Medicine and Health Sciences Commons^™

Nurturing The Whole Body: The Benefits Of Supplementing Tuberculosis Chemotherapy With Traditional Chinese Medical Practices, Rachel Levine

Independent Study Project (ISP) Collection

Although modern medicine has found a cure for Tuberculosis (TB), it remains a worldwide health threat. Due to poor adherence to TB chemotherapya multi-drug resistant strain of the TB bacteria (MDR-TB) has been created.It has been found that poor adherence is caused by many factors, two of which include the high cost of treatment and the many uncomfortable side effects. Through a month of research based in Kunming, China including interviews, observations and surveys,this project hoped to compare Western biomedicine and Traditional Chinese Medicine (TCM) to determine the potential benefits TCM holds for TB patients. TCM improves a TB patient’s …

Weza Motrin Pichikeche Meu: El Entendimiento Cultural De La Obesidad Infantil En El Pueblo Mapuche, Katherine Shaffer

Independent Study Project (ISP) Collection

Research Question: How do the Mapuche people interpret childhood obesity, and how do they use this interpretation to treat and prevent this disease?

Objective: To describe the Mapuche concept of childhood obesity used by families and community leaders in Makewe, Chile, and how this concept is used to treat and prevent this disease.

Background: Childhood obesity is a growing problem throughout much of the world, including Chile, with grave effects on physical and mental health. There are a plethora of causes of this disease, from individuals with an imbalance in calorie expenditure, to national and international policies in economy and …

Illuminating Rlung: The Vital Energy Of Tibetan Medicine, Alma Rominger

Independent Study Project (ISP) Collection

According to Tibetan Medicine, rlung is one of the three principal energies of the human body; rlung can be translated loosely as “wind” because its predominate element is air. It is responsible for all movement internal and external to the body, from the circulation of blood to the movement of limbs. rLung is the “vehicle” of consciousness, the force which holds and moves the mind. According to the rGyud-bZhi, the traditional Tibetan medical text, rlung is the beginning and end of disease because of its pervasive nature and its close relationship with the mind; it has the power to spread …

Department Of Surgery Update, October 2013, Wright State University Department Of Surgery

Department of Surgery Updates

A three page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity and more.

Combined Erp/Fmri Evidence For Early Word Recognition Effects In The Posterior Inferior Temporal Gyrus, Joseph Dien, Eric S. Brian, Dennis L. Molfese, Brian T. Gold

Center for Brain, Biology, and Behavior: Faculty Publications

Two brain regions with established roles in reading are the posterior middle temporal gyrus and the posterior fusiform gyrus. Lesion studies have also suggested that the region located between them, the posterior inferior temporal gyrus (pITG), plays a central role in word recognition. However, these lesion results could reflect disconnection effects since neuroimaging studies have not reported consistent lexicality effects in pITG. Here we tested whether these reported pITG lesion effects are due to disconnection effects or not using parallel ERP/fMRI studies. We predicted that the Recognition Potential (RP), a left-lateralized ERP negativity that peaks at about 200–250 ms, might …

The Impact Of Big Data On The Healthcare Information Systems, Kuo Lane Chen, Huei Lee

Transactions of the International Conference on Health Information Technology Advancement

This article explores the possible impact of big data on healthcare information systems. Possible research issues include: 1). What applications in healthcare information systems are impacted most? 2). What algorithm/programs will be used for big data? 3). What privacy, security, and ethical issues are there for big data? In the biology area, big data becomes the newest technology for genomics. Other possible areas include pharmacovigilance, patient care, and medical supply chain management.

Managing Government Regulatory Requirements For Security And Privacy Using Existing Standard Models, Gregory Schymik, Dan Shoemaker

Transactions of the International Conference on Health Information Technology Advancement

This paper posits the use of a well-established standard approach to Federal compliance, which can be easily adapted to satisfy all legal and regulatory requirements for protection of patient personally identifiable information (PII) in health organizations. This approach is embodied in the three standards that dictate how to comply with the Federal Information Security Management Act (FISMA). These standards also provide an excellent foundation for organizing a secure operation anywhere. The discussion revolves around the application of the FIPS 199 and FIPS 200/NIST 800-53(4) standard approach to the satisfaction of the present and upcoming legal and regulatory requirements for health …

Hdqm2: Healthcare Data Quality Maturity Model, Javier Mauricio Pinto-Valverde, Miguel Ángel Pérez-Guardado, Lorena Gomez-Martinez, Martha Corrales-Estrada, Juan Carlos Lavariega-Jarquín

Transactions of the International Conference on Health Information Technology Advancement

Data Quality is a central issue within the development of Healthcare Systems, for both the delivery of the service as well as for the establishment of public policies. Public and private Healthcare Systems in Latin America do not have a framework of reference which allows them to have knowledge of the level of Data Quality (DQ). In other frameworks found within literature the evaluation of DQ has been centered within the dimensions. The intention of this research is to build an evaluation model for DQ based on maturity. This research contributes an innovating and comprehensive model, based on the data …

The Role Of Mobile Technology In Enhancing The Use Of Personal Health, Mohamed Abouzahra, Joseph Tan

Transactions of the International Conference on Health Information Technology Advancement

Healthcare industry is essential for the wellbeing of society members, however this industry is characterized by high cost and by plagued by serious medical errors. Personal health records (PHR) can play an important role in solving healthcare problems by enhancing patients’ involvement in their treatment, and improving patient-provider communication. Despite the potential importance of PHR systems, they suffer from low adoption rate because of several factors such as digital divide and lack of training. In this paper we propose that mobile PHR systems (MPHR) can aid in overcoming barriers to adopt PHR. We present a theoretical model based on theory …

A Study On Generic Prescription Substitution Policy As A Cost Containment Approach For Michigan’S Medicaid System, Khandaker Nayeemul Islam

Transactions of the International Conference on Health Information Technology Advancement

High health care costs have left millions of people unable to buy health insurance and has broadened the state’s responsibility to protect low-income families through Medicaid programs. Increasing health care costs have created severe toll on fiscal management of federal and state governments. Prescription drugs are a significant part of Michigan’s Medicaid costs. Due to the economic recession and the downsizing of auto sector the number of Medicaid beneficiaries in Michigan has increased over the years. Thus it has increased Medicaid prescription drugs program costs at a fast pace, which creates fiscal burden on Michigan in administering the program and …

Preparing Public Librarians For Consumer Health Information Service: A Nation-Wide Study, L. Luo, Van M. Ta Park

Faculty Publications

A nationwide survey study was conducted to gain understanding as to how to prepare public librarians for consumer health information service. Findings indicate that the popular health information needs encountered by public librarians cover a wide variety of topics, including the human body, a medical/health condition, a disease, a medical concept, and fitness/diet/nutrition. The top two challenges faced by public librarians when providing consumer health information service are difficulty in interpreting patrons' questions and lack of knowledge about available and trusted/appropriate medical/health information sources. Public librarians wish to receive training on a number of topics that could help address the …

Plan B Topic: Annotated Resource List, Payton Roberts

Undergraduate Research Award

No abstract provided.

Vest Chest Physiotherapy Airway Clearance Is Associated With Nitric Oxide Metabolism., Joseph H. Sisson, Todd A. Wyatt, Jacqueline A. Pavlik, Pawanjit S. Sarna, Peter J. Murphy

Journal Articles: Pulmonary & Critical Care Med

Background. Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism. Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism. Methods. Both normal subjects and stable CF subjects had pre- and post-VCPT airway clearance assessed using nasal saccharin transit time (NSTT) followed by a collection of exhaled breath condensate (EBC) analyzed for NO metabolites (NO x ). Results. VCPT shorted NSTT by 35% in normal and stable CF subjects with no difference observed between the groups. EBC NO x concentrations decreased 68% in control subjects after …

Marshall University Joan C. Edwards School Of Medicine, Professional Enhancement Newsletter, Fall 2013, Darshana Shah Ph.D.

Professional Enhancement News (PEN)

Fall 2013, Volume 5, Number 2

We Are… Bridging Medicine And Science, Vol. 1, Issue 3, Fall 2013, Marshall University Biomedical Sciences

We Are... Bridging Medicine Science

No abstract provided.

Randomized Clinical Trial Examining Duration Of Voucher-Based Reinforcement Therapy For Cocaine Abstinence., Kimberly C Kirby, Carolyn M Carpenedo, Karen L Dugosh, Beth J Rosenwasser, Lois A Benishek, Alicia Janik, Rachel Keashen, Elena Bresani, Kenneth Silverman

College of Science & Mathematics Departmental Research

BACKGROUND: This is the first study to systematically manipulate duration of voucher-based reinforcement therapy (VBRT) to see if extending the duration increases abstinence during and following VBRT.

METHODS: We randomized cocaine-dependent methadone-maintained adults to Standard (12 weeks; n=62) or Extended (36 weeks; n=68) VBRT and provided escalating voucher amounts contingent upon urinalysis verification of cocaine abstinence. Urinalysis was scheduled at least every 2 weeks during the 48-week study and more frequently during VBRT (3/week) and 12 weeks of Aftercare (2/week).

RESULTS: Extended VBRT produced longer durations of continuous cocaine abstinence during weeks 1-24 (5.7 vs 2.7 weeks; p=0.003) and proportionally …

Gsk-3Β Function In Bone Regulates Skeletal Development, Whole-Body Metabolism, And Male Life Span, J. R. Gillespie, J. R. Bush, G. I. Bell, L. A. Aubrey, H. Dupuis, F. Ferron, B. Kream, G. Dimattia, S. Patel, J. R. Woodgett, G. Karsenty, D. A. Hess, F. Beier

Paediatrics Publications

Glycogen synthase kinase 3 β (GSK-3β) is an essential negative regulator or “brake” on many anabolic-signaling pathways including Wnt and insulin. Global deletion of GSK-3β results in perinatal lethality and various skeletal defects. The goal of our research was to determine GSK-3β cell-autonomous effects and postnatal roles in the skeleton. We used the 3.6-kb Col1a1 promoter to inactivate the Gsk3b gene (Col1a1-Gsk3b knockout) in skeletal cells. Mutant mice exhibit decreased body fat and postnatal bone growth, as well as delayed development of several skeletal elements. Surprisingly, the mutant mice display decreased circulating glucose and insulin levels despite normal expression of …

The Touchscreen Operant Platform For Testing Learning And Memory In Rats And Mice., Alexa E Horner, Christopher J Heath, Martha Hvoslef-Eide, Brianne A Kent, Chi Hun Kim, Simon R O Nilsson, Johan Alsiö, Charlotte A Oomen, Andrew Holmes, Lisa M Saksida, Timothy J Bussey

Brain and Mind Institute Researchers' Publications

An increasingly popular method of assessing cognitive functions in rodents is the automated touchscreen platform, on which a number of different cognitive tests can be run in a manner very similar to touchscreen methods currently used to test human subjects. This methodology is low stress (using appetitive rather than aversive reinforcement), has high translational potential and lends itself to a high degree of standardization and throughput. Applications include the study of cognition in rodent models of psychiatric and neurodegenerative diseases (e.g., Alzheimer's disease, schizophrenia, Huntington's disease, frontotemporal dementia), as well as the characterization of the role of select brain regions, …

The Touchscreen Operant Platform For Testing Working Memory And Pattern Separation In Rats And Mice., Charlotte A Oomen, Martha Hvoslef-Eide, Christopher J Heath, Adam C Mar, Alexa E Horner, Timothy J Bussey, Lisa M Saksida

Brain and Mind Institute Researchers' Publications

The automated touchscreen operant chamber for rats and mice allows for the assessment of multiple cognitive domains within the same testing environment. This protocol presents the location discrimination (LD) task and the trial-unique delayed nonmatching-to-location (TUNL) task, which both assess memory for location. During these tasks, animals are trained to a predefined criterion during ∼20-40 daily sessions. In LD sessions, touching the same location on the screen is rewarded on consecutive trials, followed by a reversal of location-reward contingencies. TUNL, a working memory task, requires animals to 'nonmatch' to a sample location after a delay. In both the LD and …

The Touchscreen Operant Platform For Assessing Executive Function In Rats And Mice., Adam C Mar, Alexa E Horner, Simon R O Nilsson, Johan Alsiö, Brianne A Kent, Chi Hun Kim, Andrew Holmes, Lisa M Saksida, Timothy J Bussey

Brain and Mind Institute Researchers' Publications

This protocol details a subset of assays developed within the touchscreen platform to measure various aspects of executive function in rodents. Three main procedures are included: extinction, measuring the rate and extent of curtailing a response that was previously, but is no longer, associated with reward; reversal learning, measuring the rate and extent of switching a response toward a visual stimulus that was previously not, but has become, associated with reward (and away from a visual stimulus that was previously, but is no longer, rewarded); and the 5-choice serial reaction time (5-CSRT) task, gauging the ability to selectively detect and …

Scarpa's Fascia And Clinical Signs: The Role Of The Membranous Superficial Fascia In The Eponymous Clinical Signs Of Retroperitoneal Catastrophe., Shanoor Ullah, Robert Grant, Marjorie Johnson, Vivian Mcalister

Data and Test Instruments

This article deals with the history of membranous superficial fascia (Antonio Scarpa, Abraham Colles), the history of clinical signs that use discoloration of the torso (Cullen's sign, Grey Turner's sign, Fox's sign, Bryant's sign) and then describes anatomical dissection studies to link the two. INTRODUCTION: The membranous superficial fascia (MSF) was described early in the 19th century, as was its role in the clinical sign of urethral disruption. Clinical signs of haemorrhage or leakage of pancreatic and biliary fluid into the retroperitoneum, which were described throughout the 20th century, all relied on circumscribed discolouration of the skin of the torso. …

Bradykinin B2 Receptor In The Adrenal Medulla Of Male Rats And Mice: Glucocorticoid-Dependent Increase With Immobilization Stress, Regina Nostramo, Andrej Tillinger, Lidia Serova, Richard Kvetnansky, Esther L. Sabban

NYMC Faculty Publications

Bradykinin, acting via the bradykinin B2 receptor (B2R), is a potent stimulator of adrenomedullary catecholamine biosynthesis and release and likely plays an important role in the adrenomedullary stress response. However, the effects of stress on the expression of this receptor in the adrenal medulla are currently unclear. Here, we examined the changes in adrenomedullary B2R gene expression in male rats in response to single (1 time) and repeated (6 times) exposure to 2 hours immobilization stress (IMO). Immediately after 1 or 6 times IMO, B2R mRNA levels were increased by 9-fold and 7-fold, respectively, and returned to unstressed control levels …

New Phenotype Of Parsonage-Turner Syndrome Involving Radial And Proximal Median Nerve: A Case Report, Matthew Mcauliffe, Md, Nancy Vuong, Md, Adam L. Schreiber, Do

Department of Rehabilitation Medicine Faculty Papers

History

A 74-year-old woman developed sudden severe left shoulder, arm, and forearm pain that suddenly developed. This pain lasted approximately 2 months. Approximately 1-2 months after the resolution of the first pain she developed a different type of pain which she described as a tingling, burning, pins and needle sensation that radiated from her shoulder past her elbow into the dorsal and palmar aspect of her hand in the thumb, index, and long fingers. Additionally, she developed numbness in her hand along the palmar thumb, index, and long fingers. Two months following the onset of the initial type of pain, …

Pharmacological Characterization Of A Novel Non-At1, Non-At2 Angiotensin Binding Site Identified As Neurolysin, Jamala D. Swindle, Kira L. Santos, Robert C. Speth

HPD Articles

The discovery of a novel non-AT1, non-AT2 binding site for angiotensins in the rodent brain and testis that is unmasked by the organomercurial compound para-chloromercuribenzoic acid (PCMB) has catalyzed efforts to purify and characterize this protein. We recently reported that this protein is neurolysin and now report upon the specificity of this binding site for various neuropeptides. Competition binding assays in rat brain and testis used (125)I-Sar(1), Ile(8) angiotensin II (Ang II) as the radioligand in the presence of saturating concentrations of AT1 and AT2 receptor antagonists and 100 μM parachloromercuribenzoate. Primary screening of 36 peptides and other compounds at …

Efinancial Health, Nan Taylor

Cornerstone 1 Reports : Expansion and Enhancements of the Thinkfinity Platform

No abstract provided.

Gastric Electrical Stimulation With Enterra Therapy Improves Symptoms Of Idiopathic Gastroparesis., Richard W. Mccallum, Irene Sarosiek, H. P. Parkaman, William J.S. Snape, Frederick J. Brody, J. Wo, Thomas V. Nowak

Medicine Faculty Publications

No abstract provided.

Incidence Of Methicillin-Resistant Staphylococcus Aureus Infection In A Children's Hospital In The Washington Metropolitan Area Of The United States, 2003-2010, Xiaoyan Song, Joanthan Cogen, Nalini Singh

Pediatrics Faculty Publications

Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a major public health threat. In this retrospective cohort study, we included patients with laboratory-confirmed MRSA infections treated at Children’s National Medical Center in Washington, District of Columbia between July 2003 and December 2010. The secular trends in the incidence rates of skin/soft tissue and invasive MRSA infections were assessed. Molecular analyses were performed on a subset of patients with invasive infections whose MRSA isolates were available for genotyping. The study identified 3750 patients with MRSA infections. The incidence of MRSA infections peaked in 2007 (incidence rate: 5.34 per 1000 patient-visits) and subsequently …

Clinical Reasoning In The Use Of Slings For Patients With Shoulder Subluxation After Stroke: A Glimpse Of The Practice Phenomenon In California, Kitsum Li, Naoko Murai, Simon Chi

Collected Faculty Scholarship

Literature reports the frequent use of shoulder slings by occupational therapists for the management of post-stroke shoulder subluxation despite the low evidence for its efficacy. To understand the clinical context that defies current research evidence, a survey was distributed among California occupational therapists. One hundred and sixty-eight participants responded to the survey, answering questions regarding the occurrences and clinical reasoning in the use of shoulder sling with patients post stroke. 81.5% of the respondents reported the use of shoulder sling. However, the actual sling prescription was limited to 28.4% of their patients. Slings were primarily prescribed for upper extremity management …

Why We Must Provide Better Support For Pakistan's Female Frontline Health Workers, Svea Closser, Rashid Jooma

Section of Neurosurgery

Svea Closser and Rashid Jooma argue that achieving polio eradication and strengthening Pakistan's health system must focus not just on international engagement but also on local partnerships with Lady Health Workers and other ground-level staff. Please see later in the article for the Editors' Summary.

Loma Linda University Dentistry - Volume 24, Number 2, Loma Linda University School Of Dentistry, Samah Omar

Articulator (Dentistry)

Contents:

10-13 | Transitions: Goodacre to Dailey
16 | Alumni Student Convention
22 | Resin Infiltration: A Serendipitous Benefit
34 | Commencement 2013: "The Only Times We Have"
39 | Robert Handysides, Associate Dean for Academic Affairs
42 | Pediatric Dentistry Turns Twenty
48 | Dr. Fred Berry Retires