Medicine and Health Sciences Commons^™

Characterization Of Stimulation-Induced Volume Changes In The Ca1 Region Of Rat Hippocampus Slices, Amanda Brooke Gutwein

Browse all Theses and Dissertations

Intrinsic optical signals (IOS) were used to evaluate volume regulation mechanisms during Schaffer collateral stimulation-induced volume changes in hippocampal slices. The effects of stimulation frequency, synaptic function, ionotropic glutamate receptor (iGluR) activation, glutamate uptake, and volume regulatory anion channels (VRAC) were examined with IOS. Data were analyzed using ANOVA with Dunnett's post hoc test (p<0.05 indicated significance). IOS changes were stimulation frequency dependent between 1 Hz and 10 Hz with full recovery of IOS within 5 min. Synaptic blockage reduced the rate of swelling by 81% compared to the control and the IOS did not fully recover. Recovery rate was reduced with iGluR inhibition. Inhibition of glutamate uptake reduced the rate of swelling by 70% compared to vehicle controls. During stimulation, action potentials, iGluR activation, and glutamate uptake contribute to swelling. Regulatory volume mechanisms during stimulation were glutamate-mediated via iGluRs and VRAC independent.

Does Fall Risk Education Tailored By Motivation Increase Fall Risk Identification And Fall Prevention Behaviors In Community-Dwelling Older Adults When Compared To Fall Risk Education Tailored By Authenticity?, Jonathan William Alonso, Brittnee Jane Witham, Cournety Brooke Mcintosh, Kitsum Li

Occupational Therapy | Critically Appraised Papers Series

To determine whether multimedia fall prevention education using different instructional strategies increases older adults’ ability to identify fall risks and implement fall prevention behaviors into their daily activities.

Are Physical, Cognitive, And Perceptual Exercises Effective At Improving Abilities Associated With Driving (Such As Behavioral Speed, Visual Attention, Psychomotor Performance, Speed Of Perception, And Executive Functioning) In Older Adults Compared To A Control Group Of Older Adults Not Participating In An Exercise Group?, Caitlin Danae Mcintyre, Regina Okun, Josue Julian Zamora, Kitsum Li

Occupational Therapy | Critically Appraised Papers Series

To study the effect of a specific exercise program on changes in performance in the areas of behavioral speed, visual attention, psychomotor performance, speed of perception, and executive functioning in older adult drivers.

Driving Characteristics Of Teens With Attention Deficit Hyperactivity And Autism Spectrum Disorder, Sherrilene Classen, Miriam Monahan, Yanning Wang

Collected Faculty Scholarship

Vehicle crashes are a leading cause of death among teens. Teens with attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), or both (ADHD–ASD) may have a greater crash risk. We examined the between-groups demographic, clinical, and predriving performance differences of 22 teens with ADHD– ASD (mean age 5 15.05, standard deviation [SD] 5 0.95) and 22 healthy control (HC) teens (mean age 5 14.32, SD 5 0.72). Compared with HC teens, the teens with ADHD–ASD performed more poorly on righteye visual acuity, selective attention, visual–motor integration, cognition, and motor performance and made more errors on the driving simulator pertaining …

Does Dance-Based Therapy Improve Balance And Mobility In Older Adults?, Emily Ann Dodge, Florina Mendoza-Battle, Tanya Elesia Orgill, Kitsum Li

Occupational Therapy | Critically Appraised Papers Series

This study explores the effects of dance-based therapy on balance and mobility in older adults living in an AIP facility.

For Community-Dwelling Older Adults With Functional Limitations, Does An Occupational Therapy Home Modification Intervention Program That Includes The Provision Of Adaptive Equipment And/Or Architectural Renovations To The Home Help Improve Occupational Performance And Satisfaction With The Ability To Perform Everyday Activities?, Sarah Jane Dequis Calub, Matthew Jordan Carlson, Monica Fernandez, Kitsum Li

Occupational Therapy | Critically Appraised Papers Series

Determine the effect of an occupational therapy home modification intervention program on occupational performance and self-reported levels of satisfaction of occupational performance.

Cost Effective Improvement In The Protocol For Detection Of Haemoglobin Variants –A Step Forward In Quality Assurance, Natasha Ali, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

Background: We report the results of a cost effective improvement in the protocol for detection of haemoglobin variants which incorporates the findings of peripheral blood film along with the results of HPLC.
Findings: A total of n = 10,844 samples were received from January 2011 till August 2011. Diagnosis of haemoglobinopathy was made in n = 1123 samples while other abnormalities included iron deficiency anaemia, megaloblastic anaemia, malarial parasite, autoimmune haemolytic anaemia and G6PD deficiency (n = 2473).
Conclusion: We diagnosed 23% of abnormalities other than haemoglobinopathy by reviewing peripheral smear of samples received for detection of …

Mixed Salmonella Infection: A Case Series From Pakistan, Binish Arif Sultan, Naima Fasih, Saba Qaiser, Erum Khan, Afia Zafar, Seema Irfan

Department of Pathology and Laboratory Medicine

Enteric fever remains a major health problem in the developing world, including Pakistan. Poor sanitation and hygienic conditions are the major predisposing factors. Salmonella infection with different strains in the same patient has rarely been reported previously. We are reporting two cases of bacteraemia with simultaneous detection of two strains of Salmonella in a single episode of infection. In both the cases, 2 different serotypes of Salmonella were causing bacteraemia leading to fever. In highly endemic area, one must be aware of mixed Salmonella infections as inappropriate diagnosis of such infections may lead to treatment failure.

Clinicopathological Spectrum Of Ovarian Sex Cord-Stromal Tumors; 20years' Retrospective Study In A Developing Country, Saroona Haroon, Aleena Zia, Romana Idrees, Aisha Memon, Saira Fatima, Naila Kayani

Department of Pathology and Laboratory Medicine

Background:
Ovarian sex cord stromal tumors are rare neoplasms as compared to epithelial tumors. No large study has been done in Pakistan to find out the frequencies of various sex cord stromal tumors and their clinicopathological behavior in our region. The purpose of our study was to determine the various histological patterns and clinical features of ovarian sex cord stromal tumors along with follow-up in our set-up.
Methods:
It is a retrospective observational study. The study was conducted in section of Histopathology, Aga Khan University Hospital, Karachi, Pakistan. All reported cases of sex cord stromal tumors of ovary during 1992 …

Frequency And Outcome Of Graft Versus Host Disease After Stem Cell Transplantation: A Six-Year Experience From A Tertiary Care Center In Pakistan, Natasha Ali, Salman Naseem Adil, Mohammad Usman Shaikh, Nehal Masood

Department of Pathology and Laboratory Medicine

Objective: The objective of this study was to evaluate the frequency and outcome of graft versus host disease after stem cell transplantation for various haematological disorders in Pakistan.
Materials and Methods: Pretransplant workup of the patient and donor was performed. Mobilization was done with G-CSF 300 mu g twice daily for five day. Standard GvHD prophylaxis was done with methotrexate 15mg/m(2) on day +1 followed by 10mg/m(2) on days +3 and +6 and cyclosporine. Grading was done according to the Glucksberg classification.
Results: A total of 153 transplants were done from April 2004 to December 2011. Out of these were …

Identification Of Non-Tuberculous Mycobacteria Isolated From Clinical Specimens At A Tertiary Care Hospital: A Cross-Sectional Study, Imran Ahmed, Kauser Jabeen, Rumina Hasan

Department of Pathology and Laboratory Medicine

Background:
Non-tuberculous mycobacteria (NTM) are opportunistic pathogens in immuno-compromised patients. They are also increasingly recognized as pathogens in immuno-competent individuals. Globally, an increase in NTM isolation is being reported with a varied geographic prevalence of different species around the world. There is lack of data on species distribution of these organisms from Pakistan. Treatment options differ according to the species isolated and its susceptibility profile. Knowledge of local species variation would help targeted therapy. This study was performed to determine frequencies of different NTM species isolated from various clinical specimens submitted at a tertiary care hospital laboratory.
Methods:
NTM isolated …

Overview Of Benign And Malignant Prostatic Disease In Pakistani Patients: A Clinical And Histopathological Perspective, Huma Arshad, Zubair Ahmad

Department of Pathology and Laboratory Medicine

Background: To present the overall clinical and histological perspective of benign and malignant prostatic disease as seen in our practice in the Section of Histopathology, Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi, Pakistan.
Materials and Methods: All consecutive prostate specimens (transurethral resection or TUR, enucleation, needle biopsies) received between July 1, 2012 and December 31, 2012 were included in the study.
Results: Of the total of 785 cases, 621 (79.1%) were TUR specimens, 80 (10.2%) enucleation specimens, and 84 (10.7%) needle biopsies. Some 595 (75.8%) were benign, while 190 (24.2%) were malignant. Mean weight of BPH specimens …

Peripheral T-Cell Lymphoma Presenting As Testicular Mass; A Diagnostic Challenge, Saroona Haroon, Arsalan Ahmed

Department of Pathology and Laboratory Medicine

Background: T-cell lymphomas involve the testis infrequently, which deserve special attention because of the poor prognosis and the need to make an appropriate diagnosis, which could lead to a better therapeutic strategy.
Case Presentation: A 40-year-old man presented with right testicular swelling for past three months. The swelling was painless, hard and rubbery. Testicular ultrasound showed diffuse increase in size of the testicle, with alteration in its echogenicity. The patient underwent orchidectomy, and based on histopathological and immunohistochemical tests, a peripheral T-cell lymphoma, not otherwise specified was diagnosed.
Conclusion: Testicular peripheral T-cell lymphomas are rare and aggressive cancers, with clinical …

Prevalence Of Drug Resistance Associated Mutations In Plasmodium Vivax Against Sulphadoxine-Pyrimethamine In Southern Pakistan, Afsheen Raza, Najia K. Ghanchi, Muhammad Shahzeb Khan, Mohammad Asim Beg

Department of Pathology and Laboratory Medicine

Background: In Pakistan, Plasmodium vivax and Plasmodium falciparum co-exist and usage of sulphadoxine-pyrimethamine (SP) against P. falciparum exposes P. vivax to the drug leading to generation of resistant alleles. The main aim of this study was to investigate frequency distribution of drug resistance associated mutations in pvdhfr, pvdhps genes and provide baseline molecular epidemiological data on SP-associated resistance in P. vivax from southern Pakistan.
Methods: From January 2008 to May 2009, a total of 150 samples were collected from patients tested slide-positive for P. vivax, at the Aga Khan University Hospital, Karachi, or its collection units located in Baluchistan and …

The Lived Experiences Of Transition To Adult Healthcare In Young Adults With Cerebral Palsy, Ellen Mclaughlin Carroll

Dissertations, Theses, and Capstone Projects

Background: Health Care Transition (HCT) describes the purposeful, planned movement of adolescents from child to adult-orientated care. The purpose of this phenomenological study is to uncover the meaning of transition to adult centered care as experienced by Young Adults with Cerebral Palsy (YA-CP) through the research question: What are the lived experiences of young adults with cerebral palsy transitioning from pediatric to adult healthcare?

Method: 6 females and 3 males, aged 19 -25 years of age, who identified as carrying the diagnosis of cerebral palsy without cognitive impairment were interviewed. Giorgi's (1985) method for analysis of phenomenology was the framework …

Hypertension Knowledge, Expectation Of Care, Social Support, And Adherence To Prescribed Medications Of African Americans With Hypertension Framed By The Roy Adaptation Model, Andrea Maria Grant

Dissertations, Theses, and Capstone Projects

Hypertension (HTN) prevalence in African Americans contribute to higher rates of disabilities and deaths from stroke, myocardial infarction, and end stage renal disease than all other racial groups in the United States. The major reason documented for these poor health outcomes is related to lower HTN control rates among African Americans compared to other racial/ethnic groups. Though overall HTN awareness, pharmacological treatments and control have significantly improved for all populations, studies found that rates of HTN control and adherence with anti-hypertensive medications are lower for African Americans compared to other subgroups.

Study Aims

The primary aim was to determine whether …

Reconciling Life Balance: A Grounded Theory Study Of Overcoming Failure, Kathleen Karsten

Dissertations, Theses, and Capstone Projects

Academic failure has been described as endemic in nursing education. Although, associate degree nursing programs graduate the largest number of nurses each year, the on-time graduation rate is 59%. Every semester students fail nursing courses and are required to successfully repeat the course before they can progress in the nursing program. Students who re-take a failed course are often called "repeaters." This qualitative Grounded Theory research explored the process of overcoming failure and becoming a successful student repeater. This emergent mode grounded theory study applied qualitative analysis techniques to prospectively verify and refine this emergent concept by delineating dimensions embedded …

Becoming Someone Different: A Grounded Theory Study Of How Nurses Integrate Pregnancy And Full Time Employment, Paul Gregory Quinn

Dissertations, Theses, and Capstone Projects

In the United States, 40% of the contemporary nursing workforce is comprised of women of childbearing age, 65% of whom are employed full-time. Hence, the likelihood of pregnancy occurring for this population at some point in their employment is high. A holistic exploration of how nurses integrate pregnancy and full-time employment has been lacking. The purpose of this research was to explore how primiparous nurses managed pregnancy and full-time employment. Using a grounded theory approach, nurses who were pregnant and delivered their first baby, while employed full-time on 12-hour work shifts, provided a firsthand account of how they incorporated pregnancy …

2013-2014 Nursing Undergraduate Student Handbook, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2013-2014 Undergraduate Student Handbook of the Department of Nursing at Morehead State University.

Inhibitory Effect Of Matrine On Blood-Brain Barrier Disruption For The Treatment Of Experimental Autoimmune Encephalomyelitis., Su Zhang, Quan-Cheng Kan, Yuming Xu, Guang-Xian Zhang, Lin Zhu

Department of Neurology Faculty Papers

Dysfunction of the blood-brain barrier (BBB) is a primary characteristic of experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been recently found to suppress clinical EAE and CNS inflammation. However, whether this effect of MAT is through protecting the integrity and function of the BBB is not known. In the present study, we show that MAT treatment had a therapeutic effect comparable to dexamethasone (DEX) in EAE rats, with reduced Evans Blue extravasation, increased expression of collagen IV, the major component of the basement …

Achieving Meaningful Medical Student Evaluations Through A Clinical Encounter Card, Liborio Larussa Md, Kris Rooney Md

Department of Pediatrics

No abstract provided.

The Need Of Paediatric Dentistry Specialists In Pakistan, Farhan Raza Khan, Sadia Mahmud, Munawar Rahman

Section of Dental-Oral Maxillofacial Surgery

In the last decade, a rapid increase has been observed in the number of dentists due to establishment of a number of dental colleges in Pakistan. Very few of these institutions have Paediatric Dentistry Department. Similarly, no postgraduate Paediatric Dentistry training program exists in the two major provinces of the country. The objectives of this study were to map the pattern of paediatric dentistry services provided by the clinicians in teaching institutions and private practices. A cross-sectional study was conducted at dental departments of academic institutions and selected dental practices in Karachi. There was a statistically significant difference in preferences, …

Lamotrigine Augmentation Of Serotonin Reuptake Inhibitors In Severe And Long-Term Treatment-Resistant Obsessive-Compulsive Disorder, Manuel Arrojo-Romero, María Tajes Alonso, Jose De Leon

Psychiatry Faculty Publications

The treatment recommendations in obsessive-compulsive disorder (OCD) after lack of response to selective serotonin reuptake inhibitors (SSRIs) include augmentation with other drugs, particularly clomipramine, a more potent serotonin reuptake inhibitor (SRI), or antipsychotics. We present two cases of response to lamotrigine augmentation in treatment-refractory OCD; each received multiple SRI trials over a >10-year period. The first patient had eleven years of treatment with multiple combinations including clomipramine and SSRIs. She had a >50% decrease of Y-BOCS (from 29 to 14) by augmenting paroxetine (60 mg/day) with lamotrigine (100 mg/day). The second patient had 22 years of treatment with multiple combinations, …

Malnutrition In Sickle Cell Anemia: Implications For Infection, Growth And Maturation, Hyacinth I. Hyacinth, Oluwatoyosi A. Adekeye, Christopher S. Yilgwan

Journal of Social, Behavioral, and Health Sciences

Sickle cell anemia (SCA) is a genetic disease that affects mostly individuals of African and/or Hispanic descent, with the majority of cases in sub-Saharan Africa. Individuals with this disease show slowed growth, delayed sexual maturity, and poor immunologic function. These complications could partly be explained by the state of undernutrition associated with the disease. Proposed mechanism of undernutrition include protein hypermetabolism, decreased dietary intake possibly from interleukin-6-related appetite suppression, increased cardiac energy demand/expenditure, and increased red cell turnover. All the above mechanisms manifest as increased resting energy expenditure. Nutritional intervention utilizing single or multiple nutrient supplementation has led to improved …

Stroop Interference In A Delayed Match-To-Sample Task: Evidence For Semantic Competition, Bradley R. Sturz, Marshall Lee Green, Lawrence Locker Jr., Ty W. Boyer

Psychology: Faculty Publications

Discussions of the source of the Stroop interference effect continue to pervade the literature. Semantic competition posits that interference results from competing semantic activation of word and color dimensions of the stimulus prior to response selection. Response competition posits that interference results from competing responses for articulating the word dimension vs. the color dimension at the time of response selection. We embedded Stroop stimuli into a delayed match-to-sample (DMTS) task in an attempt to test semantic and response competition accounts of the interference effect. Participants viewed a sample color word in black or colored fonts that were ongruent or incongruent …

Vowel Production In Mandarin Accented English And American English: Kinematic And Acoustic Data From The Marquette University Mandarin Accented English Corpus, An Ji, Jeffrey J. Berry, Michael T. Johnson

Speech Pathology and Audiology Faculty Research and Publications

Few electromagnetic articulography (EMA) datasets are publicly available, and none have focused systematically on non-native accented speech. We introduce a kinematic-acoustic database of speech from 40 (gender and dialect balanced) participants producing upper-Midwestern American English (AE) L1 or Mandarin Accented English (MAE) L2 (Beijing or Shanghai dialect base). The Marquette University EMA-MAE corpus will be released publicly to help advance research in areas such as pronunciation modeling, acoustic-articulatory inversion, L1-L2 comparisons, pronunciation error detection, and accent modification training. EMA data were collected at a 400 Hz sampling rate with synchronous audio using the NDI Wave System. Articulatory sensors were placed …

Speech Sensorimotor Learning Through A Virtual Vocal Tract, Jeffrey J. Berry, Cassandra North, Benjamin Meyers, Michael T. Johnson

Speech Pathology and Audiology Faculty Research and Publications

Studies of speech sensorimotor learning often manipulate auditory feedback by modifying isolated acoustic parameters such as formant frequency or fundamental frequency using near real-time resynthesis of a participant's speech. An alternative approach is to engage a participant in a total remapping of the sensorimotor working space using a virtual vocal tract. To support this approach for studying speech sensorimotor learning we have developed a system to control an articulatory synthesizer using electromagnetic articulography data. Articulator movement data from the NDI Wave System are streamed to a Maeda articulatory synthesizer. The resulting synthesized speech provides auditory feedback to the participant. This …

Digestibility And Ige-Binding Of Glycosylated Codfish Parvalbumin, Harmen H. J. De Jongh, Carlos López Robles, Eefjan Timmerman, Julie A. Nordlee, Poi-Wah Lee, Joseph L. Baumert, Robert G. Hamilton, Steve L. Taylor, Stef J. Koppelman

Department of Food Science and Technology: Faculty Publications

Food-processing conditions may alter the allergenicity of food proteins by different means. In this study, the effect of the glycosylation as a result of thermal treatment on the digestibility and IgE-binding of codfish parvalbumin is investigated. Native and glycosylated parvalbumins were digested with pepsin at various conditions relevant for the gastrointestinal tract. Intact proteins and peptides were analysed for apparent molecular weight and IgE-binding. Glycosylation did not substantially affect the digestion. Although the peptides resulting from digestion were relatively large (3 and 4 kDa), the IgE-binding was strongly diminished. However, the glycosylated parvalbumin had a strong propensity to form dimers …

Neisseria Oralis Sp. Nov., Isolated From Healthy Gingival Plaque And Clinical Samples, William J. Wolfgang, Teresa V. Passaretti, Reashma Jose, Jocelyn Cole, An Coorevits, Andrea N. Carpenter, Sherly Jose, Anita Van Landschoot, Jacques Izard, Donna J. Kohlerschmidt, Peter Vandamme, Floyd E. Dewhirst, Mark A. Fisher, Kimberlee A. Musser

Department of Food Science and Technology: Faculty Publications

A polyphasic analysis was undertaken of seven independent isolates of gram-negative cocci collected from pathological clinical samples from New York, Louisiana, Florida, and Illinois and healthy subgingival plaque from a patient in Virginia, USA. The 16S rRNA gene sequence similarity among these isolates was 99.7–100 %, and the closest species with a validly published name was Neisseria lactamica (96.9 % similarity to the type strain). DNA–DNA hybridization confirmed that these isolates are of the same species and are distinct from their nearest phylogenetic neighbor, N. lactamica. Phylogenetic analysis of 16S and 23S rRNA gene sequences indicated that the …

Warning Signal: Unaware Of An In Absentia Conviction, South African Cancer Specialist Jailed On Return To The United Arab Emirates., Philip R Cohen, Razelle Kurzrock, Lawrence Parish

Department of Dermatology and Cutaneous Biology Faculty Papers

In 2002, Dr. Cyril Karabus, a specialist in pediatric cancers and retired head of the Oncology and Hematology Unit of Red Cross Children's Hospital in Capetown, South Africa, spent a brief locum at Sheikh Khalifa Medical City, a hospital in Abu Dhabi in the United Arab Emirates (UAE). He was there for only 5 weeks, during which time he treated a young girl who died of acute myeloblastic leukemia. After Karabus returned home, the girl's father complained to police about his daughter's death, and Karabus was convicted of murder in absentia. Karabus knew nothing of the charges or of the …