Medicine and Health Sciences Commons^™

Evaluation Of Effect Of 17% Edta And 5.25% Sodium Hypochloride Irrigating Solutions On Surface Hardness Of Brasseler Endosequence Root Repair Material, Himanshu Sharma

Master's Theses (2009 -)

Introduction: Root Perforation is an artificial communication between the root canal system and supporting tissue. Various endodontic researchers have published that sealing the perforation immediately has the best prognosis but this predisposes the repair material to come in contact with various root canal irrigants during the course of treatment. The aim of this study was to evaluate the effect of 17% EDTA and 5.25% sodium hypochlorite irrigating solutions on surface hardness of Endosequence Root Repair Material Putty (ERRM).

Method: ERRM, 5.25% Sodium Hypochlorite, 17% EDTA and Deionized water were used. 42 samples were prepared and divided into 2 groups. Each …

Flexibility Of Various Nickel-Titanium Rotary Endodontic Files, Chelsea Selin

Master's Theses (2009 -)

Introduction: Nickel-titanium rotary files were originally developed to allow for greater flexibility when instrumenting root canals. The increased flexibility of nickel-titanium instruments allowed operators to negotiate canal curvatures with greater ease. File design is continually changing. Manufacturers are trying to produce files that will work more efficiently and safely. Knowing the properties of files marketed is especially important in helping to choose an appropriate file system. Current ISO standards require force measurements at a static point along the file. The purpose of this study was to evaluate the flexibility of four different nickel-titanium files at three different points along the …

Combination Therapy Of Hyaluronic Acid Mesotherapic Injections And Sclerotherapy For Treatment Of Lower Leg Telangiectasia Without Major Venous Insufficiency: A Preliminary Clinical Study, Tommaso Iannitti, Valentina Rottigni, Federica Torricelli, Beniamino Palmieri

Physiology Faculty Publications

Background. Telangiectasia is the dilation of dermal capillaries mainly due to hypertension and vein insufficiency. Treatments of choice for this condition are sclerotherapy with foam liquid or intradermal fiber optic laser energy delivery. Aim. The aim of this study was to assess the efficacy of a new therapeutic approach consisting in the use of polymerized hyaluronic acid mesotherapicinjections following sclerotherapy in the areas of the skin affected by telangiectasia in patients without major vein insufficiency. Materials and Methods. A total of 20 women, aged between 19 and 64 years, affected by recurrent lower leg telangiectasia, were included in this study. …

Selling Life To Abortion-Seekers: A Content Analysis Of Passive And Active Persuasion In Crisis Pregnancy Center Marketing, Alexander Kocman

Masters Theses

For supporters of the pro-life cause, crisis pregnancy centers (or CPC's) have become the "darlings of the movement," according to the New York Times (Belluck, 2013), offering women with unplanned pregnancies free advice, information, classes, childcare, and needed supplies. For abortion advocates, such establishments are intended to seduce vulnerable abortion-seekers into a situation where they will be counseled out of an abortion and possibly even proselytized. Yet for as much controversy as exists in the news media, medical community, and legal realm about CPC's, there is an unsettling lack of understanding of how--and why--CPC's market themselves the way they do. …

Alcohol And Drug Prevention, Intervention, And Treatment Literature: A Bibliography For Best Practices, Laura Burney Nissen

School of Social Work Faculty Publications and Presentations

Addictions remain a persistent challenge to mental health practice. There is a need for mental health educators, students, and practitioners to be aware of, critique, contribute to, and, where relevant, utilize emerging scholarly literature to inform their intervention strategies. This comprehensive addictions bibliography draws from a wide variety of sources, perspectives, and ideologies to hasten the rate at which academics and practitioners can more meaningfully participate in this rapidly developing field of practice.

Relating The Metatranscriptome And Metagenome Of The Human Gut, Eric A. Franzosa, Xochitl C. Morgan, Nicola Segata, Levi Waldron, Joshua Reyes, Ashlee M. Earl, Georgia Giannoukos, Matthew R. Boylan, Dawn Ciulla, Dirk Gevers, Jacques Izard, Wendy S. Garrett, Andrew T. Chan, Curtis Huttenhower

Department of Food Science and Technology: Faculty Publications

Although the composition of the human microbiome is now well-studied, the microbiota’s > 8 million genes and their regulation remain largely uncharacterized. This knowledge gap is in part because of the difficulty of acquiring large numbers of samples amenable to functional studies of the microbiota. We conducted what is, to our knowledge, one of the first human microbiome studies in a well-phenotyped prospective cohort incorporating taxonomic, metagenomic, and metatranscriptomic profiling at multiple body sites using self-collected samples. Stool and saliva were provided by eight healthy subjects, with the former preserved by three different methods (freezing, ethanol, and RNAlater) to validate self-collection. …

Overexpression Of Thioredoxin Binding Protein (Tbp-2) Increases Oxidation Sensitivity And Apoptosis In Human Lens Epithelial Cells, Yibo Yu, Kuiyi Xing, Rilwan Badamas, Charles A. Kuszynski, Hongli Wuand, Marjorie F. Lou

School of Veterinary and Biomedical Sciences: Faculty Publications

Thioredoxin (Trx) is an important redox regulator with cytosolic Trx1 and mitochondrial Trx2 isozymes. Trx has multi-physiological functions in cells and its bioavailability is negatively controlled through active site binding to a specific thioredoxin binding protein (TBP-2). This paper describes the delicate balance between TBP-2 and Trx, and the effect of overexpression of TBP-2 in the human lens epithelial cells. Cells overexpressing TBP-2 (TBP-2 OE) showed a 7- fold increase of TBP-2, and a nearly 40% suppression of Trx activity but no change in Trx expression. The TBP-2 OE cells grew slower and their population decreased to 30% by day …

Validation Of A Food Frequency Questionnaire For Assessing Macronutrient And Calcium Intake In Adult Pakistani Population, Romaina Iqbal, Mohammad Ali Haroon, Farhan Javed Dar, Mujtaba Bilgirami, Gulshan Bano, Aysha Habib Khan

Community Health Sciences

Objective: To develop and validate a food frequency table (FFQ) for use in urban Pakistani population.
Study design: A validation study.
Place and duration of study: The Aga Khan University, Karachi, from June to November 2008.
Methodology: Healthy adult females, aged ³ 18 years who consented to be included in the study were inducted, while males, unhealthy females, aged below 18 years or who did not consent were excluded. The FFQ was administered once while 4, 24 hours recalls spread over a period of one year were administered as the reference method. Daily intakes for energy, protein, fat, and calcium …

Forecasting The Spread Of Raccoon Rabies Using A Purpose-Specific Group Decision-Making Process., Aaron M. Anderson, Stephanie A. Shwiff, Richard B. Chipman, Todd C. Atwood, Tyler Cozzens, Frank Fillo, Robert Hale, Brody Hatch, Joanne Maki, Olin E. Rhodes Jr., Erin E. Rees, Charles E. Rupprecht, Rowland Tinline, Kurt C. Vercauteren, Dennis Slate

United States Department of Agriculture Wildlife Services: Staff Publications

The Centers for Disease Control (CDC) and USDA Wildlife Services (WS) have been involved in an oral rabies vaccination (ORV) program for raccoons (Procyon lotor) that has slowed the westward spread of raccoon rabies. The objective of this study was to forecast the spread of the disease if an ORV zone was not maintained. A group decision-making process was designed to address the forecasting problem and was implemented using a group of 15 experts and 4 support personnel at a meeting at the USDA National Wildlife Research Center. Ten expansion regions were constructed that described the spread of …

Jeffhope News-Summer 2014

JeffHOPE News

Issue includes:

• Question of the Day
• Creating an Education Program at Mercy
• The Impact of a Simple Intervention
• Reevaluating Our Population's Needs
• JeffHOPE Goes Electronic EMR at Clinic

Shape Validated Secondary Structures Of Mason-Pfizer Monkey Virus (Mpmv) And Mouse Mammary Tumor Virus (Mmtv) Packaging Signal Rnas Reveal Pal Helix Loops Functioning As Dimerization Initiation Sites (Dis) Controlling Their Genomic Rna (Grna) Packaging, Suriya Jahan Aktar

Dissertations

The “diploid” genome of retroviruses consists of two strands of RNA that are non-covalently linked as a “dimer” at their 5’ ends. The ubiquitous presence of a dimeric genome among retroviruses suggests that dimerization plays a crucial role in gRNA packaging during viral life-cycle. For almost all retroviruses, determinants of gRNA dimerization and packaging, which are for the most part physically and genetically indistinguishable, reside at the 5’ end of the gRNAs and have been shown to assume higher order structures. Employing a combination of genetic and structural prediction approaches, we have earlier shown that Mason-Pfizer monkey virus (MPMV) and …

Architecture Of Viral Genome-Delivery Molecular Machines., Anshul Bhardwaj, Adam S. Olia, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

From the abyss of the ocean to the human gut, bacterial viruses (or bacteriophages) have colonized all ecosystems of the planet earth and evolved in sync with their bacterial hosts. Over 95% of bacteriophages have a tail that varies greatly in length and complexity. The tail complex interrupts the icosahedral capsid symmetry and provides both an entry for viral genome-packaging during replication and an exit for genome-ejection during infection. Here, we review recent progress in deciphering the structure, assembly and conformational dynamics of viral genome-delivery tail machines. We focus on the bacteriophages P22 and T7, two well-studied members of the …

Abo-Incompatible Organs A Viable And Necessary Source For Transplants, Rachel J. Macpherson

Senior Honors Theses

Despite the astounding technological advancements of modern society, failure to receive a timely organ transplant accounts for the death of approximately 18 U.S. citizens each day. As the population continues to expand, so does the shortage of donor-recipient matching organs. In order to alleviate this deficit, medical researchers have addressed the most common barrier that accounts for donor-recipient denial: blood typing. Within recent years, immunological understanding has progressed leading researchers to believe ABO-incompatible organs may be a viable source for transplantation with unparalleled potential to expand donor availability. It is the intent of this review to increase public awareness of …

Impact Of Family Presence In The Healthcare Setting, Michelle Mccabe

Senior Honors Theses

Family presence at the patient’s bed side is promoted and encouraged within the healthcare arena. Healthcare staff strive for reports of satisfaction from patients and families. Positive and negative outcomes of family presence on units within the hospital have been assessed, with suggestions for visitation practices and solutions for common concerns. Positive patient outcomes, including accelerated recovery time, increased reports of comfort, and decreased duration of hospital stay are the ultimate goals of hospital care. Research shows that patient outcomes are impacted greatly by family presence. Patient- and family-centered care represent the future model of healthcare. Knowledge of these policies …

Volume 06, Kristen Gains, Amanda Willis, Holly Backer, Monika Gutierrez, Cara O'Neal, Sara Nelson, Sasha Silberman, Jessica Beardsley, Jamie Gardner, Edward Peeples, Matthew Sakach, Tess Lione, Emily Wilkins, Kelsey Holt, Jessica Page, Jamie Clift, Charles Vancampen, Gilbert Hall, Jenny Nehrt, Kasey Dye, Amanda Tharp, Jamie Leeuwrik, Ashley Mcgee, Emily Poulin, Michael Kropf, Nick Pastore, Austin Polasky, Morgan Glasco, Laura L. Kahler, Melinda L. Edwards, Brandon C. Smith, Mariah Asbell, Cabell Edmunds, Amelia D. Perry, Alyssa Hayes, Irina Boothe, Perry Bason, James Early

Incite: The Journal of Undergraduate Scholarship

Introduction from Dean Dr. Charles Ross

Caught Between Folklore and the Cold War: The Americanization of Russian Children's Literature by Kristen Gains

Graphic Design by Amanda Willis

Graphic Design by Holly Backer

Prejudices in Swiss German Accents by Monika Gutierrez

Photography by Cara O'Neal

Photography by Sara Nelson

Edmund Tyrone's Long Journey through Night by Sasha Silberman

Photography by Jessica Beardsley

Photography by Jamie Gardner and Edward Peeples

The Republican Razor: The Guillotine as a Symbol of Equality by Jamie Clift

Graphic Design by Matthew Sakach

Genocide: The Lasting Effects of Gender Stratification in Rwanda By Tess Lione and Emily …

Health, Wellness, And The Pursuit Of Happiness: Common Ground For Adults With Cerebral Palsy And Modern Physical Therapists, Lisa Blumberg, Mary E. Gannotti, Diana J. Larocco, Yvette Blanchard

Physical Therapy Faculty Publications

Health, wellness, and happiness are important long-term goals for adulthood, especially for children with cerebral palsy (CP). Physical therapists (PTs) can assist individuals with CP realize these goals; however it requires PTs to have a greater understanding of how to apply impairment, functional, or contextual interventions to meet these goals. A critical gap in knowledge exists about perceptions of happiness and health priorities of adults with CP. The purpose of this paper is to describe the beliefs, feelings, and perceptions of happiness and health of adults with CP as compared to adults without CP, specifically PTs.

Culture & Schizophrenia: How The Manifestation Of Schizophrenia Symptoms In Hue Reflects Vietnamese Culture, Rebecca Gaines

Independent Study Project (ISP) Collection

Although schizophrenia has the same essential cognitive basis in all people, the content of the hallucinations and delusions of patients varies significantly across the world. Schizophrenia is a culture-bound illness, which means that a difference in culture can influence how it manifests. Western societies tend to view schizophrenia symptoms as a medical issue, while Eastern societies treat it as a spiritual or supernatural phenomenon. Vietnam has many specific cultural factors rooted in collectivism and Confucian and Buddhism traditions that make sufferers of schizophrenia present drastically different symptoms than patients from Western societies. The role of family, ancestor veneration, traditional healing, …

The Use Of The Term "Paco" By Street Youth In The City Of Buenos Aires And The Strategies Used By The Center For Integral Attention On Childhood And Adolescence To Help In Treating The Problematic Consumption Of Drugs, Sophie Kligler

Independent Study Project (ISP) Collection

Información contextual: En los últimos años, Argentina ha experimentado un aumento rápido en la prevalencia y uso del paco, la pasta base de la cocaína. Esta droga se ha convertido en una de las drogas más comunes en la calle debido a su precio bajo, su accesibilidad y sus cualidades adictivas. El paco es particularmente prevalente entre los chicos que viven en la situación de calle porque su acceso es muy fácil y barato y les ayuda escapar, por algunos momentos, de la dura realidad de sus vidas. La droga puede tener consecuencias graves para la salud de un consumidor, …

Fatigue And Work Schedules, Jamie Cucit

Nursing Masters

Purpose: The purpose of this research is to investigate the relationship of fatigue in nurses and to determine what factors influence the self-reported fatigue levels. Background and Significance: Shift work is comprised of working outside of the standard 7am to 7pm. Many institutions have a day, evening, and night rotation. Much of the problem with rotating shifts comes from not getting enough sleep or not getting consistent sleep. It is understood that shift work causes fatigue among all professions. Shift work has other adverse health effects. There is research to support a positive correlation between shift work and fatigue, multiple …

Emergency Bedside Ultrasound Guided Intravenous Access, Megan E. Didas

Nursing Masters

A comprehensive literature review was completed to demonstrate the impact on patient care and workflow in the ED by changing the way nurses place patient intravenous access. Patient perspectives, and cost-effectiveness in performing imaging at the bedside, nurses’ willingness to complete the education and willingness to employ the technology were all taken into consideration.

Attendance At Cervical Cancer Screening And Use Of Diagnostic And Therapeutic Procedures On The Uterine Cervix Assessed From Individual Health Insurance Data (Belgium, 2002-2006), Marc Arbyn, Valérie Fabri, Marleen Temmerman, Cindy Simoens

Obstetrics and Gynaecology, East Africa

Objective: To assess the coverage for cervical cancer screening as well as the use of cervical cytology, colposcopy and other diagnostic and therapeutic interventions on the uterine cervix in Belgium, using individual health insurance data.

Methods: The Intermutualistic Agency compiled a database containing 14 million records from reimbursement claims for Pap smears, colposcopies, cervical biopsies and surgery, performed between 2002 and 2006. Cervical cancer screening coverage was defined as the proportion of women aged 25-64 that had a Pap smear within the last 3 years.

Results: Cervical cancer screening coverage was 61% at national level, for the target population of …

Hematopoietic Cell Transplant Co-Morbidity Index (Hct-Ci): Ability To Predict Outcomes In Haploidentical (Hi) Hematopoietic Stem Cell Transplantation (Hsct), Neil D. Palmisiano, Md, Sameh Gaballa, Md, Onder Alpdogan, Matthew Carabasi, Md, Joanne Filicko-O'Hara, Md, Margaret Kasner, Md, Ubaldo E. Martinez-Outshoorn, Md, John L. Wagner, Md, Mark Weiss, Md, Neal Flomenberg, Md, Dolores Grosso, Dnp

Department of Medical Oncology Faculty Papers

Introduction

We developed a 2 step approach to HI HSCT in which a fixed dose of allogeneic T cells are infused after reduced intensity (RIC) or myeloablative conditioning (HSCT step 1). After 2-3 days, cyclophosphamide (CY) 60 mg/kg/d x 2 is given to establish bidirectional tolerance. One day after the CY, a CD 34 selected stem cell product is infused (HSCT step 2).

This approach has been associated with a low incidence of non-relapse mortality (NRM) resulting in a significant improvement in overall survival (OS) in patients (pts) undergoing HI HSCT at our institution. This abstract examined the predictability of …

Outcomes Of Older Patients Undergoing 2-Step Approach To Haploidentical And Matched Related Peripheral Blood Hematopoietic Stem Cell Transplantation (Hsct): A Single Institutional Experience, Sameh Gaballa, Md, Seyfettin Onder Alpdogan, Md, Matthew Carabasi, Md, Joanne Filicko-O'Hara, Md, Margaret Kasner, Md, Benjamin E Leiby, Phd, Ubaldo E. Martinez-Outshoorn, Md, Edward C Pequignot, Md, Sarah Rosado, Shannon Rudolph, Ms, John L Wagner, Md, Mark Weiss, Md, Neal Flomenberg, Md, Dolores Grosso, Dnp

Department of Medical Oncology Faculty Papers

Introduction:

HSCT is a curative option for many patients (pts) with hematological malignancies.

Significant advances in supportive care and conditioning regimens over the past decade have allowed the extension of this therapy to older individuals.

Information regarding the outcomes of this older subset of pts undergoing HSCT is limited, especially those undergoing haploidential (HI) HSCT.

Objectives:

To describe the outcomes of patients 60 years of age or older undergoing haploidential and matched related (MR) HSCT using the 2-step approach.

Current Trends In Undergraduate Medical And Dental Research: A Picture From Pakistan, Waqar Jeelani, Sanaa Masood Aslam, Asrar Elahi

Department of Surgery Docs

Abstract

BACKGROUND:

Initiatives taken over the last few years have led us to the day when most of the medical and dental institutions in the developed countries have established a strong research culture at undergraduate level but the situation is quite the contrary in Pakistan. This study was carried out to investigate the current trends in undergraduate medical and dental research and to highlight the research barriers.

METHODS:

A cross-sectional study was conducted at six medical and dental colleges of Rawalpindi and Islamabad. A structured questionnaire was used to collect data from 300 students. Results were recorded as percentages. Findings …

Sex Differences In Human Fatigability: Mechanisms And Insight To Physiological Responses, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Sex-related differences in physiology and anatomy are responsible for profound differences in neuromuscular performance and fatigability between men and women. Women are usually less fatigable than men for similar intensity isometric fatiguing contractions. This sex difference in fatigability, however, is task specific because different neuromuscular sites will be stressed when the requirements of the task are altered, and the stress on these sites can differ for men and women. Task variables that can alter the sex difference in fatigability include the type, intensity and speed of contraction, the muscle group assessed and the environmental conditions. Physiological mechanisms that are responsible …

The Stroke-Related Effects Of Hip Flexion Fatigue On Over Ground Walking, Megan M. Rybar, Eric R. Walker, Henry Kuhnen, Daniel R. Ouellette, Reivian Berrios, Sandra K. Hunter, Allison S. Hyngstrom

Exercise Science Faculty Research and Publications

Individuals post stroke often rely more on hip flexors for limb advancement during walking due to distal weakness but the effects of muscle fatigue in this group is not known. The purpose of this study was to quantify how stroke affects the influence of hip flexor fatigue on over ground walking kinematics and performance and muscle activation. Ten individuals with chronic stroke and 10 without stroke (controls) participated in the study. Maximal walking speed, walking distance, muscle electromyograms (EMG), and lower extremity joint kinematics were compared before and after dynamic, submaximal fatiguing contractions of the hip flexors (30% maximal load) …

Concordance Between The Chang And The International Society Of Pediatric Oncology (Siop) Ototoxicity Grading Scales In Patients Treated With Cisplatin For Medulloblastoma, Johnnie Bass, Jie Huang, Arzu Onar-Thomas, Kay Chang, Shaum Bhagat, Murali Chintagumpala, Ute Bartels, Sridharan Gururangan, Tim Hassall, John Heath, Geoffrey Mccowage, Richard Cohn, Michael Fisher, Giles Robinson, Alberto Broniscer, Amar Gajjar, James Gurney

Faculty Publications

BackgroundReporting ototoxicity is frequently complicated by use of various ototoxicity criteria. The International Society of Pediatric Oncology (SIOP) ototoxicity grading scale was recently proposed for standardized use in reporting hearing loss outcomes across institutions. The aim of this study was to evaluate the concordance between the Chang and SIOP ototoxicity grading scales. Differences between the two scales were identified and the implications these differences may have in the clinical setting were discussed.ProceduresAudiological evaluations were reviewed for 379 patients with newly diagnosed medulloblastoma (ages 3–21 years). Each patient was enrolled on one of two St. Jude clinical protocols that included craniospinal …

Pharmacy Newsletter : April 2014, Pharmacy Department

Department of Pharmacy Archives

Content:

• Investiture of Clean Room Pharmacy, Epitomize USP Chapter
• 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults
• Anticoagulation Clinic - Enhancing Patient Care
• Clinical Quality and Patient Safety Indicators

Barriers To Successful Cervical Cancer Screening In Rural Kwazulu-Natal, Cato Manor, And Cape Town, Amanda Comai

Independent Study Project (ISP) Collection

In 2000, the South African Department of Health produced a nationwide policy intended to combat the growing crisis of cervical cancer. Nearly fifteen years later, however, the disease remains a significant cause of death among certain female populations, especially those who are rural, poor, and HIV-positive. It is undeniable that challenges of access, awareness, resource demand, and stigmatization stand in the way of complete policy enactment.

In this study, I explore in detail the barriers that prevent successful implementation of the policy. My research combines interviews with a variety of individuals and participant observation at the Cancer Association of South …

Schoolgirls’ Experience Of Menstruation Ss Expressed Through Body Mapping In A Quasi-Rural South African Village, Angela Zablotny

Independent Study Project (ISP) Collection

The aim of this independent study project was to gain an understanding of menstruation as experienced by school aged girls in a quasi-rural village in the KwaZulu-Natal Province of South Africa. Though a fact of life for roughly half of the world’s population, menstruation continues to be a taboo topic and has implications related to both traditional Zulu beliefs as well as expectations for females in a largely patriarchal society.

The qualitative research method of body mapping was used with teenage girls in an effort to facilitate both reflection and discussion on their lived experiences with their periods. Supplemental interviews …