Medicine and Health Sciences Commons^™

Stress And Burdens In Parents Of Children Who Came To Child Psychiatric Clinic Of King Chulalongkorn Memorial Hospital, S Thongchit, U. Trangkasombat

Chulalongkorn Medical Journal

Background : It is widely accepted that parents of children with mental illness are vulnerable to stress. However, few studies have been conducted to identify the relationship between the stress level and the burden in parents of children who come to the Child Psychiatric Clinic. Understanding the stress and its related factors is important to help provide better resources and supports to parents. Objective : To determine the stress level, the relationship between stress and burdens and to study factors associate with the stress and burden levels. Design : A cross – sectional descriptive study. Setting : King Chulalongkorn Memorial …

The Validity And Reliability Of The Proactive Coping Inventory (Pci): Thai Version, O Tatha, P Laurujisawat, E. Greenglass

Chulalongkorn Medical Journal

Background : The Proactive Coping Inventory (PCI), a research instrument, which takes a multidimensional approach to and positive facet of coping that aims for self-regulatory goal attainment and personal growth rather than focuses on self-regulatory threat appraisal. At the moment, PCI has not been officially developed into Thai version. Objective : To develop and test the validity and reliability of The Proactive Coping Inventory: Thai Version for use as a multidimensional research instrument in Thai society. Design : The translation of psychometric instrument with validity and reliability assessment. Setting : Chulalongkorn University Materials and Methods : Subjects were 308 Chulalongkorn …

คำขอบคุณ, N/A

Chulalongkorn Medical Journal

No abstract provided.

ดรรชนีผู้แต่งจุฬาลงกรณ์เวชสาร 2013, N/A

Chulalongkorn Medical Journal

No abstract provided.

ดรรชนีบทความจุฬาลงกรณ์เวชสาร 2013, N/A

Chulalongkorn Medical Journal

No abstract provided.

Insulin Responsiveness In Metabolic Syndrome After Eight Weeks Of Cycle Training, Charles A. Stuart, Mark A. South, Michelle L. Lee, Melanie P. Mccurry, Mary E. A. Howell, Michael W. Ramsey, Michael H. Stone

ETSU Faculty Works

Introduction Insulin resistance in obesity is decreased after successful diet and exercise. Aerobic exercise training alone was evaluated as an intervention in subjects with the metabolic syndrome.

Methods Eighteen nondiabetic, sedentary subjects, 11 with the metabolic syndrome, participated in 8 wk of increasing intensity stationary cycle training.

Results Cycle training without weight loss did not change insulin resistance in metabolic syndrome subjects or sedentary control subjects. Maximal oxygen consumption (V˙O2max), activated muscle AMP-dependent kinase, and muscle mitochondrial marker ATP synthase all increased. Strength, lean body mass, and fat mass did not change. The activated mammalian target of rapamycin was not …

Psychosocial Experiences Of Women With Vesicovaginal Fistula: A Qualitative Approach., Farah Naz Farid, Maimoona Azhar, Sunil Sadruddin Samnani, Saleema Allana, Angeela Naz, Farzana Bohar, Shershah Syed

Department of Surgery Docs

Abstract

Vesicovaginal fistula (VVF) is a condition associated with a number of physical and psychological consequences. In order to gain a deeper understanding of the issues faced by women diagnosed with VVF, a qualitative exploratory study was carried out to explore the experiences of women suffering from VVF. The study included 8 women hospitalized with the diagnosis of vesicovaginal fistula at Kohi Goth Women's Hospital, Karachi, Pakistan. Semi structured interviews of each participant were conducted, recorded, and transcribed. Five major themes were identified, among which all of the participants experienced physical discomforts, psychological disturbances, issues with social and interpersonal relationships …

Suprachiasmatic Astrocytes Modulate The Circadian Clock In Response To Tnf-Α, José M. Duhart, María Juliana Leone, Natalia Paladino, Jennifer A. Evans, Oscar Castanon-Cervantes, Alec J. Davidson, Diego A. Golombek

Biomedical Sciences Faculty Research and Publications

The immune and the circadian systems interact in a bidirectional fashion. The master circadian oscillator, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, responds to peripheral and local immune stimuli, such as proinflammatory cytokines and bacterial endotoxin. Astrocytes exert several immune functions in the CNS, and there is growing evidence that points toward a role of these cells in the regulation of circadian rhythms. The aim of this work was to assess the response of SCN astrocytes to immune stimuli, particularly to the proinflammatory cytokine TNF-α. TNF-α applied to cultures of SCN astrocytes from Per2^luc knockin mice altered …

Oral Branched-Chain Amino Acid Supplements That Reduce Brain Serotonin During Exercise In Rats Also Lower Brain Catecholamines, Sujean Choi, Briana Disilvio, Madelyn H. Fernstrom, John D. Fernstrom

Biomedical Sciences Faculty Research and Publications

Exercise raises brain serotonin release and is postulated to cause fatigue in athletes; ingestion of branched-chain amino acids (BCAA), by competitively inhibiting tryptophan transport into brain, lowers brain tryptophan uptake and serotonin synthesis and release in rats, and reputedly in humans prevents exercise-induced increases in serotonin and fatigue. This latter effect in humans is disputed. But BCAA also competitively inhibit tyrosine uptake into brain, and thus catecholamine synthesis and release. Since increasing brain catecholamines enhances physical performance, BCAA ingestion could lower catecholamines, reduce performance and thus negate any serotonin-linked benefit. We therefore examined in rats whether BCAA would reduce both …

Unique Microbial Communities Persist In Individual Cystic Fibrosis Patients Throughout A Clinical Exacerbation, Katherine E. Price, Thomas H. Hampton, Alex H. Gifford, Emily L. Dolben, Deborah A. Hogan, Hilary G. Morrison, Mitchell L. Sogin, George A. O’Tooled

Dartmouth Scholarship

Cystic fibrosis (CF) is caused by inherited mutations in the cystic fibrosis transmembrane conductance regulator gene and results in a lung environment that is highly conducive to polymicrobial infection. Over a lifetime, decreasing bacterial diversity and the presence of Pseudomonas aeruginosa in the lung are correlated with worsening lung disease. However, to date, no change in community diversity, overall microbial load or individual microbes has been shown to correlate with the onset of an acute exacerbation in CF patients. We followed 17 adult CF patients throughout the course of clinical exacerbation, treatment and recovery, using deep sequencing and quantitative PCR …

Design And Configuration Of Laser Tweezers Microscopy For Force Measurements On Single Dna Molecules, Carlos Jeziel Gonzalez Banuelos

Theses and Dissertations - UTB/UTPA

In this study, a detailed description of the optical tweezers microscopy technique is presented, as well as the methodologies used to prepare the DNA molecule for mechanical measurements at the nanoscale. The main objective is to initiate and extend the experimental biophysical studies on the DNA-proteins interactions at the University of Texas at Brownsville (UTB). DNA-binding proteins control almost all aspects of cellular function, such as transcription; chromosome maintenance, replication and DNA repair depend on the interaction of proteins with DNA. In view of such an important role played by DNA–protein interactions, various techniques have evolved over the years to …

Harnessing Poverty Alleviation To Reduce The Stigma Of Hiv In Sub-Saharan Africa, Alexander C. Tsai, David Bangsberg, Sheri D. Weiser

OHSU-PSU School of Public Health Faculty Publications and Presentations

HIV is highly stigmatized throughout sub-Saharan Africa. In studies conducted among general population samples, stigma has been shown to impede uptake of HIV testing and increase sexual risktaking behavior. Among HIV-infected persons, stigma has also been associated with inhibited serostatus disclosure to sexual partners and potential treatment supporters, delays in HIV antiretroviral therapy (ART) initiation, and ART nonadherence. The stigma of HIV also intensifies the poverty, stress, and insecurity endemic to many resource-limited settings, resulting in worsened mental health, itself an important determinant of AIDS-related mortality. Until we can better understand how to effectively intervene to reduce the stigma of …

Factors Associated With Pruritic Papular Eruption Of Human Immunodeficiency Virus Infection In The Antiretroviral Therapy Era, S. L. Chua, E. H. Amerson, K. S. Leslie, T. H. Mccalmont, P. E. Leboit, J. N. Martin, David Bangsberg, T. A. Maurer

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background—Pruritic papular eruption (PPE) of HIV is common in HIV-infected populations living in the tropics. Its aetiology has been attributed to insect bite reactions and it is reported to improve with antiretroviral therapy (ART). Its presence after at least 6 months of ART has been proposed as one of several markers of treatment failure.

Objectives—To determine factors associated with PPE in HIV-infected persons receiving ART.

Methods—A case–control study nested within a 500-person cohort from a teaching hospital in Mbarara, Uganda. Forty-five cases and 90 controls were enrolled. Cases had received ART for ≥ 15 months and had an itchy papular …

1,000 Miles Next Door: Lessons Learned And Next Steps, Margaret A. Hadinger Edd, Ms, Jennifer D. Mccormick Mba, J Alan Otsuki Md, Mba

Department of Education

No abstract provided.

Select Readiness: Results Of A Comprehensive Assessment Of The Clinical Learning Environment Of A Branch Medical Campus, Margaret A. Hadinger Edd, Ms, Hubert K. Huang Ms, Med, Erica T. Mahady Ma, Jody Millard Ma, Edward R. Norris Md, Fapa, Fapm, J Alan Otsuki Md, Mba

Department of Education

No abstract provided.

1,000 Miles Next Door: The Development Of A Branch Medical Campus, Margaret A. Hadinger Edd, Ms, Jennifer D. Mccormick Mba, J Alan Otsuki Md, Mba

Department of Education

No abstract provided.

Sensing Charges Of The Ciona Intestinalis Voltage-Sensing Phosphatase, Carlos A. Villalba-Galea, Ludivine Frezza, Walter Sandtner, Francisco Bezanilla

School of Pharmacy Faculty Articles

Voltage control over enzymatic activity in voltage-sensitive phosphatases (VSPs) is conferred by a voltage-sensing domain (VSD) located in the N terminus. These VSDs are constituted by four putative transmembrane segments (S1 to S4) resembling those found in voltage-gated ion channels. The putative fourth segment (S4) of the VSD contains positive residues that likely function as voltage-sensing elements. To study in detail how these residues sense the plasma membrane potential, we have focused on five arginines in the S4 segment of the Ciona intestinalis VSP (Ci-VSP). After implementing a histidine scan, here we show that four arginine-to-histidine mutants, namely R223H to …

A Transformative Experience For Occupational Therapy Students In A Simulated Learning Environment, Kitsum Li, Barbara Mccamish

Collected Faculty Scholarship

Simulation is being integrated into nursing and medical curriculum nationally and it is well integrated into the Nursing program at Dominican University of California, However, use of simulation in allied health professionals is only an emerging practice. The aim of this program is to integrate simulation into the OT curriculum in order to facilitate the development of therapy foundation skill.

Personality Disorders And Health Problems Distinguish Suicide Attempters From Completers In A Direct Comparison, Lucas Giner, Hilario Blasco-Fontecilla, M. Mercedes Perez-Rodriguez, Rebeca Garcia-Nieto, Jose Giner, Julio A. Guija, Antonio Rico, Enrique Barrero, Maria Angeles Luna, Jose De Leon, Maria A. Oquendo, Enrique Baca-Garcia

Psychiatry Faculty Publications

Background

Whether suicide attempters and completers represent the same population evaluated at different points along a progression towards suicide death, overlapping populations, or completely different populations is a problem still unresolved.

Methods

446 Adult suicide attempters and knowledgeable collateral informants for 190 adult suicide probands were interviewed. Sociodemographic and clinical data was collected for both groups using semi-structured interviews and structured assessments. Univariate analyses and logistic regression models were conducted to explore the similarities and differences between suicide attempters and completers.

Results

Univariate analyses yielded significant differences in sociodemographics, recent life events, impulsivity, suicide intent, and distribution of Axis I …

Nfkb Disrupts Tissue Polarity In 3d By Preventing Integration Of Microenvironmental Signals, Sabine Becker-Weimann, Gaofeng Xiong, Saori Furuta, Ju Han, Irene Kuhn, Uri-David Akavia, Dana Pe'er, Mina J. Bissell, Ren Xu

Markey Cancer Center Faculty Publications

The microenvironment of cells controls their phenotype, and thereby the architecture of the emerging multicellular structure or tissue. We have reported more than a dozen microenvironmental factors whose signaling must be integrated in order to effect an organized, functional tissue morphology. However, the factors that prevent integration of signaling pathways that merge form and function are still largely unknown. We have identified nuclear factor kappa B (NFkB) as a transcriptional regulator that disrupts important microenvironmental cues necessary for tissue organization. We compared the gene expression of organized and disorganized epithelial cells of the HMT-3522 breast cancer progression series: the non-malignant …

In Vitro Manual Therapy And Biorobotic Simulation Of Glenohumeral Joint Mobilization Techniques, Hunter Johnson Smith

Theses and Dissertations (ETD)

Physical therapists (PT) employ mobilization techniques for restoring range of motion to joints. Few studies have attempted to quantify the biomechanics of manual therapy on the glenohumeral (GH) joint. The objectives of this study were to develop an in vitro protocol to determine the biomechanical effects of joint mobilization on the GH joint, and to then simulate these mobilizations in the University of Tennessee Health Science Center (UTHSC) Joint Implant Biomechanics Laboratory’s Robotic Testing Platform (RTP).

The GH joint is an incredibly shallow socket joint. This gives the joint an unusually large range of motion (ROM) compared to other ball …

The Biology And Taxonomy Of Head And Body Lice: Implications For Louse-Borne Disease Prevention, Denise L. Bonilla, Lance A. Durden, Marina E. Eremeeva, Gregory A. Dasch

Harold W. Manter Laboratory of Parasitology: Library Materials

Sucking lice (Phthiraptera: Anoplura) are obligate blood-feeding ectoparasites of placental mammals including humans. Worldwide, more than 550 species have been described and many are specific to a particular host species of mammal. Three taxa uniquely parasitize humans: the head louse, body louse, and crab (pubic) louse. The body louse, in particular, has epidemiological importance because it is a vector of the causative agents of three important human diseases: epidemic typhus, trench fever, and louse-borne relapsing fever. Since the advent of antibiotics and more effective body louse control measures in the 1940s, these diseases have markedly diminished in incidence. However, due …

Journal Club: Role Of Endoscopic Third Ventriculostomy And Ventriculoperitoneal Shunt In Idiopathic Normal Pressure Hydrocephalus: Preliminary Results Of A Randomized Clinical Trial., George M. Ghobrial, Md, Michael J. Lang, Md

Department of Neurosurgery Faculty Papers

1. Significance/Context and Importance of the Study:

Idiopathic normal pressure hydrocephalus (INPH) was first defined by Hakim and colleagues in 1965¹, and its symptoms later classified by the clinical triad of gait dysfunction, urinary incontinence, and dementia. The exact pathophysiology of this disease is not well understood.² Surgical options for the treatment of INPH are ventriculoperitoneal shunt (VPS) placement (most commonly with a programmable valve), and endoscopic third ventriculostomy (ETV). VPS is by far the most common method used to treat INPH worldwide. Debate exists as to the superiority between the two management options. Historically, VPS placement …

Controversies In Dermatology: Part V., Ronni Wolf, Lawrence Parish

Department of Dermatology and Cutaneous Biology Faculty Papers

“It were not best that we should all think alike; it is difference of opinion that makes horse-races” Mark Twain (Samuel L. Clemens) in The Tragedy of Pudd’nead Wilson, Ch. 19, “Pudd’nead Wilson’s Calendar”.

Part V of Controversies in Dermatology continues the precedent of earlier issues by providing a platform for discussion of a broad range of contemporary and controversial issues. In this issue of Clinics in Dermatology, we will forego the temptation to expose hidden agendas and witches brews, rather, we shall focus on accepted beliefs, principles, doctrines, and paradigms, which you may find even more astonishing.

Barrier-Repair Prescription Moisturizers: Do We Really Need Them? Facts And Controversies., Ronni Wolf, Lawrence Parish

Department of Dermatology and Cutaneous Biology Faculty Papers

There is now scientific evidence of genetically driven skin-barrier anomalies in atopic patients. These barrier anomalies facilitate sustained antigen ingress through the defective barrier, which can bring about a Th2-dominant response. It enhances the transepidermal water loss, resulting in dry skin and leading to the release of preformed proinflammatory cytokines and to a cascade of events ending up in inflammation.

Clinical Phenotypes And Abcc6 Gene Mutations In Brazilian Families With Pseudoxanthoma Elasticum., Caroline Silvério Faria, Qiaoli Li, Haitao Guo, Jouni Uitto, Sylvia Satomi Takeno, Marilia De Arruda Cardoso Smith, Dertia Villalba Freire-Maia

Department of Dermatology and Cutaneous Biology Faculty Papers

Pseudoxanthoma elasticum (PXE; OMIM 264800) manifests with characteristic skin lesions of yellowish papules which coalesce into plaques of inelastic and leathery skin on the predilection sites (1). The ocular findings consist of angioid streaks, choroidal neovascularization and subretinal hemorrhages resulting in loss of visual acuity and occasional blindness. Cardiovascular problems include hypertension, intermittent claudication, and occasional myocardial infarcts and stroke. The prevalence of PXE is estimated to be in the range of 1:50,000-70,000 and to be more frequent in females than in males. The diagnosis can be challenging to clinicians due to late-onset of clinical manifestations and considerable heterogeneity. PXE …

Phenotypic Parameters Predict Time To Normalization In Infants With Hypogammaglobulinemia., Robert C. Van Winkle, Walter W. Hauck, Stephen J. Mcgeady

Department of Pediatrics Faculty Papers

PURPOSE: Infants with recurrent infection may be found to have hypogammaglobulinemia without impaired specific antibody responses. Many will be diagnosed with transient hypogammaglobulinemia of infancy.

METHODS: This study used a parametric survival analysis of 100 infants with hypogammaglobulinemia to predict time to normalization.

RESULTS: Aggregate initial immunoglobulins (IgG + IgA + IgM), as a percentage of age-adjusted normal, predicted time to resolution: median time to resolution for the infants in the lowest quartile of aggregate levels (≤81 % of age-adjusted lower limits) was greater than 5 years, with 34 % resolving in 3 years. For infants in the highest quartile …

Neuropathy, Neuropathic Pain, And Sickle Cell Disease., Samir K. Ballas, Deepika S Darbari

Cardeza Foundation for Hematologic Research

No abstract provided.

Time-Dependence Of Risperidone And Asenapine Sensitization And Associated D2 Receptor Mechanism, Jun Gao, Ming Li

Department of Psychology: Faculty Publications

When an antipsychotic drug is given repeatedly and intermittently, there is often a long-term increase in its behavioral efficacy, termed antipsychotic sensitization. With the passage of time, the magnitude of antipsychotic sensitization may increase or decrease depending on the principle of Time-Dependent Sensitization (TDS) or memory decay, respectively. In the present study, we examined the time-dependent feature and possible dopamine D₂ receptor mechanism of sensitization induced by the antipsychotics risperidone and asenapine in the conditioned avoidance response test. Well-trained male adult Sprague-Dawley rats were first repeatedly treated with risperidone (1.0 mg/kg) or asenapine (0.2 mg/kg) and tested for avoidance …

Lifestyle, Dietary Factors, And Antibody Levels To Oral Bacteria In Cancer-Free Participants Of A European Cohort Study, Dominique S. Michaud, Jacques Izard, Zachary Rubin, Ingegerd Johansson, Elisabete Weiderpass, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Laure Dossus, Rudolf Kaaks, Verena A. Katzke, Heiner Boeing, Jana Foerster, Antonia Trichopoulou, Androniki Naska, Giana Ziara, Paolo Vineis, Sara Grioni, Domenico Palli, Rosario Tumino, Amalia Mattiello, Petra Hm Peeters, Peter D. Siersema, Aurelio Barricarte, José-María Huerta, Esther Molina-Montes, Miren Dorronsoro, J. Ramón Quirós, Eric J. Duell, Bodil Ohlsson, Bengt Jeppsson, Anders Johansson, Pernilla Lif, Kay-Tee Khaw, Nick Wareham, Ruth C. Travis, Tim J. Key, Heinz Freisling, Talita Duarte-Salles, Magdalena Stepien, Elio Riboli, H. Bas Bueno-De- Mesquita

Department of Food Science and Technology: Faculty Publications

Background: Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria.

Methods: Data on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot …