Medicine and Health Sciences Commons^™

Characterization Of Bioreducible Poly(B-Amino Ester) Nanoparticles For Sirna Delivery, Bolivia Hurtado De Mendoza

Theses and Dissertations

Glioblastoma multiforme (GBM) is one of the most malignant brain tumors affecting adults. It is characterized by necrotic tissue and abnormal vasculature, making it highly resistant to current cancer treatments. A promising alternative to standard cancer therapeutics is the use of drug delivery systems such as polymeric nanoparticles (NP) that deliver silencing RNA (siRNA) exclusively to tumor cells for gene knockdown. Presently, nonviral delivery vectors, such as poly(B-amino ester) (PBAE) NP, are beneficial delivery systems because they are less immunogenic and easier to chemically modify than vectors delivered by viruses. Although current formulations of PBAEs allow cargo release via hydrolytic …

Management Of The Medically Fragile Child In The K- Fifth Grade Classroom Setting, Mandy M. Cranney

Theses and Dissertations

The aim of this focused project was to explore perceptions and identify needs of teachers of medically fragile children (MFC), in the grade setting, with the hope of designing educational modules to be utilized as supportive measures by the teachers for the classroom setting. The focused project consisted of an extensive literature review of medical fragility in school age children as well as a literature review of teachers' perceptions and needs identified in the past. Nola Pender's Health Promotion Model served as the conceptual framework in designing the study. Two focus groups were conducted among grade teachers enrolled in Masters …

State-By-State Variation In Emergency Versus Elective Colon Resections: Room For Improvement., Augustine C. Obirieze, Mehreen Kisat, Caitlin W. Hicks, Tolulope A. Oyetunji, Eric B. Schneider, Darrell J. Gaskin, Elliott R. Haut, David T. Efron, Edward E. Cornwell, Adil H. Haider

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Compared with elective surgical procedures, emergency procedures are associated with higher cost, morbidity, and mortality. This study seeks to investigate potential state-by-state variations in the incidence of emergent versus elective colon resections.

METHODS: A retrospective analysis of all adult patients (aged ≥18 years) included in the Nationwide Inpatient Sample from 2005 to 2009 who underwent hemicolectomy (right or left) or sigmoidectomy was conducted. Discharge-level weights were applied, and generalized linear models were used to assess the odds of a patient undergoing emergent versus elective colon surgery nationally and for each state after adjusting for patient and hospital factors. Odds …

The Cultural Manifestations Of Anorexia Nervosa, Aaron Volk

Tredway Library Prize for First-Year Research

No abstract provided.

Prediction Of Advanced Fibrosis In Nonalcoholic Fatty Liver Disease: An Enhanced Model Of Bard Score., Tae Hoon Lee, Seung Hye Han, Ju Dong Yang, Donghee Kim, Monjur Ahmed

Department of Medicine Faculty Papers

UNLABELLED: BACKGROUNDAIMS: The BARD score is a model to detect advanced liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients. The aims of this study were to identify additional factors and then to build an enhanced version of the BARD score.

METHODS: One hundred seven patients with biopsy-proven NAFLD were enrolled retrospectively. Logistic regressions were performed to identify independent risk factors for advanced liver fibrosis (stage 3 or 4). An enhanced model of the BARD score (BARDI score) was built and evaluated with a receiver operating characteristic (ROC) curve.

RESULTS: In multivariate analysis, age (odds ratio [OR], 0.89; p=0.04), aspartate …

Post-Concussive Syndrome In A Female Basketball Player: A Case Study, Sarah L. Strand

Health and Human Sciences Faculty Works

The objective of this case study was to identify the signs and symptoms of concussion and post-concussive syndrome in a collegiate, female basketball player, as well as her progress to becoming symptom free. The patient, a previously healthy, 21-year-old with no previous head injuries, experienced a concussion and continued to participate in her sport. Even though the athlete knew the risks of playing while symptomatic, she did not report her symptoms, and continued playing until the season ended. This case highlights that even when patients know the risks, they may be willing to overlook them to continue playing and it …

Anxiety Symptoms In Individuals With High Functioning Autism, Jane C. Kelleher

Honors Scholar Theses

Research indicates a complicated relationship between anxiety disorders and autism spectrum disorders (ASDs). The current study examined the relationship between anxiety symptoms and ASD in 30 Optimal Outcome (OO) individuals, 33 High Functioning Autism (HFA) individuals, and 34 Typically Developing (TD) individuals. The groups were compared on the K-SADS measure of anxiety symptoms. The HFA group presented greater anxiety than both the OO and TD groups, and the OO and TD groups only differed on one anxiety symptom. Across all three groups, there was a significant association between greater anxiety symptoms and a higher level of social and communicative impairment. …

In Vitro Characterization Of Avian Influenza Virus Isolates With A Truncated Ns1 Gene Segment, Aaron Dick

Honors Scholar Theses

Avian Influenza Virus represents a significant threat to the world poultry population, and is a potential threat to humans due to the possibility of cross-species AIV infection. Our approach is to characterize a number of avian virus populations with respect to their content of biologically active particles that include hemagglutinating particles (HAP), plaque forming particles (PFP), interferon inducing particles (IFP), interferon induction-suppressing particles (ISP), defective-interfering particles (DIP), cell-killing particles (CKP) and non-infectious cell killing particles (niCKP) using unique in vitro assays developed for avian influenza virus in the Marcus-Sekellick Laboratory. Specifically, we will use a strain of Avian influenza virus, …

The Impact Of Technology Attitudes And Skills Of Rural Health Clinic Nurses On The Level Of Adoption Of Electronic Health Records In Mississippi, Jennifer Lynn Styron

Dissertations

The evolution of health information technology continues to reform the delivery of efficient, safe, and equitable healthcare in the United States. One such example is the emergence of electronic health records (EHRs) and the discerning emphasis placed on using this technology in meaningful ways. While the integration of EHRs into daily practice impacts all healthcare professionals, nurses remain a prominent driver in the successful adoption and usage of these systems. It is therefore imperative to understand the impact of nurses’ technology attitudes and skills on the level of EHR adoption in Mississippi.

This quantitative study examined the technology attitudes and …

Toward A Model For Predicting Depression Among Veterans, Nita Aurora Magee-Cornelius

Dissertations

Major depression, identified as a leading cause of disability in the United States, is often first diagnosed by primary care providers. This disability is associated with increased morbidity, mortality, and a lower quality of life. With approximately one in every three veteran diagnosed with depression and the rate of suicide increasing in the United States military (Department of Veterans Affairs, 2009), the Patient Health Questionnaire-2 items (PHQ-2) can be instrumental in identification and monitoring of depressive symptoms. The purposes of this retrospective study were to determine the prevalence of depression, as measured by the federally mandated PHQ-2 in the VA, …

Perceptions Of Workplace Bullying Among Practicing Registered Nurses, Crystal Regina Threadgill

Dissertations

Workplace bullying (WPB) is a social and organizational problem. Within the health care arena, employees, particularly registered nurses, are at risk. WPB has several adverse effects and has been cited in the literature as closely associated with burnout and nurses leaving their positions. This quantitative study examined workplace bullying among practicing registered and its relationship with burnout and nurses’ intent to leave their current position.

The surveys utilized were the Negative Acts Questionnaires-Revised (NAQ-R), Maslach Burnout Inventory Survey, Intention to Turnover Scale and a demographic survey. Of the surveys distributed, a total of 185 were returned from one selected hospital …

A Public Health Response Against Strongyloides Stercoralis: Time To Look At Soil-Transmitted Helminthiasis In Full., Alejandro J Krolewiecki, Patrick Lammie, Julie Jacobson, Albis-Francesco Gabrielli, Bruno Levecke, Eugenia Socias, Luis M Arias, Nicanor Sosa, David Abraham, Ruben Cimino, Adriana Echazú, Favio Crudo, Jozef Vercruysse, Marco Albonico

Department of Microbiology and Immunology Faculty Papers

Strongyloides stercoralis infections have a worldwide distribution with a global burden in terms of prevalence and morbidity that is largely ignored. A public health response against soil-transmitted helminth (STH) infections should broaden the strategy to include S. stercoralis and overcome the epidemiological, diagnostic, and therapeutic challenges that this parasite poses in comparison to Ascaris lumbricoides, Trichuris trichiura, and hookworms. The relatively poor sensitivity of single stool evaluations, which is further lowered when quantitative techniques aimed at detecting eggs are used, also complicates morbidity evaluations and adequate drug efficacy measurements, since S. stercoralis is eliminated in stools in a larval stage. …

Comparison Of Oral Ketamine-Midazolam And Chloral Hydrate-Meperidine-Hydroxyzine Sedation Regimens In Pediatric Dentistry, David Merrell

Theses and Dissertations

Purpose: The purpose of this study was to create an experimental design to compare the regimen of ketamine-midazolam to chloral hydrate-meperidine-hydroxyzine for moderate oral conscious sedation. Methods: Patients between 36 and 83 months of age have been randomly assigned to receive 1 of the 2 regimens. Dosages, times, and vital signs will be recorded. Procedures will be recorded on video for assessment of sedation level and behavior. Patients will be contacted to evaluate postoperative sleeping, discomfort, and amnesia. Data will be analyzed using two-group t-tests (TOST) of equivalence in means to compare the two groups across the study period. Results: …

Decreasing Fall Risk In Older Adults With Serious Mental Illness, Reynaldo Joseph Ballesteros Jr., Kellie Ann Hislop, Chanita Mary Panchasarp

Dissertations, Masters Theses, Capstones, and Culminating Projects

This thesis project was created to help promote fall risk awareness in older adults who are living in the community with a serious mental illness. This project consisted of a 3-part multifactorial intervention plan that focused on increasing fall risk awareness and promoting participation in healthy lifestyles. Environmental modifications were made to the facility to create a safe environment and minimize the risk of falls. An exercise video was created and piloted with the residents of a facility for people with serious mental illness. The video included strength and balance exercises which minimize the risks of falling. An inservice was …

Increasing Fall Self-Efficacy And Awareness Of Fall Risks Among Community-Dwelling Older Adults, Dona Diane Andersen, Brian Edwin Dinozo, Heather Vengco Enrile, Brittany Anne Hutchison

Dissertations, Masters Theses, Capstones, and Culminating Projects

Objective: The purpose of this study was to examine the effectiveness of a modified version of the Stepping On fall prevention program in increasing fall self-efficacy and awareness of fall risks in community-dwelling older adults.

Method: This research study utilized a quantitative, quasi-experimental pretest-posttest singlegroup design with a qualitative element. The fall prevention program was the intervention of this study. The Modified Falls Efficacy Scale (MFES) was a pre and post measurement tool. The Timed Up & Go Test (TUG), the Romberg test, and the Saint Louis University Mental Status Examination (SLUMS) were screening tools. Fourteen older adults aged 75 …

Developing A Comprehensive Handwriting Curriculum Utilizing The Handwriting Without Tears™ Approach For Typically Developing Elementary School Aged Children, Taryn Nicole Clough, Jane C. Malone, Christina Marilyn Robertson

Dissertations, Masters Theses, Capstones, and Culminating Projects

It is estimated that 27% of school-aged children in the United States have handwriting difficulties (McHale & Cermak, 1992). According to Hammerschmidt and Sudsawad (2004), illegible handwriting is the most common reason for referral to occupational therapy services; 49.2% of total referrals. Previous research on handwriting intervention supports that task-oriented handwriting instructional methods, such as Handwriting Without Tears™ (HWT), are among the most effective handwriting intervention approaches (Lust & Donica, 2011; Olsen, 2011; Weintraub et al., 2009). The purpose of this project was to develop a comprehensive handwriting curriculum based on the HWT™ technique, including the new IPad application and …

Kindergarten Readiness: The Impact Of Sensory Integration On Preschool Children's Readiness For The Transition To Kindergarten, Laura Alexandria Boyd, Shannon Logan Sobieraj

Dissertations, Masters Theses, Capstones, and Culminating Projects

The goal of this quantitative, descriptive pilot study was to identify the frequency of sensory processing disorders (SPD) in preschool students who are preparing for the transition into kindergarten. The research also explored the relationship between preschool teachers' perspectives of challenging classroom behavior and parents' reports of sensory processing in the home. Researchers distributed the Sensory Processing Measure for Preschoolers (SPM-P) assessment to parents and a behavioral questionnaire to teachers in three northern California preschools. Thirty-two SPM-P assessments were distributed to parents and 15 (47%) were accurately completed and returned. Of this sample, 2 (13%) student scores on the SPM-P …

Healthy Seniors: A Program Evaluation, Andrea Edith Maffei, Matthew Alexander Patjawee, Jamie Christine Thompson

Dissertations, Masters Theses, Capstones, and Culminating Projects

OBJECTIVE: The purpose of this research study was to perform a summative evaluation of the Healthy Seniors program at Dominican University of California, a wellness program for older adults facilitated by occupational therapy students and faculty.

METHOD: A non-experimental mixed-methods descriptive research design composed of quantitative and qualitative methods was used to analyze data from the 2011 Healthy Seniors sessions.

RESULTS: The majority of participants in the Dominican University of California Healthy Seniors program were women between the ages of 75 and 85. Overall, participants in the Healthy Seniors program improved in functional status and were satisfied with their experience. …

Circles Of Connection: Finding Social Connectedness And Meaning Within Group Process, Julianna F. Bratsberg, Aundrea Marcella Roberts, Susan R. Untiedt

Dissertations, Masters Theses, Capstones, and Culminating Projects

Social participation is an area of occupation that can increase and enhance an individual’s participation in life. This is particularly true in senior housing communities where common issues of aging and adjustment can be addressed while reducing feelings of social isolation. The purpose of this demonstration project was to provide a venue where older adults living at The Redwoods, a senior housing community in Mill Valley, California, could share and develop meaningful strategies for living, and ultimately foster a sense of connectedness, which would affect quality of life. The project’s goals were to create and implement a series of process …

Bridging The Gap For First Generation Students (Bg4fgs): An Occupation-Based Peer Mentoring Program At Dominican University Of California, Victoria Danielle Rivera, Marion De Celis Sarte, Alison Jean Wiggam

Dissertations, Masters Theses, Capstones, and Culminating Projects

Attending college is a major milestone in the lives of students. The transition to college can be a challenging process for new students, particularly first-generation students, impacting their ability to meet the more rigorous academic demands and to integrate socially into the campus community (Prospero & Vohra-Gupta, 2007; Ramos-Sanchez & Nichols, 2007). To ease the transition to college, peer mentoring programs can assist new college students by offering guidance, one-on-one and group sessions, providing information about campus life and resources, and referring them to support services (Ferrari, 2004; Lennox & Leonard, 2007). The project developers collaborated with Dominican University of …

An Analysis Of Occupational Therapists’ Listening Behaviors During Treatment Sessions, Steven Joseph Devilbiss, Andreanna Marie Rodriquez, Maria Tolentino

Dissertations, Masters Theses, Capstones, and Culminating Projects

Background and purpose. Given the importance of listening in establishing a therapeutic relationship between healthcare providers and clients, there is a lack of research investigating the listening behaviors occupational therapists (OTs) use in clinical settings. The purpose of this study was to analyze what verbal and nonverbal listening behaviors OTs employ in clinical treatment sessions.

Subjects. Convenience and snowball sampling were used to recruit five OTs and five clients working with those OTs.

Methods. An observational study was used to investigate the verbal and nonverbal listening behaviors OTs employed during the first five minutes of each clinical treatment session. Each …

Malignant Vascular Tumours Associatedwith The Breast: A Study Of 7 Cases, Azizun-Nisa, Zeeshanuddin, Naila Kayani

Department of Pathology and Laboratory Medicine

Angiosarcomas account for less than 0.05% of the malignant neoplasms of the breast. We present here 7 cases of malignant vascular neoplasms of the breast, including 2 cases of postmastectomy Stewart-Treves syndrome. In this case series, most of the patients were young. Tumour was bilateral at presentation in one case. The size of the tumours ranged from 1.6 cm to 11 cm. Although breast angiosarcomas are rare neoplasms, with the increasing use of radiation therapy for breast cancer patients, post-radiation skin lesions should not be ignored.

Conservative Management Of Invasive Cervical Resorption: A Case Report, Fahad Umer, Samira Adnan, Farhan Raza Khan

Section of Dental-Oral Maxillofacial Surgery

Abstract

Invasive cervical resorption is a condition that affects the root surface area below the epithelial attachment. Multiple treatment modalities are advocated, involving exposure of the invasive defect, removal of the granulation tissue and sealing with various restorative materials. This report demonstrates conservative treatment of a patient presenting with peri-apical periodontitis in upper right central and lateral incisors, along with Class II invasive resorption defect cervically on the mesial aspect of the central incisor, as a result of trauma. As the patient was not willing for any surgical intervention, only ortho-grade root canal treatment was carried out in both teeth, …

In Vitro And In Vivo Characterization Of The Infection Efficiency Of A Modified Retrovirus Envelope Glycoprotein For Targeting Gene Transduction, Robin L. Krueger

Theses and Dissertations (ETD)

Attributes of both the viral glycoprotein and its cellular receptor play key roles in determining the outcome of infection. This body of work endeavors to illustrate how these two components influence the efficiency of virus infection in in vitro and in vivo systems with an emphasis on characterizing the transduction capacity of a novel entry-targeting glycoprotein. In previous work, the Moloney murine leukemia virus (MLV) envelope glycoprotein (Env) was modified to generate the Sst-RBS glycoprotein. This glycoprotein was created by replacing the wild type (WT) receptor binding site (RBS), located on the surface subunit (SU) of the Env, with the …

Gene Therapy And Stem Cell Therapy To Improve The Outcome Of Human Islet Transplantation, Hao Wu

Theses and Dissertations (ETD)

Since its first introduction in 1990s, the Edmonton Protocol for human islet transplantation has helped more than 500 patients with type 1 diabetes worldwide and met great success from bench to bedside. The Edmonton Protocol involves isolating islets from a cadaveric donor pancreas by enzymatic digestion and infusing into the patient's portal vein. Each recipient usually receives islets from two or three donors for an optimal outcome and is dosed with two immunosuppressive drugs, sirolimus and tacrolimus and a monoclonal antibody drug daclizumab to prevent the graft rejection. However, despite the administration of immunosuppressive drugs and the recent improvement in …

Bone Properties Of Recombinant Inbred Line - Bxd Mouse, Yueying Angela Zhang

Theses and Dissertations (ETD)

Osteoporosis is identified by reduced bone mass, decreased bone quality and altered bone micro-architecture. These traits are quantitative and also highly regulated by genetic and environmental factors. As a powerful tool for collaborative analysis of quantitative traits and gene function, BXD recombinant inbred (RI) lines mice have been used to identify genetic effects for bone density.

For the first time, we investigated the bone properties of BXD RI mice by analyzing femur and tibia and compared their phenotypes of different compartments. In this study, microcomputed tomography (µCT) provided an accurate measurement on characterizing bone quality and bone architecture ex-vivo; three-point …

Building A Foundation For Interprofessional-Education (Ipe) Between Dietetic Students And Dental Hygiene Students At East Tennessee State University (Etsu), Monique Richard

Electronic Theses and Dissertations

Nutrition education is an integral part of dental education as well as a variety of other healthcare professions¹, but interprofessional education (IPE) between the fields of dietetics and dental hygiene is limited. The purpose of this pilot study was to define areas of opportunity to establish a foundation for the implementation of complimentary curriculum between the dietetics and dental hygiene programs at ETSU. A 76-question survey was developed and administered to dietetic interns (n=26), dental hygiene students (n=49), dietetic faculty (n=23), and dental hygiene faculty (n=19) at ETSU and Baylor College of Dentistry at Texas A&M Health Science …

A Mathematical Model For Antibiotic Resistance In A Hospital Setting With A Varying Population, Edward H. Snyder

Electronic Theses and Dissertations

Antibiotic-resistant bacteria(ARB) is causing increased health risk and cost to society. Mathematical models have been developed to study the transmission of resistant bacteria and the efficacy of preventive measures to slow its spread within a hospital setting. The majority of these models have assumed a constant total hospital population with the admission and discharge rates being equal throughout the duration. But a typical hospital population varies from day to day and season to season. In this thesis, we apply variable admission and discharge daily rates to existing deterministic and stochastic models which examine the transmission of single and dual resistant …

Genetic Imbalances In Endometriosis Detected By Oligonucleotide-Array Based Comparative Genomic Hybridization, Natalie Burke

Electronic Theses and Dissertations

Endometriosis is one of the most common gynecological diseases as it is thought to affect up to 15% of the female population. Characterized by the growth and proliferation of endometrial tissue outside of the uterine cavity, it is a complex condition with varying degrees of severity and can affect multiple regions of the body with symptoms ranging from a total lack of symptoms to debilitating pain and infertility. The most accepted theory of how endometriosis initiates is that of retrograde menstruation; however, approximately 90% of women with unobstructed fallopian tubes are thought to have some menstrual debris in the peritoneal …

Effect Of Aquatic Immersion On Static Balance, Talin J. Louder

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Objective To quantitatively assess measures of static balance and limits of stability (LOS) in an aquatic environment compared to on land. Methods Fifteen healthy, young adults (23 + or - 2 years) performed 90 s static balance trials on land and aquatic immersion at two different depths (greater trochanter, xiphoid process). Measures of 95% ellipse area and center of pressure (CoP) mean velocity were computed from the force data. Additionally, participants completed a visual analog scale (VAS) of perceived stability for each environmental condition. Following the static balance trials, participants performed anterior-posterior and medial-lateral LOS assessments. Results Significant differences in …