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2013

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Articles 7381 - 7410 of 7930

Full-Text Articles in Medicine and Health Sciences

The Role Of Gadd45b In Hippocampus-Dependent Cognition, Synaptic Plasticity And Activity-Associated Transcriptional Dynamics, Faraz Sultan Jan 2013

The Role Of Gadd45b In Hippocampus-Dependent Cognition, Synaptic Plasticity And Activity-Associated Transcriptional Dynamics, Faraz Sultan

All ETDs from UAB

An expanding body of literature argues for a pivotal role of molecular epigenetic mechanisms in memory. Defined as mechanisms that regulate gene expression in the absence of DNA sequence modifications, these regulate various stages of memory-associated transcription. These phenomena are present at diverse anatomical subregions of the central nervous system (CNS) and regulate corresponding behaviors. Epigenetic mechanisms comprise a unique category of behavioral and physiological modulators because of their potential to modify the cellular phenotype in a stable manner. Hence, epigenetics offers a novel potential solution to a central paradox in memory retention: the finding that most putative molecular substrates …

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The Role Of O-Glcnacylation In Synaptic Function, Erica Wynette Taylor Jan 2013

The Role Of O-Glcnacylation In Synaptic Function, Erica Wynette Taylor

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O-GlcNAcylation is a dynamic protein posttranslational modification that adds the monosaccharide ß-N-acetylglucosamine (GlcNAc) to specific serine and threonine residues on nucleocytoplasmic proteins. The hippocampus is a part of brain that has been shown to play a crucial role in learning and memory. Hippocampal neurons have high expression of O-GlcNAc transferase and O-GlcNAcase, which catalyze the addition and removal of GlcNAc from proteins respectively. Moreover, synaptic plasticity which is the strengthening or weakening of synaptic function on short- and long-term time scales is believed to be a cellular correlate of learning and memory. Several forms of synaptic plasticity have been characterized …

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Understanding The Predictors Of Patient Trust And Its Role In Utilization And Outcomes, Sheikilya Lewis Thomas Jan 2013

Understanding The Predictors Of Patient Trust And Its Role In Utilization And Outcomes, Sheikilya Lewis Thomas

All ETDs from UAB

The purpose of this dissertation is to examine patient-related factors that predict trust in one's physician, and subsequently identify the role of patient trust in health care utilization and clinical outcomes among African Americans with hypertension. Three separate studies are conducted using an adapted version of the Interaction Model for Client Health Behavior (IMCHB). The first paper is a three-step review of quantitative studies investigating the (a) patient characteristics that influence trust; (b) impact of trust on health care utilization; and (c) impact of trust on outcomes. Based on the predictors identified, the second study examines the significance of these …

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An Investigation Of Trem-Like Transcript 2 Expression, Kimberly Anne Thomas Jan 2013

An Investigation Of Trem-Like Transcript 2 Expression, Kimberly Anne Thomas

All ETDs from UAB

Acute inflammation is a necessary component for the clearance of pathogens. Cells at the site of infection utilize highly conserved receptors to both recognize microbes and induce the production of pro-inflammatory stimuli. These stimuli set off a chain reaction that includes localized vasodilation, leukocyte infiltration, and tissue destruction, collectively known as inflammation. Tightly controlled, this process is protective, and can compartmentalize the damage to a defined area, but when dysregulated can be catastrophic, inducing chronic inflammation and even death. Families of innate receptors can modulate inflammatory processes, and in doing so, increase or decrease their severity, as well as tailor …

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Influence Of Implant Angulation On The Fracture Resistance Of Zirconia Abutments, Shreedevi Thulasidas Jan 2013

Influence Of Implant Angulation On The Fracture Resistance Of Zirconia Abutments, Shreedevi Thulasidas

All ETDs from UAB

Zirconia-based implant abutments are widely used in prosthetic dentistry. Custom made abutments are utilized to correct for non-ideal implant positions and can successfully accommodate the morphologic requirements of the overlying crown. It was hypothesized that there will be difference in fracture strength and fracture mode of artificially aged zirconia implant abutments supported by implants at varying angulation, when load is applied to failure on overlying zirconia crowns. The implant-abutment-crown assemblies were subjected to steam autoclaving to induce some degree of phase transformation from tetragonal to weaker monoclinic form and to thermo-cycling to artificially age the samples. The effects of loading …

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Role Of Kca3.1, A Calcium-Activated Potassium Channel, In Cell Migration In The Adult Brain, Kathryn L. Turner Jan 2013

Role Of Kca3.1, A Calcium-Activated Potassium Channel, In Cell Migration In The Adult Brain, Kathryn L. Turner

All ETDs from UAB

A limited amount of migration occurs in the adult brain, including migration of neuroblasts during adult neurogenesis and pathological migration of primary brain tumors. Ion channels are commonly utilized during migration to allow shape and volume changes required for cell movement, and we specifically examine the role of KCa3.1 in the adult brain. These channels are well-suited to facilitate movement because they respond to common migration signals, i.e. intracellular Ca2+ changes, and efflux K+, allowing the outflow of water and cell volume regulation. Our findings suggest that KCa3.1 is highly expressed in migratory cells, adult neuroblasts and glioma cells, but …

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Neutropenia And Progenitor Cell Mobilization In Ap3-B1 Mutant Pearl Mice, Matthew Vallejo Jan 2013

Neutropenia And Progenitor Cell Mobilization In Ap3-B1 Mutant Pearl Mice, Matthew Vallejo

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Mutations in the AP3-ß1 gene are known to cause Hermansky-Pudlak syndrome type 2 (HPS2) in humans and canine cyclic hematopoiesis (CH) in gray collie dogs. HPS2 patients have severe congenital neutropenia (SCN), and dogs have cyclic neutropenia (CN). The mechanism behind neutropenia is uncertain. Pearl mice have an AP3-ß1 mutation, but whether they actually have neutropenia has not yet been evaluated. This dissertation presents a discussion of the evaluation of neutropenia in pearl mice, hematopoietic progenitor cell mobilization defect in pearl mice and finally an evaluation of methods of dog-to-mouse xenotransplantation to establish a xenotransplant model of the dog hematopoietic …

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The Effects Of Nicotine On The Human Adult Visual Pathway And Processing, Stefanie B. Varghese Jan 2013

The Effects Of Nicotine On The Human Adult Visual Pathway And Processing, Stefanie B. Varghese

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Nicotine, the primary addictive component found in tobacco/cigarettes, can bind to nicotinic acetylcholine receptors (nAChR), which are found throughout the central nervous system including the retina of the eye. Previous studies have shown nAChR expression in the retina of non-human and human (Hutchins & Hollyfield, 1985; Liu et al., 2009). By use of electrophysiologic measures, i.e. electroretinograms (ERGs), early reports indicated that nicotine and/or cigarette smoking affects vision and visual processing in different species (Jurklies, Kaelin-Lang, & Niemeyer, 1996; Jünemann & Damaske, 1968). Because previous human studies have used only cigarette smokers, there are questions about what role nicotine, itself, …

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Intrinsic Properties Of Rna Polymerase I And Trans-Acting Factors Control Transcription Elongation Efficiency, Olga V. Viktorovskaya Jan 2013

Intrinsic Properties Of Rna Polymerase I And Trans-Acting Factors Control Transcription Elongation Efficiency, Olga V. Viktorovskaya

All ETDs from UAB

Transcription of ribosomal (r) DNA by RNA polymerase I (Pol I) is the initial step of ribosome synthesis. Pol I transcription is unique in its high rate of initiation, specific organization within the nucleolus and tight connection to cell growth and proliferation. Moreover, transcription elongation by Pol I is functionally coupled with rRNA processing and assembly of the ribosomes. Regulatory insights into transcription elongation by Pol I and its interface with rRNA processing are limited, despite decades of research. To fulfill that gap, we asked several important questions: Do the obvious functional divergences between Pol I and other eukaryotic polymerases …

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Association Between Cruciferous Vegetable Intake And Risk Of Colorectal Cancer Among Men In Shanghai, China, Emily Vogtmann Jan 2013

Association Between Cruciferous Vegetable Intake And Risk Of Colorectal Cancer Among Men In Shanghai, China, Emily Vogtmann

All ETDs from UAB

Colorectal cancer (CRC) is a major global health concern and the intake of certain foods, such as cruciferous vegetables, has been studied for their potential protective effects against cancer development. The observed association between cruciferous vegetable consumption and CRC has been inconsistent, possibly related to glutathione S-transferase (GST) gene polymorphisms. Therefore, we aimed to (1) evaluate the association between fruits and vegetables, including cruciferous vegetables, on the risk of CRC; (2) determine factors associated with urinary isothiocyanate (ITC), a biomarker of cruciferous vegetable intake; and (3) evaluate the association between cruciferous vegetable consumption and CRC and to estimate the potential …

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Gender Norms, Sexual And Reproductive Behaviors And Acceptability Of Male Circumcision Among Men In Western Jamaica, Melonie Walcott Jan 2013

Gender Norms, Sexual And Reproductive Behaviors And Acceptability Of Male Circumcision Among Men In Western Jamaica, Melonie Walcott

All ETDs from UAB

This dissertation consists of three papers designed to assess the association between gender norms and men's sexual behaviors, reproductive practices, and acceptability of male circumcision (MC). The data for this study were obtained from a cross-sectional, interviewer-administered questionnaire survey of 549 men aged 19-54 years, conducted in the western region of Jamaica between June to August 2011. In the first paper we found increased odds of reporting multiple sex partners among men with moderate (AOR =2.2; 95% CI=1.4 - 3.5) and high (AOR = 4.4; 95% CI =2.2 - 8.8) support for inequitable gender norms. Similarly, men with moderate (AOR= …

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The Role Of Pneumococcal Choline-Binding Protein A (Pcpa) In The Mechanism Of Virulence And Protective Immunity, Melissa Marie Walker Jan 2013

The Role Of Pneumococcal Choline-Binding Protein A (Pcpa) In The Mechanism Of Virulence And Protective Immunity, Melissa Marie Walker

All ETDs from UAB

pcpA is under control of the Mn 2-dependent repressor PsaR. In the high manganese environment of mucosal sites pcpA gene expression is repressed and at the low manganese environment of the lung and blood derepression of pcpA gene expressionis observed. Previous data has shown that immunization of mice with rPcpA elicits protection against pneumonia and sepsis but had no effect on nasal colonization. We and others have shown that pcpA expression significantly enhances adherence of pneumococci to lung epithelial cell lines and although it is a virulence factor for pneumonia in mice there is no biologically relevant role for PcpA …

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Glioma-Vasculature Interactions, Stacey Watkins Jan 2013

Glioma-Vasculature Interactions, Stacey Watkins

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Malignant gliomas are highly invasive brain tumors, which lack effective treatment options. To date, the standard therapy includes surgical debulking followed by chemotherapy and radiation. Despite efforts to eradicate the disease, the median patient survival time is only 14 months. In an attempt to discover novel therapies, research has focused on understanding the heterogeneous biological mechanisms employed by these cells. Uniquely, they do not metastasize through the vasculature or lymphatics like other solid cancers but alternatively, glioma cells utilize the abluminal surface of the vasculature to guide invasion and migration throughout the brain. The intimate association between glioma cells and …

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The Relationship Of Religiosity, Spirituality And High-Risk, Tommie Lee Watkins Jan 2013

The Relationship Of Religiosity, Spirituality And High-Risk, Tommie Lee Watkins

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Religion and spirituality are important concepts for many Black MSM. While many social factors may be associated with the increasing disparity of HIV infection among Black MSM, high levels of religiosity and spirituality prevalent in Black culture may be correlated with high risk behavior among Black MSM and may help explain this population's increasing incidence of HIV infection. Research supports a relationship between religiosity, spirituality, and high risk behavior among populations. Some research has suggested that religiosity and spirituality among Black MSM may be correlated but are multifaceted constructs. Conclusions suggest that among Black MSM these constructs account for certain …

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Effect Of A Faith-Based Initiative On Hospital Readmissions, Joseph Webb Jan 2013

Effect Of A Faith-Based Initiative On Hospital Readmissions, Joseph Webb

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EFFECT OF A FAITH-BASED INITIATIVE ON HOSPITAL READMISSIONS JOSEPH WEBB ADMINISTRATION-HEALTH SERVICES ABSTRACT The purpose of this study was to examine the relationship between a faith-based initiative and hospital readmissions. The main data source used was the inpatient data-base of Methodist LeBonheur Healthcare System (MLH) in Memphis, TN. Data were collected from admissions that occurred during years 2008 through 2012 at four of MLH's five adult acute-care hospitals. Data from the U.S. Census Bureau's American Community Survey were also used in the study. This study uses theoretical tenets from the Social Justice and Equity Theory and the Chronic Care Model …

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Anti-Group B Streptococci Monoclonal Antibodies Protect Against Invasive Aspergillosis, Rebekah Wharton Jan 2013

Anti-Group B Streptococci Monoclonal Antibodies Protect Against Invasive Aspergillosis, Rebekah Wharton

All ETDs from UAB

Aspergillus fumigatus is a ubiquitous saprophytic fungus which can potentially cause life-threatening infections in immunocompromised individuals. Although a serious threat, current treatments are largely ineffective at reducing morbidity and mortality. To this end, we have characterized a monoclonal antibody generated against Group B Streptococci, type Ib, which also recognizes Aspergillus fumigatus conidia and hyphae. We show that this antibody appears to bind a similar epitope on both pathogens and provides a significant degree of protection in a murine model of invasive aspergillosis via a mechanism that appears to be dependent on complement. The studies we performed using this antibody should …

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Blood Pressure And Tobacco Exposure Among Rural Adolescents Ages 15-18, Luz Huntington-Moskos Jan 2013

Blood Pressure And Tobacco Exposure Among Rural Adolescents Ages 15-18, Luz Huntington-Moskos

All ETDs from UAB

High blood pressure is a prevalent precursor to cardiovascular disease. An estimated 3% of US adolescents have hypertension. In addition, prehypertension is predictive of hypertension in adolescents, with progression between these stages at approximately 7% per year. Tobacco use/exposure is strongly linked to cardiovascular risk and disease in adults. Further, rural communities have higher tobacco use prevalence and fewer community policies restricting tobacco use. Little is known about the effects of tobacco exposure on blood pressure and the mediating effects of inflammation (salivary C-reactive protein (CRP)) in rural adolescents. The purpose of this study is to determine the relationships between …

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Genetic And Biochemical Characterizations Of The Capsular Glycosyltransferases In Streptococcus Pneumoniae Serotype 2, David Boyd Anthony James Jan 2013

Genetic And Biochemical Characterizations Of The Capsular Glycosyltransferases In Streptococcus Pneumoniae Serotype 2, David Boyd Anthony James

All ETDs from UAB

The principle objective of this dissertation is to develop a thorough understanding of the genetics and biochemistry of capsule synthesis. Specifically, it involves the identification and characterization of the capsular glycosyltransferases in Streptococcus pneumoniae serotype 2, with investigations into their regulation. S. pneumoniae (the pneumococcus) is a significant human pathogen that has the ability to persist as a commensal and then transition to a virulent state, the latter of which is a major contributor to global morbidity and mortality. The capsular polysaccharide (CPS) of S. pneumoniae is a protective surface structure that plays an integral role in this disease process. …

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Intracellular Quantitation And Pharmacokinetic Modeling Of Nucleoside Analogs In The Female Genital Tract, Amanda Marie James Jan 2013

Intracellular Quantitation And Pharmacokinetic Modeling Of Nucleoside Analogs In The Female Genital Tract, Amanda Marie James

All ETDs from UAB

Human Immunodeficiency Virus (HIV) is one of the leading infectious diseases in the world. In spite of substantial progress in the advancement of antiretroviral therapy for HIV treatment, new infections outpace the number of infected persons initiating ART. Therefore, the prevention of HIV remains a crucial health issue. Pre-Exposure Prophylaxis, (PrEP), which involves using one or more antiretroviral agents to reduce the risk of HIV infection prior to potential exposure, has shown effectiveness at reducing HIV transmission in study volunteers with different sexual orientation around the world. The clinical pharmacology of antiretroviral drugs, specifically tenofovir (TFV) and emtricitabine (FTC), in …

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Marcks Is A Regulator Of Growth, Radiation Sensitivity And Is A Novel Prognostic Factor For Glioblastoma Multiforme, John Jarboe Jan 2013

Marcks Is A Regulator Of Growth, Radiation Sensitivity And Is A Novel Prognostic Factor For Glioblastoma Multiforme, John Jarboe

All ETDs from UAB

Glioblastoma multiforme (GBM) is the most common and deadly primary brain malignancy necessitating improved understanding of GBM biology. In this study, we explore the role of Myristoylated Alanine Rich C-Kinase Substrate (MARCKS) in the context of GBM. We have discovered that the MARCKS protein regulates GBM growth as well as response to radiation therapy through its effects on proliferation, senescence, and DNA repair based on our studies in cell culture and in patient-derived xenograft tumors implanted in mice. Importantly, our analysis of clinical patient data demonstrates that MARCKS is an independent predictor for outcome in GBM patients. Indeed, high MARCKS …

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Usp49 And H2b Deubiquitination In Chromatin And Cellular Function, Amanda E. Jones Jan 2013

Usp49 And H2b Deubiquitination In Chromatin And Cellular Function, Amanda E. Jones

All ETDs from UAB

Histones are globular proteins which help package and organize DNA in the eukaryotic nucleus. The four core histones, H2A, H2B, H3 and H4, combine with approximately 146 base pairs of DNA to form a nucleosome, the fundamental unit of chromatin. Post-translational modifications to the C-terminal and N-terminal histone tails regulate chromatin structure and function, and play important roles in transcriptional regulation, replication, DNA damage response, and mRNA processing. Histone H2B ubiquitination is an evolutionarily conserved modification with roles in gene expression and DNA damage repair. In addition, H2B ubiquitination may also regulate mRNA splicing. Here, we identify USP49, a cysteine …

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Bonds And Contact Angles Produced With Surface Alterations To Lithium Disilicate, Vamsi Krishna Kalavacharla Jan 2013

Bonds And Contact Angles Produced With Surface Alterations To Lithium Disilicate, Vamsi Krishna Kalavacharla

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The success of ceramic restorations depends upon factors like the composite resin cement, the adhesive, cementation procedure and the substrate. With the introduction of newer ceramic and adhesive systems the factors that contribute to the most durable bond strength remains unclear. The objective of the study was to measure 24 hour and thermocycled shear bond strength of a composite to lithium disilicate glass ceramic with a universal single bottle adhesive. A combination of surface treatments of hydrofluoric acid, silane, salivary contamination and subsequent cleaning were also evaluated. Blocks of lithium disilicate (e.max CAD) were sectioned, polished with a rotational polishing …

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The Effect Of An Intensive Oral Hygiene Regimen On Gingival Inflammation During Pregnancy: Clinical And Laboratory Analysis, Maninder Kaur Jan 2013

The Effect Of An Intensive Oral Hygiene Regimen On Gingival Inflammation During Pregnancy: Clinical And Laboratory Analysis, Maninder Kaur

All ETDs from UAB

Background: Recent evidence suggests that systemic inflammation as host immune response to oral microbial challenge may well underlie the observed association between periodontal disease and preterm birth/low birth weight (PTB/LBW). The aim of this pilot study was to evaluate the effect of vigorous oral hygiene regimen on gingival inflammation and gingival crevicular fluid (GCF)/serum biomarkers (TNF-&alpha, IL-1&beta and IL-6) during pregnancy and its impact on pregnancy outcome. Methods: 120 participants with pregnancy between 16-24 weeks gestation and with gingival index (GI) scores &ge 2 at &ge 50 % of tooth sites were recruited from the available pool of patients at …

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The Role Of Histone Deacetylase Inhibitors In Ameliorating Memory Dysfunction Of An Alzheimer's Disease Mouse Model, Mark Kilgore Jan 2013

The Role Of Histone Deacetylase Inhibitors In Ameliorating Memory Dysfunction Of An Alzheimer's Disease Mouse Model, Mark Kilgore

All ETDs from UAB

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid beta plaques and neurofibrillary tangles, along with cognitive impairments that progress to dementia and eventually death. The development of drug treatments that rescue memory deficits could be a promising therapy given in the early stages of AD. In the following studies, we tested the potential for systemic treatment with histone deacetylase (HDAC) inhibitors to ameliorate cognitive deficits in a mouse model of AD. Using the APPSwe/PS1dE9 mouse model of AD, we showed that giving HDAC inhibitors systemically for 3 weeks reversed contextual memory deficits, stably maintained memories over a 2-week …

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The Impact Of Weight Status On The Adoption Of Self-Care Behaviors Among Heart Failure Patients, Bern'nadette Knight Jan 2013

The Impact Of Weight Status On The Adoption Of Self-Care Behaviors Among Heart Failure Patients, Bern'nadette Knight

All ETDs from UAB

Self-care is a major component of heart failure management. Excess weight is a disease that may negatively affect a patient's ability to effectively practice self-care. The project aimed to assess 1) the relationship between weight status and heart failure self-care behaviors and 2) the modification of the relationship between social support and heart failure self-care by weight status. This cross sectional study utilized baseline data from a cohort of African-American and Caucasian participants diagnosed with heart failure. The heart failure cohort was formed from three larger studies (n=690) designed to assess the relationships among social support, self-care behaviors and hospital …

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Hard On Your Heart: A Qualitative Description Of Adolescent Prenatal Stress, Candace Clayton Knight Jan 2013

Hard On Your Heart: A Qualitative Description Of Adolescent Prenatal Stress, Candace Clayton Knight

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Introduction: Pregnancy during adolescence is potentially stressful due to the concurrent tasks of navigating the typically tumultuous adolescent stage of development and the life altering experience of pregnancy (Kaye, 2008). There is a growing body of research linking prenatal stress to poor birth and developmental outcomes such as premature birth and low birth weight infants (K. Keenan, Sheffield, & Boeldt, 2007; Mulder et al., 2002), which makes describing the relatively unexplored perceptions and experience of stress during adolescent pregnancy important. The life course framework, with its emphasis on social, environmental, and family risk factors, has implications for reducing disparities among …

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Virus-Induced Inflammation And Central Nervous System Development, Kate Kosmac Jan 2013

Virus-Induced Inflammation And Central Nervous System Development, Kate Kosmac

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Congenital human cytomegalovirus (HCMV) infection is a complex cause of central nervous system (CNS) disease. Infection with HCMV during pregnancy results in virus transmission across the placenta and infection of the fetus. With a seroconversion rate in pregnant women between 1% and 4%, HCMV is the most frequently transmitted virus from mother to developing child. Each year between 2,000 and 4,000 infants will suffer from long-term neurologic deficits as a result of congenital infection. The well documented CNS sequelae resulting from congenital HCMV infection have described a wide range of damage without a specific set of pathologic markers for disease. …

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Regional In Vitro Retention Of Fiber Posts, Shayma Kyson Jan 2013

Regional In Vitro Retention Of Fiber Posts, Shayma Kyson

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The overall objective of this in vitro study was to determine the biomechanical retention along fiber post interfaces to root canal dentin of four different fiber posts systems combined with five different resin cements (total-etch, self-etch and self adhesive systems) tested within different regions of dentin (cervical, middle and apical levels) and the core material alone. Scanning electron microscopy (SEMs) was used to evaluate the failure characteristics of the systems for root canal dentin and core material interfaces. Roots of freshly extracted first mandibular premolars, without caries, cracks or defects were selected. Radiographs made from mesiodistal and buccolingual directions were …

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In Vitro Wear Of Nine Cements Against Enamel, Mohamad Kyson Jan 2013

In Vitro Wear Of Nine Cements Against Enamel, Mohamad Kyson

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The objective of this study was to measure and compare in vitro wear resistance of nine cements against human enamel cusps in glycerol media using UAB second generation wear machine (hit and slide). Six cements were dual cured polymer-based cements; total-etch: Variolink II (Ivoclar Vivadent), self-etch: Multilink Automix (Ivoclar Vivadent) and self-adhesives: Maxcem Elite (Kerr), RelyX Unicem 2 (3m ESPE), PANAVIA SA (Kuraray) and G-CEM LinkAce (GC America). Three cements were water-based chemical cured cements; Zinc-phosphate: Harvard Cement (Harvard) and resin modified glass ionomers cements: RelyX Luting Plus (3M ESPE) and GC FujiCEM 2 (GC America). Samples were scanned after …

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Cyclic Gmp Phosphodiesterase As A Novel Target For Colorectal Cancer Chemoprevention, Nan Li Jan 2013

Cyclic Gmp Phosphodiesterase As A Novel Target For Colorectal Cancer Chemoprevention, Nan Li

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Nonsteroidal anti-inflammatory drugs (NSAIDs) display promising antineoplastic activity for colorectal and other cancers, but toxicity from cyclooxygenase (COX) inhibition limits their long-term use for chemoprevention. However, many investigators have concluded that COX-independent mechanisms are responsible for their antineoplastic activity. We previously reported that cyclic guanosine monophosphate phosphodiesterase (cGMP PDE) is a non-COX target of sulindac sulfide (SS). However, the specific isozyme families involved have not been well studied. Here we demonstrate that SS inhibits the growth of colon tumor cells through a novel mechanism involving inhibition of two cGMP degrading isozymes, PDE5 and PDE10, to activate cGMP-dependent protein kinase (PKG). …

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