Medicine and Health Sciences Commons^™

Health-Related Quality Of Life And Hemophilic Arthropathy In Hemophilia Patients, Chih-Ya Chang, Hui-Yi Su, Yung-Tsan Wu, Yu-Chin Chen, Liang-Cheng Chen, Shin-Tsu Chang, Tsung-Ying Li

Rehabilitation Practice and Science

Introduction: Hemophilia is an X-linked recessive bleeding disorder caused by a deficiency of coagulation factor VIII (hemophilia A) or IX (hemophilia B). The prevalence of hemophilia is approximately 1 per 105 in the general population. Repeated joint bleeding leads to chronic synovitis, cartilage damage, and bone destruction, yielding reduced range of motion (ROM), painful joints, and muscle atrophy. Hemophilic arthropathy can negatively influence perceptions of health-related quality of life (HRQOL) among hemophilia patients. This study explored the correlation between hemophilic arthropathy and HRQOL among hemophilia patients in Taiwan. Methods: The participants comprised 86 patients enrolled from a hemophilia center. We …

Intramedullary Astrocytoma Presenting As Cervical And Upper Back Pain: A Casereport, Chao-Pin Yang, Chun-Yuan Cheng, Ying-Hsuan Li

Rehabilitation Practice and Science

Intramedullary astrocytomas are rare, accounting for 3% of all central nervous system astrocytomas. Pain is the most common clinical symptom, although symptoms can vary. These tumors typically progress over a period of months to years before the diagnosis is established. An intramedullary astrocytoma and cervical intervertebral disc herniation may coexist; the early symptoms maybe similar and an intramedullary astrocytoma might go undetected and be misdiagnosed as cervical disc herniation. This paper reports a 30-year-old male who presented with cervical and upper back pain extending to the right upper limb. Initially, the diagnosis was a cervical radiculopathy. After rehabilitation, for two …

Effectiveness Of Resistance (Strength) Training For Patients With Chronic Heart Failure, Yan-Wen Chen

Rehabilitation Practice and Science

The recent advancements in cardiac disease treatments have remarkably enhanced the survival rate of patients with chronic heart failure. In patients with exercise intolerance, the accompanied peripheral myopathy plays an important role. Resistance training is beneficial for musculoskeletal function in patients with chronic heart failure. However, the left ventricular myocardial remodeling progression and the hemodynamic response are controversial. Some studies showed that for those with stable heart failure (New York Heart Association functional classes I to III level), the adequate resistance training was beneficial in improvement of aerobic capacity, muscle histology, metabolic function, and left ventricular ejection fraction. In this …

Lipoma Arborescens On Mr Imaging And The Associated Lesions: A Reviewarticle Of 78 Cases, Cheng-Yuan Lin, Cheng-Ming Chiu, Tsung-Ching Lin, Shun-Lung Li, Chia-Yi Shang, Yu-Chiang Chen

Rehabilitation Practice and Science

Objective: To identify the different morphologic patterns of lipoma arborescens (LA) and the associated lesions on magnetic resonance (MR) imaging and to evaluate their clinical implication.Methods: We conducted a retrospective reviewarticle of the MR images and medical records of 78 patients diagnosed with LA of the knee (n=73) and shoulder (n=5). The diagnosis of LA was confirmed by the histologic findings in two cases and by the characteristic MR imaging features in the other 76.Results: A typical pattern of villous lipomatous proliferation of the synovium was identified on MR imaging in all cases, as a typical frond-like pattern in 38% …

The Relationships Between Using The Rating Of Perceived Exertion, Metabolic Equivalent And Maximum Heart Rate At Ventilatory Threshold Into Determine Appropriate Exercise Prescription For Intensity In Obese Diabetic Patients: A Preliminary Study, Yan-Wen Chen, Francois Liang, Sen-Wei Tsai, Shih-Yi Lin, I. T. Lee, Sheu-Chen Liu, Shin-Shan Lu

Rehabilitation Practice and Science

Background: The rating of perceived exertion (RPE), metabolic equivalent (MET) and maximum heart rate (HRmax) at ventilatory threshold (VT) are commonly used methods as physiological parameters for monitoring exercise intensity. However, the appropriate levels of training intensity for obese type 2 diabetic diabetes mellitus (type 2 DM) patients have not been established.Purpose: To examine the parameters in obese Type 2 DM patients at ventilatory threshold, the exercise capacity of obese Type 2 DM patients, and to determine the appropriate levels of exercise intensity for exercise prescription in obese type 2 DM patients was investigated.Methods: Twenty obese type 2 DM patients …

Compressive Femoral Neuropathy Caused By Iliopsoas Muscle Hematoma: A Casereport, Szu-Hung Tsao, Yu-Ting Hsieh, Tai-Yi Wu, Shu-Hua Lin

Rehabilitation Practice and Science

Femoral neuropathy is uncommon compared with other mononeuropathies. We report a case of femoral neuropathy in a 53-year-old man who has cardiovascular disease and took Coumadin for 8 years. He has left lower extremity pain and weakness because of femoral nerve and lumbar plexus compression caused by an iliopsoas hematoma, which resulted from a period of prolonged bleeding. The patient’s condition improved after surgery and rehabilitation. We also reviewarticle the anatomy and pathophysiology of the femoral nerve, the clinical presentation of femoral neuropathy, the diagnostic tools used, the treatment method, and the prognosis.

台灣復健醫學雜誌通訊繼續教育測驗題, The Editors

Rehabilitation Practice and Science

No abstract provided.

Efficacy Of Echo-Guided Extracorporeal Shock Wave Therapy For Calcific Supraspinatus Tendinopathy: A Case Series Study, Ju-Wen Cheng, Wen-Chung Tsai, Chien-Hung Chen, Chien-Hung Chen

Rehabilitation Practice and Science

Approximately 50% of patients with calcific tendinitis of the rotator cuff experience shoulder pain. Shock wave therapy is a non-invasive alternative treatment that is effective in pain relief, function restoration, and deposit resorption. In our study, we used ultrasonography-guided shock wave therapy for the targeted treatment of calcific supraspinatus tendinopathy.We retrospectively assessed 9 patients (8 women, 1 man; age 33-57 years) who had received echo-guided extracorporeal shock wave therapy for calcific supraspinatus tendinopathy from 2006 to 2012. Pain measured by the numerical rating scale (NRS) was compared before and after therapy. The length and width of the calcification spot on …

The Effects Of Hyaluronic Acid And Glucosamine On The Migration And Proliferation Of Tenocytes, Chien-Hung Chen, Jin-Fu Huang, Li-Lun Chen, Wen-Chung Tsai, Jong-Hwei S. Pang, Yu-Hsin Liao, Tung-Yang Yu

Rehabilitation Practice and Science

Tendinopathy or tendon rupture is a common disease. Studies have showed that hyaluronic acid and glucosamine benefit the process of tendon repair. Tendon healing requires the migration of tenocytes to the repair site, followed by the proliferation and synthesis of the extracellular matrix. However, the effects of hyaluronic acid and glucosamine on tenocytes remain to be explored. Here, we treated tenocytes from rat Achilles tendons with hyaluronic acid or glucosamine. The ability of tenocytes to migrate and proliferate was assessed by transwell filter migration assay and MTT (3-[4,5-Dimethylthiazol-2-yl]-2,5- diphenyltetrazolium bromide) assay, respectively. Results from transwell filter migration assays showed that …

Effects Of Low Power Laser On Pain And Balance Dysfunction Caused By Periostitis Of Lower Limb: A Case Series, Hui-Yi Su, Yu-An Hu, Wei-Chun Hsu, Shih-Chi Li, Shin-Tsu Chang

Rehabilitation Practice and Science

Periostitis of the lower limb is a common problem in sports injury, and an appropriate treatment option is required for this medical issue. The purpose of this study was to assess pain reduction and functional improvement after low power laser therapy in the lower limbs with periostitis. A total of 29 adults (20-40 year-old) who had periostitis at our outpatient clinic were enrolled. The diagnosis of periostitis in the lower limbs was confirmed by skeletal scintigraphy. The treatment protocol adopted rehabilitation intervention involving low power laser treatment 3 times a day for 5 days, and a low-energy dosage of 1.4 …

Early Rehabilitation Intervention Can Reduce The Admission Duration Of Rotator Cuff Repair-Introducing The Rehabilitation Protocol, Kun Hung, Bu-Yu Han, Jian-Huang Guo, Tai-Yi Wu, Shu-Hua Lin, Chung-Sheng Ho, Yu-Ting Hsieh

Rehabilitation Practice and Science

Currently, there is no standardized rehabilitation protocol for postoperative rotator cuff repair, particularly at acute stage. The purpose of the study was to evaluate the efficiency of preoperative patient education and acute stage rehabilitation, which may contribute in constructing a suitable rehabilitation protocol. The prospective observational study was conducted in a local teaching hospital over a period of 3 months. Twenty patients including 11 men and 9 women with a history of supraspinatus tear were enrolled in this study. The rehabilitation protocol involved preoperative patient education, postoperative proper positioning, passive range of motion exercises, and the usage of continuous passive …

Incidental Finding Of A Simple Dysraphic State Of A Closed Spinal Dysraphism And Tethered Cord In An Adult Patient With Low Back Pain: A Casereport, Lin-Chien Lee, Hung-Fu Lee, Fu-Kong Lieu

Rehabilitation Practice and Science

The recognition of a closed spinal dysraphism without a subcutaneous mass and cutaneous stigmata depends on the development of relevant neurological and urological symptoms and signs. It can also be an incidental finding when symptoms that do not originate from it are investigated. We describe a 39-year-old man who presented with spondylolysis-related low back pain. Plain film showed posterior spina bifida of S1 and magnetic resonance imaging of the L-spine revealed one intradural lipoma at the L5 level and cord tethering. Conservative treatment was suggested because no relevant symptoms or signs of a mass effect of the lipoma or tethered …

Effects Of Exercise Training On Cardiorespiratory Fitness And Cardiac Function Among Heart Failure Patients With Decreased Left Ventricular Function: A Pilot Study, Chia-Huei Lin, Bing-Hsiean Tzeng, Li-Chi Chiang, Wen-Chii Tzeng, Liang-Cheng Chen, Shang-Lin Chiang

Rehabilitation Practice and Science

Background: Exercise is not only beneficial for physical and psychological health but can also improve cardiac contractility; thus, exercise can result in the improvement of the functional status of patients who suffer from irreversible damage from heart failure. However, there are limited local data on the effects of moderate-intensity exercise training on cardiorespiratory fitness and left ventricular function among patients with heart failure. Purpose: The aim of our study was to investigate the effects of moderate-intensity exercise training on cardiorespiratory fitness and left ventricular function among patients with heart failure. Methods: This is a pilot study with a single group …

The Effects Of Nesting Environment On Neonatal Hypoxic-Ischemic Injury, Laura Grace Rollins

Graduate Masters Theses

Term neonates with hypoxic-ischemic (HI) injury are at risk for devastating neurological sequelae. The objective of this study is to determine if altering the early environment for maternal care-taking impacts the immediate and long-term sequelae of HI offspring. The Rice-Vannucci model was used to induce HI in postnatal day (PND) 7 Long-Evans pups. Litters were assigned to a closed nest (CN) or normal standard housing (SH) condition. Neurobehavioral development, cognitive ability, and stress response were assessed to establish any benefits of the CN condition. Finally, postmortem brain tissue was analyzed for morphometric markers of injury.

Pengaruh Latihan Fartlek Dengan Treadmill Dan Lari Di Lapangan Terhadap Daya Tahan Kardiorespirasi, Maya Kurnia, B.M. Wara Kushartanti

Jurnal Keolahragaan

Tujuan penelitian ini untuk mengungkapkan pengaruh dari latihan fartlek dengan treadmill, latihan fartlek dengan lari di lapangan, dan kapasitas vital paru terhadap daya tahan kardiorespirasi. Penelitian ini menggunakan desain eksperimen faktorial 2 x 2. Data dikumpulkan menggunakan tes daya tahan kardiorespirasi (tes Cooper 12 menit), dihitung jarak maksimal yang dapat ditempuh dalam waktu 12 menit tersebut. Hasil penelitian adalah sebagai berikut: (1) Ada perbedaan daya tahan kardiorespirasi antara kelompok latihan fartlek dengan treadmill dan kelompok latihan fartlek dengan lari di lapangan. Daya tahan kardiorespirasi kelompok latihan fartlek dengan lari di lapangan menunjuk-kan pengaruh lebih baik dibandingkan kelompok latihan fartlek …

Concepts Of Illness Among The Swahili Of Lamu, Kenya, Rebecca Gearhart, Munib Abdulrehman

Rebecca Gearhart

Jefferson Digital Commons Quarterly Report: October-December 2012, Daniel G. Kipnis, Msi

Jefferson Digital Commons Reports

Jefferson Digital Commons quarterly report includes statistics, top 10 most downloaded items and new assets added to the collection.

Loss Of Atrx Does Not Confer Susceptibility To Osteoarthritis, Lauren A. Solomon, Bailey A. Russell, David Makar, Nathalie G. Bérubé, Frank Beier

Paediatrics Publications

The chromatin remodelling protein ATRX is associated with the rare genetic disorder ATR-X syndrome. This syndrome includes developmental delay, cognitive impairment, and a variety of skeletal deformities. ATRX plays a role in several basic chromatin-mediated cellular events including DNA replication, telomere stability, gene transcription, and chromosome congression and cohesion during cell division. We have used a loss-of-function approach to directly investigate the role of Atrx in the adult skeleton in three different models of selective Atrx loss. We specifically targeted deletion of Atrx to the forelimb mesenchyme, to cartilage and to bone-forming osteoblasts. We previously demonstrated that loss of ATRX …

The Public Health Pbrn Program: A Summative Report, Glen P. Mays

Glen Mays

This report provides a six-year summary of the work of the Public Health Practice-Based Research Networks Program, supported by the Robert Wood Johnson Foundation.

What's Happening: December 30, 2013, Maine Medical Center

What's Happening

No abstract provided.

Novel And Predominant Pathogen Responsible For The Enterovirus-Associated Encephalitis In Eastern China, Lei Zhang, Jie Yan, David M. Ojcius, Huakun Lv, Ziping Miao, Yin Chen, Yanjun Zhang, Jvying Yan

All Dugoni School of Dentistry Faculty Articles

Enteroviruses (EV) have been increasingly identified as the causative agent for unknown etiological encephalitis in many parts of the world, but the long period surveillance for enterovirus-associated encephalitis (EAE) was not reported in China. From 2002-2012 in Zhejiang, Coxsackieviruses A9, B1, B2, B3, B4, B5; and echoviruses 3, 4, 6, 9, 14, 25, 30 were detected from the unknown etiological encephalitis cases, with coxsackievirus B4 been identified here for the first time. From 2002-2004 and 2010-2012, echovirus 30 was found to be the periodically predominant serotype for in the EAE. The molecular typing results showed that all the EV isolates …

The Public Health Pbrn Program: A Summative Report, Center For Public Health Systems And Services Research

UKCPHSSR Research Briefs and Reports

This program seeks to expand the volume and quality of evidence on how best to organize, finance, and deliver public health services by: (1) helping to organize and develop practice-based research networks (PBRNs) comprised of public health agencies and skilled research institutions; (2) selecting grantees to receive funding and technical assistance for PBRN research projects; and (3) facilitating the successful development, implementation, and translation of research projects through PBRNs by providing technical assistance, fostering peer learning, and leading selected multi-network research activities.

Sphingosine-1-Phosphate-Mediated Mobilization Of Hematopoietic Stem/Progenitor Cells During Intravascular Hemolysis Requires Attenuation Of Sdf-1-Cxcr4 Retention Signaling In Bone Marrow, Kasia Mierzejewska, Yuri M. Klyachkin, Janina Ratajczak, Ahmed Abdel-Latif, Magda Kucia, Mariusz Z. Ratajczak

Saha Cardiovascular Research Center Faculty Publications

Sphingosine-1-phosphate (S1P) is a crucial chemotactic factor in peripheral blood (PB) involved in the mobilization process and egress of hematopoietic stem/progenitor cells (HSPCs) from bone marrow (BM). Since S1P is present at high levels in erythrocytes, one might assume that, by increasing the plasma S1P level, the hemolysis of red blood cells would induce mobilization of HSPCs. To test this assumption, we induced hemolysis in mice by employing phenylhydrazine (PHZ). We observed that doubling the S1P level in PB from damaged erythrocytes induced only a marginally increased level of mobilization. However, if mice were exposed to PHZ together with the …

Role Of Defensins In The Pathogenesis Of Chronic Lung Allograft Rejection, Venkataswarup Tiriveedhi, Babak Banan, Saini Deepti, Angaswamy Nataraju, Ramsey Hachem, Elbert Trulock, Patterson G. Alexander, Thalachallour Mohanakumar

Biology Faculty Research

Chronic rejection predominantly manifested as bronchiolitis obliterans syndrome (BOS), still remains a major problem affecting long-term outcomes in human lung transplantation (LTx). Donor specific antibodies (DSA) and infiltration of neutrophils in the graft have been associated with the development of BOS. This study determines the role of defensins, produced by neutrophils, and its interaction with α-1-antitrypsin (AAT) towards induction of airway inflammation and fibrosis which are characteristic hallmarks of BOS. Bronchoalveolar lavage (BAL) and serum from LTx recipients, BOS+ (n=28), BOS− (n=26) and normal healthy controls (n=24) were analyzed. Our results show that BOS+ LTx recipients had higher α-defensins (HNP1–3) …

Trypanosomatid Aquaporins: Roles In Physiology And Drug Response, Goutam Mandal, Jose F. Orta, Mansi Sharma, Rita Mukhopadhyay

HWCOM Faculty Publications

In the class Kinetoplastida, we find an order of parasitic protozoans classified as Trypanosomatids. Three major pathogens form part of this order, Trypanosoma cruzi, Trypanosoma brucei, and Leishmania, which are responsible for disease and fatalities in millions of humans worldwide, especially in non-industrialized countries in tropical and sub-tropical regions. In order to develop new drugs and treatments, the physiology of these pathogenic protozoans has been studied in detail, specifically the significance of membrane transporters in host parasites interactions. Aquaporins and Aquaglyceroporins (AQPs) are a part of the major intrinsic proteins (MIPs) super-family. AQPs are characterized for their ability to facilitate …

Spatial Analysis Of Factors Influencing Long-Term Stress In The Grizzly Bear (Ursus Arctos) Population Of Alberta, Canada, Mathieu Bourbonnais, Trisalyn Nelson, Mark Cattet, Chris T. Darimont, Gordon Stenhouse

Physiology Collection

Non-invasive measures for assessing long-term stress in free ranging mammals are an increasingly important approach for understanding physiological responses to landscape conditions. Using a spatially and temporally expansive dataset of hair cortisol concentrations (HCC) generated from a threatened grizzly bear (Ursus arctos) population in Alberta, Canada, we quantified how variables representing habitat conditions and anthropogenic disturbance impact long-term stress in grizzly bears. We characterized spatial variability in male and female HCC point data using kernel density estimation and quantified variable influence on spatial patterns of male and female HCC stress surfaces using random forests. Separate models were developed for regions …

Primary Care-Based Educational Interventions To Decrease Risk Factors For Metabolic Syndrome For Adults With Major Psychotic And/Or Affective Disorders: A Systematic Review, Cynthia Nover, Sarah S. Jackson

Epidemiology Faculty Publications

Background

Individuals with major psychotic and/or affective disorders are at increased risk for developing metabolic syndrome due to lifestyle- and treatment-related factors. Numerous pharmacological and non-pharmacological interventions have been tested in inpatient and outpatient mental health settings to decrease these risk factors. This review focuses on primary care-based non-pharmacological (educational or behavioral) interventions to decrease metabolic syndrome risk factors in adults with major psychotic and/or affective disorders.

Methods

The authors conducted database searches of PsychINFO, MEDLINE and the Cochrane Database of Systematic Reviews, as well as manual searches and gray literature searches to identify included studies.

Results

The authors were …

Beyond Perceptual Expertise: Revisiting The Neural Substrates Of Expert Object Recognition, Assaf Harel, Dwight J. Kravitz, Chris I. Baker

Psychology Faculty Publications

Real-world expertise provides a valuable opportunity to understand how experience shapes human behavior and neural function. In the visual domain, the study of expert object recognition, such as in car enthusiasts or bird watchers, has produced a large, growing, and often-controversial literature. Here, we synthesize this literature, focusing primarily on results from functional brain imaging, and propose an interactive framework that incorporates the impact of high-level factors, such as attention and conceptual knowledge, in supporting expertise. This framework contrasts with the perceptual view of object expertise that has concentrated largely on stimulus-driven processing in visual cortex. One prominent version of …

Men At Risk; A Qualitative Study On Hiv Risk, Gender Identity And Violence Among Men Who Have Sex With Men Who Report High Risk Behavior In Kampala, Uganda., Rachel King, Joseph Barker, Sylvia Nakayiwa, David Katuntu, George Lubwama, Danstan Bagenda, Tim Lane, Alex Opio, Wolfgang Hladik

Journal Articles: Epidemiology

In Uganda, men who have sex with men (MSM) are at high risk for HIV. Between May 2008 and February 2009 in Kampala, Uganda, we used respondent driven sampling (RDS) to recruit 295 MSM≥18 years who reported having had sex with another man in the preceding three months. The parent study conducted HIV and STI testing and collected demographic and HIV-related behavioral data through audio computer-assisted self-administered interviews. We conducted a nested qualitative sub-study with 16 men purposively sampled from among the survey participants based on responses to behavioral variables indicating higher risk for HIV infection. Sub-study participants were interviewed …

Inflammatory Cytokine Gene Expression In Mesenteric Adipose Tissue During Acute Experimental Colitis, William Conan Mustain, Marlene E. Starr, Joseph Daniel Valentino, Donald A. Cohen, Daiki Okamura, Chi Wang, B. Mark Evers, Hiroshi Saito

Markey Cancer Center Faculty Publications

BACKGROUND: Production of inflammatory cytokines by mesenteric adipose tissue (MAT) has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Animal models of colitis have demonstrated inflammatory changes within MAT, but it is unclear if these changes occur in isolation or as part of a systemic adipose tissue response. It is also unknown what cell types are responsible for cytokine production within MAT. The present study was designed to determine whether cytokine production by MAT during experimental colitis is depot-specific, and also to identify the source of cytokine production within MAT.

METHODS: Experimental colitis was induced in 6-month-old C57BL/6 …