Medicine and Health Sciences Commons^™

Hydroxylamine Acutely Activates Glucose Uptake In L929 Fibroblast Cells, Larry L. Louters, Jared P. Scripture, David P. Kuipers, Stephen M. Gunnink

University Faculty Publications and Creative Works

Nitroxyl (HNO) has a unique, but varied, set of biological properties including beneficial effects on cardiac contractility and stimulation of glucose uptake by GLUT1. These biological effects are largely initiated by HNO's reaction with cysteine residues of key proteins. The intracellular production of HNO has not yet been demonstrated, but the small molecule, hydroxylamine (HA), has been suggested as possible intracellular source. We examined the effects of this molecule on glucose uptake in L929 fibroblast cells. HA activates glucose uptake from 2 to 5-fold within two minutes. Prior treatment with thiol-active compounds, such as iodoacetamide (IA), cinnamaldehyde (CA), or phenylarsine …

The Clinical Education Experience Of Student-Physiotherapists Within A Transformed Model Of Healthcare, Serela Ramklass

Internet Journal of Allied Health Sciences and Practice

Purpose: The democratisation of the health system was a cornerstone of post-apartheid South Africa. Primary healthcare (PHC) was adopted for increased access, broader participation, and equity in health. Hereafter, physiotherapy and other health sciences curricula, research function, and teaching staff would have to be re-oriented towards enabling implementation and sustainability of the new model. This is an important consideration for the design of clinical education programmes, a learning trajectory within professional curricula that is fundamental to the education, training, and professional socialisation of emerging healthcare personnel. This study explored how student-physiotherapists experienced clinical education practice within the model of PHC. …

Family Planning Knowledge, Attitude And Practice Among Married Couples In Jimma Zone, Ethiopia, Tizta Tilahun, Gily Coene, Stanley Luchters, Wondwosen Kassahun, Els Leye, Marleen Temmerman, Olivier Degomme

Population Health, East Africa

Background: Understanding why people do not use family planning is critical to address unmet needs and to increase contraceptive use. According to the Ethiopian Demographic and Health Survey 2011, most women and men had knowledge on some family planning methods but only about 29% of married women were using contraceptives. 20% women had an unmet need for family planning. We examined knowledge, attitudes and contraceptive practice as well as factors related to contraceptive use in Jimma zone, Ethiopia.

Methods: Data were collected from March to May 2010 among 854 married couples using a multi-stage sampling design. Quantitative data based on …

Antimicrobial Resistance Patterns In Extended-Spectrum Β-Lactamase Producing Escherichia Coli And Klebsiella Pneumoniae Isolates In A Private Tertiary Hospital, Kenya, Daniel Maina, Paul Makau, Andrew Nyerere, Gunturu Revathi

Pathology, East Africa

Background: Extended-Spectrum β-Lactamase (ESBL) producing Enterobacteriaceae have become widespread in hospitals and are increasing in community settings where they cause a variety of infections. In addition to hydrolyzing most beta-lactam agents, bacteria harboring these enzymes display resistance to other unrelated antimicrobial agents and thus often pose a therapeutic dilemma. Though these resistance patterns have been studied elsewhere within Africa, such data from hospitals in Kenya are scanty. We therefore undertook to determine these patterns at the Aga Khan University hospital by studying multidrug resistant Escherichia coli and Klebsiella pneumoniae isolates from patients' samples.

Findings: A total of 159 isolates (109 …

Relationship Between Exercise Induced Dyspnea And Functional Capacity With Doppler-Derived Diastolic Function, Sumera Nasim, Najaf Nadeem, Aysha Zahidie, Tabbasum Sharif

Community Health Sciences

Background

Dyspnea is the frequent cause of exercise intolerance and physical inactivity among patients referred for exercise tolerance test. Diastolic dysfunction has shown significant correlation with exercise capacity and exercise induced dyspnea. To find out the frequency of diastolic dysfunction (DD) and the relationships between impaired exercise capacity and exercise induced dyspnea with DD by Doppler-derived indices among patients referred for stress test in a tertiary care hospital of Karachi.

Methods

For this study 135 consecutive patients who were referred for stress test at our non-invasive lab were screened for eligibility. Patients with valvular pathology, atrial fibrillation (AF) and coronary …

Nutrition Intervention To Decrease Symptoms In Patients With Advanced Heart Failure, Terry A. Lennie, Debra K. Moser, Martha J. Biddle, Darlene Welsh, Geza G. Bruckner, D. Travis Thomas, Mary Kay Rayens, Alison L. Bailey

Nursing Faculty Publications

For a majority of patients with advanced heart failure, there is a need for complementary, non-pharmacologic interventions that could be easily implemented by health care providers to provide palliative care. Three major pathologic pathways underlying heart failure symptoms have been identified: fluid overload, inflammation, and oxidative stress. Prior research has demonstrated that three nutrients-sodium, omega-3 fatty acids, and lycopene-can alter these pathologic pathways. Therefore, the purposes of this study are to test the effects of a 6-month nutrition intervention of dietary sodium reduction combined with supplementation of lycopene and omega-3 fatty acids on heart failure symptoms, health-related quality of life, …

Psychometrics Of The Depressive Cognition Scale In Caregivers Of Persons With Autism Spectrum Disorders, Abir K. Bekhet, Jaclene A. Zauszniewski

College of Nursing Faculty Research and Publications

Caregivers of persons with autism spectrum disorders (ASD) are prone to depression, and early identification of cognitive depressive symptoms is important to prevent the development of clinical depression. The Depressive Cognition Scale (DCS) can be used for early detection, but the scale's psychometrics has not been tested in caregivers of persons with ASD. In this study, 95 caregivers of persons with ASD completed the eight-item DCS and measures of caregiver burden and resourcefulness. A Cronbach's alpha of .90 indicated internal consistency. Construct validity was supported by significant correlations with caregiver burden (.59) and resourcefulness (− .57). Principal component factor analysis …

Lack Of Father Involvement In Research On Children With Autism Spectrum Disorder: Maternal Parenting Stress And Family Functioning, Norah L. Johnson, Pippa Simpson

College of Nursing Faculty Research and Publications

Autism Spectrum Disorder (ASD) has an estimated prevalence of greater than 1% of people in the US. Caring for children with ASD is stressful and challenging for parents. The purpose of the study is to understand the ramifications of the findings of a spouse/father's lack of participation for a study focused on stress and family functioning that attempted to recruit both parents of a child with ASD. The Kruskal-Wallis test compared medians of three groups of mothers of children with ASD in order to assess differences in parenting stress and family functioning discrepancy depending on their marital status and spouse …

A Review Of G6pd Deficiency In Pakistani Perspective, Bushra Moiz

Department of Pathology and Laboratory Medicine

No abstract provided.

Frequency Of Precancerous Lesions In Endoscopic Gastric Biopsies In Chronic Gastritis, Saroona Haroon, Naveen Faridi, Faisal Rashid Lodhi, Shafaq Mujtaba

Department of Pathology and Laboratory Medicine

Objective:
To determine the frequency of precancerous lesions in endoscopic gastric biopsies of patients with chronic gastritis.STUDY Design: A case series.
Place and duration of study:
Department of Histopathology, Liaquat National Hospital, Karachi, from July 2008 to January 2009.METHODOLOGY: Over 6 months, 375 endoscopic gastric biopsies of patients with age group of 15-65 years having endoscopic chronic gastritis were included. From final biopsy report, basic information like patient demographics and presence of precancerous lesions i.e. activity (chronic active gastritis), atrophy (atrophic gastritis), intestinal metaplasia and dysplasia were recorded on proforma. Results were described as proportions and frequency.
Results:
The frequency …

My Patient Had A Small Vessel Stroke, Are Two Antiplatelet Agents Better Than One?, Muhammad Faisal Wadiwala, Ayeesha Kamran Kamal

Department of Medicine

No abstract provided.

Reducing Catheter Associated Urinary Tract Infections: A Nurse-Driven Urinary Catheter Removal Protocol, Jennifer Devine Bsn, Rn, Cmsrn

Patient Care Services / Nursing

No abstract provided.

Genomics Unbound: The Scientific And Legal Case Against Patents Based On Naturally Occurring Dna Sequences, Fazal Khan

Scholarly Works

While there have been mixed opinions as to whether gene patents were dead in light of Prometheus,this Article argues that a proper understanding of patent law, genomics, and public policy concerns should lead to no other result. The primary focus of this piece is to rebut certain vested interests in the biotechnology industry and affirm the normative claim that gene patents improperly fetter genomics research and development. First, through the lens of the Myriad case, we will recount why there was such a strong public interest movement against recognizing such patents. Specifically, we will show how patents on naturally occurring …

Comparison Of Hemodynamic Response To Tracheal Intubation With Macintosh And Mccoy Laryngoscopes, Mehtab A. Haidry, Fauzia A. Khan

Department of Anaesthesia

Background: Use of McCoy blade laryngoscope avoids the lifting force in the vallecula and theoretically should lead to a lower hemodynamic response related to laryngoscopy and tracheal intubation. The available literature on the topic is conflicting.MATERIALS AND Methods: We studied the hemodynamic response to laryngoscopy and tracheal intubation in 60 ASA 1 AND 2 adult patients using either Macintosh or McCoy laryngoscopes. The change in systolic, diastolic, mean arterial pressure, and heart rate (HR) was observed for 10 min post intubation. Arrhythmias and ST changes were also observed.Results: The maximum change in HR was 18.7% in the Macintosh and 7.7% …

Reductions In Cardiovascular, Cerebrovascular, And Respiratory Mortality Following The National Irish Smoking Ban: Interruped Time-Series Analysis, Sericea Stallings-Smith, Ariana Zeka, Patrick J. Goodman, Zubair Kabir, Luke Clancy

Articles

Background:

Previous studies have shown decreases in cardiovascular mortality following the implementation of comprehensive smoking bans. It is not known whether cerebrovascular or respiratory mortality decreases post-ban. On March 29, 2004, the Republic of Ireland became the first country in the world to implement a national workplace smoking ban. The aim of this study was to assess the effect of this policy on all-cause and cause-specific, non-trauma mortality.

Methods:

A time-series epidemiologic assessment was conducted, utilizing Poisson regression to examine weekly age and gender-standardized rates for 215,878 non-trauma deaths in the Irish population, ages $35 years. The study period was …

Access To Oral Health Care In Nebraska, Aastha Chandak, Kim Mcfarland, Preethy Nayar, Jim P. Stimpson

Reports: Center for Health Policy

Oral health contributes to overall health; therefore, it is important to understand the level of access to oral health care in Nebraska. Our analysis of the most recently available data in Nebraska on access to oral health care and on the oral health workforce indicates that in 2010, 68.4% of Nebraskans aged 18 years and older visited a dentist within the past year. The total number of dentists practicing in Nebraska in 2012 was 1,028, compared to 1,017 in 2008; however, the number of dentists per 100,000 population decreased by 2.85% between 2008 and 2012, and the number of dentists …

Intra-Tumoral Heterogeneity In Metastatic Potential And Survival Signaling Between Iso-Clonal Hct116 And Hct116b Human Colon Carcinoma Cell Lines., Sanjib Chowdhury, Melanie Ongchin, Elizabeth Sharratt, Ivan Dominguez, J. Wang, Michael G. Brattain, Ashwani Rajput

Journal Articles: Eppley Institute

BACKGROUND: Colorectal cancer (CRC) metastasis is a leading cause of cancer-related deaths in the United States. The molecular mechanisms underlying this complex, multi-step pathway are yet to be completely elucidated. Recent reports have stressed the importance of intra-tumoral heterogeneity in the development of a metastatic phenotype. The purpose of this study was to characterize the intra-tumoral phenotypic heterogeneity between two iso-clonal human colon cancer sublines HCT116 and HCT116b on their ability to undergo metastatic colonization and survive under growth factor deprivation stress (GFDS).

MATERIALS AND METHODS: HCT116 and HCT116b cells were transfected with green fluorescence protein and subcutaneously injected into …

Effects Of Aging And Spectral Shaping On The Sub-Cortical (Brainstem) Differentiation Of Contrastive Stop Consonants, Dania A. Rishiq

Theses and Dissertations (ETD)

Purpose: The objectives of this dissertation are to: (1) evaluate the influence of aging on the sub-cortical (brainstem) differentiation of voiced stop consonants (i.e. /b-d-g/); (2) determine whether potential aging deficits at the brainstem level influence behavioral identification of the /b-d-g/ stimuli, (3) investigate whether spectral shaping diminishes any aging impairments at the brainstem level; and (4) if so, whether minimizing these deficits improves the behavioral identification of the speech stimuli.

Subjects: Behavioral and electrophysiological responses were collected from 11 older adults (> 50 years old) with near-normal to normal hearing and were compared to those of 16 normal-hearing younger …

Burn Disaster Management Planning: A Preparedness Toolkit (Poster), Brian S. Joho Msn, Rn, Daniel D. Lozano Md, Patrick Pagella Msn, Arnp, Michael Wargo Mba, Rn, Hamed Amani Md, Facs

Patient Care Services / Nursing

No abstract provided.

It’S All About The Culture – Creating A Culture Of Inquiry And Passion For Quality Improvement, Jennifer Devine Bsn, Rn, Cmsrn

Patient Care Services / Nursing

No abstract provided.

Forging A Niche To Strengthen The Inpatient Geriatric Service Line - Lessons From The Field, Tracie Heckman Msn, Rn, Cmsrn, Carolyn L. Davidson Rn, Phd

Patient Care Services / Nursing

No abstract provided.

Development Of Clinical Practice Guidelines: Care Of The Patient Following Anesthesia (Poster), Cheryl Barr Bsn, Rn, Cpan, Ruth Safi-Litz Rn, Bsn, Cpan

Patient Care Services / Nursing

No abstract provided.

Breaking The Barriers With The Perioperative Round Table (Poster), Toni J. Perez Adn, Rn, Amanda L. Knoll Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Conference Learnings, Elizabeth Partington Rn, Bsm

Patient Care Services / Nursing

No abstract provided.

Conference Learnings, Kelli Erb Rn-Bc

Patient Care Services / Nursing

No abstract provided.

Determinants Of Health-Related Quality Of Life In Arab American Patients With Type 2 Diabetes, Yousef Zakarni Phd

Dissertations

HRQL is an important aspect of chronic illnesses such as diabetes and needs to be considered by healthcare providers. It is one of the most important outcomes of healthcare interventions, representing an integral public health goal in Healthy People 2000, 2010, and 2020. Arab Americans (AAs), one of the most rapidly growing minorities in United States, tend to have a high prevalence of type 2 diabetes. The purpose of this study was to describe determinants of HRQL, including social support attitude, religiosity, and select demographics for AA patients with type 2 diabetes. A descriptive correlational study using a cross sectional …

Counselor Educator Knowledge, Experience, Attitudes And Beliefs Toward Complementary And Alternative Medicine, Jennifer Mills Langeland

Dissertations

Following growing public interest and widespread use, many health professions have begun to explore the attitudes toward, knowledge of and experience with complementary and alternative medicine (CAM) of the various stakeholders within their professions. This foundational information has enabled disciplines such as medicine, nursing, psychology, and marriage and family therapy to take a closer look at how students, patients, clients, and faculty think about and utilize CAM and its relevance to their professions. Surveying the practices and attitudes of stakeholders has been an important starting point for professions undertaking the task of integrating these practices into training programs.

This study …

Medical School Watercooler Newsletter - March 31, 2013, Lindsey Lyle

Watercooler Newsletter

This is the March 31, 2013 edition of the Frederick P. Whiddon College of Medicine's newsletter, watercooler.

Contents Include

• Memorial Fund Established to Honor Wynona "Nona" Odom

• USA Biomedical Library Celebrates PB&J Day

• April 11th DSS to Feature Dr. David Askew

• Sir Philip Cohen to Give Charles M. Baugh Lecture

• USA College of Medicine to Host Gumbo Chili Showdown This Weekend

• April Med School Café - 'The Ups and Downs of GERD'

Hidden Surveillance On Consumer Health Information Websites, Jacquelyn A. Burkell, Alexandre Fortier

FIMS Publications

Behavioural tracking presents a significant privacy risk to Canadians, particularly when their online behaviours reveal sensitive information that could be used to discriminate against them. This concern is particularly relevant in the context of online health information seeking, since searches can reveal details about health conditions and concerns that the individual may wish to keep private. The privacy threats are exacerbated because behavioural tracking mechanisms are large invisible to users, and many are unaware of the strategies and mechanisms available to track online behaviour. In this project, we seek to document the behavioural tracking practices of consumer health websites, and …

Sampson, Flemon Davis, 1875-1967 (Sc 964), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid only for Manuscripts Small Collection 964. Family correspondence, 1945-1958 (60 items), chiefly of Governor Flemon Davis Sampson, Barbourville, Kentucky and his daughters Emolyne (Sampson) Churchill and Paula (Sampson) Risen, Louisville, Kentucky. Also business correspondence and papers about Sampson’s incompetency and his financial affairs, 1955-1967 (38).