Medicine and Health Sciences Commons^™

Effectiveness Of Individualizing Interventions Informed By The Hierarchic Dementia Scale (Hds), Used By Nursing Staff, To Reduce Aggressive Behaviors In An Individual With Alzheimer’S Disease, Nicki E. Relan

Honors Theses

Alzheimer’s disease (AD) is the most common form of dementia, representing 60 percent of all cases, and is described as a chronic, progressive, degenerative cognitive disorder. With loss of independence due to cognitive impairment, AD patients become more confused and anxious, which leads to a higher incidence of aggression towards nursing staff. It is paramount that the nursing community seeks new evidence-based healthcare innovations to reduce aggression and to protect caregivers. The aim of this study was to determine the effectiveness of individualizing interventions informed by the Hierarchic Dementia Scale (HDS) to reduce aggressive behaviors in people with Alzheimer’s disease. …

Effect Of Cannabinoids On Pain-Stimulated And Pain-Depressed Behavior In Rats, Andrew Kwilasz

Theses and Dissertations

Cannabinoids produce antinociception in many preclinical models of acute and chronic pain. In contrast, cannabinoids produce inconsistent analgesia in humans, showing little or no efficacy in treating acute pain, with modest efficacy in treating chronic inflammatory pain. This discrepancy may reflect an overreliance on preclinical assays of pain-stimulated behaviors, defined as behaviors that increase in rate or intensity following delivery of a noxious stimulus. In these assays, antinociception is indicated by a reduction in pain-stimulated behaviors, and antinociception is produced either by a reduction in sensory sensitivity to the noxious stimulus (i.e. true analgesia) or by false positive motor impairment. …

The Impact Of Medicaid Reform On Dental Practice Setting, Barrett W. R. Peters

Theses and Dissertations

Purpose: To assess the impact of dental Medicaid reform in Virginia on dental practice settings (private practice, corporate practice and safety net clinics). Methods: This retrospective cohort study of 16.2 million dental claims is from the Virginia Department of Medical Assistance Services, which included claims for providers participating in Virginia’s Medicaid program during a 10-year period (2002-2012). The dividing date for the reform was July 1, 2005. The outcome measure was mean claims per participating provider. A Poisson regression model was used to predict the mean number of claims per provider with the following predictors: reform period, practice setting, provider …

Himmelfarb Library Liaison Letter - May 2013, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Does Emotion Invalidation Cause Emotion Dysregulation? Evidence From A Healthy Sample Of College Students And Implications For The Development Of Borderline Personality Disorder, Melissa Jean Zielinski

Graduate Theses and Dissertations

Linehan's BioSocial theory is a widely accepted model of the development of borderline personality disorder (BPD). However, the tenet that experiences of invalidation causally influence the development of the emotion dysregulation that characterizes BPD has been subject to relatively little empirical attention. The purpose of this study thus was to experimentally investigate the effects of validation and invalidation on indices of emotion dysregulation including self-invalidation, distress tolerance, and Social problem solving. The current study used a laboratory-based emotion induction procedure in which ninety college students participated in validating or invalidating conversations about emotional events with a peer confederate. Contrary to …

Influence Of Horn Flies And Breed Type On Milk Production, Calf Production Traits, Pasture Behavior, And Temperament Measurements In Beef Cattle, Angela Rene Mays

Graduate Theses and Dissertations

An experiment conducted in El Reno, Oklahoma during the fly season (May - September/October) evaluated the effects of horn flies on milk production, calf performance, and pasture behavior and temperament measurements of beef cow calf pairs. Cows (n = 53) sired by Bonsmara (BONS; n = 7), Brangus (BRAN; n = 13), Charolais (CHAR; n = 8), Gelbvieh (GELV; n = 5), Hereford (HERF; n = 12), and Romosinuano (ROMO; n = 8) from Brangus dams and their Angus sired calves (n = 51) were used in the study. Horn fly counts (HFC) and milk yield and quality estimates were …

B-Type Natriuretic Peptide Versus Amino Terminal Pro-B Type Natriuretic Peptide: Selecting The Optimal Heart Failure Marker In Patients With Impaired Kidney Function, Lena Jafri, Waqar Kashif, Javed Tai, Imran Siddiqui, Iqbal Azam, Hira Shahzad, Farooq Ghani

Department of Pathology and Laboratory Medicine

Background: The effect of impaired kidney function on B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) is vague. This study was performed to examine the effect of kidney dysfunction on the afore-mentioned markers and determine appropriate cutoffs for systolic heart failure (SHF).

Methods: In this cross sectional study adults with estimated glomerular filtration rate (eGFR)/min for ≥3 months were identified in consulting clinics from June 2009 to March 2010. SHF was defined as documented by a cardiologist with ejection fraction of < 40% and assessed by New York Heart Association classification (NYHA). Plasma was assayed for creatinine (Cr), BNP and NT-proBNP.

Results: A total of 190 subjects were enrolled in the study, 95 with and 95 without SHF. The mean …

Should I Say Something? Whether To Offer Unsolicited Health Information Inside And Outside The Workplace As A Healthcare Professional - Flyer, Nicholas Church

Student-led Mini-Grants

Whether on-duty in medical centers, offices, and pharmacies, or off-duty out in the world, health professionals are often the first to notice a decline in health status of a fellow human being. Yet, many professionals report feeling conflicted about offering health information or advice to someone who is not expecting it. This event reviews the ethical, legal and practical implications of offering unsolicited health information; it touches on several dangerous, visible medical conditions that many Americans unknowingly live with; and it explores communication barriers and caveats through group discussion. Fictional scenarios with “what-if” variations will prompt discussion, and guests with …

Should I Say Something? Whether To Offer Unsolicited Health Information Inside And Outside The Workplace As A Healthcare Professional, Nicholas Church

Student-led Mini-Grants

Whether on-duty in medical centers, offices, and pharmacies, or off-duty out in the world, health professionals are often the first to notice a decline in health status of a fellow human being. Yet, many professionals report feeling conflicted about offering health information or advice to someone who is not expecting it. This event reviews the ethical, legal and practical implications of offering unsolicited health information; it touches on several dangerous, visible medical conditions that many Americans unknowingly live with; and it explores communication barriers and caveats through group discussion. Fictional scenarios with “what-if” variations will prompt discussion, and guests with …

The Association Of Diet And Physical Activity With Stroke Mortality Results From The Adventist Health Study-1, Tahereh Zamansani

Loma Linda University Electronic Theses, Dissertations & Projects

Stroke is one of the leading causes of death and disability, with major global public health implications. Stroke ranks No. 4 among all causes of death, behind heart disease, cancer, and chronic lower respiratory disease (CLRD). Stroke accounts for almost 1 of every 18 deaths in the United States. Women accounted for 60.6% of stroke deaths. Death certificate data show that the mean age at stroke death was 79.6 years; males had a younger mean age (76.3) than females.

There is still a great scientific uncertainty among researchers and epidemiologists about the magnitude of any preventive effect, mechanisms of action …

Neuropathogenesis Of Highly Pathogenic Avian Influenza In Ferrets Following Intranasal Instillation Or Aerosol Exposure To Low Doses, Jennifer Rose Plourde

Biomedical Sciences ETDs

Highly pathogenic avian influenza (HPAI), subtype H5N1, has continued to infect humans every year since its initial outbreak in 1997. The overall mortality is approximately 60% and while the emergence of this avian influenza virus has yet to reach the Western Hemisphere, its high lethality and pandemic potential warrant attention from the research community to better understand HPAI disease. Neuroinvasiveness of H5N1 virus is poorly understood and using two HPAI strains of varying lethality in the ferret model provide a basis for comparing differences in neuropathogenesis and its contribution to lethality. The studies described herein used two methods of HPAI …

Induction Of Interleukin-10 Within The T(H)17 Effector Population Using The Gper Agonist G-1, Ryan Lennex Brunsing

Biomedical Sciences ETDs

A critical mechanism in immune homeostasis is the ability to stop an ongoing inflammatory response once the inciting agent has been destroyed or neutralized. Failure to do so can lead to autoimmune disease. One mechanism the immune system utilizes to self regulate is the secretion of immunosuppressive cytokines. For example, the cytokine interleukin-10 (IL10) is a potent suppressor of numerous key immune cell populations. Among the cells that secrete IL10 are several subsets of the CD4+ T cell family. As CD4+ T cells are commonly found within diseased tissue in the setting of autoimmune disease, medications capable of inducing IL10 …

Beliefs About Complementary And Alternative Medicine In Hiv-Infected Black Women Using The Theory Of Planned Behavior, Stephanie G. Lino

Loma Linda University Electronic Theses, Dissertations & Projects

Background. Black women make up 12% of the female population in the U.S, yet they account for 66% of new HIV infections. In 2002, AIDS was the most cited reason for death among Black women age 25-34. While prevention remains, a major effort targeting treatment efficacy and modalities for this sub-group need to be better understood.

Purpose. The purpose of this study is to assess whether HIV-positive Black women’s attitudes, subjective norms and perceived behavioral control are related to intention of dietary supplements and spiritual practices use in their HIV treatment.

Method. In phase one, Grounded Theory methods (N= …

Improving Cervical Cancer Nodal Boost Radiation Therapy By Quantifying Uncertainties And Exploring Advanced Radiation Therapy Modalities, Zhiqian Yu

Dissertations and Theses (Open Access)

Radiation therapy for patients with intact cervical cancer is frequently delivered using primary external beam radiation therapy (EBRT) followed by two fractions of intracavitary brachytherapy (ICBT). Although the tumor is the primary radiation target, controlling microscopic disease in the lymph nodes is just as critical to patient treatment outcome. In patients where gross lymphadenopathy is discovered, an extra EBRT boost course is delivered between the two ICBT fractions. Since the nodal boost is an addendum to primary EBRT and ICBT, the prescription and delivery must be performed considering previously delivered dose. This project aims to address the major issues of …

Mechanisms Underlying The Heterogeneous Sensitivities Of Cancer Cells To Proteasome Inhibitors, Matthew C. White

Dissertations and Theses (Open Access)

The mechanisms underlying cellular response to proteasome inhibitors have not been clearly elucidated in solid tumor models. Evidence suggests that the ability of a cell to manage the amount of proteotoxic stress following proteasome inhibition dictates survival. In this study using the FDA-approved proteasome inhibitor bortezomib (Velcade®) in solid tumor cells, we demonstrated that perhaps the most critical response to proteasome inhibition is repression of global protein synthesis by phosphorylation of the eukaryotic initiation factor 2-α subunit (eIF2α). In a panel of 10 distinct human pancreatic cancer cells, we showed marked heterogeneity in the ability of cancer cells to induce …

Behavioral Responses To Methylphenidate: Correlations With Neuronal Activity In The Caudate Nucleus, Catherine M. Claussen

Dissertations and Theses (Open Access)

Methylphenidate is currently a drug of abuse and readily prescribed to both adolescents and adults. Chronic methylphenidate (MPH) exposure results in an increase in DA in the motive circuit, including the caudate nucleus (CN), similar to other drugs of abuse. This study focuses on research aimed to elucidate if there are intrinsic underlying differences in the CN electrophysiological activity of animals exhibiting different chronic responses to the same dose of MPH. Behavioral and caudate nucleus (CN) neuronal activity following acute and chronic doses of MPH was assessed by simultaneously recording the behavioral and neuronal activity. The experimental protocol lasted for …

Targeting Histone Deacetylases (Hdac) For The Treatment Of Soft Tissue Sarcoma, Gonzalo Lopez

Dissertations and Theses (Open Access)

Targeting Histone deacetylases (HDAC) for the treatment of genetically complex soft tissue sarcoma

Histone deactylase inhibitors (HDACi) are a new class of anticancer therapeutics; however, little is known about HDACi or the individual contribution of HDAC isoform activity in soft tissue sarcoma (STS). We investigated the potential efficacy of HDACi as monotherapy and in combination with chemotherapy in a panel of genetically complex STS. We found that HDACi combined with chemotherapy significantly induced anti-STS effects in vitro and in vivo. We then focused our study of HDACi in malignant peripheral nerve sheath tumor (MPNST), a subtype of highly aggressive, …

The Impact Of Family History On Medullary Thyroid Cancer In Men2a Patients, Nicole D. Mohrbacher

Dissertations and Theses (Open Access)

The American Thyroid Association recently classified all MEN2A-associated codons into increasing risk levels A-C and stated that some patients may delay prophylactic thyroidectomy if certain criteria are met. One criterion is a less aggressive family history of MTC but whether families with the same mutated codon have variable MTC aggressiveness is not well described. We developed several novel measures of MTC aggressiveness and compared families with the same mutated codon to determine if there is significant inter-familial variability. Pedigrees of families with MEN2A were reviewed for codon mutated and proportion of RET mutation carriers with MTC. Individuals with MTC were …

The Influence Of Immunization Route On The Adjuvant Effect Of Alpha-Galactosylceramide, Ameerah M. Wishahy

Dissertations and Theses (Open Access)

Potent vaccine formulations ideally include adjuvants to activate innate immune responses and enhance antigen-specific adaptive immunity. The synthetic glycolipid alpha-Galactosylceramide (α-GalCer) effectively activates the innate immune mediating NKT cells to produce cytokines and activate downstream immune cells, resulting in development of humoral and cell mediated immune responses to co-administered antigens. While a single intravenous immunization of α-GalCer strongly activates NKT cells, multiple doses by this route are well documented to induce anergy in NKT cells. Anergy is defined as the deficiency in NKT proliferation and cytokine production, including IL-4 and IFNγ. However, our studies have shown that two doses of …

Common Peroneal Nerve Palsy Following Total Hip Arthroplasty: Prognostic Factors For Recovery., Jai Hyung Park, Bryan Hozack, Peter Kim, Robert Norton, Steven Mandel, Camilo Restrepo, Javad Parvizi

Rothman Institute Papers

BACKGROUND: Common peroneal nerve palsy, although rare, is a serious complication of total hip arthroplasty. Although several publications have dealt with the risk factors for peroneal nerve palsy, there is little literature regarding the time it takes for the nerve to recover and the factors that influence its recovery. The purpose of this study was to elucidate the clinical course of this injury and identify prognostic factors for recovery.

METHODS: From January 2000 to December 2007, 7969 primary and 1601 revision total hip arthroplasties were performed at our institution. Common peroneal nerve palsy developed following thirty-one (0.32%) of these procedures. …

Molecular Diagnosis Of Metabolic Fast Growth Related Diseases In Broiler, Adnan Ali Khalaf Al-Rubaye

Graduate Theses and Dissertations

Pulmonary Hypertension Syndrome (PHS) and lameness are important metabolic diseases that affect rapidly growing broilers. The research reported in the first section of this dissertation focused on developing qPCR assays to identify differences in the expression levels of four candidate genes possibly associated with PHS: angiotensin II type 1 receptor (AGTR1): urotensin receptor 2D (UTS2D); serotonin receptor/transporter type 2Bn (HTR2B); and angiotensinogen cleaving enzyme (ACE). Expression levels of these candidate genes were examined in four different tissues. We established ribosomal protein S14 (RPS14) and RNA polymerase subunit 2B (RP2B) as suitable reference genes because they showed the most consistent deltaCt …

Dive Into The Pit: Moshing And Its Effects On Perceived Stress, Sense Of Belonging, & Self-Esteem In College Undergraduates, William Tyler Edwards

Honors Theses

Moshing has been underrepresented in the research field. This is especially true in the area of Therapeutic Recreation. Moshing has been seen as a dangerous and violent form of dance. However, in a controlled environment moshing has the potential to be used as a therapeutic modality.

This study examined the effects of moshing on perceived stress, sense of belonging, and self esteem in undergraduate college students at the University of Southern Mississippi. Data was collected during a five-week moshing dance session through the use of three assessments/surveys, which included the Perceived Stress Scale (PSS), Rosenburg Self-Esteem Scale (RSES), and the …

Attitudes Of Clinically Practicing Registered Nurses In Southern Mississippi Toward Physician-Assisted Death, Robin E. Smith

Honors Theses

Problem

The purpose of this study is to discover unique themes related to the attitudes of nurses in Southern Mississippi toward physician-assisted death (PAD).

Methods

This study is a qualitative, inductive content analysis. The sample comprised three registered nurses currently practicing in Southern Mississippi. The researcher guided each participant’s one-hour interview with questions, then recorded and transcribed the texts for data analysis; and coded and analyzed data. Themes were selected if there was inter-rater agreement of 100% between the researcher and thesis adviser.

Results

The interview questions focused on (a) the presence or absence of support for legalization of PAD, …

The Effect Of Patient Behavior And Race/Ethnicity On The Titration Of Opioid Analgesia, Kirstin N. Kellar

Honors Theses

The undertreatment of pain following surgery is an international problem that the majority of postoperative patients experience. Despite immense technological advances in pain management, the literature remains replete with examples of patients who experience postoperative oligoanalgesia. Because registered nurses play a vital role in the management of patient pain, their practices must be studied. This study examines the correlation between patient race/ethnicity and the titration of opioids in the postoperative setting. The study also explores the knowledge and attitudes that registered nurses possess regarding opioid administration. A convenience sample of 21 perioperative registered nurses was obtained from a hospital in …

Examining Stage At Diagnosis And Survival In Three Cancers With Definitive Screening Guidelines For Average-Risk Adults: The Role Of Marital Status, David J. Blackley

Electronic Theses and Dissertations

Each year there are more than 350 000 new cases and nearly 100 000 deaths attributed to colorectal, female breast, and cervical cancer in the United States. Screening tests can reduce morbidity and mortality associated with these cancers. Patient marital status has been associated with health outcomes, but no study has focused on the relationship of marriage with disease stage and survival for the 3 cancers with established screening guidance. It is critical to identify special populations that may be at risk for poor cancer outcomes.

The objective of this study was to examine the relationship of marital status with …

Access To Essential Medicines In Pakistan: Policy And Health Systems Research Concerns., Shehla Zaidi, Maryam Bigdeli, Noureen Aleem, Arash Rashidian

Community Health Sciences

NTRODUCTION:

Inadequate access to essential medicines is a common issue within developing countries. Policy response is constrained, amongst other factors, by a dearth of in-depth country level evidence. We share here i) gaps related to access to essential medicine in Pakistan; and ii) prioritization of emerging policy and research concerns.

METHODS:

An exploratory research was carried out using a health systems perspective and applying the WHO Framework for Equitable Access to Essential Medicine. Methods involved key informant interviews with policy makers, providers, industry, NGOs, experts and development partners, review of published and grey literature, and consultative prioritization in stakeholder's Roundtable. …

Prevalence Of Gerd In A Community-Based Examination In Thailand, S Treeprasertsuk, T Thongbai, T Rattanachuek, V. Mahachai

Chulalongkorn Medical Journal

Background : Gastroesophageal reflux disease (GERD) is highly prevalent, affecting 10 - 30% of the population in Western countries. In Asia, the prevalence of GERD is lower, ranging from 2.5 - 7.1% in most population-based studies. Recently, GERD has been increasingly encountered in clinical practices in Asian countries. Objectives : To describe the prevalence of GERD in a community-based endoscopic examination in Thailand and to assess the relationship between the endoscopic findings of esophagitis and GERD symptoms. Materials and Method : The adults aged of at least 18 years old with uninvestigated dyspeptic symptoms or the adults aged of at …

Increasing Health Care Costs And Its Adverse Impact On Healthcare, Waris Qidwai

Department of Emergency Medicine

No abstract provided.

Display Of Peptides And Single-Chain Antibodies On Bacteriophage Ms2 Virus-Like Particles, Christopher Andrew Lino

Biomedical Sciences ETDs

Phage display is a powerful technology for selection of novel binding functions from large populations of peptide or antibody fragments. From a sufficiently complex library, phage bearing peptides or antibodies with practically any desired binding activity can be physically isolated by affinity selection, and, since each particle carries in its genome the genetic information for its own replication, the selectants can be amplified in bacteria. Existing display systems are based mostly on the filamentous phage M13. It is a powerful technology, but it has limitations for certain applications. Our work has concentrated on development of a new display platform based …

Partial Versus Complete Trapeziectomy For Treatment Of Carpometacarpal Joint Arthritis: A Cadaveric Biomechanical Comparison, Deana Mercer

Biomedical Sciences ETDs

Purpose: We aimed to evaluate the stability of the thumb carpometacarpal joint following either complete removal of the trapezium(TR) or partial removal of the trapezium and of the base of the first metacarpal (PTR). We utilized local capsular tissue for interposition graft in both cases. Methods: Right and left fresh frozen cadaveric hands from the same donor were randomized so that TR or PTR repair was performed randomly on the right or left hand of each pair. In the TR group we removed the entire trapezium. In the PTR group we removed 2mm of distal trapezium and 2mm of thumb …