Medicine and Health Sciences Commons^™

Animal Health Matters, Russ Daly

Animal Health MATTERS Newsletter

[Page] 1- Dave Zeman Retires as Department Head and Director [Page] 2- Interim Director's Message: Transitions [Page] 3- Dr. Ying Fang Awarded Distinguished Researcher Award at SDSU [Page] 3- Ag Day at Washington Pavilion Specimen Receiving and Necropsy Sections [Page] 4- Serology Section at ADRDL [Page] 5- Effect of Safe-Guard Free-Choice Mineral Blocks on Tri-Chostrongyle Nematodes in Pastured Cattle from Eastern South Dakota [Page] 6- Travis Clement Recognized for Professional Staff Excellence [Page] 6- Lucinda Bloker Joins ADRDL Workforce [Page] 7- Bailey Herd Health Conference Covers Sheep and Goat Medicine [Page] 7- Continuing Education Events

Pancreatic Angiotensin-Converting Enzyme 2 Improves Glycemia In Angiotensin Ii-Infused Mice, Kavaljit H. Chhabra, Huijing Xia, Kim Brint Pedersen, Robert C. Speth, Eric Lazartigues

HPD Articles

An overactive renin-angiotensin system (RAS) is known to contribute to type 2 diabetes mellitus (T2DM). Although ACE2 overexpression has been shown to be protective against the overactive RAS, a role for pancreatic ACE2, particularly in the islets of Langerhans, in regulating glycemia in response to elevated angiotensin II (Ang II) levels remains to be elucidated. This study examined the role of endogenous pancreatic ACE2 and the impact of elevated Ang II levels on the enzyme's ability to alleviate hyperglycemia in an Ang II infusion mouse model. Male C57bl/6J mice were infused with Ang II or saline for a period of …

Ada News - 04/15/2013, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

What's Happening: April 15, 2013, Maine Medical Center

What's Happening

No abstract provided.

Development Of A Case-Mix Funding System For Adults With Combined Vision And Hearing Loss, Dawn M. Guthrie, Jeff Poss

Kinesiology and Physical Education Faculty Publications

Background: Adults with vision and hearing loss, or dual sensory loss (DSL), present with a wide range of needs and abilities. This creates many challenges when attempting to set the most appropriate and equitable funding levels. Case-mix (CM) funding models represent one method for understanding client characteristics that correlate with resource intensity.

Methods: A CM model was developed based on a derivation sample (n = 182) and tested with a replication sample (n = 135) of adults aged 18+ with known DSL who were living in the community. All items within the CM model came from a standardized, …

Chemically Diverse Microtubule Stabilizing Agents Initiate Distinct Mitotic Defects And Dysregulated Expression Of Key Mitotic Kinases., Cristina C. Rohena, Jiangnan Peng, Tyler A. Johnson, Phillip Crews, Susan L. Mooberry

Natural Sciences and Mathematics | Faculty Scholarship

Microtubule stabilizers are some of the most successful drugs used in the treatment of adult solid tumors and yet the molecular events responsible for their antimitotic actions are not well defined. The mitotic events initiated by three structurally and biologically diverse microtubule stabilizers; taccalonolide AJ, laulimalide/fijianolide B and paclitaxel were studied. These microtubule stabilizers cause the formation of aberrant, but structurally distinct mitotic spindles leading to the hypothesis that they differentially affect mitotic signaling. Each microtubule stabilizer initiated different patterns of expression of key mitotic signaling proteins. Taccalonolide AJ causes centrosome separation and disjunction failure to a much greater extent …

Angiotensin Type 1 Receptor Resistance To Blockade In The Opossum Proximal Tubule Cell Due To Variations In The Binding Pocket, Ravi Nistala, Bradley T. Andresen, Lakshmi Pulakat, Alex Meuth, Catherine Sinak, Chirag Mandavia, Thomas Thekkumkara, Robert C. Speth, Adam Whaley-Connell, James R. Sowers

HPD Articles

Blockade of the angiotensin (ANG) II receptor type 1 (AT(1)R) with angiotensin receptor blockers (ARBs) is widely used in the treatment of hypertension. However, ARBs are variably effective in reducing blood pressure, likely due, in part, to polymorphisms in the ARB binding pocket of the AT(1)R. Therefore, we need a better understanding of variations/polymorphisms that alter binding of ARBs in heterogeneous patient populations. The opossum proximal tubule cell (OKP) line is commonly used in research to evaluate renal sodium handling and therefore blood pressure. Investigating this issue, we found natural sequence variations in the opossum AT(1)R paralleling those observed in …

Holobiont Nutrition: Considering The Role Of The Gastrointestinal Microbiota In The Health Benefits Of Whole Grains, Jens Walter, Ines Martinez, Devin J. Rose

Food for Health: Publications

Intake of whole grains and other food products high in dietary fiber have long been linked to the prevention of chronic diseases associated with inflammation. A contribution of the gastrointestinal microbiota to these effects has been suggested, but little is known on how whole grains interact with gut bacteria. We have recently published the first human trial that made use of next-generation sequencing to determine the effect of whole grains (whole grain barley, brown rice or a mixture of the two) on fecal microbiota structure and tested for associations between the gut microbiota and blood markers of inflammation, glucose and …

Alcohol And The Heart: To Abstain Or Not To Abstain?, Rajesh Movva, Md, Mrcp, Vincent M. Figueredo, M.D.

Division of Cardiology Faculty Papers

Alcohol has been consumed by most societies over the last 7000 years. Abraham Lincoln said "It has long been recognized that the problems with alcohol relate not to the use of a bad thing, but to the abuse of a good thing." Light to moderate alcohol consumption reduces the incidence of coronary heart disease (CHD), ischemic stroke, peripheral arterial disease, CHD mortality, and all-cause mortality, especially in the western populations. However, heavy alcohol consumption is detrimental causing cardiomyopathy, cardiac arrhythmias, hepatic cirrhosis, pancreatitis, and hemorrhagic stroke. In this article, we review the effects of alcohol on CHD, individual cardiovascular risk …

Smooth Muscle Fascicular Reorientation Is Required For Esophageal Morphogenesis And Dependent On Cdo., Anthony I Romer, Jagmohan Singh, Satish Rattan, Robert S Krauss

Department of Medicine Faculty Papers

Postnatal maturation of esophageal musculature involves proximal-to-distal replacement of smooth muscle with skeletal muscle by elusive mechanisms. We report that this process is impaired in mice lacking the cell surface receptor Cdo and identify the underlying developmental mechanism. A myogenic transition zone containing proliferative skeletal muscle precursor cells migrated in a proximal-distal direction, leaving differentiated myofibers in its wake. Distal to the transition zone, smooth muscle fascicles underwent a morphogenetic process whereby they changed their orientation relative to each other and to the lumen. Consequently, a path was cleared for the transition zone, and smooth muscle ultimately occupied only the …

Medical School Watercooler Newsletter - April 14, 2013, Lindsey Lyle

Watercooler Newsletter

This is the April 14, 2013 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler

Contents Include

• Senior Medical Students Return from Medical Mission Trip to Rwanda, Africa

• Med School Café - Expert Advice for the Community

• April 25th DSS to Feature Dr. Ann Richmond

• USA Medical Student Among Winners of National Medical Students Competition

Ohio Academy Of Medical History Annual Meeting Program, April 13, 2013, Ohio Academy Of Medical History

Annual Conference Programs

This program is from the annual meeting of the Ohio Academy of Medical History held on April 13, 2013 at Heidelberg University in Tiffin, Ohio. The program details the events and presentations of the meeting.

A Case Of Congenital Unilateral Absence Of The Vas Deferens, Bi Mo, Vishnu Garla, Lawrence M. Wyner M.D.

Surgery

Background

Congenital unilateral absence of the vas deferens occurs in 0.5%–1.0% of males. It has been associated with various genitourinary abnormalities, including renal agenesis. We report a case of congenital unilateral absence of the vas deferens found incidentally during vasectomy in a patient with known unilateral renal agenesis.

Case presentation

A 24-year-old male presented to our urology clinic requesting vasectomy. His past history was significant for left renal agenesis. Following successful right vasectomy, several attempts to locate the left vas deferens were unsuccessful. We diagnosed congenital unilateral absence of the vas deferens. Follow-up semen analysis showed azoospermia.

Conclusion

As vasectomies …

Dr. Snook And The Coed: The Theora Hix Affair And Murder, James R. Hennessy

Annual Conference Presentations, Papers, and Posters

Dr. James Howard Snook was born in South Lebanon, Ohio in Warren County in 1879. He was both an alumnus and later a faculty member of the Ohio State University College of Veterinary Medicine. In 1922 Dr. Snook married Helen Marple and had a daughter. In 1926 Dr. Snook began an affair with an OSU medical student, Theora Hix. The affair lasted about 2 years. During a visit in 1929 Theora Hix allegedly threatened to harm Dr. Snook's wife and child. Dr. Snook murdered her and was sentenced to death in February of 1930.

The Murder Trials Of Harry K. Thaw (1907 And 1908) And Dr. Arthur Waite (1916) And The Perplexing Concept Of “Constitutional Inferiority”, Emil R. Pinta

Annual Conference Presentations, Papers, and Posters

The murder trials of Harry Thaw, in 1907 and 1908, and dentist Dr. Arthur Waite, in 1916, were “celebrity trials” that received widespread newspaper coverage. As such, they brought psychiatry and psychiatric diagnosis into the public’s awareness.

Identification Of Roach’S Concepts Of Caring In Sophomore Nursing Students At A Women’S Prison, Mary Ann Burnam, Mary Mckelvey

Annual Conference Presentations, Papers, and Posters

The concept of caring has been identified with nursing since its professional organization. Several theories of caring have been developed and some adopted for instruction and implementation in nursing programs. This study’s aim was to identify caring attributes exhibited in a group of sophomore nursing students who had their maternity experience in a women’s prison. A focus group of six students responded in a semi-structured interview about their experiences with pregnant prisoners. The interview was recorded, transcribed and analyzed for Roach’s five caring concepts. The qualitative analysis revealed that sophomore nursing students manifested the caring concepts in their experience with …

Method For Measuring The Contribution Of The Vastus Lateralis To Cycling In Incremental Tests To Fatigue In Women, Tori Haggett, Hunter Wilhoit, Nathan Klabunde

Furman Engaged!

The purpose of this study is to determine whether or not there is a significant increase in the muscle activity of the vastus lateralis at different stages of a resistance ramp test to fatigue during cycling. The vastus lateralis is the quadriceps muscle on the lateral side of the leg. Basically, this study is figuring out if this muscle is more active at a higher power, or higher resistance, during cycling.

Comparison Of Muscle Activity Between The Tsunami BarbellTm And An Olympic Barbell, Jason Jakiela, Tony Caterisano, Randolph Hutchison, Raymond Moss

Furman Engaged!

No abstract provided.

12th Annual Undergraduate Student Symposium, Farquhar Honors College

Undergraduate Student Symposium

The Undergraduate Student Symposium, sponsored by the Farquhar College of Arts and Sciences, presents student projects through presentations, papers, and poster displays. The event serves as a “showcase” demonstrating the outstanding scholarship of undergraduate students at NSU. The Symposium is open to undergraduate students from all disciplines. Projects cover areas of student scholarship ranging from the experimental and the applied to the computational, theoretical, artistic, and literary. They are taken from class assignments as well as from independent projects. The projects do not have to be complete; presentations can represent any stage in the concept’s evolution, from proposal and literature …

Mek And The Inhibitors: From Bench To Bedside, Akintunde Akinleye, Muhammad Furqan, Nikhil Mukhi, Pavan Ravella, Delong Liu

NYMC Faculty Publications

Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been identified. MEK1 and MEK2 are the prototype members of MEK family proteins. Several MEK inhibitors are in clinical trials. Trametinib is being evaluated by FDA for the treatment of metastatic melanoma with BRAF V600 mutation. Selumetinib has been studied in combination with docetaxel in phase II randomized trial in previously treated patients with advanced lung cancer. Selumetinib group had better response rate and progression-free survival. This review also summarized new MEK inhibitors in clinical development, including pimasertib, refametinib, PD-0325901, TAK733, MEK162 (ARRY 438162), RO5126766, WX-554, RO4987655 (CH4987655), GDC-0973 …

Better Drug Therapy For The Children Of Africa: Current Impediments To Success And Potential Strategies For Improvement, Stuart M. Macleod, Janet K. Finch, William Macharia, Gabriel M. Anabwani

Paediatrics and Child Health, East Africa

A commentary is presented on the urgent need for a comprehensive effort to improve the practice of pediatric therapeutics in Africa. A call for action is addressed to a variety of practitioners internationally, many of whom possess skills that could be fruitfully applied to the improvement of health outcomes for African children. Successful engagement with the many challenges requires the complementary effort of researchers in basic and clinical pharmacology and toxicology, nurses, pharmacists, physicians, clinical pharmacologists, clinical pharmacists, and political leaders and civil servants. While a comprehensive or systematic review of the relevant literature has not been attempted, the authors …

Sea Water Acidification Affects Osmotic Swelling, Regulatory Volume Decrease And Discharge In Nematocytes Of The Jellyfish Pelagia Noctiluca, Rossana Morabito, Angela Marino, Peter K. Lauf, Norma C. Adragna, Giuseppa La Spada

Pharmacology and Toxicology Faculty Publications

Ion transporters are the molecular basis for ion homeostasis of the cell and the whole organism. The anion exchanger pendrin is only one of a number of examples where a complete or partial loss of function and/or deregulation of expression of ion transporters may lead or contribute to pathological conditions in humans. A complete understanding of the function of ion transporters in health and disease may pave the way for the identification of new and focused therapeutic approaches. Exchange of knowledge and connectivity between the experts in the feld of transport physiology is essential in facing these challenging tasks. The …

White Light-Informed Optical Properties Improve Ultrasound-Guided Fluorescence Tomography Of Photoactive Protoporphyrin Ix, Brendan P. Flynn, Alisha V. Dsouza, Stephen C. Kanick, Scott C. Davis, Brian W. Pogue

Dartmouth Scholarship

Subsurface fluorescence imaging is desirable for medical applications, including protoporphyrin-IX (PpIX)-based skin tumor diagnosis, surgical guidance, and dosimetry in photodynamic therapy. While tissue optical properties and heterogeneities make true subsurface fluorescence mapping an ill-posed problem, ultrasound-guided fluorescence-tomography (USFT) provides regional fluorescence mapping. Here USFT is implemented with spectroscopic decoupling of fluorescence signals (auto-fluorescence, PpIX, photoproducts), and white light spectroscopy-determined bulk optical properties. Segmented US images provide a priori spatial information for fluorescence reconstruction using region-based, diffuse FT. The method was tested in simulations, tissue homogeneous and inclusion phantoms, and an injected-inclusion animal model. Reconstructed fluorescence yield was linear with PpIX …

Wright State University Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts Friday, April 12, 2013, Wright State University Office Of Undergraduate Research And Stemm Activities

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's second annual Celebration of Research, Scholarship and Creative Activities on April 12, 2013.

Development Of Antagonists Targeting Chemokine Receptor Ccr5 And The Chemokine Receptor Ccr5 – Mu Opioid Receptor Heterodimer, Christopher Kent Arnatt

Theses and Dissertations

The chemokine receptor CCR5 (CCR5) plays an integral role within the inflammatory network of cells. Importantly, CCR5 is a mediator in several disease states and can be targeted using small molecule antagonists. Within this work, CCR5’s role in prostate cancer and HIV/AIDS has been exploited in order to develop potential therapeutics and probes. First, a series of novel compounds was designed by using pharmacophore-based drug design based upon known CCR5 antagonists and molecular modeling studies of the CCR5 receptor’s three-dimensional conformation. Once synthesized, these compounds were tested for their CCR5 antagonism and their anti-proliferative effects in several prostate cancer cell …

The Effects Of An Educational Intervention Based On "Visual Cues" And A "Buddy System" On The Incidence And Prevalence Of Pressure Ulcers, Rosa Filomeno, Gloria Rueda, Adriana Garay, Shelly Commock, Erica Cuthbert, Maria Ojeda

All Publications

No abstract provided.

The Influence Of Faculty Mentors On Junior Pharmacy Faculty Members’ Career Decisions, Nicholas E. Hagemeier, Matthew M. Murawski, Nicholas G. Popovich

ETSU Faculty Works

Objective. To assess junior faculty members’ perceptions regarding the impact of past faculty-mentoring relationships in their career decisions, including the decision to pursue postgraduate training and ultimately an academic career.

Methods. A mixed-mode survey instrument was developed and an invitation to participate in the survey was sent to 2,634 pharmacy faculty members designated as assistant professors in the American Association of Colleges of Pharmacy (AACP) directory data.

Results. Usable responses were received from 1,059 pharmacy faculty members. Approximately 59% of respondents indicated that they had received encouragement from 1 or more faculty mentors that was very or extremely influential in …

Scale - Skin Changes At Life's End: An Educational Intervention For Intensive Care, And Medical Surgical Nurses, Rosa Filomeno, Sophie Boudreau, Maria Ojeda

All Publications

No abstract provided.

Fluorescent Affibody Peptide Penetration In Glioma Margin Is Superior To Full Antibody, Kristian Sexton, Kenneth Tichauer, Kimberley S. Samkoe, Jason Gunn, P. Jack Hoopes, Brian W. Pogue

Dartmouth Scholarship

Object: Fluorescence imaging has the potential to significantly improve neurosurgical resection of oncologic lesions through improved differentiation between normal and cancerous tissue at the tumor margins. In order to successfully mark glioma tissue a fluorescent tracer must have the ability to penetrate through the blood brain barrier (BBB) and provide delineation in the tumor periphery where heterogeneously intact BBB may exist. In this study it was hypothesized that, due to its smaller size, fluorescently labeled anti-EGFR Affibody protein (~7 kDa) would provide a more clear delineation of the tumor margin than would fluorescently labeled cetuximab, a full antibody (~150 kDa) …

Use Of A Blog In An Undergraduate Capstone Course, Shelly J. Reed, Debra Edmunds

Faculty Publications

A blog was utilized in a nursing capstone course to allow a venue for reflection and used in two separate capstone course. Focus group interviews were conducted to obtain student views of the blog and blogging activity. Students were positive about blog use, and identified the blog as helpful for debriefing/reflection, socialization and connectedness with peers, as well as progression toward becoming a registered nurse following graduation.