Medicine and Health Sciences Commons^™

Understanding Turnover Propensity Via Affective Beliefs, Adam Bradshaw

Theses and Dissertations

Three latent variable models examined relationships among neuroticism, situation-specific affective beliefs, and turnover propensity and were evaluated with Structural Equation Modeling to determine model fit. Results provided additional insight into how affective belief systems relate to turnover propensity reinforcing and expanding upon previous research by Binning, Bradshaw, LeBreton, and Scheier (2010) as the Correlated Antecedents and the Mediated Antecedents Models fit the data as proposed. Neuroticism and situation-specific affective beliefs continue to play distinguishable roles in explaining turnover propensity. Research by Binning et al. (2010) and the present study make it increasingly clear that understanding how affective belief systems relate …

A Genome-To-Genome Analysis Of Associations Between Human Genetic Variation, Hiv-1 Sequence Diversity, And Viral Control, Istvan Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. Mclaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio Lopez-Galindez, Concepcion Casado, Andri Rauch, Huldrych F. Gunthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltan Kutalik, Todd M. Allen, Viktor Muller, P. Richard Harrigan, David Heckerman, Amalio Telenti, Jacques Fellay

Biology Faculty Articles

HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence variation and plasma viral load (VL), while considering human and viral population structure. We observed significant human SNP associations to a total of 48 HIV-1 amino acid variants (p<2.4 × 10⁻¹²). All associated SNPs mapped to the HLA class I region. Clinical relevance of host and pathogen variation was assessed using VL results. We identified two critical advantages to the use of viral variation …

The Effect Of Water Storage On The Bending Properties Of Esthetic, Fiber-Reinforced Composite Orthodontic Archwires, Ju-Han Chang, David W. Berzins, Jessica E. Pruszynski, Richard W. Ballard

School of Dentistry Faculty Research and Publications

Objective: To study the effect of water storage on the bending properties of fiber-reinforced composite archwires and compare it to nickel-titanium (NiTi), stainless steel (SS), and beta-titanium archwires.

Materials and Methods: Align A, B, and C and TorQ A and B composite wires from BioMers Products, 0.014-, 0.016, and 0.018-inch, and 0.019 × 0.025-inch NiTi, 0.016-inch SS, and 0.019 × 0.025-inch beta-titanium archwires were tested (n  =  10/type/size/condition). A 20-mm segment was cut from each end of the archwire; one end was then stored in water at 37°C for 30 days, while the other was stored dry. The segments were …

Nurses’ Self-Report Of Behavior Changes Following Needlestick Or Other Sharp Instrument Injuries, Lucille Christensen Woolston, Dr. Renea L. Beckstrand

Journal of Undergraduate Research

My research questions regarded needlestick and sharp instrument injuries, how many were reported, and what behavior changes have been made following the injury. I approached nurse managers at Utah Valley Regional Medical Center and gave surveys to nurses in staff meetings. I received results that I expected. I found most injuries that are not reported are clean injuries and so the staff feels the injuries are not worth reporting.

Parent And Child Perceptions Of Clinical Trials, Jaclyn F. Wood, Dr. Barbara Mandleco

Journal of Undergraduate Research

The purpose of this research project was to determine parental perceptions surrounding the involvement of their children in a clinical trial. A secondary purpose was to talk to the children and obtain their perceptions surrounding their own involvement in the clinical trial. For this ORCA funded project I analyzed interviews with the parents to find out their perceptions. In a future project (for which I will be applying for an ORCA grant) I hope to analyze interviews with the children and gain their insight into their involvement in the clinical trial.

Siblings Of Children With Down Syndrome: Perceptions Of Their Experiences, Allison Ash Malnar, Dr. Barbara Mandleco

Journal of Undergraduate Research

Approximately 350,000 families in the United States are affected by Down syndrome, and the vast majority of these families include one or more nondisabled children (National Down Syndrome Society, 1999). Because of this, many researchers are interested in how this disability affects the family. Marsha Van Riper (1999) writes, “…While the birth of a child with Down syndrome involves a ‘change of plans’ for families, it does not have to be a negative experience. In fact for many families, it is a positive, growth producing experience” (p. 3). While much research in the past concerned interviewing parents of children with …

Patients’ Perceptions Of Mechanical Ventilation: What Hurt And What Helped?, Lisa M. Ewert, Dr. Renea Beckstrand

Journal of Undergraduate Research

When a patient is on a ventilator, it’s the critical care nurse’s role to recognize and respond to any factors that cause the patient distress. Anytime a patient is ill, the illness causes both physiological and emotional stress. However, an acute illness that is severe enough to require mechanical ventilation intensifies the physical and psychological distress with which the patient and their family must cope (1).

Assessment Of Family Satisfaction Of Intensive Care Unit Experience, Breann Brady, Dr. Joan Baldwin

Journal of Undergraduate Research

When a patient enters the Intensive Care Unit (ICU), the experience is stressful and traumatic, for both the patient and their family members. The fast paced environment may seem scary to those unfamiliar with it. Families are left in a waiting room, only to enter and see their loved one in a strange environment full of equipment and beeping machinery. The family is sometimes left confused and unsure of what is happening in the care of their loved one. Nurses need to be aware of families’ needs. By meeting their needs, nurses can be invaluable to families of ICU patients.

Empowering Students With Assessment Data, Jane M. Souza, Karen D.C. Bobak

Pharmacy Faculty/Staff Publications

Students’ perspective on assessment may be limited to summative grades for semester performance. However, providing access to data tracking their progress formatively could empower them to be more proactive in preparing for success. Examples of empowering students through access to data will be shared from two campuses. One campus will demonstrate how requiring students to reflect on longitudinal reports of their performance on learning outcomes can assist in targeting their studies. The second campus will exhibit how assessment data can be linked to peer mentoring. Participants will strategize how to engage students actively in the use of assessment data.

Proggene: Gene Expression Based Survival Analysis Web Application For Multiple Cancers., Chirayu Pankaj Goswami, Harikrishna Nakshatri

Department of Surgery Faculty Papers

BACKGROUND: Identification of prognostic mRNA biomarkers has been done for various cancer types. The data that are published from such studies are archived in public repositories. There are hundreds of such datasets available for multiple cancer types in public repositories. Wealth of such data can be utilized to study prognostic implications of mRNA in different cancers as well as in different populations or subtypes of same cancer.Description: We have created a web application that can be used for studying prognostic implications of mRNA biomarkers in a variety of cancers. We have compiled data from public repositories such as GEO, EBI …

Perceptions Of The Maintenance Of Dignity In Women Giving Birth, Rachel Matthews, Dr. Lynn Callister

Journal of Undergraduate Research

Entering a hospital is often an intimidating and stressful event for patients. They enter a world about which they often know very little. They may enter with apprehension about the unknown, their illness, or excitement about starting a new phase of life with the birth of a child. As they are experiencing the unknown, patients are often put into situations where they are told what to do and when to do it, sometimes with little or no explanation. Tasks that health care personnel consider routine are not only unfamiliar, but also are often very invasive, leaving patients feeling uncomfortable, helpless, …

Pain Assessment In Pediatric Post-Tonsillectomy Patients, Tamara Baird, Dr. Renea L. Beckstrand

Journal of Undergraduate Research

A nurse’s obligation to manage pain and relieve patients’ suffering is an integral part of the commitment to patient care. Adequate pain assessment and management benefits the patient by shortening the hospital stay, speeding recovery, reducing costs, and promoting physical activity. Specific populations who may have difficulty communicating their pain require special attention, especially children. Although many effective techniques are available for pain management in children, studies indicate that their pain is managed less well than pain in adults (United States Department of Health and Human Services, 1992).

How Is Nursing Facing The Nursing Faculty Shortage?, J. R. Meadows, Dr. Barbara Mandleco

Journal of Undergraduate Research

A severe nursing shortage has been growing across the United States over the past six years and the outlook on immediate signs of recovery is bleak. It has become an increasing worry to the federal and state governments, nurses, health-care providers and hospitals, current nursing students, and nursing schools. Despite efforts, the need for nurses continues to rise, tabulating to 75% of all hospital personnel vacancies. Nursing schools and colleges are faced with the dilemma of how to produce more nursing faculty while health-care providers are making decisions on how to recruit more nurses to their institutions.

Community Health News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Quality Improvement

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Quality Improvement

The Predictive Value Of Renal Ultrasound Of Vesicoureteral Reflux After First Urinary Tract Infection In Neonates And Infants 0-24 Months, Richard J. Mazzaccaro Md, Michael J. Weiss Mph

Department of Pediatrics

No abstract provided.

Thoracic Multidisciplinary Clinic (Tmdc) And The Treatment Of Stage Iii Non-Small Cell Lung Cancer, Eliot L. Friedman Md, Michael F. Szwerc Md, Robert Kruklitis Md, Michael J. Weiss

Department of Medicine

No abstract provided.

Lpa, Hgf, And Egf Utilize Distinct Combinations Of Signaling Pathways To Promote Migration And Invasion Of Mda-Mb-231 Breast Carcinoma Cells, Susan M. W. Harrison, Teresa Knifley, Min Chen, Kathleen L. O'Connor

Markey Cancer Center Faculty Publications

BACKGROUND: Various pathways impinge on the actin-myosin pathway to facilitate cell migration and invasion including members of the Rho family of small GTPases and MAPK. However, the signaling components that are considered important for these processes vary substantially within the literature with certain pathways being favored. These distinctions in signaling pathways utilized are often attributed to differences in cell type or physiological conditions; however, these attributes have not been systematically assessed.

METHODS: To address this question, we analyzed the migration and invasion of MDA-MB-231 breast carcinoma cell line in response to various stimuli including lysophosphatidic acid (LPA), hepatocyte growth factor …

Recruitment And Retention Of Rural Nursing Students: A Retrospective Study, J. Bigbee, D. Mixon

Nursing Faculty Publications and Presentations

Introduction: The shortage of registered nurses is an issue globally, but particularly in rural and remote areas. Previous research in medicine suggests that recruiting students from rural backgrounds is an effective strategy to enhance the supply of rural healthcare providers. This strategy has not been widely adopted or evaluated in nursing. The purpose of this study was to compare rural and urban nursing students in relation to application, admission, and retention/graduation trends at a metropolitan state university in the Pacific Northwest area of the USA.
Methods: A retrospective longitudinal descriptive design was used, analyzing existing data from 2005 to …

Cutaneous Manifestations Of Giant Cell Arteritis, Christina E. Borchers, Ronald E. Warwar

Pharmacology and Toxicology Faculty Publications

A 68 year old woman with advanced giant cell arteritis presented with progressive tongue, lip, and scalp necrosis. She was initially misdiagnosed and treated for oral thrush by her primary care physician and emergency department personnel. She was ultimately correctly diagnosed with giant cell arteritis after she developed a left central retinal artery occlusion, ischemic optic neuropathy, and third cranial nerve palsy. She was treated with corticosteroids and the vasculitis was arrested. She was left with permanent defects in her tongue and lip as well as blindness in the left eye.

New Oral Anticoagulants Are Not Superior To Warfarin In Secondary Prevention Of Stroke Or Transient Ischemic Attacks, But Lower The Risk Of Intracranial Bleeding: Insights From A Meta-Analysis And Indirect Treatment Comparisons, Partha Sardar, Saurav Chatterjee, Wen-Chih Wu, Edgar Lichstein, Joydeep Ghosh, Shamik Aikat, Debabrata Mukherjee

Internal Medicine Faculty Publications

PURPOSE: Patients with Atrial Fibrillation (AF) and prior stroke are classified as high risk in all risk stratification schemes. A systematic review and meta-analysis was performed to compare the efficacy and safety of New Oral Anticoagulants (NOACs) to warfarin in patients with AF and previous stroke or transient ischemic attack (TIA).

METHODS: Three randomized controlled trials (RCTs), including total 14527 patients, comparing NOACs (apixaban, dabigatran and rivaroxaban) with warfarin were included in the analysis. Primary efficacy endpoint was ischemic stroke, and primary safety endpoint was intracranial bleeding. Random-effects models were used to pool efficacy and safety data across RCTs. RevMan …

Microrna-200c Modulates The Expression Of Muc4 And Muc16 By Directly Targeting Their Coding Sequences In Human Pancreatic Cancer., Prakash Radhakrishnan, Ashley M. Mohr, Paul M. Grandgenett, Maria M. Steele, Surinder K. Batra, Michael A. Hollingsworth

Journal Articles: Biochemistry & Molecular Biology

Transmembrane mucins, MUC4 and MUC16 are associated with tumor progression and metastatic potential in human pancreatic adenocarcinoma. We discovered that miR-200c interacts with specific sequences within the coding sequence of MUC4 and MUC16 mRNAs, and evaluated the regulatory nature of this association. Pancreatic cancer cell lines S2.028 and T3M-4 transfected with miR-200c showed a 4.18 and 8.50 fold down regulation of MUC4 mRNA, and 4.68 and 4.82 fold down regulation of MUC16 mRNA compared to mock-transfected cells, respectively. A significant reduction of glycoprotein expression was also observed. These results indicate that miR-200c overexpression regulates MUC4 and MUC16 mucins in pancreatic …

Research Brief: "Investing In Vets: Strategies To Help Returning Gulf War Vets Enter The Civilian Work Force Successfully", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This study found that corporate leadership, veteran-specific training, and a long-term commitment to veterans’ employment were all significant factors in diminishing barriers to veteran employment and reintegration. In practice, social workers who understand business and organizational change can be leaders in supporting veterans in the workplace, and also in advocating for positive social change for veterans and their families. For employers, increased cultural competence concerning military populations would be helpful. In policy, organizations should work on creating coalitions of corporate leaders who have the power to change policies, programs, and practices, and who will monitor the success of these policy …

The Santa Clara, 2013-10-24, Santa Clara University

The Santa Clara

No abstract provided.

Public Health Services & Systems Research: Building The Science Of Public Health Delivery, Glen P. Mays

Health Management and Policy Presentations

The extreme heterogeneity in how public health activities are organized, financed, and implemented across U.S. states and communities provides compelling opportunities for research on the comparative effectiveness and efficiency of public health delivery. This talk highlights some of the most compelling and policy-relevant opportunities for research on public health organization and financing issues, and examines some of the ongoing studies in the field.

Evaluation Of Etoricoxib In Patients Undergoing Total Knee Replacement Surgery In A Double-Blind, Randomized Controlled Trial., Narinder Rawal, Eugene R. Viscusi, Paul M Peloso, Harold S Minkowitz, Liang Chen, Sandhya Shah, Anish Mehta, Denesh K Chitkara, Sean P Curtis, Dimitris A Papanicolaou

Department of Anesthesiology Faculty Papers

BACKGROUND: Optimal postoperative pain management is important to ensure patient comfort and early mobilization.

METHODS: In this double-blind, placebo- and active-controlled, randomized clinical trial, we evaluated postoperative pain following knee replacement in patients receiving placebo, etoricoxib (90 or 120 mg), or ibuprofen 1800 mg daily for 7 days. Patients >=18 years of age who had pain at rest >=5 (0--10 Numerical Rating Scale [NRS]) after unilateral total knee replacement were randomly assigned to placebo (N = 98), etoricoxib 90 mg (N = 224), etoricoxib 120 mg (N = 230), or ibuprofen 1800 mg (N = 224) postoperatively. Co-primary endpoints included …

Prolonged Febrile Seizures Cause Reversible Reductions In White Matter Integrity☆, M. Yoong, K. Seunarine, M. Martinos, R. F. Chin, C. A. Clark, R. C. Scott

Dartmouth Scholarship

Prolonged febrile seizures (PFS) are the commonest cause of childhood status epilepticus and are believed to carry a risk of neuronal damage, in particular to the mesial temporal lobe. This study was designed to determine: i) the effect of prolonged febrile seizures on white matter and ii) the temporal evolution of any changes seen.

33 children were recruited 1 month following PFS and underwent diffusion tensor imaging (DTI) with repeat imaging at 6 and 12 months after the original episode of PFS. 18 age-matched healthy control subjects underwent similar investigations at a single time point. Tract-based spatial statistics (TBSS) was …

Collagen Content In Skin And Internal Organs Of The Tight Skin Mouse: An Animal Model Of Scleroderma., Jayanthi Manne, Marina Markova, Linda D Siracusa, Sergio A Jimenez

Department of Microbiology and Immunology Faculty Papers

The Tight Skin mouse is a genetically induced animal model of tissue fibrosis caused by a large in-frame mutation in the gene encoding fibrillin-1 (Fbn-1). We examined the influence of gender on the collagen content of tissues in C57BL/6J wild type (+/+) and mutant Tight Skin (Tsk/+) mice employing hydroxyproline assays. Tissue sections were stained with Masson's trichrome to identify collagen in situ. Adult Tsk/+ mice skin contains ~15% more collagen, on average, than skin from +/+ mice of the same gender. The heart of Tsk/+ males had significantly more collagen than that of +/+ males. No significant gender differences …

Pre-Diagnosis Oophorectomy, Estrogen Therapy And Mortality In A Cohort Of Women Diagnosed With Breast Cancer, Hazel B. Nichols, Amy Trentham-Dietz, Polly A. Newcomb, Kathleen M. Egan, Linda J. Titus, John M. Hampton, Kala Visvanathan

Dartmouth Scholarship

Introduction:

Pre-diagnosis oophorectomy and estrogen therapy could impact mortality due to breast cancer and cardiovascular disease (CVD) among breast cancer survivors. Elective bilateral oophorectomy at the time of hysterectomy for benign conditions is not uncommon among US women.

Methods:

We examined the association between pre-diagnosis total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAHBSO) and both overall and cause-specific mortality in the Collaborative Breast Cancer Studies cohort. Medical history and prior estrogen use were collected during standardized telephone interviews. Vital status, including date and cause of death, was obtained by linkage with the National Death Index. Multivariate hazard ratios (HR) and 95% …

Business Ethics: The Impact On Healthcare Professionals, Paul D. Longenecker

Health and Sport Sciences Faculty Scholarship

No abstract provided.