Medicine and Health Sciences Commons^™

A Phenomenological Exploration Of The Childfree Choice In A Sample Of Australian Women, Joanne Doyle, Julie Ann Pooley, Lauren Breen

Research outputs 2012

Choosing not to have children is considered a deviation from cultural norms, particularly the dominant pronatalist discourse; this is especially so for women. However, little research has documented the experience of Australian women who have consciously chosen to remain childless. Ten voluntarily childfree women participated in unstructured interviews about their choice and its ramifications. The data analysis revealed three broad themes – the experiences and processes of making the choice; the ongoing effects of their choice, ranging from support and acceptance to pressure and discrimination; and no regret as the women described engaging in meaningful, generative activities that contributed to …

Crime Prevention: The Role Of Individual Resilience Within The Family, Catherine Ferguson, Craig Harms, Julie Ann Pooley, Lynne Cohen, Stuart Tomlinson

Research outputs 2012

Resilience is context dependent but for resilience to be present, two elements must co-occur: adversity (i.e., high-risk situation/threat) and successful adaptation/competence. An understanding of resilience is important for professionals dealing with at-risk families. This exploratory research investigated how individuals caring for a family member with a mental illness adapted to the role of carer or supporter. Fifteen participants mostly aged 50 years or more were interviewed. Content analysis was used to develop themes from the interview transcripts. Seven themes were elicited from the data. Three of these fit with existing knowledge about challenges faced by offenders’ families. The article concludes …

Inhibition Of Protein Translocation At The Endoplasmic Reticulum Promotes Activation Of The Unfolded Protein Response, Craig Mckibbin, Alina Mares, Michela Piacenti, Helen Williams, Peristera Roboti, Marjo Puumalainen, Anna Callan, Karolina Lesiak-Mieczkowska, Stig Linder, Hanna Harant, Stephen High, Sabine Flitsch, Roger Whitehead, Eileithyia Swanton

Research outputs 2012

Selective small-molecule inhibitors represent powerful tools for the dissection of complex biological processes. ESI (eeyarestatin I) is a novel modulator of ER (endoplasmic reticulum) function. In the present study, we show that in addition to acutely inhibiting ERAD (ER-associated degradation), ESI causes production of mislocalized polypeptides that are ubiquitinated and degraded. Unexpectedly, our results suggest that these non-translocated polypeptides promote activation of the UPR (unfolded protein response), and indeed we can recapitulate UPR activation with an alternative and quite distinct inhibitor of ER translocation. These results suggest that the accumulation of non-translocated proteins in the cytosol may represent a novel …

Two Maximal Isometric Contractions Attenuate The Magnitude Of Eccentric Exercise-Induced Muscle Damage, Hsin-Lian Chen, Kazunori Nosaka, Alan Pearce, Trevor C Chen

Research outputs 2012

This study investigated whether maximal voluntary isometric contractions (MVC-ISO) would attenuate the magnitude of eccentric exercise-induced muscle damage. Young untrained men were placed into one of the two experimental groups or one control group (n = 13 per group). Subjects in the experimental groups performed either two or 10 MVC-ISO of the elbow flexors at a long muscle length (20° flexion) 2 days prior to 30 maximal isokinetic eccentric contractions of the elbow flexors. Subjects in the control group performed the eccentric contractions without MVC-ISO. No significant changes in maximal voluntary concentric contraction peak torque, peak torque angle, range of …

Strength Gains: Block Versus Daily Undulating Periodization Weight Training Among Track And Field Athletes, Keith Painter, Guy Haff, Michael Ramsey, Jeff Mcbride, Travise Triplett, William Sands, Hugh Lamont, Margaret Stone, Michael Stone

Research outputs 2012

Recently, the comparison of "periodized" strength training methods has been a focus of both exercise and sport science. Daily undulating periodization (DUP), using daily alterations in repetitions, has been developed and touted as a superior method of training, while block forms of programming for periodization have been questioned. Therefore, the purpose of this study is to compare block to DUP in Division I track and field athletes. Thirty-one athletes were assigned to either a 10-wk block or DUP training group in which sex, year, and event were matched. Over the course of the study, there were 4 testing sessions, which …

Performance Analysis Of A World-Class Sprinter During Cycling Grand Tours, Paolo Menaspà, Chris Abbiss, David Martin

Research outputs 2012

This investigation describes the sprint performances of the highest internationally ranked professional male road sprint cyclist during the 2008-2011 Grand Tours. Sprint stages were classified as won, lost, or dropped from the front bunch before the sprint. Thirty-one stages were video-analyzed for average speed of the last km, sprint duration, position in the bunch, and number of teammates at 60, 30, and 15 s remaining. Race distance, total elevation gain (TEG), and average speed of 45 stages were determined. Head-to-head performances against the 2nd-5th most successful professional sprint cyclists were also reviewed. In the 52 Grand Tour sprint stages the …

Multiple Effects Of Physical Activity On Molecular And Cognitive Signs Of Brain Aging: Can Exercise Slow Neurodegeneration And Delay Alzheimer's Disease?, Belinda Brown, J J Peiffer, Ralph Martins

Research outputs 2012

Western countries are experiencing aging populations and increased longevity; thus, the incidence of dementia and Alzheimer's disease (AD) in these countries is projected to soar. In the absence of a therapeutic drug, non-pharmacological preventative approaches are being investigated. One of these approaches is regular participation in physical activity or exercise. This paper reviews studies that have explored the relationship between physical activity and cognitive function, cognitive decline, AD/dementia risk and AD-associated biomarkers and processes. There is now strong evidence that links regular physical activity or exercise to higher cognitive function, decreased cognitive decline and reduced risk of AD or dementia. …

Association Between The G-Protein Β3 Subunit C825t Polymorphism With Essential Hypertension: A Meta-Analysis In Han Chinese Population, Jaipeng Lu, Q Guo, Ling Zhang, Wei Wang

Research outputs 2012

We aimed to evaluate the contribution of the G-protein β3 subunit C825T (GNB3-C825T) polymorphism to essential hypertension (EH) in Han Chinese population by performing meta-analysis. A meta-analysis was performed in 12 case–control genetic association studies including 3,020 hypertension patients and 2,790 controls from MEDLINE (PubMed) and the China National Knowledge Infrastructure platforms. The STATA 10.0 software was used in analysis. Overall, there was no significant association between the GNB3-C825T polymorphism and EH in neither additive [TT vs. CC: OR (95 % CI) = 1.11 (0.74–1.69), P = 0.61; TC vs. CC: OR (95 % CI) = 1.08 (0.89–1.31), P = …

The Fate Of Frozen Human Embryos When Transferred Either On The Day Ofthawing Or After Overnight Culture, Yanhe Liu, Kellie Peirce, Kailin Yap, Kate Mckenzie, Jay Natalwala, Vince Chapple, Margo Norman, Phillip Matson

Research outputs 2012

Objective: To study the performance of thawed zygotes and cleavage stage embryos transferred either on the day of thaw or after overnight culture. Methods: A retrospective study of 864 frozen embryo transfer cycles. Cryosurvival rates per thawed embryo and implantation rates were analysed for embryos frozen on Day 1, Day 2 or Day 3 relative to oocyte collection (Day 0) and transferred on the day of thaw or after overnight culture, together with clinical pregnancy rates and prevalence of multiple gestations. Results: Survival of Day 3 embryos was significantly lower than those frozen on Day 1 (P=0.017) or Day 2 …

Human Semen Can Be Air-Dried Prior To Testing For Sperm Dna Fragmentation With The Halosperm® G2 Kit, Kailin Yap, Phillip Matson

Research outputs 2012

Objective: To explore a method of semen storage prior to assessment of sperm DNA fragmentation. Methods: This study examined a simplified alternative of air-drying semen on a microscope slide and reconstituting in seminal plasma prior to assessment of sperm DNA fragmentation using the halosperm® G2 kit. Results: It showed that semen could be air-dried and stored overnight at room temperature with no detrimental effect on DNA quality. A significant correlation between results existed for 20 semen samples both air-dried and snap-frozen in liquid nitrogen (r=0.982, P=0.000). A mean difference between the results of only −1.98% confirmed the effectiveness of air-drying …

Anthropometric Characteristics, Upper-Body Strength, And Sprint Paddling Performance In Competitive Surfers, Jeremy Sheppard, Mark Osborne, Dale Chapman, Mark Andrews

Research outputs 2012

The present study examined the potential differences in anthropometric characteristics, upper-body strength, and sprint paddling performance between youth and senior competitive surfers. Twenty competitive male surfers (19.1±6.8 years, 168.2±11.3 cm, 61.7±13.6 kg) were assessed for stature, mass, arm-span, ∑ 7 site skinfold thickness, Lean-Mass Ratio (LMR, ∑ 7 site skinfold/kg body-mass), pronated pull-up 1 repetition maximum (1 RM) and sprint paddling performance from a stationary start to 15 m. Independent t-tests were used to compare potential differences between youth (n:10) and senior group (n:10) of competitive surfers, with Cohen’s Effect Size (d) applied to reflect the magnitude of any differences …

Practicing Field Hockey Skills Along The Contextual Interference Continuum: A Comparison Of Five Practice Schedules, Jadeera Cheong, Brendan Lay, J. Robert Grove, Nikola Medic, Rizal Razman

Research outputs 2012

To overcome the weakness of the contextual interference (CI) effect within applied settings, Brady (2008) recommended that the amount of interference be manipulated. This study investigated the effect of five practice schedules on the learning of three field hockey skills. Fifty-five pre-university students performed a total of 90 trials for each skill under blocked, mixed or random practice orders. Results showed a significant time effect with all five practice conditions leading to improvements in acquisition and learning of the skills. No significant differences were found between the groups. The findings of the present study did not support the CI effect …

The Impact Of Management Styles Upon Organisational Change And Safety Cultures, Susanne Bahn, Llandis Barratt-Pugh

Research outputs 2012

In this paper we discuss the findings of two large studies conducted during 2005/06 that illuminated the role of managers as change agents. We draw the findings together to conceptualise and model the leadership styles and behaviours that appear to be successful in reshaping organisational safety culture. The first study identified the instrumental influence that managers have on the safety culture within organisations. The second study revealed the influential role of managers as change agents during a cultural change initiative when they applied a flexible approach using formal and informal agencies of change. The paper situates these two studies in …

An Investigation Of Health Problems Among Female Hairdressers In Western Australia, Mary O'Loughlin, Jacques Oosthuizen

Research outputs 2012

Female hairdressers in Western Australia were surveyed to determine the occurrence of health problems that may be associated with their work environment. The cohort of 238 hairdressers reported poor health behaviours including a poor dietary and fluid intake; a high prevalence of smoking; and a low level of glove usage when undertaking wet work and handling non-discolouring chemicals. Younger hairdressers were found to be most at risk of increased respiratory illness, musculoskeletal problems, skin conditions, bowel issues and general poor health. When compared with data obtained from the Australian Longitudinal Study on Women’s Health (ALSWH), younger hairdressers reported a higher …

Limitations Associated With The Pooling Of Historical Data Sets: An Analysis Of Dust Monitoring Data Collected At A Typical Remote Australian Mine 2004 - 2008, Jacques Oosthuizen

Research outputs 2012

Dust monitoring data collected over a period of 5 years at a remote Australian mine site were pooled in order to create a large data set for analysis. Results adjusted for a 12-hour shift were compared to exposure standards and 90% of the respirable and 97% of the inhalable dust samples were found to be within the exposure standards. Median values appear to better describe exposures than the mean which is influenced by outliers. There was a declining trend in respirable dust results over time. However, inhalable dust levels remained fairly constant over the sampling period. Inhalable dust levels were …

The Development Of An Interdisciplinary Research Agenda At Ngala: An Innovative Case Study, E Bennett, Y Hauck, S Bindahneem, Vicki Banham, M Owens, L E Priddis, G Wells, W Sinclair, L Shields

Research outputs 2012

Background Ngala is an early parenting, not-for-profit organisation in Western Australia (WA). Research academics from three universities in Perth had been involved in separate research activities over recent years at Ngala. During 2007, a strategic decision was made to forge formal links and articulate an interdisciplinary research framework to promote a research culture amongst Ngala practitioners. Aim To describe an organisational case study of the development of an interdisciplinary research agenda within Ngala. Methods Collaborative methods were used. An action learning project was undertaken over a two-year period with the involvement of researchers, managers and practitioners across the five disciplines …

Lsk Derived Lsk– Cells Have A High Apoptotic Rate Related To Survival Regulation Of Hematopoietic And Leukemic Stem Cells, Cong Peng, Yaoyu Chen, Yi Shan, Haojian Zhang, Zhiru Guo, Dongguang Li, Shaoguang Li

Research outputs 2012

A balanced pool of hematopoietic stem cells (HSCs) in bone marrow is tightly regulated, and this regulation is disturbed in hematopoietic malignancies such as chronic myeloid leukemia (CML). The underlying mechanisms are largely unknown. Here we show that the Lin⁻Sca-1⁺c-Kit^- (LSK⁻) cell population derived from HSC-containing Lin⁻Sca-1⁺c-Kit⁺ (LSK) cells has significantly higher numbers of apoptotic cells. Depletion of LSK cells by radiation or the cytotoxic chemical 5-fluorouracil results in an expansion of the LSK⁻ population. In contrast, the LSK⁻ population is reduced in CML mice, and …

Effects Of Short-Term Training With Uncoupled Cranks In Trained Cyclists, Jack Burns, Jeremiah Peiffer, Chris Abbiss, Greig Watson, Angus Burnett, Paul Laursen

Research outputs 2012

Purpose: Manufacturers of uncoupled cycling cranks claim that their use will increase economy of motion and gross efficiency. Purportedly, this occurs by altering the muscle-recruitment patterns contributing to the resistive forces occurring during the recovery phase of the pedal stroke. Uncoupled cranks use an independentclutch design by which each leg cycles independently of the other (ie, the cranks are not fixed together). However, research examining the efficacy of training with uncoupled cranks is equivocal. The purpose of this study was to determine the effect of short-term training with uncoupled cranks on the performance-related variables economy of motion, gross efficiency, maximal …

Lower Extremity Kinematics And Kinetics When Landing From Unloaded And Loaded Jumps, Ina Janssen, Jeremy Sheppard, Andrew Dingley, Dale Chapman, Wayne Spratford

Research outputs 2012

Countermovement jumps loaded with a weighted vest are often used for the training of lower body power to improve jump performance. However, it is currently unknown how this added load affects the lower extremity kinematics and kinetics, in particular whether this results in an increased injury risk. Therefore, the purpose of this investigation was to determine how lower extremity kinematics and kinetics during landing are affected by loaded jumps as demonstrated in a volleyball block jump landing. Ten elite male volleyball players performed block jump landings in an unloaded and loaded (9.89 kg) condition. Kinematic and kinetic landing data from …

Effects Of Two Contrast Training Programs On Jump Performance In Rugby Union Players During A Competition Phase, C K Argus, N D Gill, J W Keogh, Michael Mcguigan, W G Hopkins

Research outputs 2012

Purpose: There is little literature comparing contrast training programs typically performed by team-sport athletes within a competitive phase. We compared the effects of two contrast training programs on a range of measures in high-level rugby union players during the competition season. Methods: The programs consisted of a higher volume-load (strength-power) or lower volume-load (speed-power) resistance training; each included a tapering of loading (higher force early in the week, higher velocity later in the week) and was performed twice a week for 4 wk. Eighteen players were assessed for peak power during a bodyweight countermovement jump (BWCMJ), bodyweight squat jump (BWSJ), …

Moving Beyond Tyrosine Hydroxylase To Define Dopaminergic Neurons For Use In Cell Replacement Therapies For Parkinson's Disease, Robert White, Meghan Thomas

Research outputs 2012

Cell replacement therapies are an attractive mode of treatment for neurodegenerative disorders as they have the potential to alleviate or modify disease symptoms and restore function. In Parkinson's disease, the cell type requiring replacement is dopamine-producing neurons of the midbrain. The source of replacement cells is contentious, with opinion still evolving. Clinical trials have previously used fetal brain tissue; however, this will likely be superseded by the use of embryonic or induced pluripotent stem cells, due to their greater availability and homogeneity. One significant caveat in the use of any cell source for therapy is that cells must first be …

The International Effort: Building The Bridge For Translational Medicine: Report Of The 1st International Conference Of Translational Medicine (Ictm), Xiaoming Chen, Roland Andersson, William Cs Cho, David Christiani, Richard Coico, Jeffery Drazen, Markus Ege, Thomas Fehniger, Hongwei Gao, Kunlin Jin, Michael N. Liebman, Elena Lopez, Giuseppe Marraro, Gyorgy Marko-Varga, Francesco M. Marincola, Laurentiu M. Popescu, Claudio Spada, Aamir Shahzad, Ena Wang, Wei Wang, Xiangdong Wang, Yong-Xiao Wang, Jinglin Xia, Jia Qu

Research outputs 2012

Background : Supported by the International Society for Translational Medicine (ISTM), Wenzhou Medical College and the First Affiliated Hospital of Wenzhou Medical College, the International Conference on Translational Medicine (ICTM) was held on October 22–23, 2011 in Wenzhou, China. Nearly 800 registrants attended the meeting, primarily representing institutes and hospitals in Europe, The United States of America, And Asia, and China. The meeting was chaired and organized by Dr. Xiangdong Wang, Xiaoming Chen, Richard Coico, Jeffrey M. Drazen, Richard Horton, Francesco M. Marincola, Laurentiu M. Popescu, Jia Qu and Aamir Shahzad.

Findings : The meeting focused on the communication of …

Chronic Low Back Pain Is Associated With Reduced Vertebral Bone Mineral Measures In Community-Dwelling Adults, Andrew Briggs, Leon Straker, Angus Burnett, John Wark

Research outputs 2012

Background: Chronic low back pain (CLBP) experienced in middle-age may have important implications for vertebral bone health, although this issue has not been investigated as a primary aim previously. This study investigated the associations between CLBP and dual energy X-ray absorptiometry (DXA)-derived vertebral bone mineral measures acquired from postero-anterior and lateral-projections, among community-dwelling, middle-aged adults. Methods. Twenty-nine adults with CLBP (11 male, 18 female) and 42 adults with no history of LBP in the preceding year (17 male, 25 female) were evaluated. Self-reported demographic and clinical data were collected via questionnaires. Areal bone mineral density (aBMD) was measured in the …

Multiple Γ-Secretase Product Peptides Are Coordinately Increased In Concentration In The Cerebrospinal Fluid Of A Subpopulation Of Sporadic Alzheimer's Disease Subjects, Saori Hata, Miyako Taniguchi, Yi Piao, Takeshi Ikeuchi, Anne Fagan, David Holtzman, Randall Bateman, Hamid Sohrabi, Ralph Martins, Sam Gandy, Katsuya Urakami, Toshiharu Suzuki

Research outputs 2012

Background: Alcadeinα (Alcα) is a neuronal membrane protein that colocalizes with the Alzheimer's amyloid-β precursor protein (APP). Successive cleavage of APP by β- and γ-secretases generates the aggregatable amyloid-β peptide (Aβ), while cleavage of APP or Alcα by α- and γ-secretases generates non-aggregatable p3 or p3-Alcα peptides. Aβ and p3-Alcα can be recovered from human cerebrospinal fluid (CSF). We have previously reported alternative processing of APP and Alcα in the CSF of some patients with sporadic mild cognitive impairment (MCI) and AD (SAD). Results: Using the sandwich enzyme-linked immunosorbent assay (ELISA) system that detects total p3-Alcα, we determined levels of …

Adjusting For Under-Identification Of Aboriginal And/Or Torres Strait Islander Births In Time Series Produced From Birth Records: Using Record Linkage Of Survey Data And Administrative Data Sources, D Lawrence, D Christensen, F Mitrou, Glenn Draper, G Davis, S Mckeown, Daniel Mcaullay, G Pearson, S R Zubrick

Research outputs 2012

Background: Statistical time series derived from administrative data sets form key indicators in measuring progress in addressing disadvantage in Aboriginal and Torres Strait Islander populations in Australia. However, inconsistencies in the reporting of Indigenous status can cause difficulties in producing reliable indicators. External data sources, such as survey data, provide a means of assessing the consistency of administrative data and may be used to adjust statistics based on administrative data sources. Methods. We used record linkage between a large-scale survey (the Western Australian Aboriginal Child Health Survey), and two administrative data sources (the Western Australia (WA) Register of Births and …

A Randomised Trial Of Robotic And Open Prostatectomy In Men With Localised Prostate Cancer, Robert Gardiner, J Yaxley, G Coughlin, N Dunglison, S Occhipinti, S Younie, R Carter, S Williams, R J Medcraft, Bennett Nigel, M F Lavin, Suzanne Chambers

Research outputs 2012

Background: Prostate cancer is the most common male cancer in the Western world however there is ongoing debate about the optimal treatment strategy for localised disease. While surgery remains the most commonly received treatment for localised disease in Australia more recently a robotic approach has emerged as an alternative to open and laparoscopic surgery. However, high level data is not yet available to support this as a superior approach or to guide treatment decision making between the alternatives. This paper presents the design of a randomised trial of Robotic and Open Prostatectomy for men newly diagnosed with localised prostate cancer …

The Genetic Associations And Epistatic Effects Of The Ccr5 Promoter And Ccr2-V64i Polymorphisms On Susceptibility To Hiv-1 Infection In A Northern Han Chinese Population, Jiapeng Lu, Aijuan Sheng, Youxin Wang, Ling Zhang, Jingjing Wu, Manchu Song, Yan He, Xinwei Yu, Feifei Zhao, Yezhou Liu, Shuang Shao, Jie Lan, Hao Wu, Wei Wang

Research outputs 2012

The outcome of human immunodeficiency virus (HIV)-1 infection and course to AIDS are variable among individuals. Both chemokine receptor 5 (CCR5) and CCR2 gene polymorphisms play essential roles in the susceptibility of HIV-1 infection. To investigate the main and epistatic effects of the CCR5 promoter and CCR2-V64I polymorphisms on HIV-1 infection in the Northern Han Chinese, subjects of 91 HIV-1-infected patients and 91 health controls were recruited. Single-nucleotide polymorphisms (SNPs) in the CCR5 promoter region and CCR2-V64I variants were genotyped. In the single-locus analysis, CCR5 58755-G and CCR5 59653-T alleles were significantly associated with HIV-1 infection (odds ratio [OR]=0.529, 95% …

Lifestyle And Late Life Cognitive Health: Sufficient Evidence To Act Now?, Bruce Barber, D Ames, Kathryn Ellis, Ralph Martins, C Masters, C Szoeke

Research outputs 2012

Not available

Evidence For A Non-Genomic Action Of Testosterone In Skeletal Muscle Which May Improve Athletic Performance: Implications For The Female Athlete, J R Dent, D K Fletcher, Michael Mcguigan

Research outputs 2012

This review will focus on the proposed second mode of testosterone action (now termed non-genomic) that appears to occur independently of the traditional transcriptional mechanism in mammalian skeletal muscle cells which may enhance skeletal muscle contractile properties. This mechanism of testosterone action differs from the traditional pathway, originating at the cell membrane, having a rapid onset of action, requiring second messengers to execute its effects and is insensitive to inhibitors of traditional androgen receptor action, transcription and protein synthesis. Importantly, unlike the traditional action of testosterone in skeletal muscle, this non-genomic pathway is shown to have a direct acute effect …

Hard Or Soft? The Relationship Between Power And Organisational Incident Rates, Susanne Bahn, Llandis Barratt-Pugh

Research outputs 2012

This paper examines the power that managers have to impact on workplace safety and how in mixed method studies our preconceptions about the hardness and softness of the relevant data may be misplaced. The civil construction industry (CCI) in WA provides the case for this discussion. Workers in this industry are constantly battling between safety compliance and production pressures in an era of economic boom. The examination of 3,882 incident reports, upon which this paper’s conclusions are drawn, revealed that these ‘‘hard’’ data may often obscure incidents that occur as organisations may be pressured into providing reportable incident figures that …