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2014

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Articles 1141 - 1170 of 9579

Full-Text Articles in Medicine and Health Sciences

Pulmonary Artery Sarcoma: A Rare Cause Of Lung Masses And Tumor Emboli, Wasin Jirisant, Napplika Kongpolprom Nov 2014

Pulmonary Artery Sarcoma: A Rare Cause Of Lung Masses And Tumor Emboli, Wasin Jirisant, Napplika Kongpolprom

Chulalongkorn Medical Journal

We reported here a case of pulmonary artery sarcoma. The patient presented with progressive dyspnea on exertion for 2 months. Chest radiography showed a large lobulated mass in the right lower lung field. Chest CT scan showed 2 pulmonary masses in the rightmiddle lobe and the right-lower lobe, with extensive filling defects in the right and left pulmonary arteries. A core needle biopsy of the larger mass showed an undetermined type of sarcoma. Pulmonary arteries were considered the primary origin of the sarcoma. Pulmonary endarterectomy with tumor debulking was performed to relieve the patient's symptoms in a combination with adjuvant …


ดรรชนีผู้แต่งจุฬาลงกรณ์เวชสาร 2014, N/A Nov 2014

ดรรชนีผู้แต่งจุฬาลงกรณ์เวชสาร 2014, N/A

Chulalongkorn Medical Journal

No abstract provided.


ดรรชนีบทความจุฬาลงกรณ์เวชสาร 2014, N/A Nov 2014

ดรรชนีบทความจุฬาลงกรณ์เวชสาร 2014, N/A

Chulalongkorn Medical Journal

No abstract provided.


Pharmacokinetic And Pharmacodynamic Interactions Between Antiepileptics And Antidepressants, Domenico Italiano, Edoardo Spina, Jose De Leon Nov 2014

Pharmacokinetic And Pharmacodynamic Interactions Between Antiepileptics And Antidepressants, Domenico Italiano, Edoardo Spina, Jose De Leon

Psychiatry Faculty Publications

INTRODUCTION: Antiepileptic-antidepressant combinations are frequently used by clinicians; their pharmacokinetic (PK) and pharmacodynamic (PD) drug interactions (DIs) have not been well studied but are frequently likely to be clinically relevant.

AREAS COVERED: This article provides a comprehensive review of PK DIs between antiepileptics and antidepressants. In the absence of PD DI studies, PD information on pharmacological mechanisms and studies on efficacy and safety of individual drugs are reviewed.

EXPERT OPINION: The clinical relevance of the inductive properties of carbamazepine, phenytoin, phenobarbital and primidone and the inhibitory properties of valproic acid and some antidepressants are well understood; correction factors are provided …


Pharmacy Law Brief: Alternative Dispute Resolution, Joseph L. Fink Iii Nov 2014

Pharmacy Law Brief: Alternative Dispute Resolution, Joseph L. Fink Iii

Pharmacy Practice and Science Faculty Publications

No abstract provided.


Non-Pharmacological Interventions For Somatoform Disorders And Medically Unexplained Physical Symptoms (Mups) In Adults, Nikki Van Dessel, Madelon Den Boeft, Johannes C. Van Der Wouden, Maria Kleinstäuber, Stephanie S. Leone, Berend Terluin, Mattijs E. Numans, Henriëtte E. Van Der Horst, Harm Van Marwijk Nov 2014

Non-Pharmacological Interventions For Somatoform Disorders And Medically Unexplained Physical Symptoms (Mups) In Adults, Nikki Van Dessel, Madelon Den Boeft, Johannes C. Van Der Wouden, Maria Kleinstäuber, Stephanie S. Leone, Berend Terluin, Mattijs E. Numans, Henriëtte E. Van Der Horst, Harm Van Marwijk

Psychology Faculty Publications

Background: Medically unexplained physical symptoms (MUPS) are physical symptoms for which no adequate medical explanation can be found after proper examination. The presence of MUPS is the key feature of conditions known as 'somatoform disorders'. Various psychological and physical therapies have been developed to treat somatoform disorders and MUPS. Although there are several reviews on non‐pharmacological interventions for somatoform disorders and MUPS, a complete overview of the whole spectrum is missing. Objectives: To assess the effects of non‐pharmacological interventions for somatoform disorders (specifically somatisation disorder, undifferentiated somatoform disorder, somatoform disorders unspecified, somatoform autonomic dysfunction, pain disorder, and alternative somatoform diagnoses …


Mode Of Coronary Revascularization And Short Term Clinical Outcomes In Patients With Chronic Kidney Disease, Ashique Ali Khoso, K. Kazmi, Saqiba Tahir, Hasanat Sharif, Safia Awan Nov 2014

Mode Of Coronary Revascularization And Short Term Clinical Outcomes In Patients With Chronic Kidney Disease, Ashique Ali Khoso, K. Kazmi, Saqiba Tahir, Hasanat Sharif, Safia Awan

Department of Surgery Docs

Abstract

BACKGROUND AND OBJECTIVE:

Percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery are two alternative methods for coronary revascularization, but it remains controversial as which one is associated with lower risks of worse clinical outcomes for chronic kidney disease (CKD) patients. We determined the mode of coronary revascularization (PCI vs. CABG) which is associated with lower risk of mortality and morbidity in CKD patients.

METHODS:

In this cross sectional study, 159 patients with CKD were enrolled from single center of coronary revascularization at Aga Khan University Hospital Karachi between January 2012 and August 2013. All patients with …


Er-Associated Degradation And Cadmium Dependent Rescue Of Pca1, Nathan Smith Nov 2014

Er-Associated Degradation And Cadmium Dependent Rescue Of Pca1, Nathan Smith

Department of Biochemistry: Dissertations, Theses, and Student Research

Protein synthesis and proper folding is an essential process for all organisms. In eukaryotes proteins of the secretory pathway are synthesized and inserted into the lumen or membrane of the endoplasmic reticulum. Eukaryotic cells maintain a mechanism for removal of proteins unable to fold properly. This process is known as ER-associated degradation (ERAD). A poorly functioning ERAD can lead to a build-up of misfolded proteins which has been implicated in several degenerative diseases such as Alzheimer’s, Amyotrophic lateral sclerosis, and Parkinson’s. Thus, the study of how proteins are recognized, extracted from the ER, and degraded is essential for determining methods …


Cardiac Herniation Following Intrapericardial Pneumonectomy In An Advanced Lung Cancer Patient With Intractable Lung Abscess, Napplika Kongpolprom Nov 2014

Cardiac Herniation Following Intrapericardial Pneumonectomy In An Advanced Lung Cancer Patient With Intractable Lung Abscess, Napplika Kongpolprom

Chulalongkorn Medical Journal

This is a case report of cardiac herniation following right lower lobe lobectomy in a non-small-cell lung cancer patient who previously underwent right upper lobe and right middle lobe lobectomies. The patient presented with obstructive shock with refractory hypoxemia at the 8th hour after the lobectomy with radical removal of the tumor and complicated lung abscess via intrapericardial approach. Chest radiography showed cardiac displacement to the right hemithorax. Cardiac herniation was diagnosed. Consequently, emergency rethoracotomy was performed to explore the cause of this complication and reduce the heart to the normal position. A large pericardial defect was found and subsequently …


Polymorphisms Of Abcc2, Abcc4, Abcc10 And Slc22a6 In Thai Hiv - Infected Patients, Siwaporn Mitruk, Anchalee Avihingsanon, Baralee Punyawudho Nov 2014

Polymorphisms Of Abcc2, Abcc4, Abcc10 And Slc22a6 In Thai Hiv - Infected Patients, Siwaporn Mitruk, Anchalee Avihingsanon, Baralee Punyawudho

Chulalongkorn Medical Journal

Background : Drug transporters including ABCC2, ABCC4, ABCC10 and SLC22A6 play important roles in regulating physiologic solute and fluid balance in the cell. They also involve in drug delivery into the organs. Therefore, genetic variations of these transporters may influence the pharmacokinetics of drugs and major pharmacological active metabolites. The information of transporter gene polymorphisms can be useful as guidance for the study of the association between genetic variations and pharmacokinetics of drugs. Objective : To determine the allele frequency of ABCC2, ABCC4, ABCC10 and SLC22A6 in Thai HIV - infected patients. Research design : Cross-sectional study. Setting : The …


Uremic Tumoral Calcinosis, Report Of A Rare Case At King Chulalongkorn Memorial Hospital, Chanat Kumtornrut, Numphung Numkarunarunrote, Pawinee Rerknimitr Nov 2014

Uremic Tumoral Calcinosis, Report Of A Rare Case At King Chulalongkorn Memorial Hospital, Chanat Kumtornrut, Numphung Numkarunarunrote, Pawinee Rerknimitr

Chulalongkorn Medical Journal

Uremic tumoral calcinosis is primarily found in patients with chronic kidney disease (CKD) or end-stage renal disease (ESRD). Its clinical and radiologic presentations are highly characteristic. We herein report a case of a 33-year-old Thai male with ESRD and tertiary hyperparathyroidism. He presented with multiple cystic nodules on the right shoulder, hands, and feet without causing joint destruction for 2 years. The plain radiographs of the right shoulder and hands showed the pathognomonic "sedimentation sign". The patient underwent subtotal parathyroidectomy, as a result, the masses significantly decreased in size 3 months later. This case should increase the awareness among dermatologists …


ความรู้สึกมีคุณค่าในตนเองและปัจจัยที่เกี่ยวข้องของวัยรุ่นตั้งครรภ์แรก, พูนสุข ช่วยทอง, บังอร นามกร, เปรมวดี คฤหเดช, สุรางค์ เชื้อวณิชชากร Nov 2014

ความรู้สึกมีคุณค่าในตนเองและปัจจัยที่เกี่ยวข้องของวัยรุ่นตั้งครรภ์แรก, พูนสุข ช่วยทอง, บังอร นามกร, เปรมวดี คฤหเดช, สุรางค์ เชื้อวณิชชากร

Chulalongkorn Medical Journal

เหตุผลของการทำวิจัย : วัยรุ่นตั้งครรภ์ควรสามารถสร้างความรู้สึกที่ดีต่อตนเองและทารกในครรภ์ ทั้งนี้เพราะวัยรุ่นตั้งครรภ์ที่มีความรู้สึกมีคุณค่าในตนเองสูงจะมีจิตใจที่เข้มแข็งมั่นคงพึงพอใจตนเองรับรู้ และยอมรับเหตุการณ์ที่เกิดขึ้นตามความเป็นจริงพร้อมที่จะเผชิญปัญหาทั้งด้านร่างกายจิตใจอารมณ์ และสังคมสามารถปรับตัวได้อย่างเหมาะสมด้วยเหตุนี้ผู้วิจัยจึงมีความสนใจที่จะศึกษาเรื่องดังกล่าวเพื่อจะได้นำผลการวิจัยใช้เป็นแนวทางในการส่งเสริมความรู้สึกมีคุณค่าในตนเองของวัยรุ่นตั้งครรภ์แรกวัตถุประสงค์ : เพื่อศึกษาความรู้สึกมีคุณค่าในตนเองของวัยรุ่นตั้งครรภ์แรก และเพื่อศึกษาปัจจัยที่สัมพันธ์กับความรู้สึกมีคุณค่าในตนเองรูปแบบการวิจัย : เป็นการวิจัยแบบสำรวจภาคตัดขวางสถานที่ทำการศึกษา : จังหวัดอุบลราชธานีตัวอย่างและวิธีการศึกษา : กลุ่มตัวอย่างจำนวน 268 รายใช้วิธีการสุ่มตัวอย่างแบบหลายขั้นตอน(Multi-Stage Random Sampling) จากวัยรุ่นตั้งครรภ์แรกที่มาฝากครรภ์ณ โรงพยาบาลส่งเสริมสุขภาพตำบล จังหวัดอุบลราชธานี เก็บรวบรวมข้อมูล โดยแบบสอบถามที่ผู้วิจัยสร้างขึ้น และแบบประเมินความรู้สึกมีคุณค่าในตนเองของโรเซนเบอร์ก (Rosenberg, 1965) มีค่าความเชื่อมั่นดังนี้ การดูแลตนเอง 0.73 ความรู้สึกมีคุณค่าในตนเอง 0.99 และการสนับสนุนทางสังคม 0.97 การวิเคราะห์ข้อมูลโดยใช้โปรแกรมสำเร็จรูป สถิติที่ใช้คือค่าร้อยละ (Percentage) ค่าเฉลี่ย (Mean)ส่วนเบี่ยงเบนมาตรฐาน (Standard Deviations) การทดสอบไคสแควร์(Chi-square test) สัมประสิทธิ์สหสัมพันธ์แบบเพียร์สัน (Pearson’sProduct Moment Correlation Coefficient)ผลการศึกษา : กลุ่มตัวอย่างมีอายุ 17 ปีมากที่สุด คิดเป็นร้อยละ 26.9 อายุต่ำสุด 13 ปีร้อยละ10.4 อาชีพรับจ้างมากที่สุดร้อยละ 41.4 ฝากครรภ์ครั้งแรกอายุครรภ์ <12 สัปดาห์มากที่สุดร้อยละ 49.3 มีความรู้สึกมีคุณค่าในตนเองระดับปานกลางมากที่สุดร้อยละ 70.9 รองลงมาต่ำและสูงร้อยละ 16.0 และ 13.1 ตามลำดับ อายุครรภ์ที่ฝากครรภ์ครั้งแรกมีความสัมพันธ์กับความรู้สึกมีคุณค่าในตนเองอย่างมีนัยสำคัญทางสถิติ(p <0.05) อายุมีความสัมพันธ์ทางลบกับความรู้สึกมีคุณค่าในตนเอง(r = -0.137) และการดูแลตนเองโดยรวม (r = 0.128) ด้านรักษาสุขภาพจิต (r = 0.167) การสนับสนุนทางสังคมด้านวัตถุสิ่งของ(r = 0.194) มีความสัมพันธ์ทางบวกกับความรู้สึกมีคุณค่าในตนเองอย่างมีนัยสำคัญทางสถิติ (p <0.05) ส่วนระดับการศึกษา สถานภาพสมรส อาชีพ รายได้ครอบครัว และการสนับสนุนทางสังคมโดยรวมไม่มีความสัมพันธ์ทางสถิติกับความรู้สึกมีคุณค่าในตนเอง (p >0.05)สรุป : หน่วยบริการการฝากครรภ์ควรส่งเสริมสิ่งแวดล้อมในการฝากครรภ์และพัฒนาวิธีจัดการรักษาความรู้สึกนับถือตนเอง เพื่อให้วัยรุ่นตั้งครรภ์แรกมีความรู้สึกมีคุณค่าในตนเองระดับสูงเพิ่มชึ้น.


Thrombolytic Therapy In Patients With Submassive Pulmonary Embolism: A Systematic Review, Donya Kittinaradorn, Nichthida Tangnuntachai, Nicha Wongjarupong, Duangthip Longchit, Songphoom Atipookanok, Thosaporn Boondarikpornpant, Titaporn Nopmaneepaisarn, Thipyada Papassornsiri, Thanion Soopanit, Tanaboon Tantirungsi, Thanapat Supakmontri, Tanavadee Rattanaphong, Tanawin Suksirivoraboot, Monvasi Pachinburavan, Pisut Katavetin Nov 2014

Thrombolytic Therapy In Patients With Submassive Pulmonary Embolism: A Systematic Review, Donya Kittinaradorn, Nichthida Tangnuntachai, Nicha Wongjarupong, Duangthip Longchit, Songphoom Atipookanok, Thosaporn Boondarikpornpant, Titaporn Nopmaneepaisarn, Thipyada Papassornsiri, Thanion Soopanit, Tanaboon Tantirungsi, Thanapat Supakmontri, Tanavadee Rattanaphong, Tanawin Suksirivoraboot, Monvasi Pachinburavan, Pisut Katavetin

Chulalongkorn Medical Journal

Background : The use of thrombolytic therapy in patients with submassive pulmonary embolism (PE) is still controversial. Objective : To evaluate the role of thrombolytic therapy in patients with submassive PE. Design : Systematic review. Setting : Faculty of Medicine, Chulalongkorn University. Methods : We performed a literature search using Pubmed, Scopus, scientific abstracts from meetings, and bibliographies of retrieved articles. Only randomized control trials were included in this systematic review. Result : Three randomized control trials were identified. All these studies excluded patients with high risk of bleeding. The evidence from randomized control trials identified in this systematic review …


Prevalence Of Vascular Thrombosis And Obstetric Complications In Systemic Lupus Erythematosus Patients With Antiphospholipid Antibody, Pailin Mahaparn, Ponlapat Rojnuckarin Nov 2014

Prevalence Of Vascular Thrombosis And Obstetric Complications In Systemic Lupus Erythematosus Patients With Antiphospholipid Antibody, Pailin Mahaparn, Ponlapat Rojnuckarin

Chulalongkorn Medical Journal

Background : The European League Against Rheumatism (EULAR) recommends primary prophylaxis with aspirin and hydroxychloroquine in systemic lupus erythematosus (SLE) patients with antiphospholipid antibodies without prior thrombosis. However, Asian populations may have lower incidence of thrombosis and the role of primary prophylaxis is unclear. Therefore, we examined the prevalence of thrombosis in Thai antiphospholipid-positive SLE patients. Methods : The medical records of SLE patients (N = 715) admitted to King Chulalongkorn Memorial Hospital from 2002 - 2012 were studied. Two hundred and eighteen patients were investigated for antiphospholipid antibodies, and 82 of them (37.6%) were positive. These 82 patients were …


คำขอบคุณ, N/A Nov 2014

คำขอบคุณ, N/A

Chulalongkorn Medical Journal

No abstract provided.


เครื่องมือประเมินความสุขของผู้สูงอายุในบ้านพักคนชรา, พลอยชมพู มณีสุขเกษม, ชาวิท ตันวีระชัยสกุล Nov 2014

เครื่องมือประเมินความสุขของผู้สูงอายุในบ้านพักคนชรา, พลอยชมพู มณีสุขเกษม, ชาวิท ตันวีระชัยสกุล

Chulalongkorn Medical Journal

เหตุผลของการทำวิจัย : ที่ผ่านมามีเครื่องมือประเมินสุขภาพของผู้สูงอายุในด้านต่าง ๆ แต่ยัง ไม่พบเครื่องมือที่ใชี้ประเมินความสุขของผู้สูงอายุ แม้ว่าความสุขจะ เป็นสิ่งที่ขึ้นอยู่กับชี้วขณะของชีวิต และขึ้นอยู่กับหลายปัจจัยที่ แตกต่างกันในแต่ละช่วงอายุแต่เครื่องมือประเมินความสุขผู้สูงอายุ ฉบับนี้พัฒนาเพื่อวัดในด้านต่าง ๆ เพื่อประเมินความสุขของผู้สูงอายุ และเป็นแนวทางในการส่งเสริมให้ผู้สูงอายุมีความสุขวัตถุประสงค์ : สร้างเครื่องมือประเมินความสุขของผู้สูงอายุ และทดลองประเมิน ความสุขของผู้สูงอายุรูปแบบการวิจัย : การสร้างและประเมินเครื่องวัดสถานที่ทำการศึกษา : บ้านพักคนชราแห่งหนึ่งในประเทศไทยตัวอย่างและวิธีการศึกษา : เก็บรวบรวมข้อมูลจากผู้สูงอายุในบ้านพักคนชราแห่งหนึ่งในประเทศ ไทย 78 คน โดยใชี้แบบสอบถามเครื่องมือประเมินความสุขของ ผู้สูงอายุ ซึ่งประกอบด้วยข้อมูลส่วนบุคคลทั่วไป และข้อคำถามของ แบบสอบถามเครื่องมือประเมินความสุขของผู้สูงอายุ และเครื่องชี้วัด คุณภาพชีวิตขององค์การอนามัยโลกชุดย่อผลการศึกษา : ค่าความเที่ยงของเครื่องมือประเมินความสุขของผู้สูงอายุพังฉบับอยู่ที่ 0.887 การหาความตรงด้านเนื้อหาเมื่อเที่ยบกับแบบสอบถามที่เป็น มาตรฐานคือเครื่องชี้วัดคุณภาพชีวิตขององค์การอนามัยโลกชุดย่อได้ ค่าสัมประสิทธิ์สหสัมพันธ์(r) เท่ากับ 0.738 (P - value <0.01) การหา ความตรงเชิงโครงสร้างขององค์ประกอบ 7 องค์ประกอบคือ 0.615 - 0.840สรุป : ค่าความเที่ยงของเครื่องมือประเมินความสุขของผู้สูงอายุทั้งฉบับ อยู่เกณฑ์สูง การหาความตรงด้านเนื้อหาพบว่ามีความสัมพันธ์ที่ดี และมีนัยสำคัญทางสถิติส่วนการหาความตรงเชิงโครงสร้าง พบว่าจาก เดิมแบ่งโดยใช้เรื่องภายนอกและภายในของผู้สูงอายุเป็นเกณฑ์ หลัง จากวิเคราะห์องค์ประกอบได้ 7 องค์ ประกอบเครื่องมือประเมิน ความสุขของผู้สูงอายุ เหมาะที่จะใช้ในผู้สูงอายุบ้านพักคนชรา.ความสุข, ผู้สูงอายุ, เครื่องมือประเมิน, บ้านพักคนชรา


Classification For Animal Vocal Fold Surgery: Resection Margins Impact Histological Outcomes Of Vocal Fold Injury, Mitsuyoshi Imaizumi, Susan L. Thibeault, Ciara Leydon Nov 2014

Classification For Animal Vocal Fold Surgery: Resection Margins Impact Histological Outcomes Of Vocal Fold Injury, Mitsuyoshi Imaizumi, Susan L. Thibeault, Ciara Leydon

Communication Disorders Faculty Publications

Objective—Extent of vocal fold injury impacts the nature and timing of wound healing, and voice outcomes. However, depth and extent of the lesion created to study wound healing in animal models vary across studies, likely contributing to different outcomes. Our goal was to create a surgery classification system to enable comparison of postoperative outcomes across animal vocal fold wound healing studies.

Study design—Prospective, controlled animal study.

Methods—Rats underwent one of three types of unilateral vocal fold surgeries classified by depth and length of resection. The surgeries were a subepithelial injury, resection of epithelium and superficial layer of the lamina propria …


Choledochal Cyst--A Different Disease In Newborns And Infants, Zafar Nazir, Munira Abdul Aziz Nov 2014

Choledochal Cyst--A Different Disease In Newborns And Infants, Zafar Nazir, Munira Abdul Aziz

Department of Surgery Docs

Abstract

We report experience of managing Choledochal Cyst (CC) in different paediatric ages. Eleven neonates and infants (aged 0-8 months) and 24 paediatric cases (aged 2.5 - 18 years) were managed over 24 years (1988 to 2012). Neonates and infants presented with jaundice, acholic stools and abdominal mass whereas most of the paediatric cases presented with intermittent non-specific abdominal pain. Morphology of CC was mostly cystic in neonates whereas it was fusiform in majority (62%) of paediatric cases. Biliary amylase was high and correlated with the presence of abnormal pancreaticobiliary junction (PBJ) in 20 /24 paediatric patients. Obstruction at the …


Effects Of Sodium/Glucose Co-Transporter Inhibitors On Contractility And Ca2+ Signalling In Ventricular Myocytes From Streptozotocin-Induced Diabetic Rats., Norin Nabil Fathalla Hamouda Nov 2014

Effects Of Sodium/Glucose Co-Transporter Inhibitors On Contractility And Ca2+ Signalling In Ventricular Myocytes From Streptozotocin-Induced Diabetic Rats., Norin Nabil Fathalla Hamouda

Theses

The prevalence of diabetes mellitus is increasing at an alarming rate worldwide. Cardiovascular (CV) disease is the major cause of morbidity and mortality in diabetic patients. The search for new treatments has led to developing alternative insulin-independent treatment strategies such as sodium/glucose co-transporter (SGLT) inhibitors. Inhibition of intestinal SGLT1 impairs dietary glucose absorption, while inhibition of renal SGLT2 promotes glucose excretion leading to calorie loss and improved glycemic control. In this study, we hypothesized that inhibiting cardiac SGLTs may alter Ca2+ mobilization in myocytes. The effects of Phlorizin (PHLOR) (non-selective SGLT1 and 2 inhibitor), Quercetin-3-O-glucoside (QUER-3-G) (selective SGLT1 inhibitor), …


Sofas And Infant Mortality., Lauren R. Rechtman, Jeffrey D. Colvin, Peter S. Blair, Rachel Y. Moon Nov 2014

Sofas And Infant Mortality., Lauren R. Rechtman, Jeffrey D. Colvin, Peter S. Blair, Rachel Y. Moon

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: Sleeping on sofas increases the risk of sudden infant death syndrome and other sleep-related deaths. We sought to describe factors associated with infant deaths on sofas.

METHODS: We analyzed data for infant deaths on sofas from 24 states in 2004 to 2012 in the National Center for the Review and Prevention of Child Deaths Case Reporting System database. Demographic and environmental data for deaths on sofas were compared with data for sleep-related infant deaths in other locations, using bivariate and multivariable, multinomial logistic regression analyses.

RESULTS: A total of 1024 deaths on sofas made up 12.9% of sleep-related infant …


Technical Performance Score Is Associated With Outcomes After The Norwood Procedure., Meena Nathan, Lynn A. Sleeper, Richard G. Ohye, Peter C. Frommelt, Christopher A. Caldarone, James S. Tweddell, Minmin Lu, Gail D. Pearson, J William Gaynor, Christian Pizarro, Ismee A. Williams, Steven D. Colan, Carolyn Dunbar-Masterson, Peter J. Gruber, Kevin Hill, Jennifer Hirsch-Romano, Jeffrey P. Jacobs, Jonathan R. Kaltman, S Ram Kumar, David Morales, Scott M. Bradley, Kirk Kanter, Jane W. Newburger, Pediatric Heart Network Investigators, Girish S. Shirali Nov 2014

Technical Performance Score Is Associated With Outcomes After The Norwood Procedure., Meena Nathan, Lynn A. Sleeper, Richard G. Ohye, Peter C. Frommelt, Christopher A. Caldarone, James S. Tweddell, Minmin Lu, Gail D. Pearson, J William Gaynor, Christian Pizarro, Ismee A. Williams, Steven D. Colan, Carolyn Dunbar-Masterson, Peter J. Gruber, Kevin Hill, Jennifer Hirsch-Romano, Jeffrey P. Jacobs, Jonathan R. Kaltman, S Ram Kumar, David Morales, Scott M. Bradley, Kirk Kanter, Jane W. Newburger, Pediatric Heart Network Investigators, Girish S. Shirali

Manuscripts, Articles, Book Chapters and Other Papers

Objectives: The technical performance score (TPS) has been reported in a single center study to predict the outcomes after congenital cardiac surgery. We sought to determine the association of the TPS with outcomes in patients undergoing the Norwood procedure in the Single Ventricle Reconstruction trial.

Methods: We calculated the TPS (class 1, optimal; class 2, adequate; class 3, inadequate) according to the predischarge echocardiograms analyzed in a core laboratory and unplanned reinterventions that occurred before discharge from the Norwood hospitalization. Multivariable regression examined the association of the TPS with interval to first extubation, Norwood length of stay, death or transplantation, …


Phosphate And Acidosis Act Synergistically To Depress Peak Power In Rat Muscle Fibers, Cassandra R. Nelson, Edward P. Debold, Robert H. Fitts Nov 2014

Phosphate And Acidosis Act Synergistically To Depress Peak Power In Rat Muscle Fibers, Cassandra R. Nelson, Edward P. Debold, Robert H. Fitts

Biomedical Sciences Faculty Research and Publications

Skeletal muscle fatigue is characterized by the buildup of H+ and inorganic phosphate (Pi), metabolites that are thought to cause fatigue by inhibiting muscle force, velocity, and power. While the individual effects of elevated H+ or Pi have been well characterized, the effects of simultaneously elevating the ions, as occurs during fatigue in vivo, are still poorly understood. To address this, we exposed slow and fast rat skinned muscle fibers to fatiguing levels of H+ (pH 6.2) and Pi (30 mM) and determined the effects on contractile properties. At 30°C, elevated Pi …


The Effects Of Enhanced Discharge Education On Knowledge Retention In First Time Stroke/Tia Patients, Edward M. Stiner Jr. Nov 2014

The Effects Of Enhanced Discharge Education On Knowledge Retention In First Time Stroke/Tia Patients, Edward M. Stiner Jr.

Theses and Dissertations - UTB/UTPA

The purpose of this study is to determine whether patients aged 40-65 years, who are admitted for stroke or a transient ischemic attack (TIA) for the first time and who receive enhanced stroke discharge education have higher levels of education retention than patients aged 40-65 years who are admitted for stroke/TIA for the first time who receive standard stroke discharge education without the enhancement. Forty male and female participants were randomly placed into either a standard discharge education N=20 or enhanced discharge education group: N=20. The standard discharge education group received the usual stroke/TIA discharge education administered by the staff …


Antiretroviral Therapy Enrollment Characteristics And Outcomes Among Hiv-Infected Adolescents And Young Adults Compared With Older Adults — Seven African Countries, 2004–2013, Andrew F. Auld, Simon G. Agolory, Ray W. Shiraishi, Fred Wabwire-Mangen, Gideon Kwesigabo, Modest Mulenga, Sebastian Hachizovu, Emeka Asadu, Moise Zanga Tuho, Virginie Ettiegne-Traore, Francisco Mbofana, Velephi Okello, Charles Azih, Julie A. Denison, Sharon Tsui, Olivier Koole, Harrison Kamiru, Harriet Nuwagaba-Biribonwoha, Charity Alfredo, Kebba Jobarteh, Solomon Odafe, Dennis Onotu, Kunomboa A. Ekra, Joseph S. Kouakou, Peter Ehrenkranz, George Bicego, Kwasi Torpey, Ya Diul Mukadi, Eric Van Praag, Joris Menten, Timothy Mastro, Carol Dukes Hamilton, Mahesh Swaminathan, E. Kainne Dokubo, Andrew L. Baughman, Thomas Spira, Robert Colebunders, David R. Bangsberg, Richard Marlink, Aaron Zee, Jonathan Kaplan, Tedd V. Ellerbrock Nov 2014

Antiretroviral Therapy Enrollment Characteristics And Outcomes Among Hiv-Infected Adolescents And Young Adults Compared With Older Adults — Seven African Countries, 2004–2013, Andrew F. Auld, Simon G. Agolory, Ray W. Shiraishi, Fred Wabwire-Mangen, Gideon Kwesigabo, Modest Mulenga, Sebastian Hachizovu, Emeka Asadu, Moise Zanga Tuho, Virginie Ettiegne-Traore, Francisco Mbofana, Velephi Okello, Charles Azih, Julie A. Denison, Sharon Tsui, Olivier Koole, Harrison Kamiru, Harriet Nuwagaba-Biribonwoha, Charity Alfredo, Kebba Jobarteh, Solomon Odafe, Dennis Onotu, Kunomboa A. Ekra, Joseph S. Kouakou, Peter Ehrenkranz, George Bicego, Kwasi Torpey, Ya Diul Mukadi, Eric Van Praag, Joris Menten, Timothy Mastro, Carol Dukes Hamilton, Mahesh Swaminathan, E. Kainne Dokubo, Andrew L. Baughman, Thomas Spira, Robert Colebunders, David R. Bangsberg, Richard Marlink, Aaron Zee, Jonathan Kaplan, Tedd V. Ellerbrock

OHSU-PSU School of Public Health Faculty Publications and Presentations

Although scale-up of antiretroviral therapy (ART) since 2005 has contributed to a decline of about 30% in the global annual number of human immunodeficiency (HIV)–related deaths and declines in global HIV incidence, estimated annual HIV-related deaths among adolescents have increased by about 50%, and estimated adolescent HIV incidence has been relatively stable. In 2012, an estimated 2,500 (40%) of all 6,300 daily new HIV infections occurred among persons aged 15–24 years. Difficulty enrolling adolescents and young adults in ART and high rates of loss to follow-up (LTFU) after ART initiation might be contributing to mortality and HIV incidence in this …


Understanding Adherence To Daily And Intermittent Regimens Of Oral Hiv Pre-Exposure Prophylaxis Among Men Who Have Sex With Men In Kenya, Peter Mwangi Mugo, Eduard J. Sanders, Gaudensia Mutua, Elisabeth Van Der Elst, Omu Anzala, Burc Barin, David Bangsberg, Frances H. Priddy, Jessica E. Haberer Nov 2014

Understanding Adherence To Daily And Intermittent Regimens Of Oral Hiv Pre-Exposure Prophylaxis Among Men Who Have Sex With Men In Kenya, Peter Mwangi Mugo, Eduard J. Sanders, Gaudensia Mutua, Elisabeth Van Der Elst, Omu Anzala, Burc Barin, David Bangsberg, Frances H. Priddy, Jessica E. Haberer

OHSU-PSU School of Public Health Faculty Publications and Presentations

A qualitative assessment of Kenyan men who have sex with men taking daily and intermittent oral HIV preexposure prophylaxis (PrEP) found stigma, sex work, mobility, and alcohol impacted adherence. We analyzed quantitative data from the same cohort to explore different definitions of intermittent adherence. Volunteers were randomized to daily emtricitabine/tenofovir or placebo, or intermittent (prescription: Mondays/Fridays/after sex, maximum1 dose/day)emtricitabine/tenofovir or placebo (2:1:2:1), and followed for 4 months. By electronic monitoring, median adherence for daily dosing was 80 %. Median adherence for intermittent dosing was 71 % per a ‘‘relaxed’’ definition (accounting for off-prescription dosing) and 40 % per a ‘‘strict’’ …


The Scoop, Vol. 1 Issue 8, "Movember" 2014, Health Sciences Library Nov 2014

The Scoop, Vol. 1 Issue 8, "Movember" 2014, Health Sciences Library

Volume 1

Latest news and events from the Health Sciences Library in our monthly newsletter for November 2014.


Arkansas Animal Science Department Report 2014, David L. Kreider, Paul Beck Nov 2014

Arkansas Animal Science Department Report 2014, David L. Kreider, Paul Beck

Arkansas Agricultural Experiment Station Research Series

No abstract provided.


Plaque Index In Multi-Bracket Fixed Appliances, Zafar Ul Islam, Attiya Shaikh, Mubassar Fida Nov 2014

Plaque Index In Multi-Bracket Fixed Appliances, Zafar Ul Islam, Attiya Shaikh, Mubassar Fida

Section of Dental-Oral Maxillofacial Surgery

Objective: To compare the plaque index in patients receiving multi-bracket fixed orthodontic treatment for various factors like age, gender, socio-economic status, brushing practices, meal habits, types of brackets, types of ligations, use of mouthwash and duration of treatment.
Study Design: Cross-sectional analytical study.
Place and Duration of Study: Orthodontics Clinic, The Aga Khan University Hospital, from September to November 2011.
Methodology: Socio-demographic and clinical modalities were defined and recorded for 131 patients having multi-bracket fixed appliances. The plaque index of subjects were recorded according to the Silness and Loe plaque index method. Independent sample t-test was used to see difference …


Jewish Dermatologists In Nazi Germany., Walter H.C. Burgdorf, Lawrence Charles Parish Nov 2014

Jewish Dermatologists In Nazi Germany., Walter H.C. Burgdorf, Lawrence Charles Parish

Department of Dermatology and Cutaneous Biology Faculty Papers

With the development of medical specialties beginning in the 1860’s, physicians could devote their time to the study of specific organ systems or surgical approaches. Although Jews had been given full rights in the new Germany by 1871, prejudice and other restrictions often precluded hospital and university appointments. Major specialities like internal medicine and surgery were almost closed to Jews, as were obstetrics and gynecology. Dermatology with its heavy emphasis on sexually transmitted diseases evolved into a suitable domain for Jewish physicians almost by default. Even those Jews who converted to Christianity were not spared from discrimination. Paul Gerson Unna …


Chlorovirus Atcv-1 Is Part Of The Human Oropharyngeal Virome And Is Associated With Changes In Cognitive Functions In Humans And Mice, Robert H. Yolken, Lorraine Jones-Brando, David D. Dunigan, Geetha Kannan, Faith Dickerson, Emily Severance, Sarven Sabunciyan, C. Conover Talbot Jr., Emese Prandovszky, James R. Gurnon, Irina V. Agarkova, Flora Leister, Kristin L. Gressitt, Ou Chen, Bryan Deuber, Fangrui Ma, Mikhail V. Pletnikov, James L. Van Etten Nov 2014

Chlorovirus Atcv-1 Is Part Of The Human Oropharyngeal Virome And Is Associated With Changes In Cognitive Functions In Humans And Mice, Robert H. Yolken, Lorraine Jones-Brando, David D. Dunigan, Geetha Kannan, Faith Dickerson, Emily Severance, Sarven Sabunciyan, C. Conover Talbot Jr., Emese Prandovszky, James R. Gurnon, Irina V. Agarkova, Flora Leister, Kristin L. Gressitt, Ou Chen, Bryan Deuber, Fangrui Ma, Mikhail V. Pletnikov, James L. Van Etten

James Van Etten Publications

Chloroviruses (family Phycodnaviridae) are large DNA viruses known to infect certain eukaryotic green algae and have not been previously shown to infect humans or to be part of the human virome. We unexpectedly found sequences homologous to the chlorovirus Acanthocystis turfacea chlorella virus 1 (ATCV-1) in a metagenomic analysis of DNA extracted from human oropharyngeal samples. These samples were obtained by throat swabs of adults without a psychiatric disorder or serious physical illness who were participating in a study that included measures of cognitive functioning. The presence of ATCV-1 DNA was confirmed by quantitative PCR with ATCV-1 DNA being …