolved means of "camouflaging" themselves, avoiding immune recognition by reducing the MHC and/or TCR binding of their constituent peptides. Computer-driven T cell epitope mapping tools have been used to evaluate the degree to which articular viruses have used this means of avoiding immune response, but most such analyses focus on MHC-facing ‘agretopes'. Here we set out a new means of evaluating the …

New Malignancies After Squamous Cell Carcinoma And Melanomas: A Population-Based Study From Norway, Trude E. Robsahm, Margaret R. Karagas, Judy R. Rees, Astri Syse

Dartmouth Scholarship

Skin cancer survivors experience an increased risk for subsequent malignancies but the associated risk factors are poorly understood. This study examined the risk of a new primary cancer following an initial skin cancer and assessed risk factors associated with second primary cancers.

Evolutionary Cognitive Therapy Versus Standard Cognitive Therapy For Depression: A Protocol For A Blinded, Randomized, Superiority Clinical Trial, Cezar Giosan, Oana Cobeanu, Cristina Mogoase, Vlad Muresan, Loretta S. Malta, Katarzyna Wyka, Aurora Szentagotai

Publications and Research

Background: Depression is estimated to become the leading cause of disease burden globally by 2030. Despite existing efficacious treatments (both medical and psychotherapeutic), a large proportion of patients do not respond to therapy. Recent insights from evolutionary psychology suggest that, in addition to targeting the proximal causes of depression (for example, targeting dysfunctional beliefs by cognitive behavioral therapy), the distal or evolutionary causes (for example, inclusive fitness) should also be addressed. A randomized superiority trial is conducted to develop and test an evolutionary-driven cognitive therapy protocol for depression, and to compare its efficacy against standard cognitive therapy for depression.

Methods/design: …

Structural And Biophysical Characterization Of Staphylococcus Aureus Samazf Shows Conservation Of Functional Dynamics, Valentina Zorzini, Lieven Buts, Mike Sleutel, Abel Garcia-Pino, Ariel Talavera, Sarah Haesaerts, Henri De Greve, Ambrose Cheung, Nico A. J. Van Nuland, Remy Loris

Dartmouth Scholarship

The Staphylococcus aureus genome contains three toxin-antitoxin modules, including one mazEF module, SamazEF. Using an on-column separation protocol we are able to obtain large amounts of wild-type SaMazF toxin. The protein is well-folded and highly resistant against thermal unfolding but aggregates at elevated temperatures. Crystallographic and nuclear magnetic resonance (NMR) solution studies show a well-defined dimer. Differences in structure and dynamics between the X-ray and NMR structural ensembles are found in three loop regions, two of which undergo motions that are of functional relevance. The same segments also show functionally relevant dynamics in the distantly related CcdB family despite divergence …

Is Sickle Cell Trait As Benign As Is Usually Assumed?, Carroll Nicole Flansburg

USF Tampa Graduate Theses and Dissertations

Abstract

Introduction Sickle cell trait carriers may experience sickling events, which can cause severe health problems. Some sickle cell haplotypes contain genetic modifiers that are associated with increased levels of fetal hemoglobin, which is resistant to sickling. The aim of this study is to determine if sickle cell trait individuals who do not carry these modifiers are more likely to experience sickling episodes than those who do carry the modifiers.

Methods: Participants were eligible for inclusion in this study if they were male, 18 years of age or older, a sickle cell trait carrier, and had previously played any level …

2014 March 18 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Prevalence Of Small-For-Gestational Age And Its Mortality Risk Varies By Choice Of Birth-Weight-For-Gestation Reference Population, Joanne D. Katz, Lauren A. Wu, Luke C. Mullany, Christian L. Coles, Anne C.C. Lee, Naoko Kozuki, James M. Tielsch

Global Health Faculty Publications

Background

We use data from rural Nepal and South India to compare the prevalence of small-for-gestational-age (SGA) and neonatal mortality risk associated with SGA using different birth-weight-for-gestation reference populations.

Methods

We identified 46 reference populations in low-, middle-, and high-income countries, of which 26 met the inclusion criteria of being commonly cited and having numeric 10th percentile cut points published. Those reference populations were then applied to populations from two community-based studies to determine SGA prevalence and its relative risk of neonatal mortality.

Results

The prevalence of SGA ranged from 10.5% to 72.5% in Nepal, and 12.0% to 78.4% in …

Mainecare Stage A Health Homes Year 1 Report: Implementation Findings And Baseline Analysis, Kimberley S. Fox Mpa, Carolyn E. Gray Mph, Katherine Rosingana, Deborah A. Thayer Mba

Population Health & Health Policy

In January 2013, Maine established Health Homes under federal authority pursuant to Section 2703 of the Affordable Care Act to improve care coordination for MaineCare members with chronic conditions. Stage A of the Health Homes initiative focuses on members with complex medical chronic conditions. Stage B, planned for early 2014, will focus on persons with severe and persistent mental health conditions and children with serious emotional disturbances. The Stage A demonstration builds off the State’s existing Maine multi-payer Patient Centered Medical Home (PCMH) Pilot project and Maine’s Medicare Advanced Primary Care Practice (MAPCP) Demonstration by providing add-on payments to primary …

Linking Brain Electrical Signals Elicited By Current Outcomes With Future Risk Decision-Making, Dandan Zhang, Ruolei Gu, Lucas S. Broster, Yang Jiang, Wenbo Luo, Jian Zhang, Yue-Jia Luo

Behavioral Science Faculty Publications

The experience of current outcomes influences future decisions in various ways. The neural mechanism of this phenomenon may help to clarify the determinants of decision-making. In this study, thirty-nine young adults finished a risky gambling task by choosing between a high- and a low-risk option in each trial during electroencephalographic data collection. We found that risk-taking strategies significantly modulated mean amplitudes of the event-related potential (ERP) component P3, particularly at the central scalp. The event-related spectral perturbation and the inter-trial coherence measurements of the independent component analysis (ICA) data indicated that the “stay” vs. “switch” electrophysiological difference associated with subsequent …

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Cholera Transmission Dynamic Models

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Public Health Services
• Cholera Transmission Dynamic Models

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Public Health Services

Using Video Feedback To Improve Horseback Riding Skills, Heather Kelley

USF Tampa Graduate Theses and Dissertations

This study used video feedback to improve the horseback riding skills of advanced beginner riders. The study focused on three skill sets, those used in jumping over obstacles, dressage riding on the flat, and jumping position riding on the flat. Baseline consisted of standard lesson procedures. Intervention consisted of video feedback in which a recorded attempt at the target behaviors was immediately shown to the rider and the instructor. The rider and instructor reviewed the video while the instructor delivered feedback. Target behaviors were scored according to checklists that correspond to each skill. For all participants, video feedback increased their …

Prevalence And Risk Factors Of Depressive Symptoms In A Canadian Palliative Home Care Population: A Cross Sectional Study, Kathryn A. Fisher, Hsien Seow, Kevin Brazil, Shannon Freeman, Trevor Frise Smith, Dawn M. Guthrie

Kinesiology and Physical Education Faculty Publications

Background: Depression in palliative care patients is important because of its intrinsic burden and association with elevated physical symptoms, reduced immunity and increased mortality risk. Identifying risk factors associated with depression can enable clinicians to more readily diagnose it, which is important since depression is treatable. The purpose of this cross-sectional study was to determine the prevalence of depressive symptoms and risk factors associated with them in a large sample of palliative home care patients.

Methods: The data come from interRAI Palliative Care assessments completed between 2006 and 2012. The sample (n = 5144) consists of adults residing …

Inferences & Connections, Tamara Kneese

Media Studies

Data-oriented systems are inferring relationships between people based on genetic material, behavioral patterns (e.g., shared geography imputed by phone carriers), and performed associations (e.g., "friends" online or shared photographs). What responsibilities do entities who collect data that imputes connections have to those who are implicated by association? For example, as DNA and other biological materials are collected outside of medicine (e.g., at point of arrest, by informatics services like 23andme, for scientific inquiry), what rights do relatives (living, dead, and not-yet-born) have? In what contexts is it acceptable to act based on inferred associations and in which contexts is it …

Ada News - 03/17/2014, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

What's Happening: March 17, 2014, Maine Medical Center

What's Happening

No abstract provided.

Influence Of Athlete Heart Rate, Rate Of Perceived Exertion, And Anxiety In Rowing Practice And Competition, Katherine Skrlj Krengel

Master's Theses and Doctoral Dissertations

The purpose of this study was to investigate whether there is a significant correlation between heart rate (HR) and rate of perceived exertion (RPE) in rowing, how athlete perception of pre-race anxiety relates to HR and RPE, and how these variables change between practice and competition. Four subjects were tested over the course of their rowing season for somatic and cognitive anxiety, self-confidence, HR, and RPE in three different 2000 meter racing conditions: indoor ergometer, on-water racing, and on-water practice. There was no correlation between HR and RPE, and only maximum HR showed a difference between trial types. Studying more …

Cd46-Mediated Transduction Of A Species D Adenovirus Vaccine Improves Mucosal Vaccine Efficacy, Zenaido T. Camacho, Michael A. Barry, Eric A. Weaver

Nebraska Center for Virology: Faculty Publications

The high levels of preexisting immunity against Adenovirus type 5 (Ad5) have deemed Ad5 unusable for translation as a human vaccine vector. Low seroprevalent alternative viral vectors may be less impacted by preexisting immunity, but they may also have significantly different phenotypes from that of Ad5. In this study we compare species D Ads (26, 28, and 48) to the species C Ad5. In vitro transduction studies show striking differences between the species C and D viruses. Most notably, Ad26 transduced human dendritic cells much more effectively than Ad5. In vivo imaging studies showed strikingly different transgene expression profiles. The …

The Effect Of Fungal Growth On Potential Phthalate Ester Exposures From Plasticized Polyvinyl Chloride, Garrick Johnson

USF Tampa Graduate Theses and Dissertations

This study examined the effects of the presence of fungal growth on the phthalate ester content of plasticized polyvinyl chloride (pPVC) used as the vapor barrier component of metal building insulation and the impact the fungal growth may have on the resulting exposure potential to the workers in the building. Individual pieces of the pPVC material exhibiting fungal growth and individual pieces of the pPVC material exhibiting no fungal growth were collected from the building being investigated. Twenty-five pieces each of the pPVC material exhibiting fungal growth and of the pPVC material exhibiting no fungal growth were weighed, reduced to …

Medical School Watercooler Newsletter - March 16, 2014, Lindsey Lyle

Watercooler Newsletter

This is the March 16, 2014 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Senior Medical Students Celebrate Residencies at Match Day 2014
• 'A Miracle in More Ways than One'
• USA's SPF 90 Team to Provide Skin Cancer Screenings at Azalea Trail Run
• USA Children’s and Women’s Hospital To Host Local Goodness April 6
• Register Now: OB-GYN Annual Conference

Genes With A Large Intronic Burden Show Greater Evolutionary Conservation On The Protein Level, Olga Gorlova, Alexey Fedorov, Christopher Logothetis, Christopher Amos, Ivan Gorlov

Dartmouth Scholarship

Background: The existence of introns in eukaryotic genes is believed to provide an evolutionary advantage by increasing protein diversity through exon shuffling and alternative splicing. However, this eukaryotic feature is associated with the necessity of exclusion of intronic sequences, which requires considerable energy expenditure and can lead to splicing errors. The relationship between intronic burden and evolution is poorly understood. The goal of this study was to analyze the relationship between the intronic burden and the level of evolutionary conservation of the gene. Results: We found a positive correlation between the level of evolutionary conservation of a gene and its …

A Central Role For Vimentin In Regulating Repair Function During Healing Of The Lens Epithelium, A. S. Menko, B. M. Bleaken, A. A. Libowitz, L. Zhang, Mary Ann Stepp, J. L. Walker

Anatomy and Regenerative Biology Faculty Publications

Mock cataract surgery provides a unique ex vivo model for studying wound repair in a clinically relevant setting. Here wound healing involves a classical collective migration of the lens epithelium, directed at the leading edge by an innate mesenchymal subpopulation of vimentin-rich repair cells. We report that vimentin is essential to the function of repair cells as the directors of the wound-healing process. Vimentin and not actin filaments are the predominant cytoskeletal elements in the lamellipodial extensions of the repair cells at the wound edge. These vimentin filaments link to paxillin-containing focal adhesions at the lamellipodial tips. Microtubules are involved …

Functional Proteomic Analysis Reveals The Involvement Of Kiaa1199 In Breast Cancer Growth, Motility And Invasiveness., Mohammad-Saeid Jami, Jinxuan Hou, Miao Liu, M L. Varney, Hesham Hassan, Jixin Dong, Liying Geng, J. Wang, Fang Yu, Xin Huang, Hong Peng, Kai Fu, Yan Li, Rakesh Singh, Shi-Jian Ding

Journal Articles: Pathology and Microbiology

BACKGROUND: KIAA1199 is a recently identified novel gene that is up-regulated in human cancer with poor survival. Our proteomic study on signaling polarity in chemotactic cells revealed KIAA1199 as a novel protein target that may be involved in cellular chemotaxis and motility. In the present study, we examined the functional significance of KIAA1199 expression in breast cancer growth, motility and invasiveness.

METHODS: We validated the previous microarray observation by tissue microarray immunohistochemistry using a TMA slide containing 12 breast tumor tissue cores and 12 corresponding normal tissues. We performed the shRNA-mediated knockdown of KIAA1199 in MDA-MB-231 and HS578T cells to …

Community Health Revolving Fund: Equity Fund For Mccs, Muhammad Ashar Malik

Community Health Sciences

No abstract provided.

Introducing And Evaluating 3d Digital Breast Tomosynthesis, Marie Hrinkonich, Susan Steigerwalt

Department of Radiology & Diagnostic Medical Imaging

No abstract provided.

A Population Of Langerin-Positive Dendritic Cells In Murine Peyer’S Patches Involved In Sampling B -Glucan Microparticles, Magdia De Jesus

Biomedical Sciences Faculty Scholarship

Glucan particles (GPs) are 2–4 mm hollow, porous shells composed of 1,3-b-D-glucan that have been effectively used for oral targeted–delivery of a wide range of payloads, including small molecules, siRNA, DNA, and protein antigens. While it has been demonstrated that the transepithelial transport of GPs is mediated by Peyer’s patch M cells, the fate of the GPs once within gut-associated lymphoid tissue (GALT) is not known. Here we report that fluorescently labeled GPs administered to mice by gavage accumulate in CD11c+ DCs situated in Peyer’s patch sub-epithelial dome (SED) regions. GPs appeared in DCs within minutes after gavage and remained …