Medicine and Health Sciences Commons^™

Role Of The Cystine/Glutamate Exchanger In Glioma Cell Biology, Toyin Adeyemi Ogunrinu

All ETDs from UAB

Changes in the glioma microenvironment including oxygen (O2) levels, supply of amino acid such as L-glutamate and L-cystine and glutathione (GSH) concentrations play a critical role in glioma biology. Previous data from our laboratory and others have implicated the L-cystine/L-glutamate exchanger, system xc- in the invasion and proliferation of cancers including glioma. The central aim of this dissertation was to characterize the contribution of L-cystine uptake, GSH synthesis and L-glutamate release to migration and proliferation of glioma cells. In my first study, I examined the role of system xc- mediated L-glutamate release on glioma migration. I show that activation of …

Fenofibrate And Insulin Resistance, Corrie E. Paeglow

All ETDs from UAB

Both animal and human models suggest that fenofibrate, a medication widely prescribed to decrease triglycerides, also decreases insulin resistance. In the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) cohort, which included 780 individual who took 160 mg of micronized fenofibrate daily for three weeks, fenofibrate was found to decrease HOMA-IR by -0.24 units, (95% CI: -0.32, -0.14), insulin by -0.65 uU/mL (95% CI: -0.97, -0.34) and glucose by 2.46 mg/dL (95% CI: -2.51, -2.42). In a meta-analysis of 19 studies that included 1,297 individuals without diabetes and 196 individuals with diabetes treated with fenofibrate for three weeks or …

Impact Of Site Development Techniques In The Soft Tissue Height On Single Implant Supported Prosthesis In The Anterior Maxilla, Juan Francisco Pardo

All ETDs from UAB

Background: Implant placement should be based on a restoration-oriented treatment plan with correct three-dimensional positioning to allow optimal support and stability of surrounding hard and soft tissues. After tooth extraction the alveolus remodels producing changes in the soft tissues contours. This may translate into the inability to place the implant or in a non-esthetic restoration. In contemporary esthetic implant dentistry, the main objective is to maintain the socket dimensions and soft tissue contours to allow ideal implant placement and to provide a harmonious restoration. Objective: To evaluate if socket grafting with FDBA with or without PRP or rhPDGF in site …

Associations Among Measures Of Engagement With Kp.Org And Clinical Outcomes, Heather J. Sobko

All ETDs from UAB

USING MEASURES OF ENGAGEMENT WITH KP.ORG TO DETERMINE ASSOCIATIONS WITH SELECTED CLINICAL OUTCOMES HEATHER J. SOBKO SCHOOL OF NURSING ABSTRACT Introduction The purpose of this retrospective cohort study was to examine patterns of use of an electronic personal health record among adults diagnosed with diabetes, hypertension or hyperlipidemia. Intermediate behavioral measures (medication possession ratios) and physiological measures of metabolic control for diabetes (hemoglobinA1c), hypertension (blood pressure) and hyperlipidemia (low density lipoprotein) were examined. Methods Administrative data from Kaiser Permanente Georgia were analyzed. Adult members of with selected chronic diseases of diabetes, hypertension or hyperlipidemia who used the Kaiser Permanente electronic …

Molecular Piracy In The Mobilization Of Staphylococcus Aureus Pathogenicity Island 1, Michael Spilman

All ETDs from UAB

Staphylococcus aureus bacteriophage 80α is a temperate, double-stranded DNA phage that serves as a "helper" phage for the mobilization of several S. aureus pathogenicity islands (SaPIs), including SaPI1. When mobilized by 80α, SaPI1 genomes are packaged into smaller phage-like transducing particles composed of 80α capsid (gp47), scaffolding (gp46) and portal (gp42) proteins. In this dissertation, I utilize electron microscopy and biochemistry to tease apart the structural and genetic controls and consequences of SaPI1 as a molecular pirate. More specifically, I show that two SaPI1 proteins shift assembly from 63-nm, T = 7 icosahedral capsids to 47-nm, T = 4 capsids, …

"The Role Of Health Promotion In Physical Therapy Survey" Reliability And Validity Testing", Jaca Stephens

All ETDs from UAB

ABSTRACT Purpose: Physical therapists (PTs) have a unique opportunity to play a meaningful role in educating patients on health and wellness to prevent chronic conditions, such as cardiac disease, cerebrovascular disease, pulmonary disease, cancer, diabetes, and obesity. No instrument has been validated to measure physical therapists' views on health promotion and their practices. The purpose of this study was to evaluate the validity and reliability of a health promotion survey designed for physical therapists. Method: An expert panel of 9 physical therapists assessed the content validity of "The Role of Health Promotion in Physical Therapy Survey." as developed by Rea …

Calcium Dynamics Of Glial Cells And Genetic Influences On Behavior Of The Nematode Caenorhabditis Elegans, Randy Franklin Stout

All ETDs from UAB

A major challenge in neuroscience is understanding how the different neural cell types work together to process information and produce a behavioral output. Glial cells of the human brain have long been thought to act as support for the fundamental cell to cell communication at the core of cognition: neuronal synaptic communication. Research over the past several decades measuring glial activity and experimentally controlling glial cells in rodent model systems has shown that the two macroglia sub-types of glial cells (astrocytes and oligodendrocytes) have active roles in establishment, maintenance, and modulation of synaptic communication in the mammalian brain. Much of …

Protective Factors Against Relapse For Practicing Nurse Anesthetists In Recovery From Anesthetic Opiates, Elizabeth Laura Wright

All ETDs from UAB

Introduction: Addiction to anesthetic opiates is an occupational hazard for anesthesia providers, which includes nurse anesthetists. Several factors influence this hazard risk, including, genetic make-up, personality traits, and job stress. Also of great concern is the risk of relapse if an anesthesia provider returns to work, which can be as high as 40%. However, there are nurse anesthetists who have successfully returned to the practice of anesthesia while in recovery from addiction to anesthetic opiates. These nurse anesthetists have first-hand experience with the challenges of recovery when faced with continual access to opiates, and their experience can help others in …

Role Of Vdr In Host Immune Response To Porphyromonas Gingivalis Infection, Gulam Yezdani

All ETDs from UAB

Porphyromonas gingivalis is one of the etiologic factors of periodontal disease, a chronic inflammatory disorder characterized by the destruction of periodontal connective tissue and the subsequent loss of alveolar bone. Epidemiological and genetic studies have indicated an association between periodontal disease and the vitamin D system. However, little is known regarding how vitamin D signaling regulates the inflammatory immune process of this disease. The purpose of the study was to understand the role of the vitamin D receptor (VDR) in regulating the host response to P. gingivalis infection by using a dual chamber mouse model. These chambers served both as …

Assessment Of Mitochondrial Stressors On Cellular Bioenergetics, Blake Reid Zelickson

All ETDs from UAB

The mitochondrion plays a central role in the maintenance of bioenergetic function through the production of ATP and essential metabolites. The development of mitochondrial bioenergetic defects is a hallmark of important pathologies such as cardiovascular and liver diseases. It is well established that a decrease in mitochondrial function, typically of 20-40%, is associated with the progression of these pathologies. Causal relationships have been more difficult to establish because of the challenge of assessing mitochondrial function in a cellular setting. Specifically, it is known that mitochondria function at less than their maximal respiratory capacity and the remainder, known as reserve or …

In Vivo Interactions Between Virus Genomes And Host Proteins For Members Of The Order Picornavirales, Erik Michael Lenarcic

All ETDs from UAB

A significant number of pathogens of economical and medical importance are positive sense RNA viruses. Their genomes enter host cells and subvert them to support virus growth. These large-scale changes involve the co-opting of cellular proteins through interactions with viral RNA and proteins. Characterizing these interactions leads to a better understanding of viral life cycles and the identification of new antiviral therapies. The order Picornavirales contains viruses that infect a wide array of eukaryotes. Their genomes serve as a messenger RNA (mRNA) that is translated by host ribosomes cap-independently through an internal ribosome entry site (IRES). Most members of the …

The Intestinal Extracellular Matix As An Innate Regulator Of Effector T-Cell Responses, Kayci Renee Huff

All ETDs from UAB

Extracellular matrix (stroma) regulation of mucosal T-cell function is incompletely understood. Here we uncovered a role for intestinal stromal products in the innate regulation of effector T-cells. Stroma-conditioned media (S-CM) derived from normal human intestinal stroma (TGF-&betahi/IL-6lo/IL-1ßlo) significantly down-regulated T-cell proliferation and IFN-&gamma production compared to S-CM derived from inflamed Crohn's mucosa (TGF-&betahi/IL-6hi/IL-1&betahi). Antibody neutralization studies showed that TGF-&beta in normal S-CM inhibited T-cell proliferation and IFN-&gamma production, whereas IL-6 plus IL-1&beta in Crohn's S-CM promoted T-cell proliferation, and the IL-1&beta alone promoted IFN-γ and IL-17 release. Importantly, stromal cells in normal tissue produce TGF-&beta and contribute to mucosal homeostasis …

Effects Of Growth Factor Induced Pathways On Differentiation Of The Human Neuronal Cell Line Sh-Sy-5y., Ashish D. Dwary

All ETDs from UAB

Background: The VSNL1 gene product, Visinin-like-protein-1 (VILIP-1), is a member of the neuronal EF-hand Ca2+-sensor protein family. Previously, VILIP-1 mRNA and protein expression were shown to be altered in animal models and in schizophrenia patients. VILIP-1 influences cytosolic cAMP levels, cell migration, exocytotic processes and differentiation in the periphery. This raises the question, whether similar to other potential schizophrenia susceptibility genes, such as Disc1, PDE4B and Akt, VILIP-1 may be associated with schizophrenia-related measures, and if it could mechanistically affect cAMP signaling and neurite outgrowth in neurons. Methods: 627 people with schizophrenia and 541 control subjects were ascertained and the …

Traditional Treatment And Altered Auditory Feedback Lead To Intelligibility Benefits In A Subset Of Speakers With Parkinson Disease, Christopher Dromey

Faculty Publications

Because relatively little evidence has been published that compares the long-term effects of different dysarthria treatments, the authors undertook a study to document changes in speech rate and intelligibility in response to two types of intervention. Rate control is taught in many speech-language pathology training programs as a means to improve speech intelligibility, and thus it was a logical choice for the present study. Likewise, AAF has been shown to impact both normal and disordered speech, in most cases resulting in reduced rate. In theory, either approach should have a positive effect on speech, since individuals with neuromotor control deficits …

Rapides Parish Fins Cases Data Analysis For The Rapides Parish Court And Fins Program, Institute For Public Health And Justice, Data Collecting And Reporting

Policy & Position Papers

No abstract provided.

Lsuhsc Facilities Biweekly Update: January 2011, Lsuhsc Property And Facilities Management

LSUHSC Facilities Biweekly Updates: 2011

LSUHSC Facilities Biweekly Updates from January 14 and 28, 2011.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Faculty Publications 2010, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 844 publications.

An Examination Of Implicit And Explicit Attitudes Toward Steroids/Hgh In A Sample Of College Athletes And Nonathletes, Dominic Gray Morais

Masters Theses

Recently, media has placed more attention on the use of anabolic-androgenic steroids (AAS) and human growth hormone (HGH) due to confessions and positive drug tests by professional athletes concerning their use. The idolization of these athletes by younger individuals, especially athletes, incites concern about their attitudes toward such substances. Therefore, the purpose of this study was to explore the attitudes toward AAS and HGH in athletes and nonathletes. One hundred forty three male and female intercollegiate athletes (N = 83) and undergraduate and graduate Kinesiology and Sports Studies majors (N=60) at a Division I Midwestern University volunteered for the study. …

Existence Of Burnout In Undergraduate Athletic Training Students In An Accredited Athletic Training Education Program, Holli Ann Newcomer

Masters Theses

Athletic training is an American Medical Association (AMA) - recognized allied health care profession. With long hours, limited time off, and a variety of people to care for, this profession is one in which the athletic trainer may experience high stress loads and burnout. Burnout is a syndrome of emotional exhaustion, depersonalization, and reduced personal accomplishment that can occur among individuals who work with people in some capacity (Maslach, Jackson, & Leiter, 1996). The purpose of this study was to examine undergraduate athletic training students and determine whether or not they displayed symptoms of burnout and to what extent. Thirty …

Nonliteral Language Used By Teachers In The Classroom, Jenna K. Szybowicz

Masters Theses

The purpose of this research project was to determine ifregular education and special education classroom teachers used a varying amount of idioms in the classroom. Two groups of subjects were involved in the study; 12 regular education classroom teachers (four first grade; four second grade; and four third grade) and 12 primary crosscategorical classroom teachers. The teachers were observed for one to two hours via naturalistic observation methods during math and language arts lessons. The sample was transcribed and analyzed using Systematic Analysis of Language Transcriptions (SALT). The transcriptions were coded for the following criteria: nonliteral idioms[n] (e.g.,just a minute); …

The Effectiveness Of Errorless Learning For Teaching Concepts And Comments To Children With Autism, Marissa L. Ulm

Masters Theses

Research has indicated that errorless learning has been an effective teaching strategy for teaching discrete skills to both typically developing children and children with a learning disability (Schimek, 1983; Storm & Robinson, 1973). Errorless learning differs from other common teaching strategies in that it only presents correct responses, eliminating the possibility of participants responding incorrectly. The purpose of this study was to examine the effectiveness of errorless learning for improving symbol acquisition in children with autism who used a high-tech augmentative and alternative communication (AAC) device. Four children previously diagnosed with autism participated in this study; subjects were required to …

Lsuhsc Facilities Daily Updates: January 2011, Lsuhsc Property And Facilities Management

LSUHSC Facilities Daily Updates: 2011

LSUHSC Facilities Daily Updates from January 2011.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Role Of Membrane Lipids In Modulating Protein Structure & Function, Ray Supriyo

Electronic Theses and Dissertations

A-B family of toxins consists of plant toxins such as ricin and bacterial toxins such as cholera. The A subunit is the enzymatic domain and the B subunit is the receptor binding domain. Commonly, these toxins bind to the target cell plasma membrane receptors through their B subunit followed by endocytosis and a transport to the endoplasmic reticulum (ER). Inside the ER, the A subunit dissociates from the rest of the toxin, unfolds and triggers the ER quality control mechanism of ER-associated degradation (ERAD). Most ERAD substrates are purged out of the ER into the cytosol for proteasomal degradation. However, …

Hybrid Adult Neuron Culture Systems For Use In Pharmacological Testing, Darin Keay Edwards

Electronic Theses and Dissertations

Neuronal culture systems have many applications, such as basic research into neuronal structure, function, and connectivity as well as research into diseases, conditions, and injuries affecting the brain and its components. In vitro dissociated neuronal systems have typically been derived from embryonic brain tissue, most commonly from the hippocampus of E18 rats. This practice has been motivated by difficulties in supporting regeneration, functional recovery and long-term survival of adult neurons in vitro. The overall focus of this dissertation research was to develop a dissociated neuronal culture system from human and animal adult brain tissue, one more functionally and developmentally correlative …

Discovery And Optimization Of Novel Small-Molecular Inhibitors Suppressing Stat3-Dependent Tumor Process, Xiaolei Zhang

Electronic Theses and Dissertations

With the critical role of aberrantly active Signal Transducer and Activator of Transcription (Stat) 3 protein in many human cancers, selective small-molecule inhibitors targeting the dimerization event which is required for stat3 activation, would be valuable as therapeutic agents. And the inhibitors will be useful chemical probes to clarify the complex biological functions of Stat3. By computational and structural analyses of the interaction between Stat3 and the lead dimerization disruptor, S3I-201, we have designed a diverse set of analogs. One of the most active analogs, S3I-201.1066 is derived to contain a cyclo-hexyl benzyl moiety on the amide nitrogen, which increases …

Evaluation Of An Emergency Preparedness Exercise Using Hseep Format, Kelly A. Lawall Ms, Bsn, Phrn, Michael Wargo Bsn, Mba, Phrn, Cmte

Department of Emergency Medicine

No abstract provided.

Who Let The Dog Out? Implementing A Successful Therapy Dog Program In An Academic Law Library, Femi Cadmus, Julian Aiken

Cornell Law Faculty Publications

No abstract provided.

Doctor Of Nursing Practice Students Advocating For Health Care Access, Quality, And Reform: From The Virtual Classroom To Capitol Hill., Mary Lou Manning, Dolores Grosso

College of Nursing Faculty Papers & Presentations

The potential for doctor of nursing practice students to inform and influence the national health care reform movement inspired faculty teaching an online Health and Social Policy course to create an assignment combining comparative effectiveness research with a trip to Capitol Hill to meet with congressional representatives. Preparing for and participating in such an assignment can present challenges for online doctoral students already busy with family and professional responsibilities. However, from both faculty and student perspectives, the lasting value and professional growth are immeasurable. Course details and the theoretical concepts of experiential education are presented, as well as trip logistics …

Assessment Of “Gene-Environment” Interaction In Cases Of Familial & Sporadic Pancreatic Cancer, Theresa Yeo, Ralph Hruban, Kieran Brune, Alison Klein, Shiela Fitzgerald, Charles Yeo

College of Nursing Faculty Papers & Presentations

Background: Pancreatic cancer (PC) is the fourth leading cause of cancer death in the United States. Reported risk factors for PC include: advancing age, a family history of PC, high-risk inherited syndromes, cigarette smoking, exposure to occupational and environmental carcinogens, African-American race, high fat/high cholesterol diet, obesity, chronic pancreatitis, and diabetes mellitus.

Purpose: The purpose of this study was to characterize one of the largest national registries of familial PC (FPC) and sporadic PC (SPC), focusing on demographics, clinical factors, self-reported environmental and occupational lifetime exposures and survival status.

Methods: Retrospective cross-sectional, case-only analysis of FPC cases (n …

Incivility In Healthcare Settings: Manifestations, Root Causes, And Downstream Effects On Patient Care And Productivity, Theresa P. Yeo, Anne Belcher, Charles J. Yeo

College of Nursing Faculty Papers & Presentations

PURPOSE: To investigate the prevalence and effects of incivility in healthcare and educational settings

METHODS: Review of the literature

SEARCH STRATEGY: CINAHL, PubMed, Joint Commission sites searched using terms: incivility, workplace violence, disruptive behavior, bullying