Medicine and Health Sciences Commons^™

Aerodynamics And Dysphagia, Mariam Baig

ETD Archive

This study investigated the influence of aerodynamic measures of Maximum Phonation Time (MPT) and the S/Z ratio on swallowing. Twelve individuals were examined, six with a diagnosis of dysphagia, and six as a control group. The study hypothesized that (1) there would be a reduced MPT in the dysphagic group compared to the control (2) there would be an S/Z ratio greater than 1.0 in the dysphagic group. The rationale for this study was that since MPT and S/Z measures are easily administered, they may prove to be useful, non-invasive, inexpensive tools to predict a patient's potential risk for aspiration. …

The Impact Of The Criminalization Of Hiv Non-Disclosure On The Health And Human Rights Of “Black” Communities, Ciann L. Wilson

Psychology Faculty Publications

The criminalization of HIV non-disclosure has become a hot topic for discussion and debate amongst human rights advocates, HIV/AIDS service providers, and people infected and affected by HIV/AIDS. This paper explores the inherent problems with HIV non-disclosure laws. These laws are ambiguous and pose a serious threat to public health policy and programming by obstructing the fundamental human rights of people infected and affected by HIV/AIDS. Using a human rights framework, this paper explores the impact of non-disclosure laws on the health and rights of African, Caribbean, and Black-Canadian communities and proposes ways to address the shortcomings of HIV non-disclosure …

Everyday Confrontation Of Discrimination: The Well-Being Costs And Benefits To Women Over Time., Mindi D. Foster

Psychology Faculty Publications

Taking action against discrimination has positive consequences for well-being (e.g., Cocking & Drury, 2004) but most of this research has focused on collective actions and has used methodologies assessing one point in time. This study therefore used a diary methodology to examine how women’s everyday confrontations of discrimination would affect measures of subjective and psychological well-being, and how these relationships would change over time. In a 28-day online diary study, women indicated their daily experience of discrimination, described their response, and completed measures of well-being. Results showed that at the beginning of the study, using indirect confrontation predicted greater well-being …

How Do Interviewers And Children Discuss Individual Occurrences Of Alleged Repeated Abuse In Forensic Interviews?, Sonja P. Brubacher, Lindsay C. Malloy, Michael E. Lamb, Kim Roberts

Psychology Faculty Publications

Police interviews (n = 97) with 5- to 13-year-olds alleging multiple incidents of sexual abuse were examined to determine how interviewers elicited and children recounted specific instances of abuse. Coders assessed the labels for individual occurrences that arose in interviews, recording who generated them, how they were used, and other devices to aid particularisation such as the use of episodic and generic language. Interviewers used significantly more temporal labels than did children. With age, children were more likely to generate labels themselves, but most children generated at least one label. In 66% of the cases, interviewers ignored or replaced …

Gaze, Goals And Growing Up: Effects On Imitative Grasping, Sonja P. Brubacher, Kim P. Roberts, Sukhvinder S. Obhi

Psychology Faculty Publications

Developmental differences in the use of social-attention cues to imitation were examined among children aged 3- and 6-years old (n = 58) and adults (n = 29). In each of 20 trials, participants watched a model grasp two objects simultaneously and move them together. On every trial, the model directed her gaze towards only one of the objects. Some object pairs were related and had a clear functional goal outcome (e.g., flower, vase), while others were functionally unrelated (e.g., cardboard square, ladybug). Owing to attentional effects of eye gaze, it was expected that all participants would more faithfully …

Virginia Dental Journal (Vol. 90, No. 3, 2013)

Virginia Dental Journal

No abstract provided.

Micromechanical Analysis Of Nanoparticle-Reinforced Dental Composites, Yi Hua, Linxia Gu, Hidehiko Watanabe

Department of Mechanical and Materials Engineering: Faculty Publications

The mechanical behavior of TiO₂ nanoparticle-reinforced resin-based dental composites was characterized in this work using a three-dimensional nanoscale representative volume element. The impacts of nanoparticle volume fraction, aspect ratio, stiffness, and interphase zone between the resin matrix and nanoparticle on the bulk properties of the composite were characterized. Results clearly demonstrated the mechanical advantage of nanocomposites in comparison to microfiber-reinforced composites. The bulk response of the nanocomposite could be further enhanced with the increased nanoparticle volume fraction, or aspect ratio, while the influence of nanoparticle stiffness was minimal. The effective Young’s modulus and yield strength of the composite was …

Neuropsychological Outcome In Relation To Duration Of Early Orphanage Experience, Jacquelyn Marie Perry Avery

Wayne State University Dissertations

In this sample of 144 children with a history of prior orphanage experience, increasing duration of institutionalization is related to decreasing performance for a number of cognitive domains, most consistently verbal measures and executive Functioning measures. The relationships with duration for measures requiring visual-spatial skills were more mixed and a visual reasoning task was found to significantly relate to duration but not a measure of visual memory or a measure of nonverbal achievement. There was little evidence to support a relationship between the duration of institutionalization and fine-motor dexterity. The strongest relationships with duration were observed for language measures followed …

Fatty Acid Fate In Determining Oxidation And Inflammation In Adipose Tissue, Emilio Patrick Mottillo

Wayne State University Dissertations

Adipose tissue (AT) is a critical regulator of energy balance through its ability to store or oxidize free fatty acids (FFAs). White adipose tissue (WAT) functions as an anabolic organ to sequester and release FAs, in contrast brown adipose tissue (BAT) is a catabolic organ that oxidizes FAs. However, a comprehensive understanding of the role that FFAs play in the function of WAT and BAT is needed. Here we demonstrate that intracellular FAs enhance the expression of inflammatory cytokines by β3-AR activation in adipocytes, in which the expression of PAI-1 is partly mediated by the de novo synthesis of ceramides/sphingolipids. …

The Lived Experience Of Weight Retention Among Postpartum African American Adolescents, Thelma Mae Phillips

Wayne State University Dissertations

Background: Obesity presents a public health challenge and is a serious chronic medical condition, which is associated with multiple co-morbidities and reduced survivability/longevity (Davis, Stange, & Howitz, 2010). African American adolescents who retain weight after pregnancy are at the highest risk of becoming obese adults. Obesity is expected to cost the United States health care system over 237 million dollars (National Institutes of health, 2011) within the next decade.

The prevalence of obesity is cause for concern because of its costs to the economic base of the country and its toll in human suffering due to related morbidity and mortality. …

Subordinate-Supervisor Demographic And Perceived Value Similarity: Relationships To Subordinate Perceptions Of Organizational Justice, Charles Levi Wells, Iv

Wayne State University Dissertations

The purpose of this study was to examine the empirical relationship between subordinate-supervisor demographic and value similarity with subordinate perceptions of organizational justice using three structural equation models. The first model indicated that subordinate-supervisor demographic and value similarity were directly related to subordinate perceptions of organizational justice (Direct Model). The second model indicated that subordinate perceived value similarity with their supervisor mediated the relationship between the subordinate-supervisor demographic similarity and subordinate perceptions of organizational justice (Mediated Model). The last model indicated subordinate perceived value similarity with their supervisor moderated the relationship between subordinate-supervisor demographic similarity and subordinate perceptions of organizational …

Predictors Of Psychosocial Adaptation To Pregnancy Among Urban African-American Primiparas, Joan M. Visger

Wayne State University Dissertations

Psychosocial adaptation to pregnancy among urban African-American women has not been well-researched. The purpose of this study was to examine predictors of psychosocial adaptation to pregnancy and to explore relationships among socioeconomic status, experiences and frequency of discrimination, personal control beliefs, social support, planned pregnancy, and model of health care among urban African-American primiparas using life course theory and Lederman's model of psychosocial adaptation to pregnancy as the framework.

One hundred and nine women participated in this descriptive, cross-sectional, correlational study. Participants were recruited from three clinical sites that provided care using medical and/or midwifery models of care. Study variables …

Multi-Modality Assessment Of Language Function, Erik Carmen Brown

Wayne State University Dissertations

The work presented as part of this dissertation represents a multi-modality study of language structure and function. The primary functional modality employed is task-related electrocorticography (ECoG). This is complemented by discussion and evaluation of previously published functional magnetic resonance imaging (fMRI) data. Language-related structure is explored using diffusion-weighted magnetic resonance imaging in conjunction with ECoG data. The scientific questions pursued are broad and include reevaluation of previously proposed theories.

We start by taking the first steps in validating our naming-related ECoG approach by comparing our results from a small cohort of patients to the clinical gold-standard technique of electrical brain …

Characterization Of Antimicrobial-Resistant Staphylococcus Spp. In Food Animals And Retail Meat, Kanika Bhargava

Wayne State University Dissertations

Antimicrobial resistance in Staphylococcus spp. is a worldwide epidemic concern in hospital and community settings. Food animals and retail meat are important reservoirs of these pathogens that can pose potential threat to humans. In this dissertation, we aimed to investigate the molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Coagulase-negative Staphylococci (MRCoNS) in food animals and retail meat to provide insight into the role of agricultural environment in transmitting bacteria of human clinical significance. Furthermore, the potential application of phytochemicals as antimicrobials and antimicrobial adjuvants to control MRSA infections was explored.

CoNS recovered from food animals were characterized by …

Striatal Dopamine Dynamics Upon Manganese Accumulation, Madiha Khalid

Wayne State University Dissertations

STRIATAL DOPAMINE DYNAMICS UPON MANGANESE ACCUMULATION

by MADIHA KHALID

August 2013

Advisor: Dr. Tiffany Mathews

Major: Chemistry (Analytical)

Degree: Doctor of Philosophy

Although manganese (Mn) is fundamental for many biological processes, exposure to excess amounts leads to a neurological disorder termed manganism. Due to its symptomatic similarity to Parkinson's disease, as well its preferential accumulation in dopamine rich brain regions, alterations in the dopamine system are implicated in the onset of manganism. In my research, Mn overexposure is mimicked via subcutaneous administration of manganese chloride to C57BL/6 mice over the course of seven days using a protocol that has been …

Linking Environmental Toxicant Exposure To Diabetes Susceptibility, Jannifer Beth Tyrrell

Wayne State University Dissertations

An important and unresolved question in the environmental health field is whether exposure to common environmental toxicants, such as dioxin and heavy metals like Pb, increase the risk of developing diabetes, especially in combination with other common metabolic stressors such as obesity.

Previous studies suggested that dioxin exposure increased peripheral insulin resistance but did not appear to cause fasting hyperglycemia or elevated hepatic glucose output. In concordance with those findings we observed that dioxin treatment caused a strong suppression of the expression of the key hepatic gluconeogenic genes PEPCK and G6Pase. However, this suppression was not solely mediated by the …

The Effect Of Proalgazyme And Its Subfractions On Lipid Metabolism In Diet Induced Hypercholesterolemic Hamsters: Correlation With Plasma Metabolomic Profile, Andreea Geamanu

Wayne State University Dissertations

ABSTRACT

THE EFFECT OF PROALGAZYME AND ITS SUBFRACTIONS ON LIPID METABOLISM IN DIET INDUCED HYPERCHOLESTEROLEMIC HAMSTRES:

CORREALTION WITH PLASMA METABOLOMIC PROFILE

by

ANDREEA GEAMANU

December 2013

Advisor: Dr. Smiti Gupta

Major: Nutrition and Food Science

Degree: Doctor of Philosophy

Background: Plasma HDL cholesterol levels are inversely related to cardiovascular disease, which is the leading cause of death worldwide. This study investigated the preventative effect of an algae infusion, ProAlgaZyme (PAZ) and its subfractions (F1, F2, F3, F4) on plasma HDL in a hamster model. Further, the study aimed to identify the biologically active fraction of PAZ and to determine the …

Sleep Homeodynamics And Wellbeing In Asymptomatic Hiv-Seropositive African American Women, Tabetha Lynn Gayton

Wayne State University Dissertations

SLEEP HOMEODYNAMICS AND WELLBEING IN ASYMPTOMATIC HIV–SEROPOSITIVE AFRICAN AMERICAN WOMEN

by

TABETHA LYNN GAYTON

December 2013

Advisor: Hossein N. Yarandi, PhD

Major: Nursing (Urban Health)

Degree: Doctor of Philosophy

BACKGROUND: HIV–related sleep disruption is a common complaint of persons with HIV infection. With the demographical shifts, African American women have now emerged as one of the fastest growing HIV populations today, yet they remain a vulnerable and underrepresented population in the sleep literature.

OBJECTIVE: The purpose of this pilot study was to explore the dynamics of HIV–related sleep disruption and wellbeing in asymptomatic HIV–seropositive AA women of childbearing age within …

White Matter Integrity And Age Related Differences In Reaction Time Components, Yiqin Yang

Wayne State University Dissertations

Reduced speed in information processing is a well-documented phenomenon associated with advanced aging. Age-related deterioration in white matter integrity might play a role in age-related increase in reaction time (RT). However, the association between microstructural differences in particular white matter regions or tracts with RT is unclear. Decomposing RT into parts might be a better way to understand the relationship due to multiple processes involved in RT. In a lifespan sample of 90 healthy normotensive participants, this study examined the association between RT components derived from the Ratcliff diffusion model with age related difference in DTI indices of a wide …

Dispositional Mediators Of Burnout Syndrome In A Sample Of Direct Care Staff Employed At Group Homes In A Midwestern State, Cristovao Bartolo Carreira

Wayne State University Dissertations

The current research examined the dispositional characteristics that mediated burnout syndrome in a sample of direct care workers who were employed in group homes for the mentally ill in a Midwestern state. Specifically, the indirect effects that the direct care staff's attachment systems and problem solving ability were examined as they applied to their potential burnout status. Attachment theory, a contemporary psychodynamic theory of personality, was used to provide a context for the study. The researcher studied the interactions between construct subcomponents to address a criticism in the literature stating that only total scores were used to study burnout and …

First-Year Medical Student Objective Structured Clinical Exam Performance And Specialty Choice, Katherine A. Backes, Nicole J. Borges, S Bruce Binder, Brenda J. Roman

Medical Education Faculty Publications

Objective: The aim of this study was to determine if first-year physical exam and interview Objective Structured Clinical Examination scores differ for medical students entering person or technique-oriented specialties. Methods: Objective Structured Clinical Examination physical exam and interview scores from 2004 to 2007 for first-year medical students (n=280) at one United States medical school were compared using t-tests based on specialty choice from this cohort of students. Results: T-test results (p<0.05) showed a significant difference in the mean physical exam (mean=92.85, sd=3.94) versus interview (mean=90.77, sd=6.76) scores for students entering person-oriented specialties (n=157, p<0.001). There was also a significant difference (p<0.05) in the mean physical exam (mean=93.46, sd=3.92) versus interview (mean=91.40, sd=5.75) scores for students entering technique-oriented specialties (n=123, p<0.001). Results indicate that physical exam scores are significantly higher than interview scores for students regardless of whether they enter person or technique-oriented specialties, except for psychiatry where interview scores were significantly higher than physical exam scores. Conclusion: Subsequent studies are needed to better understand the relationship of Objective Structured Clinical Examination performance and specialty choice by medical students.

Accountable Care Organizations: Elements Of Success, Sheila A. Haas

Nursing: School of Nursing Faculty Publications and Other Works

No abstract provided.

Affordable Care Act: Options For Accessing Health Insurance, Sheila A. Haas

Nursing: School of Nursing Faculty Publications and Other Works

No abstract provided.

Opportunities For The Uninsured To Access Affordable Health Insurance And Care, Sheila A. Haas

Nursing: School of Nursing Faculty Publications and Other Works

No abstract provided.

Brain Ras: Hypertension And Beyond, Marc De Gasparo, Robert C. Speth, Ovidiu C. Baltatu, Patrick Vanderheyden

HPD Articles

No abstract provided.

Immunohistochemical Localization Of At1a, At1b, And At2 Angiotensin Ii Receptor Subtypes In The Rat Adrenal, Pituitary, And Brain With A Perspective Commentary, Courtney Premer, Courtney Lamondin, Ann Mitzey, Robert C. Speth, Mark S. Brownfield

HPD Articles

Angiotensin II increases blood pressure and stimulates thirst and sodium appetite in the brain. It also stimulates secretion of aldosterone from the adrenal zona glomerulosa and epinephrine from the adrenal medulla. The rat has 3 subtypes of angiotensin II receptors: AT1a, AT1b, and AT2. mRNAs for all three subtypes occur in the adrenal and brain. To immunohistochemically differentiate these receptor subtypes, rabbits were immunized with C-terminal fragments of these subtypes to generate receptor subtype-specific antibodies. Immunofluorescence revealed AT1a and AT2 receptors in adrenal zona glomerulosa and medulla. AT1b immunofluorescence was present in the zona glomerulosa, but not the medulla. Ultrastructural …

Adenoviral And Adeno-Associated Viral Vectors-Mediated Neuronal Gene Transfer To Cardiovascular Control Regions Of The Rat Brain, Yanling Zhang, Yongxin Gao, Robert C. Speth, Nan Jiang, Yingying Mao, Colin Sumners, Hongwei Li

HPD Articles

Viral vectors have been utilized extensively to introduce genetic material into the central nervous system. In order to investigate gene functions in cardiovascular control regions of rat brain, we applied WPRE (woodchuck hepatitis virus post-transcriptional regulatory element) enhanced-adenoviral (Ad) and adeno-assoicated virus (AAV) type 2 vectors to mediate neuronal gene delivery to the paraventricular nucleus of the hypothalamus, the nucleus tractus solitarius and the rostral ventrolateral medulla, three important cardiovascular control regions known to express renin-angiotensin system (RAS) genes. Ad or AAV2 harboring an enhanced green fluorescent protein (EGFP) reporter gene or the angiotensin type 2 receptor gene were microinjected …

Children's Mercy Hospital Annual Report 2012, Children's Mercy Hospital

Children's Mercy Annual Reports

Annual report for The Children's Mercy Hospital in Kansas City MO, a pediatric medical center.

Ixodid Ticks Associated With Feral Swine In Texas, David M. Sanders, Anthony L. Schuster, P. Wesley Mccardle, Otto F. Strey, Terry L. Blankenship, Pete D. Teel

United States Army: Publications

Ixodid ticks were collected from feral swine in eight Texas ecoregions from 2008-2011. Sixty-two percent of 806 feral swine were infested with one or more of the following species: Amblyomma americanum, A. cajennense, A. maculatum, Dermacentor albipictus, D. halli, D. variabilis, and Ixodes scapularis. Juvenile and adult feral swine of both sexes were found to serve as host to ixodid ticks. Longitudinal surveys of feral swine at four geographic locations show persistent year-round tick infestations of all gender-age classes for tick species common to their respective geographic locations and …

The Feasibility Of Implementing The Acp-215 At The Dayton Community Blood Center: A Cost-Benefit Analysis, Angela Albrecht

Master of Public Health Program Student Publications

The community blood supply is a limited resource with a relatively short shelf-life. To ensure an adequate supply, a balance must be maintained between the numbers of donors providing blood and blood products required by hospitals to meet patient needs. Any change in the number of blood donors or in the volume of blood required by hospitals can create a blood shortage. During times of disaster, a blood shortage may be inevitable. Additional strategies must be in place to ensure availability of blood for essential transfusions across the community. Cryopreservation of red blood cells to build and maintain a blood …