Medicine and Health Sciences Commons^™

Association Among Serum Insulin–Like Growth Factor–I, Backfat Thickness, And Age At First Observed Estrus In Gilts, Atthaporn Roongsitthichai, Seri Koonjaenak, Padet Tummaruk

The Thai Journal of Veterinary Medicine

The present study investigated the association among serum insulin-like growth factor-I (IGF-I), backfatthickness, and age at first observed estrus in replacement gilts. In total, 80 replacement gilt, Landrace (L, n = 48) andYorkshire (Y, n = 32), were included. The gilts were determined for age at first observed estrus between 167 to 212days of age. They were categorized according to age at first observed estrus into ≤ 200 days (n = 41) and > 200 days (n= 36) groups. Backfat thickness, body weight, and serum IGF–I concentration were measured before mating. Age atfirst mating, interval from boar exposure to first observed …

Modulating Neurogenesis In Embryoid Body Using A Selective Tgf Beta1/Alk Inhibitor Affects Gene Expression Of Embryonic Stem Cell-Derived Motor Neurons, Nuttha Klincumhom, Theerawat Tharasanit, Chommanart Thongkittidilok, Narong Tiptanavattana, Andras Dinnyes, Mongkol Techakumphu

The Thai Journal of Veterinary Medicine

Mouse embryonic stem (ES) cells have been served as potential model for investigation of underlying mechanisms at cellular and molecular levels of neurological disorders. The improvement of motor neuron differentiation is prospected to gain more understanding aimed at overcoming several incurable motor neuron diseases. In this study, we examined the effects of selective inhibitor of TGF-β type I receptor on the efficacy of neuronal differentiation of mouse embryonic stem cells toward motor neuron. Pluripotent ES cells were induced to form as EB in suspension medium supplemented with retinoic acid using -4/+4 protocol. Thereafter, 8-day old EBs were further induced to …

Differentiation Of Secreted Proteins From A Virulent And An Avirulent Strain Of Streptococcus Suis Serotype 2, Xiao Wei Yang, Cui Wei Li1, Zhi Biao Yang, Li Ping Wu, Xiu Guo Hua

The Thai Journal of Veterinary Medicine

The present study aimed to identify specific and upregulated proteins in virulent SS2 strain that mightconfer pathogenicity. We performed a comparative proteomic assay to analyze the difference in secretome betweenvirulent SH-08 strain and avirulent SH-YH07 strain. Virulence of tested strains was determined using porcine andzebrafish models. The supernatant from bacterial cultures was collected at early exponential phase (OD600 = 0.4).Proteomic assay identified 52 proteins from the virulent strain supernatant and 29 proteins from the avirulent strainsupernatant. Twenty-three proteins were found in the culture medium from both strains. Among these commonproteins, eleven were upregulated by the virulent strain compared to the …

The Role Of Kisspeptin Signaling In Reproduction Of Ruminant, Thuchadaporn Chaikhun, Pongsiwa Sotthibandhu, Siriwat Suadsong

The Thai Journal of Veterinary Medicine

In the present decade, kisspeptin has been a fascinating topic in the reproductive spotlight. Kisspeptin is a neuropeptide, produced mainly in the hypothalamus from Kiss1 gene. This gene was initially discovered in 1996 as a tumor suppressor gene in human malignant melanoma. Then in the year 2003, researchers found that mutations of the G protein-coupled receptor (GPR54), which is the strongly cognate receptor of kisspeptin, were associated with hypogonadotropic hypogonadism in mice and humans. There are many kisspeptin distribution and function studies (both in vitro and in vivo) in mammals. In ruminants, kisspeptin has been studied mainly in sheep and …

Mediating Trophoblast Uptake Of Methylaminoisobutyric Acid And Glutamine By Absence Of Extra- Or Intracellular Glutamine, Boonrit Thongsong

The Thai Journal of Veterinary Medicine

Glutamine is known to modulate the uptake activity of nutrient transporters in mammalian cells. The aim of the study was to elucidate the influence of absence of extra- or intracellular glutamine on the uptake activity of the amino acid transport system A in placental BeWo cells. Extracellular glutamine was absent by culturing the cells in regular medium without glutamine. Intracellular glutamine was depleted by culturing the cells in regular medium without glutamine and by treating the cells for 16 hours with methionine sulfoximine (MSX), an inhibitor of glutamine synthetase. When BeWo cells were treated with glutamine-free culture medium for 1-30 …

Effect Of L-Cysteine On Chilled Carp (Cyprinus Carpio) Semen Qualities, Kan Kledmanee, Somrat Taweedet, Prawporn Thaijongruk, Panida Chanapiwat, Kampon Kaeoket

The Thai Journal of Veterinary Medicine

The aim of the present study was to study the effects of L-cysteine on chilled carp (Cyprinus carpio) semen qualities. Pooled semen samples were prepared from eight fish, and divided into five groups according to the concentrations of L-cysteine as follows: 0 (T1), 0.5 (T2), 1.0 (T3), 1.5 (T4) and 2 (T5) mM. The sperm motility, duration of sperm motility and sperm viability were evaluated at 0, 12, 24, 48, 72 hours after chilled storage. Comparing between treatment and control groups, the percentage of sperm motility, duration of sperm motility and the percentage of sperm viability in the treatment groups …

A Survey To Determine The Presence Of The N-Acetylglucosamine-6-Sulfatase (G6s) Gene Mutation In Anglo-Nubian Goats In Southern Thailand, Siriwat Wasiksiri, Sirichai Sripongpun, Adisorn Ratanaphan, Panom Sookras

The Thai Journal of Veterinary Medicine

Mutation of the G6S gene in Anglo-Nubian (AN) goat causes non-function of the N-acetylglucosamide 6- sulfatase enzyme within lysosomes, which increases heparin sulfate accumulation and induces pathogenesis of the internal organs. Transversion of base C to T at nucleotide 322 changes decoding of an amino arginine to a stop codon (R322X) and produces a truncated protein. This mutation is detrimental to the health of a goat kid leading to delay in nervous development and death. It was found first time in goats of a Michigan herd in the US, but has not yet been reported in Thailand. This study aimed …

The Impact Of Volunteering On Seniors’ Health And Quality Of Life: An Assessment Of The Retired And Senior Volunteer Program, Theodore W. Mcdonald, Erica L. Chown, Jordan E. Tabb, Amy K. Schaeffer, Elsa K. M. Howard

Public and Population Health Faculty Publications and Presentations

Past research suggests that senior citizens often face challenges related to deteriorating physical and men- tal health, and the quality of their lives may suffer as a result. Past research also suggests that volunteering can improve the health and quality of life for seniors. In the present study, 451 volunteers enrolled in the Retired and Senior Volunteer Program (RSVP) completed surveys including questions regarding their volunteer experiences and how these experiences have affected their health and quality of life. The results suggest that volunteering through RSVP is associated with improvements in health and quality of life across a variety of …

Warum Gesunde Menchen Immer Häufiger Fur Psychisch Krank Erklärt Werden, Lisa Cosgrove

Counseling, School Psychology & Sport Faculty Publication Series

zuerst einmal nicht schaden": Das ist der wohl wichtigste Grundsatz der Medizin. Aber diese Mission droht durch den Einfluss großer Pharmafirmen unterhöhlt zu werden. Der Vorwurf einer Verstrickung von Ärzten und Arzneimittelherstellern ist schon in fast allen medizinischen Fachrichtungen aufgekommen. Vor allem aber die Psychiatrie steckt in einer Glaubwürdigkeitskrise. Das zeigt sich in der aktuellen Debatte um die neue Auflage des "Diagnostischen und Statistischen Manual Psychischer Störungen" (DSM).

Dieses von der US-Psychiater-Vereinigung APA herausgegebene Handbuch definiert, was eine psychische Erkrankung ist. Die Bedeutung dieser Wertung geht weit über die USA hinaus - das Handbuch nimmt oft Definitionen der Weltgesundheitsorganisation vorweg. …

Kerlan-Jobe Orthopaedic Clinic Overhead Athlete Scores In Asymptomatic Professional Baseball Pitchers., Matthew J Kraeutler, Michael G Ciccotti, Christopher C Dodson, Robert W Frederick, Brian Cammarota, Steven B. Cohen

Rothman Institute Papers

BACKGROUND: The Kerlan-Jobe Orthopaedic Clinic (KJOC) Shoulder and Elbow score is a subjective questionnaire that has been validated and been shown to be more specific in overhead athletes than the American Shoulder and Elbow Surgeons scale. The purpose of this study was to determine a mean KJOC score and reasonable range of KJOC scores within which a healthy asymptomatic professional baseball pitcher will fall. It was hypothesized that healthy professional baseball pitchers would have very high KJOC scores.

MATERIALS AND METHODS: KJOC questionnaires were given to all healthy pitchers before the start of the season at all levels in 1 …

Serving God In The Midst Of Multiple Sclerosis: A Holistic And Spiritual Model For Physical Sustainment, Timothy Harville

Doctoral Dissertations and Projects

Multiple Sclerosis is a devastating disease that affects not only the one who suffers with MS, but also their family and relationships leaving the patient feeling depressed and without hope. If the disease is disclosed, many churches and the International Mission Board will reject the person's application because of the potential cost and medical care needed. This author was diagnosed with an aggressive form of Relapsing Multiple Sclerosis in 2008. This writer has experienced the obstacles described above. This model will serve as a motivational tool to help all of us who suffer with MS to use the disability for …

Prevalence Of Hypertension In Healthy School Children In Pakistan And Its Relationship With Body Mass Index, Proteinuria And Hematuria, Arshalooz Jamila Rahman, Farah Naz Qamar, Sohail Ashraf, Zubair Ali Khowaja, Shafaq Binte Tariq, Hira Naeem

Department of Paediatrics and Child Health

To determine the prevalence of high blood pressure (BP) in healthy school Pakistani children and its association with high body mass index (BMI), asymptomatic hematuria and proteinuria, we studied 661 public school children and measured their body weight, height and BP and urine dipstick for hematuria performed on a single occasion. Hypertension (BP >95 th centile) and pre-hypertension (BP >90 th centile) were defined based on the US normative BP tables. Over-weight and obesity were defined according to the World Health Organization (WHO) classification of BMI. The mean age of the children was 14 ± 1.3 years. The mean BMI …

Impact Of Sugar Substitutes On Glucose Control In Diabetic Patients, Mckenzie C. Ferguson, Erin Marie Timpe Behnen, Amy Carlson

Pharmacy Faculty Research, Scholarship, and Creative Activity

Objective: To evaluate the impact of nonnutritive sugar substitutes on glycemic control in patients with diabetes.

Data Sources: A comprehensive review of the literature was conducted in PubMed (1966-March 2012) and Scopus. A combination of MeSH terms and keywords were used, including acesulfame, aspartame, diabetes, neotame, rebiana, saccharin, stevia, and sucralose.

Study Selection and Data Extraction: Clinical studies evaluating the impact of nonnutritive sweeteners on measures of diabetic control, including, but not limited to, blood glucose levels, postprandial blood glucose, and hemoglobin A_1c were selected for review. Searches were limited to only nonnutritive sweeteners available in the US.

Data …

The Young And Suicide, Hatim A. Omar, Joav Merrick

Pediatrics Faculty Publications

No abstract provided.

A New Simulation Model Of Intraocular Pressure Estimation By Finger Palpation., S Omapinyan, A Mavichak, W. Santipas

Chulalongkorn Medical Journal

การวัดความดันลูกตา เป็นสิ่งที่จำเป็นในการตรวจตาทั่วไป ตามมาตรฐานการวัดความลูกดันตาจะใช้เครื่องมือ Goldman applanation tonometer ซึ่งเป็นการวัดความดันลูกตาโดยใช้เครื่องมือกดลงบนกระจกตาจนทำให้ผิวของกระจกตาราบในระดับหนึ่งแล้ววัดค่าความดันลูกตาในหน่วยมิลลิเมตรปรอท ข้อจำกัดของวิธีนี้คือ ผู้ป่วยที่มีปัญหาที่ผิวกระจกตา หรือผู้ป่วยที่ได้รับอุบัติเหตุต่อดวงตานอกจากนี้ ยังมีความจำกัดด้านทรัพยากรบุคคลที่มีความชำนาญด้านการตรวจ อีกทั้งตัวอุปกรณ์เองและสถานที่ จึงมีความจำเป็นที่จะต้องประมาณค่าความดันตาด้วยการคลำด้วยนิ้วมือในบางครั้งซึ่งวิธีนี้เป็นวิธีที่ง่าย สะดวก และเกิดอันตรายน้อย เนื่องจากวิธีการประมาณค่าความดันลูกตาด้วยนิ้วมือนั้น ยังมีความไม่แน่นอนในการคลำ และยังไม่ทราบถึงค่าความละเอียดที่บอกความสามารถในการคลำด้วยนิ้วมือ การทดลองที่จะหาค่าความละเอียดของการประมาณค่าความดันลูกตาด้วยนิ้วมือในผู้ป่วยจริงนั้นอาจทำให้เกิดปัจจัยรบกวนต่าง ๆ ดังนั้นคณะผู้วิจัยจึงเลือกที่จะทดลองในดวงตาจำลองก่อน จึงเป็นที่มาของการผลิตอุปกรณ์แบบจำลองเพื่อการประเมินค่าความดันลูกตาชนิดนี้

Comparison Of The Efficacy And Adverse Effects Of Bipolar Radiofrequency Turbinate Reduction With And Without Lateral Outfracture In The Treatment Of Inferior Turbinate Hypertrophy: A Randomized Controlled Trial, S Aeumjaturapat, P Limchatpaiboon, Y Chatwiwat, S Chusakul, C Phannaso, W Tulvatana, S Thanaviratananich, W. Punyasang

Chulalongkorn Medical Journal

Background : Radiofrequency inferior turbinate reduction has been proven to reduce the volume of the inferior turbinate. The aim of lateral outfracture of the inferior turbinate is to displace the position of the inferior turbinate laterally which makes the nasal cavity wider. The efficacy of the lateral outfracture is questionable. However, some authors usually combine lateral outfracture of the inferior turbinate with other techniques of inferior turbinate reduction. Objective : To compare efficacy and adverse effects between bipolar radiofrequency turbinate reduction with lateral outfracture (BRTR with LO) and bipolar radiofrequency turbinate reduction alone (BRTR alone) in chronic rhinitis patients with …

Sequence Analysis Of Ancylostoma Secreted Protein 2 Of Necator Americanus From Thai Isolates, C Ungcharoensuk, U Pattanawong, T Tia, C Putaporntip, S. Jongwutiwes

Chulalongkorn Medical Journal

Problem/background : Hookworm infection is one of the major neglected tropical infectious diseases causing both overt and cryptic morbidity among ~600 million people living in tropical areas. As conventional hookworm control measures by improving sanitation and mass anthelminthic drug administration are not sustainable, development of hookworm vaccines is mandatory. One of the major vaccine candidates is Ancylostoma secreted protein-2 of Necator americanus (Na-ASP-2). To date, only one Na-ASP-2 sequence is available; therefore, it remains unknown whether the effectiveness of a vaccine derived from this molecule may be compromised by antigenic diversity in hookworm population. Objectives : To determine the Na-ASP-2 …

Bioequivalence Of Azithromycin For Oral Suspension After A Single Dose 600 Mg Oral Administration, P Banharnsupawath, W Thanindratarn, U. Suvanakoot

Chulalongkorn Medical Journal

Background : Azithromycin is a broad spectrum azalide antibiotic which was suggested to be first-line treatment in children for some respiratory tract infections, urethritis and mycobacterium avium complex infection with AIDs complications. The drug is well absorbed and has long half-life which supports a short time administration at higher dose regimens. Pharmacokinetic and bioequivalence of azithromycin have been extensively studied in many oral dosage forms at the standard dose of 500 mg; however, there is no bioequivalence study at higher dose carried out in an oral suspension dosage form. Objective : To investigate bioequivalence of azithromycin powder for oral suspension …

Management Of Persistent Bile Leak After Complex Liver Injury With A Rendezvous Procedure: Report Of A Case, S Prichayudh, S Pungpapong, P Kranokpiraksa, S Sriussadaporn, P Samorn, R Pak-Art, S Sriussadaporn, K. Kritayakirana, P Limpavitayaporn, A. Rongviriyapanich

Chulalongkorn Medical Journal

Bile leak after liver injury is not uncommon, especially in complex liver injury.Endoscopic retrograde cholangiopancreatography (ERCP) with sphincterotomy and biliarystent insertion is an effective treatment of bile leak after liver injury. However, ERCP is notalways successful, resulting in the need of alternative interventions. We report a case withpersistent bile leak after complex liver injury who had had a failed ERCP and subsequentlyunderwent a successful rendezvous procedure for internal biliary stent placement.

Contrast Enhanced Magnetic Resonance Cholangiography (Ce-Mrc), P Ratasirayakorn, N. Tanpowpong

Chulalongkorn Medical Journal

Hepatocyte specific contrast agent has been developed to detect and characterize liver lesions by magnetic resonance imaging (MRI). As this contrast agent is taken up into the functional hepatocyte and is excreted via the biliary system, it has potential to be an intrabiliary contrast agent. There has been increased diagnostic confidence when it is used in combination with conventional T2 magnetic resonance cholangiography (MRC) by giving both morphologic and functional informations of the biliary system. This article reviews clinical applications of contrast enhanced magnetic resonance cholangiography (CE-MRC) with two available hepatocyte specific contrast agents in Thailand, i.e. Gd-BOPTA and Gd-EOB-DTPA. …

Behavior Modification By Parents In Children With Attention Deficit Hyperactivity (Adhd) Attending Child Psychiatric Unit At King Chulalongkorn Memorial Hospital And Nakhon Ratchasima Rajanagarindra Psychiatric Hospital, W Pattanaworapong, N. Pittayarattanasatern

Chulalongkorn Medical Journal

Background : Thailand has many medical treatments of behavior modification in children with ADHD but there is still no research on behavior modification in ADHD children by their guardians. With these reasons the researcher has taken interest to study whether or not the guardian has roles in behavior modification in a child with ADHD or not since parents and guardians play important roles in preventing ADHD from developing into bad behaviors. Objective : To study of behavior modification and factors related to behavior modification by parent in ADHD children which in this research behavior modification of the guardian means the …

Integrating Spiritual Care Into Nurse Practitioners’ Practice: Improving Patient Health Indicators While Limiting Cost, Barbara Vincensi

Faculty Presentations

No abstract provided.

Caring For The Spirit To Decrease Healthcare Costs: Are Nurse Practitioners Able To Recognize The Cues And Behaviors Of Spiritual Care Concerns And Provide Spiritual Care To Patients?, Barbara Vincensi

Faculty Presentations

No abstract provided.

Optimizing Parametrial Aperture Design Utilizing Hdr Brachytherapy Isodose Distribution., Katherine L Chapman, Nitin Ohri, Timothy N Showalter, Laura A Doyle

Department of Radiation Oncology Faculty Papers

Treatment of cervical cancer includes combination of external beam radiation therapy (EBRT) and brachytherapy (BRT). Traditionally, coronal images displaying dose distribution from a ring and tandem (R&T) implant aid in construction of parametrial boost fields. This research aimed to evaluate a method of shaping parametrial fields utilizing contours created from the high-dose-rate (HDR) BRT dose distribution. Eleven patients receiving HDR-BRT via R&T were identified. The BRT and EBRT CT scans were sent to FocalSim (v4.62)(®) and fused based on bony anatomy. The contour of the HDR isodose line was transferred to the EBRT scan. The EBRT scan was sent to …

Health Profile Of Nebraska's Latino Population, Athena K. Ramos, Shireen Rajaram, Lourdes Gouveia, Yuriko Doku, Drissa Toure, Anthony Zhang, Sondra Manske

Reports: Health Promotion, Social & Behavioral Health

No abstract provided.

The Perceptions Of Behavioral Health Psychology Held By Medical Personnel In Oregon, Carleton H. Lloyd

Doctor of Psychology (PsyD)

The purpose of the current research was to obtain medical personnel perceptions about the role of behavioral health psychology within their medical care practices in Oregon. Four hypotheses were explored. Hypothesis 1 asserted that medical personnel from urban, suburban, and rural locations would hold significantly different views; Hypothesis 2 suggested that the sample would more likely refer the more acute patients; Hypothesis 3 posited that medical personnel would make more referrals if they knew a mental health provider; Hypothesis 4 stated that there would be significant differences between the perceptions and practices of female and male members of this sample. …

Tobacco Endgame Strategies: Challenges In Ethics And Law, Bryan P. Thomas, Lawrence O. Gostin

Georgetown Law Faculty Publications and Other Works

There are complex legal and ethical tradeoffs involved in using intensified regulation to bring smoking prevalence to near-zero levels. The authors explore these tradeoffs through a lens of health justice, paying particular attention to the potential impact on vulnerable populations. The ethical tradeoffs explored include the charge that heavy regulation is paternalistic; the potentially regressive impact of heavily taxing a product consumed disproportionately by the poor; the simple loss of enjoyment to heavily addicted smokers; the health risks posed by, for example, regulating nicotine content in cigarettes—where doing so leads to increased consumption. Turning to legalistic concerns, the authors explore …

Pediatric Dentistry Training For Dentists In Pakistan, Farhan Raza Khan, Sadia Mahmud, Munawar Rahman

Section of Dental-Oral Maxillofacial Surgery

OBJECTIVE: In the last decade, a rapid growth has been observed in the number of dentists due to establishment of number of dental colleges in Karachi, Pakistan. There is an acute dearth of Pediatric Dentistry faculty in Pakistani dental institutions. Similarly, no post graduate Pediatric Dentistry fellowship program exists in the country. The objectives of this study are to map the pattern of pediatric dentistry services provided by the clinicians in teaching institutions and private practices of Karachi. METHODOLOGY: A cross sectional study conducted at dental departments of academic institutions and selected dental practices in different parts of Karachi. The …

Comparison Of Myofascial Pain Syndrome And Lomplaipattakad Diagnosis In Thai Traditional Medicine Clinic, U Yodtor, C. Nimnuan

Chulalongkorn Medical Journal

Background : Myofascial pain syndrome (MFPS) diagnosed in modern medicine and lomplaipattakad in Thai traditional medicine are similar in case of definition. However, there has been no empirical study to examine similarities and differences between these two conditions. Objective : To compare general and clinical characteristics of MFPS and lomplaipattakad. Design : A cross - sectional descriptive study. Setting : Thai Traditional Medicine Clinic, Suratthani Hospital. Materials and Methods : Two hundreds and seventy-three patients were recruited. Demographic data, Thai Hospital Anxiety and Depression scale and WHO Quality of life were collected using standardized questionnaires. The diagnoses of MFPS and …

Role Of Garlic Usage In Cardiovascular Disease Prevention: An Evidence-Based Approach, Waris Qidwai, Tabinda Ashfaq

Department of Family Medicine

Introduction:.Rapidly growing prevalence of cardiovascular disease is a major threat for the developed as well as developing world warranting urgent need of intervention. Complementary and alternative medicines are gaining popularity among general population because of their safety profile and easy administration. Garlic, in particular, is considered to be one of the best disease-preventive foods because of its potent and widespread effects. This study was done to find out the role of garlic usage in cardiovascular disease prevention.

Methodology : .Major databases including Google, PubMed,MEDLINE, and Cochrane library view were used for the literature search. Clinical trials conducted on humans assessing …