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2013

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Articles 781 - 810 of 7931

Full-Text Articles in Medicine and Health Sciences

An Overview Of The Healthcare System In Argentina, Derya Arkonac Nov 2013

An Overview Of The Healthcare System In Argentina, Derya Arkonac

CwiC-PH

Poster outlines:

  1. The Health Care System
  2. The Population
  3. The Politics
  4. Conclusion


Role Of Traditional Chinese Medicine In Modern Healthcare, Gealina Dun Nov 2013

Role Of Traditional Chinese Medicine In Modern Healthcare, Gealina Dun

CwiC-PH

Theories of Traditional Chinese Medicine (TCM)

Traditional Chinese Medicine (TCM), a form of complementary and alternative medicine (CAM), has been practiced for over 2500 years, and approaches health as an interrelated and holistic state of being. Using multiple methods, the theories of TCM aim to balance:

  • Qi
  • Yin and Yang (Fig. 1)
  • The Five Elements
  • ZangFu Organs


A Place For Mindfulness In Successful Addiction Recovery, Susannah Eckman Nov 2013

A Place For Mindfulness In Successful Addiction Recovery, Susannah Eckman

CwiC-PH

The difficulties that women face during substance abuse recovery and re-integration into society after incarceration are staggering in number and combined severity. Over the last several decades, a substantial body of research has investigated the psychological, neurobiological, and public health aspects of the actual experience – as well as the sustained perception of – resource depletion that everyday life in low-income communities creates. The tide of research is now headed towards evaluating new treatment strategies that respond to the understanding gained from this research. Mindfulness Training (MT) is one strategy that promises particular efficacy in addressing the root of these …


Successful Aging In Philadelphia: Examining The Needs Of The Geriatric Community, Mollie Woehling Nov 2013

Successful Aging In Philadelphia: Examining The Needs Of The Geriatric Community, Mollie Woehling

CwiC-PH

INTRODUCTION

  • As more adults continue to live until older ages they will have a greater reliance on the formal aging care system and continue to use a large proportion of healthcare resources
  • From 2000 to 2010, the US 65+ population grew 15.1% compared to the total population that grew 9.7%1
  • CDC estimates that adults who make it to 65 can expect to live for 19 more years, 14 of those in relatively good health2
  • Adults 65 years and older comprise over 12% of the population of Philadelphia1
  • In 2002, 19% of Philadelphia’s seniors 65+ lived in poverty, …


Decision-Making In Accessing The Emergency Department Versus Primary Care, Lev Malevanchik, Rickie Brawer, Mph, Phd, Priya Mammen, Md, Mph, Bernard Lopez, Md, Ms Nov 2013

Decision-Making In Accessing The Emergency Department Versus Primary Care, Lev Malevanchik, Rickie Brawer, Mph, Phd, Priya Mammen, Md, Mph, Bernard Lopez, Md, Ms

CwiC-PH

  • 95% of emergency department (ED) visits from patients living in Jefferson’s (TJUH) community benefit area (CBA) were for conditions with lower priority

Emergency Severity Index (ESI) numbers of 3, 4, or 5 in FY 2011 & 2012.

– Many of these visits were non-emergent.

  • The aim of this study was to document how community members chose between going to the ED or their primary care physician (PCP).


The State Of Healthcare For Bhutanese Refugees In South Philadelphia: Challenges & Progress, Sarah Wells Nov 2013

The State Of Healthcare For Bhutanese Refugees In South Philadelphia: Challenges & Progress, Sarah Wells

CwiC-PH

Who the Bhutanese Refugees Are [1]

  • Mid-19th Century: Nepalese farmers recruited to work farmlands of Southern Bhutan (called Lhotshampa, or “southerners”)
  • Lhotshampa retained Nepali and Hindu customs, but lived in peace with the Drukpa (Buddhist elite) majority for many years
  • 1989: “One Nation, One People” policy of ethnic cleansing: Drukpa culture imposed on all Bhutanese
  • Torture, sexual assault and murder forced over 130,000 Lhotshampa to flee Bhutan
  • These refugees spent decades of their lives in camps in Nepal (many still remain there)
  • Over 68,000 have resettled to the USA, many coming to South Philadelphia [2]


An Assessment Of Food Insecurity In A Lower North Philadelphia Community Health Center, Carly Sedlock, James D. Plumb, Md, Mph, Rickie Brawer, Mph, Phd Nov 2013

An Assessment Of Food Insecurity In A Lower North Philadelphia Community Health Center, Carly Sedlock, James D. Plumb, Md, Mph, Rickie Brawer, Mph, Phd

CwiC-PH

Food insecurity describes the inability to access enough food at all times to lead an active, healthy life. While food insecurity is associated with several negative health outcomes, screening for food insecurity in the clinical setting is not consistently performed. The goals of this pilot study were to: explore the prevalence of food insecurity among patients attending St. Elizabeth's Wellness Center in Lower North Philadelphia, explore the impact of food insecurity on health and disease management, and assess how to better address food insecurity in the primary care setting.


Women’S Perspective: The Underlying Factors Leading To Malnutrition In Poor Women In India, Tanuja Devaraj Nov 2013

Women’S Perspective: The Underlying Factors Leading To Malnutrition In Poor Women In India, Tanuja Devaraj

CwiC-PH

AIM

A qualitative pilot study aimed to understand the socioeconomic aspects leading to malnutrition in urban poor women in Bangalore, India.


Embracing A Competency-Based Specialty Curriculum For Community-Based Nursing Roles, Pamela F. Levin, Susan M. Swider, Susan Breakwell, Julia M. Cowell, Virginia Reising Nov 2013

Embracing A Competency-Based Specialty Curriculum For Community-Based Nursing Roles, Pamela F. Levin, Susan M. Swider, Susan Breakwell, Julia M. Cowell, Virginia Reising

College of Nursing Faculty Research and Publications

The Quad Council competencies for public health nursing (PHN) provide guidance in developing curricula at both the generalist and specialist level. However, these competencies are based on nursing roles in traditional public health agencies and community/public health is defined more broadly than official agency practice. The question arises as to whether community-based specialties require largely the same knowledge and skill set as PHN. The purpose of the competency cross-mapping project reported here was to (a) assess the intersection of the Quad Council competencies with four community-based specialties and (b) ensure the appropriateness of a Quad Council-based curriculum to prepare graduates …


Cyclin E Induction And Oncolytic Replication Of E1b-Deleted Adenoviruses., Pei-Hsin Cheng Nov 2013

Cyclin E Induction And Oncolytic Replication Of E1b-Deleted Adenoviruses., Pei-Hsin Cheng

Electronic Theses and Dissertations

Virus-mediated oncolysis has been considered as a new and promising cancer therapeutic approach. Although adenoviruses (Ads) with deletion of E1b55K preferentially replicate in cancer cells and have been used in numerous cancer treatments, the selective replication mechanism of this kind of virus still remains controversial. The lack of a well-established studies focusing on possible mechanisms enabling tumor selectivity of oncolytic Ads has hindered the further development of virotherapies and limits their clinical applications. Therefore, uncovering the molecular basis behind the tumor-killing phenomena will fill critical gaps in our understanding of the oncolytic adenovirology. Previously our laboratory has demonstrated that Ad …


Ebp Fellows²: A Model For Sharing Science In The Oncology Setting And Beyond..., Elena Brinker Rn, Laura Herbener Rn, Ocn Nov 2013

Ebp Fellows²: A Model For Sharing Science In The Oncology Setting And Beyond..., Elena Brinker Rn, Laura Herbener Rn, Ocn

Patient Care Services / Nursing

No abstract provided.


Health Promotions 2.0: The Future Of Wellness Programs In America, Rajiv Kumar Nov 2013

Health Promotions 2.0: The Future Of Wellness Programs In America, Rajiv Kumar

Center for Policy Research

In no small part because of technology, the way we live and work is being transformed. I believe that those of us who are interested in health policy can play an important role in guiding that transformation. I submit to you that unhealthy living is a social issue; that conditions such as obesity and diabetes are social diseases and that their prevalence is a social problem. If we have a social problem, then we need a social solution. I believe part of that solution can be found in the worksite health promotion and wellness programs that have taken root across …


Modeling Acute Respiratory Illness During The 2007 San Diego Wildland Fires Using A Coupled Emissions-Transport System And General Additive Modeling, Brian Thelen, Nancy H. F. French, Benjamin W. Koziol, Michael Billmire, Robert Chris Owen, Jeffrey Johnson, Michele Ginsberg, Tatiana Loboda, Shiliang Wu Nov 2013

Modeling Acute Respiratory Illness During The 2007 San Diego Wildland Fires Using A Coupled Emissions-Transport System And General Additive Modeling, Brian Thelen, Nancy H. F. French, Benjamin W. Koziol, Michael Billmire, Robert Chris Owen, Jeffrey Johnson, Michele Ginsberg, Tatiana Loboda, Shiliang Wu

Michigan Tech Research Institute Publications

Background

A study of the impacts on respiratory health of the 2007 wildland fires in and around San Diego County, California is presented. This study helps to address the impact of fire emissions on human health by modeling the exposure potential of proximate populations to atmospheric particulate matter (PM) from vegetation fires. Currently, there is no standard methodology to model and forecast the potential respiratory health effects of PM plumes from wildland fires, and in part this is due to a lack of methodology for rigorously relating the two. The contribution in this research specifically targets that absence by modeling …


Construction Workers' Crystalline Silica Exposure: Statistical Analysis Of A Literature-Based Database, Jean-François Sauvé, Charles Beaudry, Denis Bégin, Chantal Dion, Michel Gérin, Jérôme Lavoué Nov 2013

Construction Workers' Crystalline Silica Exposure: Statistical Analysis Of A Literature-Based Database, Jean-François Sauvé, Charles Beaudry, Denis Bégin, Chantal Dion, Michel Gérin, Jérôme Lavoué

Rapports de recherche scientifique

L’exposition prolongée par inhalation à des poussières de taille respirable contenant de la silice cristalline est reconnue pour causer des maladies respiratoires, dont le cancer du poumon et la silicose. De nombreuses études ont relevé la surexposition des travailleurs de la construction à la silice cristalline, puisque ce composé est présent dans de nombreux matériaux utilisés sur les chantiers. L’évaluation de l’exposition à la silice cristalline dans cette industrie constitue un défi en raison de la multitude de conditions de travail et de la nature temporaire des chantiers.

Dans le but d’améliorer les connaissances sur les conditions de travail pouvant …


Inverse Lichen Planus, Michael D Lee, Laurel R Schwartz Nov 2013

Inverse Lichen Planus, Michael D Lee, Laurel R Schwartz

Department of Dermatology and Cutaneous Biology Faculty Papers

A Case of Inverse Lichen Planus

Lichen planus (LP) is a pruritic, papular eruption characterized by its violaceous color and polygonal shape. It is most commonly found on the flexor surfaces of the upper extremities, on the genitalia, and on the mucous membranes. We herein report a classic case of LP in an inverse distribution.


Maternal Anaemia And Duration Of Zidovudine In Antiretroviral Regimens For Preventing Mother-To-Child Transmission: A Randomized Trial In Three African Countries, Benn K.D. Sartorius, Matthew F. Chersich, Mary Mwaura, Nicolas Meda, Marleen Temmerman, Marie Louise Newell, Timothy M. M. Farley, Stanley Luchters, The Kesho Bora Study Group Nov 2013

Maternal Anaemia And Duration Of Zidovudine In Antiretroviral Regimens For Preventing Mother-To-Child Transmission: A Randomized Trial In Three African Countries, Benn K.D. Sartorius, Matthew F. Chersich, Mary Mwaura, Nicolas Meda, Marleen Temmerman, Marie Louise Newell, Timothy M. M. Farley, Stanley Luchters, The Kesho Bora Study Group

Obstetrics and Gynaecology, East Africa

Background: Although substantiated by little evidence, concerns about zidovudine-related anaemia in pregnancy have influenced antiretroviral (ARV) regimen choice for preventing mother-to-child transmission of HIV-1, especially in settings where anaemia is common.

Methods: Eligible HIV-infected pregnant women in Burkina Faso, Kenya and South Africa were followed from 28 weeks of pregnancy until 12–24 months after delivery (n = 1070). Women with a CD4 count of 200-500cells/mm3 and gestational age 28–36 weeks were randomly assigned to zidovudine-containing triple-ARV prophylaxis continued during breastfeeding up to 6-months, or to zidovudine during pregnancy plus single-dose nevirapine (sd-NVP) at labour. Additionally, two cohorts were …


Males Show Improved Perspective-Taking Performance When Females Images Occupy Locations In The Spatial Array: Preliminary Evidence Consistent With Sexual Selection Of Spatial Skills?, Bradley R. Sturz, Karen Z. Naufel Nov 2013

Males Show Improved Perspective-Taking Performance When Females Images Occupy Locations In The Spatial Array: Preliminary Evidence Consistent With Sexual Selection Of Spatial Skills?, Bradley R. Sturz, Karen Z. Naufel

Psychology: Faculty Presentations (2009-2022)

One tenet of sexual selection theory posits that females select males on the basis of physical attributes because these attributes serve as indicators of fitness. Relatively recently, evolutionary psychologists have suggested that females also select males on the basis of cognitive attributes because such attributes also serve as indicators of fitness. Spatial abilities are hypothesized to be one such cognitive attribute, but evidence supporting this hypothesis is lacking. We tested this hypothesis by having human male participants engage in a perspective-taking task (imagine standing at object A, facing object B, point to object C). We manipulated the content of the …


Dental Hygienists' Knowledge Of Hiv, Attitudes Towards People With Hiv And Willingness To Conduct Rapid Hiv Testing, Anthony J. Santella, B Krishnamachari, Susan H. Davide, Marilyn Cortell, Winnie Furnari, B Watts, Sarah C. Hayden Nov 2013

Dental Hygienists' Knowledge Of Hiv, Attitudes Towards People With Hiv And Willingness To Conduct Rapid Hiv Testing, Anthony J. Santella, B Krishnamachari, Susan H. Davide, Marilyn Cortell, Winnie Furnari, B Watts, Sarah C. Hayden

Publications and Research

This study was aimed to determine the dental hygienists' knowledge of HIV, attitudes towards people living with HIV and willingness to conduct rapid HIV testing.


Job's Syndrome With An Atypical Presentation, Abbas Ali Tasneem, Sabahat Sarfaraz, Syed Mujahid Hassan, Nasir Hassan Luck, Sabiha Anis, Zaigham Abbas Nov 2013

Job's Syndrome With An Atypical Presentation, Abbas Ali Tasneem, Sabahat Sarfaraz, Syed Mujahid Hassan, Nasir Hassan Luck, Sabiha Anis, Zaigham Abbas

Section of Gastroenterology

Hyper Immunoglobulin E syndrome also called Job's or Buckley Syndrome is a rare primary immunodeficiency disease characterized by elevated serum IgE levels (> 2000 IU/ml), recurrent infections and eosinophilia. Other features include coarse facies and non-immunologic abnormalities of the dentition, bones, vasculature and connective tissues. We are reporting a case of a twenty four years old male with coarse facies who presented with severe pallor and upper gastrointestinal bleeding. Investigations revealed markedly elevated serum IgE levels (11,800 IU/ml), severe anaemia, esophageoduodenal erosions, Helicobacter pylori (H. pylori) gastritis and oro-esophageal candidiasis.


Multicenter Study Comparing Shunt Type In The Norwood Procedure For Single-Ventricle Lesions: Three-Dimensional Echocardiographic Analysis., Gerald R. Marx, Girish S. Shirali, Jami C. Levine, Lin T. Guey, James F. Cnota, Jeanne M. Baffa, William L. Border, Steve Colan, Gregory Ensing, Mark K. Friedberg, David J. Goldberg, Salim F. Idriss, J Blaine John, Wyman W. Lai, Minmin Lu, Shaji C. Menon, Richard G. Ohye, David Saudek, Pierre C. Wong, Gail D. Pearson, Pediatric Heart Network Investigators Nov 2013

Multicenter Study Comparing Shunt Type In The Norwood Procedure For Single-Ventricle Lesions: Three-Dimensional Echocardiographic Analysis., Gerald R. Marx, Girish S. Shirali, Jami C. Levine, Lin T. Guey, James F. Cnota, Jeanne M. Baffa, William L. Border, Steve Colan, Gregory Ensing, Mark K. Friedberg, David J. Goldberg, Salim F. Idriss, J Blaine John, Wyman W. Lai, Minmin Lu, Shaji C. Menon, Richard G. Ohye, David Saudek, Pierre C. Wong, Gail D. Pearson, Pediatric Heart Network Investigators

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: The Pediatric Heart Network's Single Ventricle Reconstruction (SVR) trial randomized infants with single right ventricles (RVs) undergoing a Norwood procedure to a modified Blalock-Taussig or RV-to-pulmonary artery shunt. This report compares RV parameters in the 2 groups using 3-dimensional echocardiography.

METHODS AND RESULTS: Three-dimensional echocardiography studies were obtained at 10 of 15 SVR centers. Of the 549 subjects, 314 underwent 3-dimensional echocardiography studies at 1 to 4 time points (pre-Norwood, post-Norwood, pre-stage II, and 14 months) for a total of 757 3-dimensional echocardiography studies. Of these, 565 (75%) were acceptable for analysis. RV volume, mass, mass:volume ratio, ejection fraction, …


Disruption Of Drosophila Melanogaster Lipid Metabolism Genes Causes Tissue Overgrowth Associated With Altered Developmental Signaling., Takeshi Sasamura, Kenji Matsuno, Mark E Fortini Nov 2013

Disruption Of Drosophila Melanogaster Lipid Metabolism Genes Causes Tissue Overgrowth Associated With Altered Developmental Signaling., Takeshi Sasamura, Kenji Matsuno, Mark E Fortini

Department of Biochemistry and Molecular Biology Faculty Papers

Developmental patterning requires the precise interplay of numerous intercellular signaling pathways to ensure that cells are properly specified during tissue formation and organogenesis. The spatiotemporal function of many developmental pathways is strongly influenced by the biosynthesis and intracellular trafficking of signaling components. Receptors and ligands must be trafficked to the cell surface where they interact, and their subsequent endocytic internalization and endosomal trafficking is critical for both signal propagation and its down-modulation. In a forward genetic screen for mutations that alter intracellular Notch receptor trafficking in Drosophila melanogaster, we recovered mutants that disrupt genes encoding serine palmitoyltransferase and acetyl-CoA carboxylase. …


Jfma Street Outreach: A Resident-Run Street Medicine Program A Retrospective Chart Review Examining The Needs Of A Vulnerable Population And Services Provided, Kenneth E. Hemba, Md, Rebecca Simon, Bs, Lara Carson Weinstein, Md Nov 2013

Jfma Street Outreach: A Resident-Run Street Medicine Program A Retrospective Chart Review Examining The Needs Of A Vulnerable Population And Services Provided, Kenneth E. Hemba, Md, Rebecca Simon, Bs, Lara Carson Weinstein, Md

Department of Family & Community Medicine Presentations and Grand Rounds

In Philadelphia it is estimated that over 12,000 people experience homelessness annually, and up to 500 individuals live on the street on any given day.1

Project HOME coordinates the City of Philadelphia’s outreach effort aimed at forming relationships with unsheltered individuals, identifying their barriers to entering permanent supportive housing and assisting them in overcoming these barriers.

Having identified this population’s need for medical services, in 2007 faculty in Jefferson Family Medicine Associates (JFMA) reached out to Project HOME and extended an ongoing community-academic partnership.

Since then Family Medicine residents and students have been traveling with the outreach team, meeting …


Cholera Vaccination Campaign Contributes To Improved Knowledge Regarding Cholera And Improved Practice Relevant To Waterborne Disease In Rural Haiti, Omowunmi Aibana, Molly F Franke, Jessica E Teng, Johanne Hilaire, Max Raymond, Louise C Ivers Nov 2013

Cholera Vaccination Campaign Contributes To Improved Knowledge Regarding Cholera And Improved Practice Relevant To Waterborne Disease In Rural Haiti, Omowunmi Aibana, Molly F Franke, Jessica E Teng, Johanne Hilaire, Max Raymond, Louise C Ivers

Faculty, Staff and Student Publications

BACKGROUND: Haiti's cholera epidemic has been devastating partly due to underlying weak infrastructure and limited clean water and sanitation. A comprehensive approach to cholera control is crucial, yet some have argued that oral cholera vaccination (OCV) might result in reduced hygiene practice among recipients. We evaluated the impact of an OCV campaign on knowledge and health practice in rural Haiti.

METHODOLOGY/PRINCIPAL FINDINGS: We administered baseline surveys on knowledge and practice relevant to cholera and waterborne disease to every 10th household during a census in rural Haiti in February 2012 (N = 811). An OCV campaign occurred from May-June 2012 after …


Case Series On Veno - Venous Extracorporeal Membrane Oxygenation (Vv-Ecmo) As A Bridge To Complete Recovery In Influenza Type A Related Refractory Ards, Renganaden Sooppan, Md, Nicholas C. Cavarocchi, Md, Harrsion Pitcher, Md, Qiong Yang, Md, Michael Baram, Md, Hitoshi Hirose, Md, Phd Nov 2013

Case Series On Veno - Venous Extracorporeal Membrane Oxygenation (Vv-Ecmo) As A Bridge To Complete Recovery In Influenza Type A Related Refractory Ards, Renganaden Sooppan, Md, Nicholas C. Cavarocchi, Md, Harrsion Pitcher, Md, Qiong Yang, Md, Michael Baram, Md, Hitoshi Hirose, Md, Phd

Department of Surgery Faculty Papers

Introduction:

Influenza A sequelae range from mild symptoms to acute respiratory distress syndrome (ARDS), which can be refractory to conventional ventilator therapy. We present a case series of three non-H1N1 Influenza patients with ARDS, who completely recovered after VV-ECMO.

Case Presentation:

In January and February 2013, we experienced three cases of Influenza A induced ARDS that failed conventional ARDS ventilator therapy. All three patients presented with typical flu-like symptoms, which deteriorated over several days, requiring intubation. They were all treated with oseltamivir. They had bilateral chest infiltrates on chest x-rays. After a few days of failing conventional treatment these patients …


Sternal Wound Infection Caused By Mycobacterium Chelonae., Shinya Unai, Joseph Miessau, Pawel Karbowski, Gurjyot Bajwa, Hitoshi Hirose Nov 2013

Sternal Wound Infection Caused By Mycobacterium Chelonae., Shinya Unai, Joseph Miessau, Pawel Karbowski, Gurjyot Bajwa, Hitoshi Hirose

Department of Surgery Faculty Papers

INTRODUCTION: Sternal wound infection caused by Mycobacterium chelonae, a member of the rapidly growing nontuberculous mycobacteria (NTM), is rare and may present without signs and symptoms of systemic infection.

METHODS: We present a patient who had a M. chelonae infection of the sternum following excision of a left atrial myxoma and conducted a review of the literature from 1976 to 2013.

RESULTS: Seventy cases of NTM sternal wound infection after cardiac surgery were identified, including six outbreaks and ten sporadic cases including the present case. Thirty-four cases were isolated coronary artery bypass grafting (CABG) surgery, 16 cases were isolated valve …


Attributed Meanings And Strategies To Prevent Challenging Behaviors Of Hospitalized Children With Autism: Two Perspectives, Norah L. Johnson, Abir K. Bekhet, Karen Marie Robinson, Dana Rodriguez Nov 2013

Attributed Meanings And Strategies To Prevent Challenging Behaviors Of Hospitalized Children With Autism: Two Perspectives, Norah L. Johnson, Abir K. Bekhet, Karen Marie Robinson, Dana Rodriguez

College of Nursing Faculty Research and Publications

Introduction

Understanding is limited of the meaning attributed to behaviors of children with autism spectrum disorder and strategies used to prevent challenging behaviors in the context of hospitalization.

Methods

This qualitative study consisted of two focus groups (n = 10; five mothers and five health care providers [HCPs]). Transcripts were analyzed using the qualitative method of narrative inquiry.

Results

The meaning attributed to behaviors by the mothers and the HCPs differed. The mothers attributed behaviors to the child's communication of frustration, hyperactivity, and self-calming. The HCPs attributed challenging behaviors to self-stimulation and child aggression. Strategies to prevent behaviors also …


Analyzing The Functions Of Human Polynucleotide Phosphorylase (Hpnpaseold-35), Upneet K. Sokhi Nov 2013

Analyzing The Functions Of Human Polynucleotide Phosphorylase (Hpnpaseold-35), Upneet K. Sokhi

Theses and Dissertations

RNA degradation plays a fundamental role in maintaining cellular homeostasis, along with being a part of normal regulatory mechanisms, whether it occurs as a surveillance mechanism eliminating aberrant mRNAs or during RNA processing to generate mature transcripts. 3’-5’ exoribonucleases are essential mediators of RNA decay pathways, and one such evolutionarily conserved enzyme is polynucleotide phosphorylase (PNPase). The human homologue of this fascinating enzymatic protein (hPNPaseold-35) was cloned a decade ago in the context of terminal differentiation and senescence through a novel ‘overlapping pathway screening’ approach. Since then, significant insights have been garnered about this exoribonuclease and its repertoire of expanding …


Intraosseous Vascular Access For Alert Patients, Stacie Hunsaker Nov 2013

Intraosseous Vascular Access For Alert Patients, Stacie Hunsaker

Faculty Publications

Nurses are often faced with the challenge of starting an IV line in a patient who is dehydrated, has suffered trauma, or is in shock. Even the efforts of the most skilled clinician may fail, while valuable time is lost. Intraosseous access is a rapid, safe, and effective route for delivering fluids and medications, and is recommended by numerous professional and specialty organizations for both pediatric and adult patients. Yet many clinicians remain unaware of the procedure. This article outlines the procedure and devices used, describes support for use in the literature, and discusses various considerations and nursing implications.


Preventing Maternal And Early Childhood Obesity: The Fetal Flaw In Australian Perinatal Care, Margaret R. Miller, Lydia A. Hearn, Paige Van Der Plight, Jane Willcox, Karen Campbell Nov 2013

Preventing Maternal And Early Childhood Obesity: The Fetal Flaw In Australian Perinatal Care, Margaret R. Miller, Lydia A. Hearn, Paige Van Der Plight, Jane Willcox, Karen Campbell

Research outputs 2013

Almost half of Australian women of child-bearing age are overweight or obese, with a rate of 30–50% reported in early pregnancy. Maternal adiposity is a costly challenge for Australian obstetric care, with associated serious maternal and neonatal complications. Excess gestational weight gain is an important predictor of offspring adiposity into adulthood and higher maternal weight later in life. Current public health and perinatal care approaches in Australia do not adequately address excess perinatal maternal weight or gestational weight gain. This paper argues that the failure of primary health-care providers to offer systematic advice and support regarding women’s weight and related …


Diagnosis, Treatment And Follow-Up In Four Children With Biotinidase Deficiency From Pakistan, Bushra Afroze, Mohammad Wasay Nov 2013

Diagnosis, Treatment And Follow-Up In Four Children With Biotinidase Deficiency From Pakistan, Bushra Afroze, Mohammad Wasay

Department of Medicine

Biotinidase deficiency is an inherited disorder in which the vitamin biotin is not recycled. If untreated, affected individuals develop neurological and cutaneous symptoms. Untreated individuals with biotinidase deficiency either succumb to disease or are left with significant morbidity. We describe clinical course and follow-up of 4 children from Pakistan. All 4 presented with classical symptoms of biotinidase deficiency and responded dramatically to oral biotin within days to weeks. Biotinidase deficiency is reported in Pakistani children from different part of world, however; there is no such report from Pakistan. This highlights lack of awareness of biotinidase deficiency among physicians in Pakistan