Medicine and Health Sciences Commons^™

Establishing Tobacco Origin From Pollen Identification: An Approach To Resolving The Debate, Shane Williams, Shelby Hubbard, Karl Reinhard, Sérgio Augusto De Miranda Chaves

Karl Reinhard Publications

Previous research into pollen content of tobacco resulted in a debate. We address this debate and determine that pollen analysis may be able to assist with identifying geographical origin of tobacco. However, the value of any results should be assessed on a case-by-case regional basis until sufficient database information is available for an objective interpretation to be undertaken on a global basis. As a first step toward developing comparative data for South America, we analyzed a tobacco sample from Brazil in an effort to identify signature taxa from the state of Minas Gerais. We also assessed the role of honey …

Effect Of A Social Script Ipad Application For Children With Autism Going To Imaging, Norah L. Johnson, Octavia Bree, Erin E. Lalley, Kelly Rettler, Pam Grande, Md O. Gani, Sheikh Iqbal Ahamed

College of Nursing Faculty Research and Publications

This randomized controlled trial feasibility study tested the effectiveness of an iPad® application (app) social script intervention for children with autism spectrum disorder (ASD) going to imaging and their parent (n = 32 parent/child dyads). Parents of the children exposed to the app (n = 16) had lower state anxiety compared to the parents whose children were not exposed to the app (n = 16) (effect size 0.33). Children exposed to the app had fewer externalized challenging behaviors than the control group (effect size 0.56). The results demonstrate feasibility and efficacy of the intervention. Further study of …

An Emerging Population: The Chronically Critically Ill, Philip Jurasinski, Christine A. Schindler

College of Nursing Faculty Research and Publications

No abstract provided.

Access Site Complications After Peripheral Vascular Interventions: Incidence, Predictors, And Outcomes, Daniel Ortiz, Arshad Jahangir, Maharaj Singh, Suhail Allaqaband, Tanvir Bajwa, Mark W. Mewissen

College of Nursing Faculty Research and Publications

Background—

Access site hematomas and pseudoaneurysms are the most frequent complications of peripheral vascular intervention (PVI); however, their incidence and risk factors remain unclear.

Methods and Results—

We retrospectively analyzed data from the multicenter Vascular Quality Initiative on 22 226 patients who underwent 27 048 PVI from August 2007 to May 2013. Primary end points included incidence and predictors of access site complications (ASCs), length of postprocedural hospitalization, discharge status, and 30-day and 1-year mortality. ASC complicated 936 procedures (3.5%). Of these, 74.4% were minor complications, 9.7% were moderate requiring transfusion, 5.4% were moderate requiring thrombin injection, and 10.5% were …

Modeling Hedonic Processing And Anhedonia In Depression, Kevin Mercado

Honors College Theses

Depression is characterized by low positive emotion and a lack of pleasurable experiences, or anhedonia. Past studies have emphasized controlling negative affect, but there is an emerging trend in the depression literature to focus on positive emotion. The current study employed several psychophysiological tools, postauricular reflex, startle blink reflex, and event-related potential (ERP) components such as P3 and the late positive potential (LPP), to assess the dissociable components in positive emotion (consummatory and anticipatory processes). In addition, several different hypotheses of emotional dysfunction were evaluated to accurately model deficits in positive emotionality. A majority of the psychophysiological tools used supported …

Voice Features Of Sjogren's Syndrome: Examination Of Relative Fundamental Frequency (Rff) During Connected Speech, Victoria Anne Lovett

Theses and Dissertations

The purpose of this study was to examine the effectiveness of relative fundamental frequency (RFF) in quantifying voice disorder severity and possible change with treatment in individuals with Primary Sjögren's Syndrome (SS). Participants completed twice-daily audio recordings during an ABAB within-subjects experimental study investigating the effects of nebulized saline on voice production in this population. Voice samples of the Rainbow Passage from seven of the eight individuals with Primary SS involved in a larger investigation met inclusion criteria for analysis, for a total of 555 tokens. The results indicated that RFF values for this sample were similar to previously reported …

Acidosis Potentiates The Host Proinflammatory Interleukin-1Β Response To Pseudomonas Aeruginosa Infection, I. M. Torres, Y. R. Patankar, Tamer B. Shabaneh, E. Dolben, Deborah Hogan, David Leib, Brent L. Berwin

Dartmouth Scholarship

Infection by Pseudomonas aeruginosa, and bacteria in general, frequently promotes acidification of the local microenvironment, and this is reinforced by pulmonary exertion and exacerbation. However, the consequence of an acidic environment on the host inflammatory response to P. aeruginosa infection is poorly understood. Here we report that the pivotal cellular and host proinflammatory interleukin-1β (IL-1β) response, which enables host clearance of the infection but can produce collateral inflammatory damage, is increased in response to P. aeruginosa infection within an acidic environment. Synergistic mechanisms that promote increased IL-1β release in response to P. aeruginosa infection in an acidic environment are …

Factors Influencing The Return To Work After Depression: The Viewpoint And Role Of Unions, Marc Corbière, Louise St-Arnaud, Marie-José Durand, Marie-France Coutu, Tania Lecomte, Alessia Negrini, Marianne Renard

Rapports de recherche scientifique

En 2005, l’Organisation mondiale de la Santé (OMS) stipulait que dans moins d’une décennie, la dépression constituerait une des premières causes d’incapacité avec les maladies cardiovasculaires (World Health Organization, 2005). En effet, on constate une augmentation des prestations d’invalidité attribuables aux troubles mentaux, notamment la dépression. Celles-ci sont à l’origine de plus de 40% de toutes les réclamations d’assurance-salaire (MSSS, 2005). Le retour au travail des employés qui ont dû s’absenter en raison d’une dépression est parfois complexe car il implique plusieurs acteurs. À notre connaissance, peu d’études se sont intéressées au point de vue des acteurs syndicaux quant aux …

Effects Of Sex And Gender On Adaptation To Space: Musculoskeletal Health, Lori Ploutz-Snyder, Susan Bloomfield, Scott M. Smith, Sandra K. Hunter, Kim Templeton, Debra Bemben

Exercise Science Faculty Research and Publications

There is considerable variability among individuals in musculoskeletal response to long-duration spaceflight. The specific origin of the individual variability is unknown but is almost certainly influenced by the details of other mission conditions such as individual differences in exercise countermeasures, particularly intensity of exercise, dietary intake, medication use, stress, sleep, psychological profiles, and actual mission task demands. In addition to variations in mission conditions, genetic differences may account for some aspect of individual variability. Generally, this individual variability exceeds the variability between sexes that adds to the complexity of understanding sex differences alone. Research specifically related to sex differences of …

Validation Of A Food Frequency Questionnaire For Vitamin D And Calcium Intake In Healthy Female College Students, Dimitrios Papandreou, Nikolaos Rachaniotis, Maryam Lari, Wafa Al Mussabi

All Works

Objective: The objective of this study was to examine the reproducibility and validity of a Food Frequency Questionnaire (FFQ) and assess calcium and vitamin D intake in health female college students. Methods: Thirty-five healthy female students were conveniently selected to participate in the study. None of the subjects were taking any supplements. The FFQ was validated against intakes from a three-day diet food record report (FR). Results: Positive correlations were observed of daily vitamin D (r = 0.82, p < 0.001) and calcium intake (r = 0.74, p < 0.001) derived from FFQ compared with the FR. The mean intake of vitamin D and calcium derived from FFQ and FR were (233 ± 90, 654 ± 391) and (231 ± 79, 611 ± 352), respectively. The FFQ overestimated vitamin D and Calcium by 2 IU /day (95% CI: –8, 9, p < 0.676 and 43 mg/d (95% CI: 20, 65, p < 0.01). Conclusions: The FFQ used in this study shows promising validation evidence to be used in the future for assessing vitamin D and calcium intakes in female students.

Integration Of Non-Communicable Diseases Into Primary Health Care: A Snapshot From Eastern Mediterranean Region, Shehla Zaidi, Abdul Latif Khan, Aftab Ali Mukhi, Yousuf Memon, Slim Slama, Samer Jabbour

Community Health Sciences

No abstract provided.

Metformin And Erlotinib Synergize To Inhibit Basal Breast Cancer, Ying-Ka Ingar Lau, Xing Du, Vinayak Rayannavar, Benjamin Hopkins, Jacquelyn Shaw, Eliana Bessler, Tiffany Thomas, Maira M. Pires, Megan Keniry

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Basal-like breast cancers (BBCs) are enriched for increased EGFR expression and decreased expression of PTEN. We found that treatment with metformin and erlotinib synergistically induced apoptosis in a subset of BBC cell lines. The drug combination led to enhanced reduction of EGFR, AKT, S6 and 4EBP1 phosphorylation, as well as prevented colony formation and inhibited mammosphere outgrowth. Our data with other compounds suggested that biguanides combined with EGFR inhibitors have the potential to outperform other targeted drug combinations and could be employed in other breast cancer subtypes, as well as other tumor types, with activated EGFR and PI3K signaling. Analysis …

Occurrence Of Rift Valley Fever In Cattle In Ijara District, Kenya, Nelson O. Owange, William O. Ogara, Hippolyte Affognon, Gathura B. Peter, Jacqueline Kasiiti, Sam Okuthe, W. Onyango-Ouma, Tobias Landmann, Rosemary Sang, Murithi Mbabu

All Peer-Reviewed Publications

Ijara district in Kenya was one of the hotspots of rift valley fever (RVF) during the 2006/2007 outbreak which led to human and animal deaths causing huge economic and public health losses. The main constraint in the control and prevention of RVF is inadequate knowledge on its occurrence during the interepidemic period. This study was aimed at understanding the occurrence of RVF in cattle in Ijara to enable the development of improved community-based disease surveillance, prediction, control and prevention.Six herds each 700-1000 cattle were identified with participatory involvement of locals and project technical team of the project. One animal per …

A Unique Mri Presentation Of Fungal Infection In The Brain, Muhammad Bilal Salman Khan, Saad Shafqat, Ather Enam

Section of Neurology

Fungal infections of CNS are common in certain geographic locations. MRI with or without contrast is a useful prediagnostic tool. However, the findings may sometimes be misleading. In this case report, the authors present unusual imaging findings in the MRI of fungal infection in an immunocompetent host, whereby hyper-intense signals were seen on T2-weighted images and patchy post-contrast enhancement was observed with surrounding edema. These findings were suggestive of a neoplastic lesion but it was identified as aspergillosis on subsequent histopathology. This unusual MRI finding of CNS highlights the need to consider fungal infection as a differential diagnosis of all …

Non Communicable Diseases In Pakistan: Burden, Challenges And Way Forward For Health Care Authorities, Mohammad Wasay, Shehla Zaidi, Maria Khan, Rashid Jooma

Section of Neurology

No abstract provided.

Effects Of Polypharmacy On Adverse Drug Reactions Among Geriatric Outpatients At A Tertiary Care Hospital In Karachi: A Prospective Cohort Study., Bilal Ahmed, Kashmira Nanji, Rakshinda Mujeeb, Muhammad Junaid Patel

Department of Medicine

Background: Adverse drug reactions (ADRs) present a challenging and expensive public health problem. Polypharmacy is defined according to the WHO criteria as the, ‘‘concurrent use of five or more different prescription medication’’. Elderly are more prone to adverse reactions due to comorbid conditions, longer lists of medications and sensitivity to drug effects. The aim of the study is to estimate the incidence and strength of association of ADRs due to polypharmacy among the geriatric cohort attending outpatient clinics at a tertiary care center.

Methods: A hospital based prospective cohort study was conducted at ambulatory care clinics of Aga Khan University …

Motivation Of Clinical Faculty Towards Teaching And Learning., M. Tariq, Syed Ahsan Ali

Department of Medicine

No abstract provided.

Outcomes Of Splenectomy For Idiopathic Thrombocytopenic Purpura In Adults: A Developing Country Perspective., Amyn Pardhan, Aamir Hameed, Hasnain Zafar, Samia Mazahir, Ghulam Murtaza

Department of Medicine

Objective: to determine the outcome of splenectomy done in adult patients of Idiopathic Thrombocytopenic Purpura over a period of 10 years and, secondarily, to determine the predictors of complete response to therapy.

Methods: The retrospective review comprised of adult patients over 14 years of age who underwent open or laparoscopic splenectomy for Idiopathic Thrombocytopenic Purpura at Aga Khan University Hospital, Karachi, from January 2000 to December 2010. Data was reviewed in January 2011 by a surgical resident. Outcome was the response to splenectomy as per new definition of response set by the American Society of Haematology 2011 evidence based practice …

Clinical Course And Outcome Of Acute Severe Asthma (Status Asthmaticus) In Adults., Ali Khawaja, Hira Shahzad, Murtaza Kazmi, Ali Bin Sarwar Zubairi

Department of Medicine

Objective: To evaluate the clinical course and outcomes in patients with acute severe asthma in a tertiary care setting.
Methods: The retrospective cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, and comprised data of patients of age 16 and above who were admitted with a diagnosis of acute severe asthma from January 2000 to December 2013.These patients had undergone clinical evaluation to assess the severity of illness as well as the complications and eventual outcomes. SPSS 16 was used for statistical analysis.
Results: Of the 50 patients in the study, 41 (82%) were females. The overall mean …

Epidemiology, Determinants And Dynamics Of Cholera In Pakistan: Gaps And Prospects For Future Research., Maliha Naseer, Tanzil Jamali

Community Health Sciences

Cholera is one of the notifiable endemic diseases in Pakistan, but the reporting of cholera cases is still unsatisfactory. Most of the diagnosed cases are never reported to the relevant authorities. In the year 1993 - 2005, the country did not report any single case of cholera to the WHO. The objectives of this review were to understand the epidemiology and to identify the possible determinants of cholera infection in Pakistan. Medscape, Medline, PakMedinet and PubMed, was searched, using key words, epidemiology and determinants of cholera infection in Pakistan during 1995 - 2010. Morbidity and mortality due to cholera infection …

The Economic Costs And Benefits Of Dental Education: An Empirical Analysis, Gary L. Stafford, Farrokh Nourzad, William K. Lobb, Jason R. Beall

School of Dentistry Faculty Research and Publications

The rising costs associated with obtaining a dental education have caused some to question the financial benefit of pursuing a dental degree. There is a concern that recent graduates may have difficulty finding professional opportunities that provide the income necessary to service their accumulated educational debt. The aim of this study was to evaluate the trends in educational costs to aid in making an accurate appraisal of the financial benefit of a dental education. Adjusted into constant dollar terms, data from a variety of sources were collected for economic variables such as tuition, fees, student indebtedness, and dentists’ earnings. These …

The Burden Of Underweight And Overweight Among Women In Addis Ababa, Ethiopia, Yibeltal Tebekaw, Charles Teller, Uriyoan Colón-Ramos

Global Health Faculty Publications

Background

Obesity and overweight are rising worldwide while underweight rates persist in low-income countries. The aim of this study was to examine changes in the prevalence of underweight and overweight/obesity among non-pregnant women aged 15-49 years, and its socio-demographic correlates in Addis Ababa, Ethiopia.

Methods

The data are from 2000, 2005 and 2011 nationally representative Ethiopian Demographic and Health Surveys in Addis Ababa. The dependent variable was women’s nutritional status measured in terms of body mass index coded in binary outcomes to examine risk of being underweight (<18.5 kg/m² vs. ≥18.5 kg/m²) or overweight/obese (>25 kg/m^{2 …}

Teaching Health Advocacy To Medical Students: A Comparison Study., Julia Belkowitz, Lee M Sanders, Chi Zhang, Gauri Agarwal, Daniel Lichtstein, Alex J Mechaber, Esther K Chung

Department of Pediatrics Faculty Papers

CONTEXT: Many encourage service learning and health advocacy training in medical student education, but related evaluation is limited.

OBJECTIVES: To assess (1) impact of a required community health advocacy training for medical students on student attitudes, knowledge, and skills; (2) student characteristics associated with higher advocacy knowledge and skills; and (3) perspectives of community-based organizations (CBOs).

DESIGN: Cross-sectional surveys.

SETTING: University of Miami Miller School of Medicine (UMMSM) Regional Medical Campus and main campus.

PARTICIPANTS: Medical students at both UMMSM campuses.

INTERVENTION: Required community health advocacy training for first- and second-year students including classroom experiences and hands-on project in partnership …

The Role Of Leadership In Creating A Strategic Climate For Evidence-Based Practice Implementation And Sustainment In Systems And Organizations, Gregory A. Aarons, Mark G. Ehrhart, Lauren R. Farahnak, Marisa Sklar

Frontiers in Public Health Services and Systems Research

There is a growing impetus to effectively implement evidence-based practices (EBPs) in health and allied health settings in order to improve the public health impact of such practices. To support implementation and sustainment of EBPs, it is important to consider that health care is delivered within the outer context of public health systems and the inner context of health care organizations and work groups (3). This article identifies two relevant types of leadership for implementation and recommends steps that leaders can take in developing a strategic climate for EBP implementation and sustainment within the outer and inner contexts of health …

Editorial Comment: What Influences The Use Of Administrative Evidence-Based Practices In Local Health Departments?, Christopher M. Maylahn

Frontiers in Public Health Services and Systems Research

In 2012, Frontiers published an article by Allen et al. about identifying administrative and management practices that make up an evidence-based local health department.¹ They recommended that local health departments (LHDs) consider using such practices to implement sustained evidence-based policies, programs, and interventions. Strategies that should be given ‘high priority’ for implementation were highlighted. My accompanying editorial² acknowledged the value of this practical advice to LHDs in optimizing their performance and achieving desired health outcomes.

What Influences The Use Of Administrative Evidence-Based Practices In Local Health Departments?, Kathleen Duggan, Peg Allen, Ross Brownson, Paul C. Erwin, Robert Fields, Rodrigo S. Reis, Carson Smith, Katherine Stamatakis

Frontiers in Public Health Services and Systems Research

Evidence based public health (EBPH) in local health departments (LHDs) is a process that involves translating the best available scientific evidence into practice. However, EBPH and implementation of evidence based programs and policies in LHDs are not widespread. This report outlines the patterns and predictors of the use of administrative evidence based practices (A-EBPs) in a national sample of LHD directors. LHDs can improve performance, prepare for accreditation and ultimately improve community health by utilizing an administrative evidence based process.

Fearless: Gettysburg Breast Cancer Survivors, Allsion P. Lauro

SURGE

As we reach the end of Breast Cancer Awareness month, Surge would like to recognize breast cancer survivors. For today’s Fearless Friday, we are honored to highlight four brave and fearless Gettysburgians:Joyce Sprague, Academic Administrative Assistant for Women, Gender and Sexuality Studies; Anne Lane, Associate Dean of Academic Advising; Julie Ramsey, Vice President for College Life and Dean of Students; and Sandy Buhrman, Administrative Services Assistant for the Center for Career Development. These women are truly fearless for persisting in the face of adversity, advocating for other women, sharing their stories and inspiring others. [ …

Diabetes Pathophysiology And Treatment Strategies, Beth Careyva Md

Department of Family Medicine

No abstract provided.

Using Multi-Compartment Ensemble Modeling As An Investigative Tool Of Spatially Distributed Biophysical Balances: Application To Hippocampal Oriens-Lacunosum/Moleculare (O-Lm) Cellns, Vladislav Sekulic, J. Josh Lawrence, Frances K. Skinner

Biomedical and Pharmaceutical Sciences Faculty Publications

Multi-compartmental models of neurons provide insight into the complex, integrative properties of dendrites. Because it is not feasible to experimentally determine the exact density and kinetics of each channel type in every neuronal compartment, an essential goal in developing models is to help characterize these properties. To address biological variability inherent in a given neuronal type, there has been a shift away from using hand-tuned models towards using ensembles or populations of models. In collectively capturing a neuron’s output, ensemble modeling approaches uncover important conductance balances that control neuronal dynamics. However, conductances are never entirely known for a given neuron …

Cama Newsletter - October, 2014, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A seven page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.