Medicine and Health Sciences Commons^™

Underutilization Of Primary Care Providers In Treating Opiate Addiction, Jennifer Jenkinson, Patricia K. Ravert

Faculty Publications

There are inadequate numbers of care providers or treatment programs to treat opioid abuse. Although many primary care nurse practitioners care for patients who are dependent on or abuse opioids, they are not allowed to prescribe the schedule 3 medications to treat them. This option is available to primary care physicians with additional training. This article discusses the effectiveness of opioid substitution therapy in a primary care setting, the patient populations, patient satisfaction, and barriers preventing primary care providers from providing treatment to opioid patients. Nurse practitioners can help overcome some of these barriers and improve access to this underserved …

Chronic Cadmium Exposure Stimulates Sdf-1 Expression In An Erα Dependent Manner, Esmeralda Ponce, Natalie B. Aquino, Maggie Louie

Collected Faculty Scholarship

Cadmium is an omnipotent environmental contaminant associated with the development of breast cancer. Studies suggest that cadmium functions as an endocrine disruptor, mimicking the actions of estrogen in breast cancer cells and activating the receptor to promote cell growth. Although acute cadmium exposure is known to promote estrogen receptor-mediated gene expression associated with growth, the consequence of chronic cadmium exposure is unclear. Since heavy metals are known to bioaccumulate, it is necessary to understand the effects of prolonged cadmium exposure. This study aims to investigate the effects of chronic cadmium exposure on breast cancer progression. A MCF7 breast cancer cell …

Intelligence And Social Behaviors Of Children With Language Impairment, Melanie Cobabe, Dr. Martin Fujiki

Journal of Undergraduate Research

Teachers and speech pathologists have noted that children with Language Impairment (LI) frequently struggle in social interactions when compared with their typical peers. They have difficulty making friends, entering on-going interactions, and are often viewed negatively by others in their own age group. The purpose of this study was to co-vary intelligence in order to eliminate it as a variable that might impact the differences in social behavior between typical and language impaired children.

Nano-Biomedical Approaches Of Cancer Therapy Using Carbon Based And Magnetic Nanomaterials, Alokita Karmakar

Theses and Dissertations

Since the inception of nanoparticles, they have affected almost each and every field of modern science and technology both in terms of research and application. Due to its subcellular level size and ease of modification for biological and medical purposes, nanoparticles have contributed greatly in various field of biomedical reaserch including cancer research. In this dissertation, emphasis has been given on an important area of research of a multi-modal anticancer therapeutic approach using carbon-based and magnetic inorganic nanoparticles. Cancer is a complex disease that has been known to be generated by mutations at the genetic level, and continue to accumulate …

Sessile Serrated Adenomas In The Proximal Colon Are Likely To Be Flat, Large And Occur In Smokers, Tarun Rustagi, Priya Rangasamy, Matthew Myers, Melinda Sanders, Haleh Vaziri, George Y. Wu, John W. Birk, Petr Protiva, Joseph C. Anderson

Dartmouth Scholarship

Aim: To examine the epidemiology and the morphology of the proximal sessile serrated adenomas (SSAs).

Methods: We conducted a retrospective study to identify patients with SSAs using a university-based hospital pathology database query from January 2007 to April 2011. Data collected included: age, gender, ethnicity, body mass index, diabetes, smoking, family history of colorectal cancer, aspirin, and statin use. We collected data on morphology of SSAs including site (proximal or distal), size, and endoscopic appearance (flat or protuberant). We also compared proximal SSAs to proximal tubular adenomas detected during same time period.

Do Life Style Factors And Socioeconomic Variables Explain Why Black Women Have A Remarkably Higher Body Mass Index (Bmi) Than White Women In The United States? Findings From The 2010 National Health Interview Survey, Mohammad Siahpush, Courtney A. Pinard, Gopal K. Singh, Melissa Tibbits, Raees A. Shaikh, Amy Yaroch

Journal of Health Disparities Research and Practice

Objective: There are marked inequalities in body mass index (BMI), overweight, and obesity across ethnic groups. We sought to examine the extent to which lifestyle factors and socioeconomic variables explain the higher BMI in Black women compared to White women in the United States.

Methods: We used data from the 2010 National Health Interview Survey (NHIS) and limited the sample to non-Hispanic Black and non-Hispanic White women (n = 9,491). We employed normal regression and compared the association of race with BMI before and after adjusting for lifestyle factors (diet, physical activity, smoking, and drinking) and socioeconomic variables (education, ratio …

Health Disparities In Colorectal Cancer Screening In United States: Race/Ethnicity Or Shifting Paradigms?, Adina Williams, Kirk Dabney, Holmes Laurens Jr

Journal of Health Disparities Research and Practice

Background: Colorectal cancer (CRC) remains the third leading cause of cancer death in the United States. The incidence, mortality, and screening vary by race/ethnicity, with African Americans and Hispanics being disproportionately represented. Early detection through screening prolongs survival and decreases mortality. CRC screening (CRCS) varies by race/ethnicity, with lower prevalence rates observed among minorities, but the factors associated with such disparities remain to be fully understood. The current study aimed to examine the ethnic/racial disparities in the prevalence of CRCS, and the explanatory factors therein in a large sample of U.S. residents, using the National Health Interview Survey, 2003. …

A Systematic Review Of Pregnancy Prevention Programs For Minority Youth In The U.S.: A Critical Analysis And Recommendations For Improvement, Sarah B. Maness, E R. Buhi

Journal of Health Disparities Research and Practice

African American and Latino youth experience disproportionate rates of both intended and unintended pregnancy in the United States. A public health priority to ameliorate the high rates among this population has been the creation and proposed expansion of pregnancy prevention programs designed specifically for minority youth. However, little is known about the role of incorporating cultural components into program curricula. To better understand the components and outcomes of existing programs for this population, this systematic review analyzed published outcome evaluations of adolescent pregnancy prevention programs for minority youth. This review of literature published from January 2002 to June 2012 and …

Up North They’Re Talking Sex: A Collaborative And Community Driven Model For Sexual Health Knowledge Mobilization, Karen Edwards, Steve Mitchell Phd, Nancy Gibson Phd, Cecilia Zoe-Martin, Anita Daniels, Jim Martin, Patrick Wansbrough Rn

Journal of Health Disparities Research and Practice

To address high STI rates in their aboriginal communities, the Tłı̨chǫ of the Northwest Territories adopted a collaborative participatory research approach to sexual health based on four key stages of development. First was community initiation and engagement, where local leaders identified a priority need and began community discussions around sexual health. Secondly, identifying that existing government statistics did not provide them with adequate information, the Tlicho Community Services Agency partnered with the University of Alberta and CIETcanda to conduct a baseline study in all four Tlicho communities, designed and administered by community-based researchers. Third, a community action research team (CART) …

Variance In Patient Access To Support Persons By Race/Ethnicity And Language Preference: An Analysis Of Patient Survey Data, Andrew J. Jager, Matthew K. Wynia

Journal of Health Disparities Research and Practice

Regulatory and accreditation organizations have advocated open visitation policies and allowance of support persons of patients’ choosing, but it is unknown if support is allowed equitably. Data from hospitalized patients were analyzed to determine access to support persons, stratified by patient-reported race/ethnicity, language, sex, age, and education. A multivariate regression model was constructed using race and language, controlling for site and patient sex, education and age. Additionally, sites’ policies explicitly allowing support persons were correlated to reports of allowance of support persons. Among 1,196 respondents, 17% reported not being allowed a support person or being unsure. African American patients had …

Racial/Ethnic Disparities In Infectious Disease Hospitalizations In Arizona, Laura Callinan, Robert Holman, Douglas Esposito, Marian Mcdonald

Journal of Health Disparities Research and Practice

Infectious disease (ID) hospitalizations in Arizona, a diverse population with nearly complete race/ethnicity data, were analyzed using the State Inpatient Database for 2005-2008. ID hospitalizations rates were calculated and compared by ID group, race/ethnicity, age, and sex. During 2005-2008, there were 383,597 ID hospitalizations reported in Arizona, resulting in an age-adjusted rate of 1498.1 per 100,000 persons. A range of racial/ethnic disparities in ID hospitalization rates were noted. Persons of Native American and black race/ethnicity had overall ID hospitalization rates higher than the rate for persons of white race/ethnicity; persons of Asian or Pacific Islander race/ethnicity had a lower rate. …

Health Disparity And Structural Violence: How Fear Undermines Health Among Immigrants At Risk For Diabetes, Janet Page-Reeves, Joshua D. Niforatos, Shiraz Mishra, Lidia Regino, Andrew Gingerich, Robert Bulten

Journal of Health Disparities Research and Practice

Diabetes is a national health problem, and the burden of the disease and its consequences particularly affect Hispanics. While social determinants of health models have improved our conceptualization of how certain contexts and environments influence an individual's ability to make healthy choices, a structural violence framework transcends traditional uni-dimensional analysis. Thus, a structural violence approach is capable of revealing dynamics of social practices that operate across multiple dimensions of people’s lives in ways that may not immediately appear related to health. Working with a Hispanic immigrant community in Albuquerque, New Mexico, we demonstrate how structural forces simultaneously directly inhibit access …

Development, Implementation, And Assessment Of Health Equity Action Training (Heat): Implications For Local Health Departments, Karen A. D'Angelo, Carmen Chaparro, Rita Kornblum, Grace Damio, Rafael Pérez-Escamilla

Journal of Health Disparities Research and Practice

As inequities in health persistently plague our nation, rates of chronic disease continue to escalate, and increasing health care costs further debilitate our economy, the profession of public health is faced with monumental challenges. As a central community health institution, the local public health department plays an essential role in eliminating health inequities and preventing chronic disease. With the objective of preparing the local public health workforce to address the root factors associated with health, the Health Equity Action Training project trained 85 staff of the Hartford Department of Health & Human Services in the social determinants of health, social …

Physical Activity And Social Cognitive Theory Outcomes Of An Internet-Enhanced Physical Activity Intervention For African American Female College Students, Rodney P. Joseph, Dorothy W. Pekmezi, Terri Lewis, Gareth R. Dutton, Lori W. Turner, Nefertiti H. Durant

Journal of Health Disparities Research and Practice

Background. African American women report low levels of physical activity (PA) and are disproportionately burdened by related chronic diseases. This pilot study tested a 6-month theory-based (Social Cognitive Theory, SCT) culturally-relevant website intervention to promote PA among African American female college students.

Materials and Methods. A single group pre-post test design (n=34) was used. PA and associated SCT constructs (outcome expectations, enjoyment, self-regulation, social support) were assessed at baseline, 3 months and 6 months.

Results. The sample was comprised of mostly obese (M BMI= 35.4, SD=6.82) young adults (M age= 21.21 years, SD=2.31). Fifty percent …

Parental Perceptions: Religiosity And Sibling Relationships In Families Raising A Child With Diabetes, Caitlin Peterson (Herrman), Dr. Barbara Mandleco

Journal of Undergraduate Research

Raising a child with diabetes (CWD) impacts the whole family, since it is a disease requiring parental vigilance to ensure dietary/ medication compliance, and sibling understanding. Clearly, religion serves as an important resource to couples and families; however, it may also act as a resource for families who are raising a CWD. In fact, qualitative and empirical studies alike show religious practices and spiritual beliefs predict relational outcomes (Richards & Bergin, 1997).

Social Problems Of Children With Specific Language Impairment, Michelle H. Hutchings, Dr. Martin Fujiki

Journal of Undergraduate Research

Specific Language Impairment (SLI) is a well documented disability among many schoolaged children. Children with SLI exhibit “significant limitations in language functioning that cannot be attributed to deficits in hearing, oral structure and function, or general intelligence” (Leonard, 1987, p. 1). SLI results in disordered patterns of communication and is associated with academic failure. Increasing evidence also shows that children with SLI suffer from significant social difficulties.

The Effect Of Family Support On Cancer Patient Quality Of Life And Coping, Laura Fisher Brown, Dr. Patricia Rushton

Journal of Undergraduate Research

This research project has been such a growing experience for me. When I applied for my first grant in October of 2007, I had no idea that I would have gained so much from the opportunity to do undergraduate research. It has been a little over a year since I have started performing research in depth on my topic and it has been full of surprises, from both the actual process of research as well as the outcomes of my study. I have learned much about available support programs for cancer patients, the factors contributing to quality of life in …

Perceptions Of Giving Birth And Adherence To Cultural Practices In Chinese Women, Megan Cutler, Dr. Lynn Clark Callister

Journal of Undergraduate Research

Chinese childbearing women living in Taiwan have cultural beliefs and practices, including the common practice of “doing the month” after giving birth. Similar practices can also be found in Japan, South Korea, the People’s Republic of China (PRC), Thailand, and Cambodia. There are an increasing number of immigrants from Asia living in the United States, and many women from these places bring with them traditions and customs that are unfamiliar to many. Considering the great diversity of America, it is important that nurses working with childbearing women provide culturally competent care for Asian childbearing women and other culturally diverse women. …

‘Predicting’ Huntington’S Disease In The Heartland, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Reproducibility Of Cine Displacement Encoding With Stimulated Echoes (Dense) Cardiovascular Magnetic Resonance For Measuring Left Ventricular Strains, Torsion, And Synchrony In Mice, Christopher M. Haggerty, Sage P. Kramer, Cassi M. Binkley, David K. Powell, Andrea C. Mattingly, Richard Charnigo, Frederick H. Epstein, Brandon K. Fornwalt

Pediatrics Faculty Publications

BACKGROUND: Advanced measures of cardiac function are increasingly important to clinical assessment due to their superior diagnostic and predictive capabilities. Cine DENSE cardiovascular magnetic resonance (CMR) is ideal for quantifying advanced measures of cardiac function based on its high spatial resolution and streamlined post-processing. While many studies have utilized cine DENSE in both humans and small-animal models, the inter-test and inter-observer reproducibility for quantification of advanced cardiac function in mice has not been evaluated. This represents a critical knowledge gap for both understanding the capabilities of this technique and for the design of future experiments. We hypothesized that cine DENSE …

A Pilot Study: Relaxation Response To Vocal Training Intervention In Nursing Students, Leah Dymock, Dr. Glenda Christiaens

Journal of Undergraduate Research

As a profession, nursing requires a constant balance between professional standards, individual values, and patient needs (Luquette, 2007.) These responsibilities lead to stress, compassion fatigue, and burnout (ibid.) Thus it follows that an implicit part of nursing school is learning to care for another person without sacrificing your own physical or psychological wellbeing. This question is then raised: What is the best way to cope with stressful situations that are encountered by nurses? Although the best thing for one person will differ from what’s best for another person, there are inherent characteristics of activities that induce a relaxation state; namely, …

Autism Spectrum Disorders And Hyperbilirubinemia, Amber Blake, Dr. Lora Jean Campbell

Journal of Undergraduate Research

Autism spectrum disorders (ASD) have increased tenfold over the past fifty years. These disorders include: autistic disorder, Asperger disorder, and pervasive developmental disorder-not otherwise specified (PDD-NOS) (Johnson & Myers, 1184). Symptoms of ASD are language delay, severe deficits in social skills, and repetitive behavioral patterns. These symptoms make it hard for children with ASD to form peer relationships, communicate effectively, and develop appropriately (Johnson, 1191-1194).

How Nurses Perceive Their Ability To Support Newly Diagnosed Cancer Patients, Hannah Ross

Journal of Undergraduate Research

This study examined nurses’ feelings as they communicated with their newly diagnosed cancer patients. Qualitative interviews with ten oncology nurses from northern and central Utah were conducted. Nursing literature demonstrated that many newly diagnosed cancer patients felt healthcare staff were not empathetic. Qualitative interviews with study participants concluded that nurses with oncology experience feel confident and competent in supporting patients. The interviews also discussed that it is important for nurses to be empathetic, compassionate, understanding, and knowledgeable to feel competent in caring for these patients.

Assessing Russia’S Perception Of Graphic Tobacco Warning Labels, Ben Wade, Dr. Gordon B. Lindsay

Journal of Undergraduate Research

Gennadiy Onishchenko, Russia’s chief state public health officer, labeled Russia’s tobacco problem “the nicotine genocide of the Russian people” (Moscow News, 2008). The Russian Federation has emerged from the socio-economic pressures of communism and its downfall to become the 4th largest consumer of cigarettes per capita worldwide (Myers, 2008). According to the World Health Organization [WHO] (2008a), in 2005 70% of Russian males smoked and almost 27% of females smoked, totaling a staggering 1 in every 2 Russians smoking. Russia also boasts a forebodingly high adolescent smoking prevelance (30.1% of adolescent males and 24.4% of adolescent females smoke), signifying that …

Apgar Scores And Oxygenation Levels: A Comparison Of Vaginal And Cesarean Section Modes Of Delivery, Allison Holt, Dr. Patricia Ravert

Journal of Undergraduate Research

Purpose Compare Apgar scores and oxygenation levels of well infants born by Cesarean section (c-section) to those delivered vaginally.

Is There A Relationship Between Parenting Styles And Sibling Relationships In A Family Containing A Child With A Disability?, Corinne Jackman (Johnson), Dr. Barbara Mandleco

Journal of Undergraduate Research

The purpose of my research was to see if 1) there is a difference in parental perceptions of parenting styles and sibling relationships according to parent gender, sibling gender and type of disability as well as to 2) examine whether or not there is a linkage between parenting styles and sibling relationships in families raising a child with a disability (CWD). We studied autism, mental retardation, an orthopedic condition, other (deafness, blindness), and multiple disabilities.

Functional Characterization Of Crip1a Knockout Mice, Joanna Jacob

Theses and Dissertations

CB1 cannabinoid receptors are G-protein-coupled receptors that mediate the central nervous system (CNS) effects of marijuana and endocannabinoids. Recently, cannabinoid receptor interacting protein 1a (CRIP1a) was discovered as a novel protein that binds to the CB1 receptor C-terminus and inhibits CB1 receptor activity without affecting CB1 expression. This thesis investigated the functions of CRIP1a by characterizing the first CRIP1a knockout (KO) mouse line. The absence of CRIP1a was confirmed in KO mice using quantitative PCR and immunoblotting. I hypothesized that CRIP1a KO mice would exhibit enhanced CB1 receptor-mediated G-protein activity in the CNS, as well as cannabimemetic phenotypes and enhanced …

The Resilient Local Health Department: Surviving The 2008 Economic Crisis, Paul C. Erwin, Gulzar H. Shah, Glen P. Mays

Frontiers in Public Health Services and Systems Research

The purpose of this study was to identify potential modifiable factors that can protect local health departments (LHDs) from job losses and budget cuts during periods of economic stress. This was a retrospective cohort study based on the 2005 and 2010 surveys of LHDs conducted by the National Association of County and City Health Officials. The outcome of interest – resiliency of the LHD – represented financial resiliency for maintaining budgets during the 2008 recession, and was based on the ratio of observed-to-predicted expenditures per capita for 2010. LHDs which successfully weathered the economic recession of 2008 represented smaller populations …

What's Happening: August 26, 2013, Maine Medical Center

What's Happening

No abstract provided.

Bioengineered Lysozyme Reduces Bacterial Burden And Inflammation In A Murine Model Of Mucoid Pseudomonas Aeruginosa Lung Infection, Charlotte C. Teneback, Thomas C. Scanlon, Matthew J. Wargo, Jenna L. Bement, Karl E. Griswold, Laurie W. Leclair

Dartmouth Scholarship

The spread of drug-resistant bacterial pathogens is a growing global concern and has prompted an effort to explore potential adjuvant and alternative therapies derived from nature's repertoire of bactericidal proteins and peptides. In humans, the airway surface liquid layer is a rich source of antibiotics, and lysozyme represents one of the most abundant and effective antimicrobial components of airway secretions. Human lysozyme is active against both Gram-positive and Gram-negative bacteria, ac