Medicine and Health Sciences Commons^™

Metformin Inhibits Androgen-Induced Igf-Ir Up-Regulation In Prostate Cancer Cells By Disrupting Membrane-Initiated Androgen Signaling., Roberta Malaguarnera, Antonella Sacco, Alaide Morcavallo, Sebastiano Squatrito, Antimo Migliaccio, Andrea Morrione, Marcello Maggiolini, Antonino Belfiore

Department of Urology Faculty Papers

We have previously demonstrated that, in prostate cancer cells, androgens up-regulate IGF-I receptor (IGF-IR) by inducing cAMP-response element-binding protein (CREB) activation and CREB-dependent IGF-IR gene transcription through androgen receptor (AR)-dependent membrane-initiated effects. This IGF-IR up-regulation is not blocked by classical antiandrogens and sensitizes cells to IGF-I-induced biological effects. Metformin exerts complex antitumoral functions in various models and may inhibit CREB activation in hepatocytes. We, therefore, evaluated whether metformin may affect androgen-dependent IGF-IR up-regulation. In the AR(+) LNCaP prostate cancer cells, we found that metformin inhibits androgen-induced CRE activity and IGF-IR gene transcription. CRE activity requires the formation of a CREB-CREB …

Loma Linda Nurse - Vol. 22, No. 01, Loma Linda University School Of Nursing

Loma Linda Nurse

Contents

From the dean

2 | Marilyn Herrmann shares her thoughts

Features

4 | International off-campus MS celebration

6 | Alumni profile - Hollie Caldwell

8 | Global nursing conference

9 | How nursing student Nicole Shea lives it

News

10 | Faculty receive award

12 | New nurse anesthesia program

Alumni

14 | Note from Alumni Association president

15 | Then & now - 2014 homecoming details

16 | 2013 honored classes

18 | 2013 Alumni of the Year

In memory

20 | Remembering beloved faculty and alumni

Development

22 | Thank-you donor lunch

23 | Planning giving

23 …

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• HPV Vaccine

Spirituality And Religiosity In Adolescents With Sickle Cell Disease: A Descriptive Qualitative Study, Dora L. Clayton-Jones

Dissertations (1934 -)

Sickle cell disease (SCD) is a serious debilitating chronic illness and global health problem. Spirituality and religiosity have been shown to have positive correlations with their health outcomes. Research addressing the spiritual and religious needs of adolescents living with SCD is limited.

The aim of this descriptive qualitative study was to examine how adolescents (Mage = 16.2 years) with SCD describe and experience spirituality and religiosity. Nine adolescents completed two semi-structured interviews. Sickle Cell Disease Interview Guides were developed using the Spiritual Development Framework developed by Benson & Roehlkepartain (2008) as a guide. The framework provided a foundation for conceptualizing …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• HPV Vaccine
• Concentrations and Distribution of Serum Lipids

Brain Blast 2014 Speakers Poster, Annie Leslie

Brain Blast

Poster from UNE's Brain Blast 2014 listing the presenters at this event.

Understanding Ultramarathoners: Identifying Markers Of Success In Ultras Through An Objective Survey Of Ultramarathoners, Renee A. Cabalka Mrs.

Senior Honors Theses

An ultramarathon (ultra) is defined as a race longer in time or distance than a marathon. Studies have been done to identify factors, which contribute to successful completion of other ultra endurance events. The purpose of this study was to determine factors that contribute to the successful completion of an ultramarathon by collecting data via an objective survey. The subjects of this survey were participants in the 2013 Mountain Masochist Trail Race (MMTR) 50 miler. The survey included factors such as gender, age, height, weight, body mass index (BMI), training age, and ultra experience. The survey data was collected and …

Tumor Radiation Therapy Creates Therapeutic Vaccine Responses To The Colorectal Cancer Antigen Gucy2c., Matthew Witek, Erik S Blomain, Michael Sullivan Magee, Bo Xiang, Scott A Waldman, Adam E. Snook

Department of Pharmacology and Experimental Therapeutics Faculty Papers

PURPOSE: Radiation therapy (RT) is thought to produce clinical responses in cancer patients, not only through direct toxicity to cancer cells and supporting tumor stroma cells, but also through activation of immunologic effectors. More recently, RT has potentiated the local and systemic effects of cancer immunotherapy (IT). However, combination regimens that maximize immunologic and clinical efficacy remain undefined.

METHODS AND MATERIALS: We evaluated the impact of local RT on adenoviral-mediated vaccination against the colorectal cancer antigen GUCY2C (Ad5-GUCY2C) in a murine subcutaneous tumor model using mouse CT26 colon cancer cells (CT26-GUCY2C). Immune responses were assessed by ELISpot, and clinical responses …

Development Of An Evidence‐Based Implementation Plan For A System‐Wide Anticoagulation Management Service, Sarah Varney

Muskie School Capstones and Dissertations

The Mercy Health System of Maine (MHSM) is a large healthcare system located in Southern Maine. It consists of three inpatient campuses, one level II Emergency Department, four Express Care centers, seven Primary Care locations and an array of specialist practices. The organization has identified a need for improved management of anticoagulation therapy within the system as a large number of patients are receiving anticoagulation therapy throughout all of the various healthcare access sites. In order to address this need, MHSM seeks to implement a system‐wide, standardized approach for managing patients receiving anticoagulation therapy.

The Changing Role Of Ancillary Health Care Service Providers: An Evaluation Of Health Diagnostic Laboratory, Inc., Steven M. Thompson, Stephen Varvel, Szilard Voros, Dawn Thiselton, Shahrzad Grami, Ralph M. Turner, John Barron

Management Faculty Publications

In an effort to reduce cost and improve quality, health care payers have enacted a number of incentives to motivate providers to focus their efforts on achieving better clinical outcomes and reducing the prevalence and progression of disease. In response to these incentives, providers are entering into new arrangements such as accountable care organizations and patient-centered medical homes to redesign delivery processes and achieve quality and cost objectives. This article reports the results of a study designed to evaluate the impact on cost and quality of care resulting from services provided by Health Diagnostic Laboratory, Inc., a clinical laboratory with …

Gender: Shaping Personality, Lives And Health Of Women In Pakistan, Narjis Rizvi, Kausar S. Khan, Babar T. Shaikh

Community Health Sciences

Background: Gender norms determine the status of Pakistani women that influence their life including health. In Pakistan, the relationship between gender norms and health of women is crucial yet complex demanding further analysis. This paper: determines the reasons for reiteration of gender roles; describes the societal processes and mechanisms that reproduce and reinforce them; and identifies their repercussions on women's personality, lives and health especially reproductive health.
Methods: As part of a six-country study titled 'Women's Empowerment in Muslim Contexts', semi-structured group discussions (n = 30) were conducted with women (n = 250) who were selected through snowballing from different …

Kajian Permasalahan Dan Potensi Perilaku Ibu Dalam Pemberian Makanan Bagi Anak Dalam Kaitannya Pada Kualitas Hidup Anak-Anak Yang Tidak Berkecukupan Gizi Di Keluarga Miskin Perkotaan, Getar Hati, Isbandi Rukminto Adi

Jurnal Ilmu Kesejahteraan Sosial

This article discusses about child welfare issues in a community related to mothers’ behavior child welfare issues of a community related to children of age 6-24 months with insufficient nutrition condition. It also describes about the factors which influenced to this condition that would be base of intervention design to solve the problems. This is an descriptive research. This research stated that parents, especially mother has the most important roles in determining their children’s life quality.

Strategi Strategi Penggalangan Dana Pada Organisasi Kemanusiaan Berbasis Agama : Studi Deskriptif Penggalangan Dana Di Dompet Dhuafa, Herlin Rahma Fauzia

Jurnal Ilmu Kesejahteraan Sosial

This study discuses about strategies of fundraising conducted by Yayasan Dompet Dhuafa with the supports and obstacles. This study used qualitative method and descriptive approach. The result of study show that Dompet Dhuafa have some strategies of fundraising. First, retail fundraising includes counter, Gerakan Donasi, Jemput Zakat and direct mail. Second is partnership with companies, another institutions and public

Evaluasi Program Wirausaha Pemula Di Kementrian Koperasi Dan Ukm Ri : Individualized Outcome Evaluation Terhadap Lima Peserta Program Wirausaha Pemula Di Dki Jakarta Tahun 2012, Andi Besse Ansar, Ety Rahayu

Jurnal Ilmu Kesejahteraan Sosial

The study discusses about individualized outcome evaluation of young entrepreneur program evaluation at ministry of cooperatives and small medium enterprises for five beneficiaries from Jakarta City in 2012. This research used a qualitative approach with evaluation research. While collecting data using in-depth interview with 7 informans which consist 5 beneficiaries program and 2 program staff. This result of study show that 4 beneficiaries has achieve an outcome program because of the trainee characteristics, training design, work environment, attitude and self concept and design entrepreneurship factors support and 1 beneficiaries has a barrier in work environment, attitude and self concept and …

Oral Health Promotion: Knowledge, Confidence, And Practices In Preventing Early-Severe Childhood Caries Of Virginia Wic Program Personnel, Lorraine Ann Fuller, Sharon C. Stull, Michele L. Darby, Susan Lynn Tolle

Dental Hygiene Faculty Publications

Purpose: This study assessed the oral health knowledge, confidence and practices of Virginia personnel in the Special Supplemental Food Program for Women, Infants and Children (WIC).

Methods: In 2009, 257 WIC personnel were electronically emailed via an investigator-designed 22-item Survey Monkey® questionnaire. Descriptive statistics, Chi-square and Fishers Exact tests compared personnel demographics and oral health knowledge, confidence and practices at the p≤0.01 and 0.05 significance level.

Results: Response rate was 68%. WIC personnel were knowledgeable about basic oral health concepts. More than half of those reporting were not confident assessing for visual signs of dental decay and do not routinely …

The Gut Reaction: How The Intestinal Microbiota Respond To Citrobacter Rodentium Colonization, Cassandra Black

Senior Honors Theses

The human intestine hosts a diverse community of bacteria known as the intestinal microbiota. The intestinal microbiota have a symbiotic relationship with the host organism. Current research does not clearly define the effect these commensal microorganisms have on the overall maintenance of gastrointestinal health, including protection from the invasion and pathogenesis of foreign bacteria known as pathogens. EHEC O157:H7 causes severe sickness and can be life-threatening, but is difficult to study in vivo. One challenge is that EHEC does not colonize the preferred animal model for human GI studies: the murine intestine. However, the murine pathogen Citrobacter rodentium has …

Stroke In Women: Burden, Challenges And Future For Pakistan, Maria Khan, Mohammad Wasay

Pakistan Journal of Neurological Sciences (PJNS)

The burden of stroke is increasing around the world in both men and women. South Asia is home to 20% of the world’s population but harbors almost 80% of world strokes. Previously sex specific data on stroke incidence, prevalence, severity and mortality was not available. Now over recent years this aspect has received attention. A systematic review in 2009 concluded that although stroke in women is less common compared to men, it has a greater severity and case fatality. Although this kind of data is not available from Pakistan, some preliminary reports suggest that this might be the case in …

Clinical Predictors Of Mechanical Ventilation In Guillain-Barré Syndrome (Gbs), Sumaira Nabi, Sadaf Khattak, Muhammad Irshad Awan

Pakistan Journal of Neurological Sciences (PJNS)

Guillain-Barre’ Syndrome is the most common cause of acute flaccid paralysis worldwide. One of the most serious complications is respiratory failure warranting mechanical ventilation which is required in about 30% of the patients. Various studies have been carried out to identify clinical factors which could help identify patients with impending respiratory failure and facilitate elective mechanical ventilation in these patients to reduce the associated mortality. Material and methods: 92 patients diagnosed with GBS were enrolled from February 6, 2013 to August 5, 2013 in department of Neurology, PIMS, Islamabad. Each patient was then be managed accordingly and monitored for therequirement …

Impact Of Guillain Barre Syndrome On Psychosocial Functionings Of Patients In Islamabad, Muhammad Naveed Babur, Farrukh Shahzad, Waqar Ahmed Awan

Pakistan Journal of Neurological Sciences (PJNS)

GuillainBarre Syndrome (GBS) is a rare autoimmune disease of unknown causes that affects peripheral nervous system. Objectives: To review the impacts of the GuillainBarre Syndrome on the psychosocial functioning of the patients and to assess the relationship between GuillainBarre Syndrome and the psychosocial functioning Methodology: Comparative cross sectional survey was conducted on 100 participants (50 GBS patients from Shifa International Hospitals and 50 normal participants from Islamabad in 6 months time from February to July 2013. Data collected through Structured Questionnaire in hospital settings for GBS patients and normal persons from Islamabad through Psychosocial functioning scale and social functioning scale …

Variants And Variations Among Gullian Barre Syndrome Presenting As Acute Flaccid Paralysis, Alam Ibrahim Siddiqui, Ghulam Rasool Bouk, Lal Chand, Sarfraz Ahmed Mahesar, Ghulam Mustafa Tunio

Pakistan Journal of Neurological Sciences (PJNS)

Acute flaccid paralysis (AFP) is a clinical syndrome characterized by rapid onset of weakness that frequently includes respiratory and bulbar weakness. An accurate and early diagnosis of the cause has important bearing on the management and prognosis. Guillian Barre Syndrome (GBS) is a post infectious polyradiculoneuropathy involving mainly motor but sometimes sensory and autonomic nerves.

Neuroradiological Manifestations Of Tuberculous Meningitis, Sumaira Nabi, Sadaf Khattak, Mazhar Badshah, Haris Majid Rajput

Pakistan Journal of Neurological Sciences (PJNS)

Tuberculous meningitis (TBM) represents the most severe form of extra pulmonarytuberculosis (1).The early and exact diagnosis of TBM is important but difficult due to time consuming definitive microbiological procedures (2).Neuroimaging is an important initial investigation in tuberculous meningitis(3).This study was conducted to evaluate the neuroradiological findings in patients with tuberculous meningitis, as a useful modality for itsearly diagnoses and prompt treatment.

Spontaneous Intracranial Hypotension, Mehwish Sayed, Ahmed Asif, Bushra Reha, Amanullah Khan

Pakistan Journal of Neurological Sciences (PJNS)

Spontaneous intracranial hypotension (SIH) is uncommon and usually undiagnosed entity which present most commonly with postural headache. The diagnosis is difficult because of the nonspecific symptoms and lack of awareness about the disease .It is important to recognize SIH as if the disease goes undiagnosed it can cause a significant delay in initiation of the treatment and exposing patient to the risks associated with the treatment for the disorders mimicking intracranial hypotension . We describe a patient with SIH and outline the important clinical and radiological features of this syndrome. The aim of presenting this case report is to emphasize …

Radiosurgery: Current Recommendations For Intracranial Lesions And Practices In Pakistan, Hussain Shallwani, Sohaib Tariq, Muhammad E Bari

Pakistan Journal of Neurological Sciences (PJNS)

Radiosurgery is defined as the use of high-dose ionizing radiation for precise and total destruction of a chosen target, avoiding concomitant or delayed harm to adjacent tissues. The three types of radiations include gamma rays (GammaKnife) by Cobalt-60, X8 rays using linear accelerator (LINAC) system, and charged-particles generated from synchocyclotron. Recommendations: Based on current evidence, radiosurgery has proven benefits as the treatment of certain brain metastases, vestibular schwannomas, meningiomas, and some skull base tumors. Conclusion: This review describes the current recommendations for use of radiosurgery for intracranial pathologies. Radiosurgery is a relatively newer modality in the developing country of Pakistan. …

Isoflavones And Alzheimer’S Disease: The Effects Of Soy In Diet, Sara Habib, Asad Ali Khan Afridi, Mohammad Wasay, Romaina Iqbal

Pakistan Journal of Neurological Sciences (PJNS)

Pathologically, Alzheimer’s disease is a result of aggregation of amyloid peptides and protein tau in the brain forming neurofibrillary tangles which are highly toxic to neuronal circuits in the brain. Recent evidences report that apart from aging, estrogen deficiency is one of the risk factors predisposing to the development of Alzheimer’s disease. Isoflavones, also known as phytoestrogens, are metabolized by the body forming compounds that are known to interfere with neurotoxic pathways and through their anti-fibrillization effects they play a role in reducing apoptosis of neurons and glial cells and promote axonal regeneration. Experimental studies on transgenic models with Alzheimer’s …

Ct Scan In Children With Acute Bacterial Meningitis: Experience From Emergency Department Of A Tertiary-Care Hospital In Karachi, Pakistan, Jabeen Fayyaz, Arshalooz Rehman, Akhter Hamid, Munawar Khursheed, Nukhba Zia, Asher Feroze, Uzma R. Khan

Department of Emergency Medicine

Objective: To determine the role of computed tomography scan in children presenting to emergency department with symptoms and signs of suspected acute bacterial meningitis.

Methods: The retrospective analysis was done on children who were admitted through the Emergency Department at Aga Khan University Hospital, Karachi, from September 2009 to September 2011 with the diagnosis of acute bacterial meningitis. Information related to age, gender, presenting complaints, clinical signs and symptoms, computed tomography scan findings and final outcome of patients was gathered from the medical records. SPSS 19 was used for statistical analysis.

Results: A total of 192 patients were admitted with …

The Influence Of Vitamin D Metabolism On Gene Expression, Matrix Production And Mineralization During Osteoprecursor Cell-Based Bone Development, Shelley S. Mason, Sean S. Kohles, Shelley R. Winn, Randy D. Zelick

Biology Faculty Publications and Presentations

Background: Multipotential precursor cell lines derived from human bone marrow, capable of differentiating into cartilage or bone, may provide a useful tissue development model for studying the regulation and metabolism of putative growth and differentiation factors necessary for tissue regeneration. In mammals, the process of bone development depends on the proliferation and differentiation of osteoblast lineage cells, and the subsequent synthesis and mineralization of bone extracellular matrix (ECM). Vitamin D metabolites play a pivotal role in bone and mineral homeostasis, and are positive factors on bone development. Recently, it was demonstrated that a human-derived engineered osteoblast precursor cell line (OPC1), …

Depression Is More Prevalent Throughout Pregnancy And The First Six Months Postpartum In Women Low In Religious Commitment And Social Support, Andrea D. Clements, Tifani A. Fletcher, Beth A. Bailey

ETSU Faculty Works

Abstract available through the Annals of Behavioral Medicine.

Influence Of Taper On The Flexibility Of Nickel-Titanium Rotary Files, Christopher J. Kingma

Master's Theses (2009 -)

Introduction: Modern nickel-titanium instruments have various tapers and have been marketed to have superior flexibility from previous generations. Current ISO standards require force measurements at a static point along the file. Unfortunately, root canal anatomy varies and produces multiple forces along the length of the file. The purpose of this study was to determine the influence of taper on the flexibility of various nickel-titanium files.

Materials and Methods: The flexibility of stainless steel hand files and nickel-titanium rotary files of various tapers was measured. The sample size was 10 for each type, taper and size. The files were measured at …

3d Visualization Architecture For Building Applications Leveraging An Existing Validated Toolkit, David A. Polyak

Master's Theses (2009 -)

The diagnostic radiology space and healthcare in general is a slow adopter of new software technologies and patterns. Despite the widespread embrace of mobile technology in recent years, altering the manner in which societies in developed countries live and communicate, diagnostic radiology has not unanimously adopted mobile technology for remote diagnostic review. Desktop applications in the diagnostic radiology space commonly leverage a validated toolkit. Such toolkits not only simplify desktop application development but minimize the scope of application validation. For these reasons, such a toolkit is an important piece of a company’s software portfolio. This thesis investigated an approach for …

A Comparison Of Two Methods To Articulate A Maxillary Cast With Lateral Cephalometry, Laura H. Lux

Master's Theses (2009 -)

The Kois Dento-Facial Analyzer, an arbitrary articulation system, is used by clinicians to articulate and evaluate clinical cases. There is, however, limited information for understanding how the Kois Dento-Facial Analyzer should be utilized. Dr. Kois and Dr. Lee originally patented the device in 2003 yet there is essentially no evidence-based research in the literature. The purpose of this study was to evaluate the outcomes of articulating the maxillary cast using the Kois Dento-Facial Analyzer in three-dimensions as compared to the position of the cast when using Panadent’s Pana-Mount Facebow. Fifteen dried human skulls were used as test subjects. Maxillary diagnostic …