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Articles 1201 - 1230 of 7931
Full-Text Articles in Medicine and Health Sciences
Transforming Patient Care Through Telehealth (Presentation), Joseph Tracy Ms, Ba, Terry A. Capuano Mba, Msn, Rn, Fache, Ne-Bc, Anne Panik Ms, Rn, Nea-Bc, Sharon Kromer Ccrc, Ctc, Lori Yesenofski Msn, Rn, Ccrn, Ctc
Transforming Patient Care Through Telehealth (Presentation), Joseph Tracy Ms, Ba, Terry A. Capuano Mba, Msn, Rn, Fache, Ne-Bc, Anne Panik Ms, Rn, Nea-Bc, Sharon Kromer Ccrc, Ctc, Lori Yesenofski Msn, Rn, Ccrn, Ctc
Patient Care Services / Nursing
No abstract provided.
Meeting The Challenges For The Plain Community In Healthcare, Mindy Brosious Bsn, Rn, Nicole Zimmerman Bsn, Rn, Nancy Humes Bsn, Rn, Patricia Christenson Rn
Meeting The Challenges For The Plain Community In Healthcare, Mindy Brosious Bsn, Rn, Nicole Zimmerman Bsn, Rn, Nancy Humes Bsn, Rn, Patricia Christenson Rn
Patient Care Services / Nursing
No abstract provided.
Contributions Of The Kölliker-Fuse Nucleus To Coordination Of Breathing And Swallowing, Joshua M. Bonis, Suzanne E. Neumueller, K. L. Krause, Lawrence Pan, Matthew R. Hodges, Hubert V. Forster
Contributions Of The Kölliker-Fuse Nucleus To Coordination Of Breathing And Swallowing, Joshua M. Bonis, Suzanne E. Neumueller, K. L. Krause, Lawrence Pan, Matthew R. Hodges, Hubert V. Forster
Physical Therapy Faculty Research and Publications
Herein we compare the effects of perturbations in the Kölliker–Fuse nucleus (KFN) and the lateral (LPBN) and medial (MPBN) parabrachial nuclei on the coordination of breathing and swallowing. Cannula was chronically implanted in goats through which ibotenic acid (IA) was injected while awake. Swallows in late expiration (E) always reset while swallows in early inspiration (I) never reset the respiratory rhythm. Before cannula implantation, all other E and I swallows did not reset the respiratory rhythm, and had small effects on E and I duration and tidal volume (VT). However, after cannula implantation in the MPBN and …
Factors That Contribute To Failed Retention In Former Athletic Trainers, Leamor Kathanov, Lindsey E. Eberman, Laura Juzeszyn
Factors That Contribute To Failed Retention In Former Athletic Trainers, Leamor Kathanov, Lindsey E. Eberman, Laura Juzeszyn
Internet Journal of Allied Health Sciences and Practice
BACKGROUND: Athletic trainer retention has been topic of concern for 20 years, with one study indicating a drastic decline within ten years of becoming certified. Burnout, life-work balance, role strain, socialization, salary, in addition to other constructs are potential reasons for a lack of retention. An assessment of individuals who have left the athletic training profession is lacking; therefore, the purpose of this study was to discover the reasons why athletic trainers leave the profession of athletic training. DESIGN: Web-based survey. Qualtrics® was used to survey of 1000 individuals who let their athletic training certification lapse within 5 years of …
Warfarin Induced Generalized Dermatitis – A Case Study, Corinne Floyd, Simon Leung
Warfarin Induced Generalized Dermatitis – A Case Study, Corinne Floyd, Simon Leung
Internet Journal of Allied Health Sciences and Practice
Despite bleeding concerns, other non-bleeding events can also occur from warfarin therapy. These non-bleeding events, occurring in less than 1%, include but are not limit to skin necrosis, “purple toe syndrome,” and dermatologic hypersensitivity reactions. Dermatologic adverse reactions from warfarin are uncommon and rarely reported in the literature. In this article, a rare case is described of warfarin induced generalized dermatitis in a 73-year-old female patient who was admitted for COPD exacerbation but later had paroxysmal atrial fibrillation (CHADS2 score of 2) and experienced an acute dermatological reaction during the initial and subsequent re-challenge of warfarin therapy. Both episodes of …
Immediate Effect Of Posture Correction Of Trapezius Activity In Computer Users Having Neck Pain – An Electromyographic Analysis, Kanwalpreet Kaur, Pooja Ghosh Das, P. K. Lenka, Shahhawaz Anwer
Immediate Effect Of Posture Correction Of Trapezius Activity In Computer Users Having Neck Pain – An Electromyographic Analysis, Kanwalpreet Kaur, Pooja Ghosh Das, P. K. Lenka, Shahhawaz Anwer
Internet Journal of Allied Health Sciences and Practice
Objectives: Aberrant activity of the trapezius muscle and associated postural abnormalities have been identified as potential factors for neck pain in computer users, thus postural correction is often advocated. The purpose of this trial was to examine the effect of specific scapular postural correction exercises on middle and lower trapezius activity. Methods: Sixty participants matched for the duration of daily computer use were included in the study. Twenty had no neck pain and exhibited “good” scapular posture (constituting Control group C), while forty reported pain (Neck Disability Index ≥ 15/100) for ≥ 3 months over 12 month period. The latter …
Promoting Health And Wellbeing For People With Attention Deficit Hyperactivity Disorder: An Occupational Perspective, Danielle Hitch, Negar Lavasani, Genevieve Pepin, Karen Stagnitti
Promoting Health And Wellbeing For People With Attention Deficit Hyperactivity Disorder: An Occupational Perspective, Danielle Hitch, Negar Lavasani, Genevieve Pepin, Karen Stagnitti
Internet Journal of Allied Health Sciences and Practice
Purpose: To provide an overview of current knowledge and practice that supports an occupational perspective to health promotion for people with attention deficit hyperactivity disorder (ADHD).Method: Evidence was identified from a range of electronic databases using inclusion and exclusion criteria. Studies were subjected to a process of critical appraisal using scales for both quantitative and qualitative research, with only those ranked in the top four levels included. The scales used for this critique were the levels of evidence for quantitative research defined by the Australian National Health and Medical Research Council (NHMRC) and the Rosalind Franklin Qualitative Research Appraisal Instrument …
Clinical Academic Faculty Perceptions Of Academic Mentorship In The Health Professions, Leamor Kathanov, Lindsey E. Eberman, Tiffany Idlewine, Lynda Melton
Clinical Academic Faculty Perceptions Of Academic Mentorship In The Health Professions, Leamor Kathanov, Lindsey E. Eberman, Tiffany Idlewine, Lynda Melton
Internet Journal of Allied Health Sciences and Practice
No abstract provided.
Narrative Means To Preventative Ends: A Narrative Engagement Framework For Designing Prevention Interventions, Michelle Miller-Day, Michael L. Hecht
Narrative Means To Preventative Ends: A Narrative Engagement Framework For Designing Prevention Interventions, Michelle Miller-Day, Michael L. Hecht
Communication Faculty Articles and Research
This article describes a Narrative Engagement Framework (NEF) for guiding communication-based prevention efforts. This framework suggests that personal narratives have distinctive capabilities in prevention. The article discusses the concept of narrative, links narrative to prevention, and discusses the central role of youth in developing narrative interventions. As illustration, the authors describe how the NEF is applied in the keepin' it REAL adolescent drug prevention curriculum, pose theoretical directions, and offer suggestions for future work in prevention communication.
Long Term Effectiveness Of Cognitive Behavior Therapy For Treatment Of Postpartum Depression: A Systematic Review And Meta-Analysis, Tahira Perveen, Sajid Mahmood, Ibrahim Gosadi, Jaishri Mehraj, Sana Sadiq Sheikh
Long Term Effectiveness Of Cognitive Behavior Therapy For Treatment Of Postpartum Depression: A Systematic Review And Meta-Analysis, Tahira Perveen, Sajid Mahmood, Ibrahim Gosadi, Jaishri Mehraj, Sana Sadiq Sheikh
Department of Obstetrics & Gynaecology
Background: The existing trials on the long term effectiveness of cognitive behavior therapy (CBT) for the treatment of postpartum depression have conflicting results. Therefore, we performed a systematic review to summarize the current evidence.
Methodology: Literature search was performed using electronic databases Medline, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and PsychINFO were explored from January 2000 to March 2013.
All peer-reviewed English-published randomized controlled trials were eligible if they assessed the long term (at least at 24 weeks post partum) effectiveness of CBT versus standard postpartum care for prevention of postpartum depression. Data from eligible studies were …
Wilson’S Disease In Pregnancy: Case Series And Review Of Literature, Ayesha Malik, Ali Khawaja, Lumaan Sheikh
Wilson’S Disease In Pregnancy: Case Series And Review Of Literature, Ayesha Malik, Ali Khawaja, Lumaan Sheikh
Department of Obstetrics & Gynaecology
Background: Wilson’s disease is a rare, autosomal recessive inherited disorder characterized by impaired liver metabolism of copper leading to decreased biliary excretion and incorporation of ceruloplasmin levels mainly in the liver and brain. Untreated Wilson’s disease has been shown to cause subfertility and even in cases where pregnancy occurs, it often results in spontaneous miscarriage.
Case presentations: We present four cases of successful pregnancy outcomes in three patients diagnosed with Wilson’s disease along with the literature review. All the patients were managed with zinc sulphate without any postnatal complications.
Conclusion: Patients with Wilson’s disease receiving regular treatment who remain asymptomatic …
Seventeenth Annual Scientific Meeting Institute Of Cardiovascular Science And Medicine
Seventeenth Annual Scientific Meeting Institute Of Cardiovascular Science And Medicine
Journal of the Hong Kong College of Cardiology
No abstract provided.
Association Of Dietary Intake Patterns With Emotion Regulation, Megan Holt
Association Of Dietary Intake Patterns With Emotion Regulation, Megan Holt
Loma Linda University Electronic Theses, Dissertations & Projects
Background: Western dietary patterns, characterized by high intakes of trans fatty acids (TFA’s), are associated with numerous preventable chronic diseases. Conversely, a Mediterranean dietary pattern is known to be favorably associated with health. Recent findings suggest a correlation between Mediterranean dietary patterns and positive affect, and an inverse correlation with negative affect. Trans fatty acid intake is also associated with negative affect. Further, affect disturbances are associated with emotion dysregulation. We have yet to understand the association of diet with emotion regulation after taking affect disturbances into consideration. The purpose of this study was to examine effects of Mediterranean diet …
Role-Emergent Model: An Effective Strategy To Address Clinical Placement Shortages, Rosemin Kassam, Mona Kwong, John B. Collins
Role-Emergent Model: An Effective Strategy To Address Clinical Placement Shortages, Rosemin Kassam, Mona Kwong, John B. Collins
Internet Journal of Allied Health Sciences and Practice
Purpose: To evaluate the effectiveness of an advanced pharmacy practice experience (APPE) delivered at “role-emergent” placement sites within long-term care (LTC) facilities that are preceptored by off-site community pharmacists.Method: Seven LTC facilities participated: five newly recruited test sites preceptored by off-site pharmacists who supervised students remotely (“role-emergent” placements), and two previously established hospital-based facilities with on-site pharmacists who provided continuous student supervision (“role-established” placements) as a comparison group. Students participated in pre-APPE training. Both qualitative and quantitative methods were used to obtain student learning performance on 13 pre-defined learning objectives and 21 indicators of site resources and skills-development opportunities. Structured …
Reducing Restraints: A Patient Safety, Staff Driven Initiative, Lisa A. Lacy, Nicole J. Urban-Miller Rn, Bsn, Denise Bodish Bsn, Rnbc, Jane Halpin Rnc, Pcc, Colleen S. Green, Kathryn P. Mercadante Rn
Reducing Restraints: A Patient Safety, Staff Driven Initiative, Lisa A. Lacy, Nicole J. Urban-Miller Rn, Bsn, Denise Bodish Bsn, Rnbc, Jane Halpin Rnc, Pcc, Colleen S. Green, Kathryn P. Mercadante Rn
Patient Care Services / Nursing
No abstract provided.
Transforming From A Freestanding Asf To A Hospital-Based Unit, Darlene Hinkle Msn, Rn, Cnor
Transforming From A Freestanding Asf To A Hospital-Based Unit, Darlene Hinkle Msn, Rn, Cnor
Patient Care Services / Nursing
No abstract provided.
Left Ventricular Thrombus Found In A Patient With Ards And Stress-Induced Cardiomyopathy Requiring Veno-Arterial Ecmo., Shreya Gupta, Bs, Joseph Miessau, Ms, Harrsion Pitcher, Md, Michael Baram, Md, Nicholas C. Cavarocchi, Md, Hitoshi Hirose, Md, Phd
Left Ventricular Thrombus Found In A Patient With Ards And Stress-Induced Cardiomyopathy Requiring Veno-Arterial Ecmo., Shreya Gupta, Bs, Joseph Miessau, Ms, Harrsion Pitcher, Md, Michael Baram, Md, Nicholas C. Cavarocchi, Md, Hitoshi Hirose, Md, Phd
Department of Surgery Faculty Papers
Presentation:
68 year-old male with a history of acute leukemia with complete remission after bone marrow transplant 4 months ago, coronary disease s/p LAD stents about 14 years ago with no chronic anti-platelet medication, and repeated episode of DVT despite appropriate anti-coagulation, presented with viral pneumonia (rhinovirus).
Bibliographic Review Of Research Publications On Access To And Use Of Medicines In Low-Income And Middle-Income Countries In The Eastern Mediterranean Region: Identifying The Research Gaps., Arash Rashidian, Nader Jahanmehr, Samer Jabbour, Shehla Zaidi, Fatemeh Soleymani, Maryam Bigdeli
Bibliographic Review Of Research Publications On Access To And Use Of Medicines In Low-Income And Middle-Income Countries In The Eastern Mediterranean Region: Identifying The Research Gaps., Arash Rashidian, Nader Jahanmehr, Samer Jabbour, Shehla Zaidi, Fatemeh Soleymani, Maryam Bigdeli
Community Health Sciences
BJECTIVES:
We assessed the situation of academic publications on access to and use of medicines (ATM) in low-income and middle-income countries (LMICs) of the Eastern Mediterranean Region (EMR). We aimed to inform priority setting for research on ATM in the region.
DESIGN:
Bibliographic review of published studies.
SETTING:
LMICs in EMR.
INCLUSION CRITERIA:
Publications on ATM issues originating from or focusing on EMR LMICs covering the period 2000-2011. Publications involving multinational studies were included if at least one eligible country had been included in the study.
INFORMATION SOURCES AND DATA EXTRACTION:
We conducted comprehensive searches of the PubMed, Social Science …
Peran Support Group Dalam Mendorong Motivasi Belajar Remaja : Action Research Pada Pelajar Sma X, Afra Afifah
Peran Support Group Dalam Mendorong Motivasi Belajar Remaja : Action Research Pada Pelajar Sma X, Afra Afifah
Jurnal Ilmu Kesejahteraan Sosial
This study discusses how support group plays a role in encouraging student’s learning motivation with action research approach. Application of support group becomes an alternative to complete counseling approach in dealing with adolescent learning problem in school. After running the program, an evaluation conducted on five students as the object of study. The result showed that student’s awareness on the low of learning motivation as a problem to be solved affects their involvement in the group. Students who have that awareness are able to engage within group well and get benefit from the existence of group.
Knowing The Standard American Diet By Its Fruits: Is Unrestrained Omnivorism Spiritually Beneficial?, Matthew C. Halteman
Knowing The Standard American Diet By Its Fruits: Is Unrestrained Omnivorism Spiritually Beneficial?, Matthew C. Halteman
University Faculty Publications and Creative Works
This essay aims to challenge the standard [North] American diet's (SAD) default status in church and among North American Christians generally. It attempts to allay some common concerns about the suitability of food ethics as a topic for serious Christian discernment, and argues that SAD is not spiritually beneficial, drawing support from five traditional sources for Christian moral deliberation, including and especially general revelation and discernment of the fruits of the spirit.
Effects Of Acute Or Chronic Ethanol Exposure During Adolescence On Behavioral Inhibition And Efficiency In A Modified Water Maze Task, Shawn K. Acheson, Craig Bearison, Mary-Louise Risher, Sabri H. Abdelwahab, Wilkie A. Wilson, H. Scott Swartzwelder
Effects Of Acute Or Chronic Ethanol Exposure During Adolescence On Behavioral Inhibition And Efficiency In A Modified Water Maze Task, Shawn K. Acheson, Craig Bearison, Mary-Louise Risher, Sabri H. Abdelwahab, Wilkie A. Wilson, H. Scott Swartzwelder
Biomedical Sciences
Ethanol is well known to adversely affect frontal executive functioning, which continues to develop throughout adolescence and into young adulthood. This is also a developmental window in which ethanol is misused by a significant number of adolescents. We examined the effects of acute and chronic ethanol exposure during adolescence on behavioral inhibition and efficiency using a modified water maze task. During acquisition, rats were trained to find a stable visible platform onto which they could escape. During the test phase, the stable platform was converted to a visible floating platform (providing no escape) and a new hidden platform was added …
Primary Blast Traumatic Brain Injury In The Rat: Relating Diffusion Tensor Imaging And Behavior, Matthew D. Budde, Alok Shah, Michael Mccrea, William E. Cullinan, Frank A. Pintar, Brian D. Stemper
Primary Blast Traumatic Brain Injury In The Rat: Relating Diffusion Tensor Imaging And Behavior, Matthew D. Budde, Alok Shah, Michael Mccrea, William E. Cullinan, Frank A. Pintar, Brian D. Stemper
Biomedical Sciences Faculty Research and Publications
The incidence of traumatic brain injury (TBI) among military personnel is at its highest point in U.S. history. Experimental animal models of blast have provided a wealth of insight into blast injury. The mechanisms of neurotrauma caused by blast, however, are still under debate. Specifically, it is unclear whether the blast shockwave in the absence of head motion is sufficient to induce brain trauma. In this study, the consequences of blast injury were investigated in a rat model of primary blast TBI. Animals were exposed to blast shockwaves with peak reflected overpressures of either 100 or 450 kPa (39 and …
A Population-Based Case–Control Study Of Urinary Arsenic Species And Squamous Cell Carcinoma In New Hampshire, Usa, Diane Gilbert-Diamond, Zhigang Li, Ann E. Perry, Steven K. Spencer, A Jay Gandolfi, Margaret R. Karagas
A Population-Based Case–Control Study Of Urinary Arsenic Species And Squamous Cell Carcinoma In New Hampshire, Usa, Diane Gilbert-Diamond, Zhigang Li, Ann E. Perry, Steven K. Spencer, A Jay Gandolfi, Margaret R. Karagas
Dartmouth Scholarship
Background: Chronic high arsenic exposure is associated with squamous cell carcinoma (SCC) of the skin, and inorganic arsenic (iAs) metabolites may play an important role in this association. However, little is known about the carcinogenicity of arsenic at levels commonly observed in the United States.
Objective: We estimated associations between total urinary arsenic and arsenic species and SCC in a U.S. population.
Methods: We conducted a population-based case–control SCC study (470 cases, 447 controls) in a U.S. region with moderate arsenic exposure through private well water and diet. We measured urinary iAs, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA), and …
Adding Obesity To The Problem List Increases The Rate Of Providers Addressing Obesity., Elaine Seaton Banerjee, Angela Gambler, Corey Fogleman
Adding Obesity To The Problem List Increases The Rate Of Providers Addressing Obesity., Elaine Seaton Banerjee, Angela Gambler, Corey Fogleman
Department of Family & Community Medicine Faculty Papers
BACKGROUND AND OBJECTIVES: Obesity is a common problem that increases risk of many other diseases, from heart disease to cancer. While counseling by a physician increases patient report of weight loss attempts and increased exercise, primary care physicians do not frequently address obesity. The objectives of this study were to determine how often obesity was included on the problem list and whether adding obesity to the problem list affected the rate at which it was addressed in future visits.
METHODS: We conducted an initial assessment, followed by a randomized controlled trial of patient records at a family medicine residency office. …
Generating Hypotheses About Care Needs Of High Utilizers: Lessons From Patient Interviews., Dawn B Mautner, Hauchie Pang, Jeffrey C Brenner, Judy A Shea, Kennen S Gross, Rosemary Frasso, Carolyn C Cannuscio
Generating Hypotheses About Care Needs Of High Utilizers: Lessons From Patient Interviews., Dawn B Mautner, Hauchie Pang, Jeffrey C Brenner, Judy A Shea, Kennen S Gross, Rosemary Frasso, Carolyn C Cannuscio
Department of Family & Community Medicine Faculty Papers
Informed by a largely secondary and quantitative literature, efforts to improve care and outcomes for complex patients with high levels of emergency and hospital-based health care utilization have offered mixed results. This qualitative study identifies psychosocial factors and life experiences described by these patients that may be important to their care needs. Semi-structured interviews were conducted with 19 patients of the Camden Coalition of Healthcare Providers' Care Management Team. Investigators coded transcripts using a priori and inductively-derived codes, then identified 3 key themes: (1) Early-life instability and traumas, including parental loss, unstable or violent relationships, and transiency, informed many participants' …
Situational Awareness: Reframing Within Fire Service Culture, Martha Dow, Len Garis, Larry Thomas
Situational Awareness: Reframing Within Fire Service Culture, Martha Dow, Len Garis, Larry Thomas
Publications and Research
There is increasing attention being paid to better understanding and consequently decreasing the incidence of on-the-job injuries and deaths within the fire service across North America. Heightening situational awareness is being explored as the most critical factor in maintaining the safety of participants in high risk, low frequency events. Situational awareness is generally defined as “understanding the current environment and being able to accurately anticipate future problems to enable effective action”. Situational awareness is cited as a critical factor in most research exploring safety in fire suppression activities and in many cases the “No. 1 factor identified by firefighters filing …
Articulatory Distinctiveness Of Vowels And Consonants: A Data-Driven Approach, Jun Wang, Jordan R. Green, Ashok Samal, Yana Yunusova
Articulatory Distinctiveness Of Vowels And Consonants: A Data-Driven Approach, Jun Wang, Jordan R. Green, Ashok Samal, Yana Yunusova
School of Computing: Faculty Publications
Purpose: To quantify the articulatory distinctiveness of 8 major English vowels and 11 English consonants based on tongue and lip movement time series data using a data-driven approach.
Method: Tongue and lip movements of 8 vowels and 11 consonants from 10 healthy talkers were collected. First, classification accuracies were obtained using 2 complementary approaches: (a) Procrustes analysis and (b) a support vector machine. Procrustes distance was then used to measure the articulatory distinctiveness among vowels and consonants. Finally, the distance (distinctiveness) matrices of different vowel pairs and consonant pairs were used to derive articulatory vowel and consonant spaces …
Chemokine-Enhanced Dna Vaccination In Cancer Immunotherapy., Olga Igoucheva, Rebecca Jonas, Vitali Alexeev
Chemokine-Enhanced Dna Vaccination In Cancer Immunotherapy., Olga Igoucheva, Rebecca Jonas, Vitali Alexeev
Department of Dermatology and Cutaneous Biology Faculty Papers
We have demonstrated that priming of intratumoral and intradermal vaccination sites with chemokines enhances cytotoxic immune response against established neoplasms. Additional insights into the molecular mechanisms that underlie these findings and the optimization of such an approach may lead to the development of cost-effective and generic immunotherapeutic regimens against cancer.
Outdated Dermatologic Drug Samples And Obligations To The Patient., Jordan Wang, Matthew Keller
Outdated Dermatologic Drug Samples And Obligations To The Patient., Jordan Wang, Matthew Keller
Department of Dermatology and Cutaneous Biology Faculty Papers
CASE SCENARIO
A 37-year-old man with a slightly raised, red, scaly patch on his left arm is seen in the clinic of an academic teaching hospital by a young dermatologist. Following examination and biopsy, he is found to have squamous cell carcinoma in situ. The patient was recently laid off from work and had lost access to his health insurance. He is struggling to make ends meet for his family, so it would be difficult for him to cover any extraneous health-related expenses. Upon relaying this information to the dermatologist, the patient is provided with a full course of 5-fluorouracil …
Small Molecule Antagonists Of Melanopsin-Mediated Phototransduction, Kenneth A. Jones, Megumi Hatori, Ludovic S. Mure, Jayne R. Bramley, Roman Artymyshyn, Sang-Phyo Hong, Mohammad Marzabadi, Huailing Zhong, Jeffrey Sprouse, Quansheng Zhu, Andrew T. E. Hartwick, Patricia J. Sollars, Gary E. Pickard, Satchidananda Panda
Small Molecule Antagonists Of Melanopsin-Mediated Phototransduction, Kenneth A. Jones, Megumi Hatori, Ludovic S. Mure, Jayne R. Bramley, Roman Artymyshyn, Sang-Phyo Hong, Mohammad Marzabadi, Huailing Zhong, Jeffrey Sprouse, Quansheng Zhu, Andrew T. E. Hartwick, Patricia J. Sollars, Gary E. Pickard, Satchidananda Panda
School of Veterinary and Biomedical Sciences: Faculty Publications
Melanopsin, expressed in a subset of retinal ganglion cells, mediates behavioral adaptation to ambient light and other non-image forming photic responses. This has raised the possibility that pharmacological manipulation of melanopsin can modulate several CNS responses including photophobia, sleep, circadian rhythms and neuroendocrine function. Here we describe the identification of a potent synthetic melanopsin antagonist with in vivo activity. Novel sulfonamide compounds inhibiting melanopsin (opsinamides) compete with retinal binding to melanopsin and inhibit its function without affecting rod/cone mediated responses. In vivo administration of opsinamides to mice specifically and reversibly modified melanopsin-dependent light responses including the pupillary light reflex and …