Medicine and Health Sciences Commons^™

The Brains Behind Mediation: Reflections On Neuroscience, Conflict Resolution And Decision-Making, Daniel Weitz

Cardozo Journal of Conflict Resolution

On September 13, 1848, an explosives charge sent a three-foot tamping iron about an inch in diameter through the head of Phineas Gage. Although Gage survived, the tamping iron, which entered just under the left eye and exited through the frontal portion of his head, destroyed his prefrontal cortex. Prior to the accident, Gage was a popular foreman of a railroad construction crew. After the accident, he was a tactless, profane, and impulsive man with a dramatically altered personality.

Maternal Exposure To The Holocaust And Health Complaints In Offspring, Janine D. Flory, Linda M. Bierer, Rachel Yehuda

Publications and Research

Although the link between chronic stress and the development of cardiovascular and metabolic diseases of adulthood has been known for some time, there is growing recognition that early environmental influences may result in developmental programming via epigenetic mechanisms, thereby affecting the developmental trajectory of disease progression. Previous studies support the idea that offspring of Holocaust survivors may have been subjected to early developmental programming. We evaluated the relationship between parental exposure to the Holocaust and selfreported health ratings and disorders made by their adult offspring (i.e., second generation Holocaust survivors). A total of 137 subjects were evaluated. Regression analyses demonstrated …

How Might Stress Contribute To Increased Risk For Schizophrenia In Children With Chromosome 22q11.2 Deletion Syndrome?, Elliott A. Beaton, Tony J. Simon

Psychology Faculty Publications

The most common human microdeletion occurs at chromosome 22q11.2. The associated syndrome (22q11.2DS) has a complex and variable phenotype with
a high risk of schizophrenia. While the role of stress in the etiopathology of schizophrenia has been under investigation for over 30 years (Walker et al. 2008), the stress–diathesis model has yet to be investigated in children with
22q11.2DS. Children with 22q11.2DS face serious medical, behavioral, and socioemotional challenges from infancy into adulthood. Chronic stress elevates glucocorticoids, decreases immunocompetence, negatively impacts brain
development and function, and is associated with psychiatric illness in adulthood. Drawing knowledge from the extant and well-developed …

A Threat Taxonomy For Mhealth Privacy, David Kotz

Dartmouth Scholarship

Networked mobile devices have great potential to enable individuals (and their physicians) to better monitor their health and to manage medical conditions. In this paper, we examine the privacy-related threats to these so-called \emphmHealth\/ technologies. We develop a taxonomy of the privacy-related threats, and discuss some of the technologies that could support privacy-sensitive mHealth systems. We conclude with a brief summary of research challenges.

Adherence Practices Of Caucasian Women With Hypertension Residing In Rural Florida An Exploratory Study, Jeanne M. Hopple

Electronic Theses and Dissertations

Hypertension, or high blood pressure, is a major risk factor for heart disease and stroke. Elevated blood pressure is often a silent process affecting multiple organ systems. Risk for heart disease is associated with poorly treated or unrecognized hypertension that is more common among women than men. Non-adherence to prescribed treatment regimens has been identified as a major reason for inadequate hypertension management. This exploratory descriptive qualitative study using narrative inquiry investigated adherence practices among Caucasian women with diagnoses of hypertension from a rural area of Florida. The purpose of this study was to gain an understanding from women who …

Effects Of A Reading Inference Strategy Intervention On The Reading And Social Inference Abilities Of Adults With Asperger Syndrome, Kimberly A. Murza

Electronic Theses and Dissertations

The ability to generate inferences is a skill that is necessary to fully comprehend a text and understand the intentions, behaviors, and emotions of a conversational partner. Individuals with Asperger syndrome (AS) have been shown to demonstrate significant difficulty in inference generation in both social contexts and in reading comprehension. Although, the reciprocity of the four components of literacy (reading, writing, listening, and speaking) has been established in the literature (Bradley & Bryant, 1983; Catts & Kamhi, 2005; Englert & Thomas, 1987; Gillon & Dodd, 1995; Hiebert, 1980; Kroll, 1981; Ruddell & Ruddell, 1994); the relationship between inference generation in …

Development, Optimization, And Validation Of A Classical Swine Fever Virus Real-Time Reverse Transcription Polymerase Chain Reaction Assay, August J. Eberling, Jill Bieker-Stefanelli, Monica M. Reising, David Siev, Barbara M. Martin, Michael T. Mcintosh, Tammy R. Beckham

Zoonotics and Wildlife Disease: Publications

Classical swine fever (CSF) is an economically devastating disease of pigs. Instrumental to the control of CSF is a well-characterized assay that can deliver a rapid, accurate diagnosis prior to the onset of clinical signs. A real-time fluorogenicprobe hydrolysis (TaqMan) reverse transcription polymerase chain reaction (RT-PCR) for CSF was developed by the United States Department of Agriculture (USDA) at the Plum Island Animal Disease Center (CSF PIADC assay) and evaluated for analytical and diagnostic sensitivity and specificity. A well-characterized panel including Classical swine fever virus (CSFV), Bovine viral diarrhea virus (BVDV), and Border disease virus (BDV) isolates was utilized in …

Nose To Brain Delivery Of Therapeutic Agents, Siva Ram Kiran Vaka

Electronic Theses and Dissertations

The potential treatment approaches for various disorders associated with central nervous system are invasive and do not allow frequent administration. Brain targeting of drugs by intranasal route is a safe and noninvasive method of drug delivery which allows frequent administration and is certainly more patient compliant than the currently folloinvasive methods. In this study, the plausibility of delivering neurotrophins [nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF)], neurotrophinogenic agents (ex: carnosic acid) and antibiotics (ex: cefotaxime) to brain via nose-brain pathway using chitosan as barrier modulating agent was investigated. In vitro permeation studies of fluorescein isothiocyanate dextran (FD40k) …

Professional Preparation Of Secondary Health Education Teachers In Mississippi, Ensley Howell

Electronic Theses and Dissertations

The purpose of this study was to examine the professional preparation of secondary health education teachers in Mississippi. All four-year institutions of higher learning were contacted to determine the requirements for an approved program in order to obtain a supplemental endorsement in health, to compare the similarities and differences, and to determine the extent to which the approved programs reflect the ten content areas of the Mississippi Comprehensive Health Framework. This study also examined the status of secondary school health education programs in Mississippi by utilizing selected data from the U.S. Department of Health and Human Services Centers for Disease …

Rodents And Other Vertebrate Invaders In The United States, Michael W. Fall, Michael L. Avery, Tyler A. Campbell, Peter J. Egan, Richard M. Engeman, David Pimentel, William C. Pitt, Stephanie A. Shwiff, Gary W. Witmer

United States Department of Agriculture Wildlife Services: Staff Publications

Contents

Introduction

Assessing impacts of rodents and other vertebrate invaders

Accounts of some important vertebrate invaders
Norway rat (Rattus norvegicus)
Roof rat (Rattus rattus)
Polynesian rat (Rattus exulans)
House mouse (Mus Musculus)
Nutria (Myocastor coypus)
Gambian giant pouched rat (Cricetomys gambianus)
Feral swine (Sus scofa)
Small Indian Mongoose (Herpestes javanicus)
Rock pigeon (Columba livia)
House sparrow (Passer domesticus)
European starling (Sturnus vulgaris)
Monk parakeet (Myiopsitta monachus)
Brown tree snake (Boiga irregularis)
Burmese python (Python …

Virginia Dental Journal (Vol. 88, No. 2, 2011)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 88, No. 3, 2011)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 88, No. 4, 2011)

Virginia Dental Journal

No abstract provided.

Simulating The Neural Correlates Of Stuttering, Dirk B. Den Ouden, Charles F. Adams, Allen A. Montgomery

Faculty Publications

No abstract provided.

Cerebral Perfusion In Chronic Stroke: Implications For Lesion-Symptom Mapping And Functional Mri, Jessica D. Richardson, Julie M. Baker, Paul S. Morgan, Chris Rorden, L. Bonilha, Julius Fridriksson

Faculty Publications

Lesion-symptom mapping studies are based upon the assumption that behavioral impairments are directly related to structural brain damage. Given what is known about the relationship between perfusion deficits and impairment in acute stroke, attributing specific behavioral impairments to localized brain damage leaves room for speculation, as impairments could also reflect abnormal neurovascular function in brain regions that appear structurally intact on traditional CT and MRI scans. Compared to acute stroke, the understanding of cerebral perfusion in chronic stroke is far less clear. Utilizing arterial spin labeling (ASL) MRI, we examined perfusion in 17 patients with chronic left hemisphere stroke. The …

Update On Pain Management In Sickle Cell Disease., Samir K Ballas

Department of Medicine Faculty Papers

Acute pain is the hallmark of sickle cell disease and is the most common cause of hospital admissions. Tissue damage due to vaso-occlusion releases numerous inflammatory mediators that initiate the transmission of painful stimuli that culminate in the perception of pain. The acute sickle cell painful crisis evolves along four phases. Each phase is coupled with changes in certain markers of the disease. Hospital readmission occurs within 1 week in about 16% of discharged patients and within 1 month in about 50% of discharged patients. Failure to treat acute pain aggressively may lead to chronic pain syndrome which, in turn, …

Specific Incorporation Of Unlabeled Aromatic Amino Acids Into 15n-Labeled Sac7d Through Use Of Glyphosate, Paul Ferguson, Mary Catherine Hames

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

The Effect Of Glp-1 Analog Use Upon C-Peptide Levels In Patients With Type 2 Diabetes Mellitus, Elizabeth Hale

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Infection Rate Of Dactylogyrus Parasites On Etheostoma Duryi And Etheostoma Zonale, Kara Million

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Recombinant Expression, Protein Purification, And Crystallization Of Thermococcus Thioreducens Str, Ogl-20, Michelle Morris

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Effects Of Modification Of The Phd-Doc Toxin/Antitoxin System On The Lac Operon In E.Coli, Carl Pattison

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Essential Oils Do Not Inhibit E. Coli Peptidyl-Trna Hydrolase, Rachel Thompson

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Care Coordination, Family-Centered Care And Functional Ability In Children With Special Health Care Needs In The United States, Madeline Marti-Morales

Walden Dissertations and Doctoral Studies

Children with special health care needs (CSHCN) generally have physical, mental, or emotional conditions that require a broader range and greater quantity of health and related services compared to typical children. Care coordination (CC) and family-centered care (FCC) are necessary in the quality of health care for CSHCN. A gap exists in the literature regarding the impact of CC and FCC on children's functional ability (FA). Previous researchers have focused on met and unmet health care needs, but not on health outcomes or functionality. The purpose of this study was to determine if there was an association between CC, FCC, …

The Experience Of Menopause As Reported By Sedentary Women, April Elizabeth Ann Rietdyk

Walden Dissertations and Doctoral Studies

Limited research exists on the experiences of sedentary women as they transition through menopause. This gap creates difficulty for public health practitioners as they strive to develop resources, implement programs, or influence policy change at the community level for this group of marginalized women. Keeping women healthy throughout the aging process, including menopause, improves their quality of life and decreases the impact aging has on the health care system. This phenomenological study, through in-depth interviews, provided the opportunity for sedentary women to share their thoughts and experiences of menopause. Thirteen sedentary women between the ages of 40 and 60, experiencing …

The Relationship Between Daily Snowfall Accumulation And Pattern And Severity Of Traumatic Injuries At A U.S. Ski Resort, S. Jason Moore

Walden Dissertations and Doctoral Studies

Throughout the relevant literature, research addressing the impact of a specific environmental factor, such as snowfall, on injury patterns or severity among alpine skiers and snowboarders is sparse. The foundation for inquiry into this relationship was developed based on principles of physics and traumatology coupled with findings in the available literature. Secondary analysis of trauma registry data coupled with daily snowfall measurements from one of the largest ski areas in North America illustrated a negative correlation between daily snowfall amount and injury severity (r = -.08). Concordant findings demonstrated an increased odds of sustaining an injury defined as severe or …

Differences In Breast Cancer Tumor Size, Stage, And Survival By Socioeconomic Position In Young Women, Julie Maureen Tomaska

Walden Dissertations and Doctoral Studies

Although the incidence of breast cancer in women under 40 years of age is somewhat rare, young women tend to present with cancer that is more advanced and with poorer prognostic characteristics. This research will be important to providers, women and their families and those seeking to clarify screening guidelines. The purpose of this quantitative, retrospective, cohort study was to evaluate differences in prognostic characteristics by socioeconomic position (SIP). The cohort was comprised of females aged 18 to 39 with a primary diagnosis of breast cancer. Data were obtained from the Surveillance, Epidemiology and End Results registry for all primary …

Assessing Doppler-Derived Pressure Gradients And Liver Echogenicity To Predict Liver Disease, Joy D. Guthrie

Walden Dissertations and Doctoral Studies

Liver disease causes an estimated 36,000 deaths in the United States each year. Currently, to detect liver disease, an invasive biopsy is required. Other, less invasive diagnostic alternatives are needed. The purpose of this study was to assess the efficacy of a modified form of sonographic screening, including portal, hepatic, and splenic venous pressure, hepatic venous waveform analysis, portal vein diameter, and echogenicity of liver parenchyma in predicting liver disease. The study was based on conversion of a velocity measurement to a pressure gradient, allowing a fluid comparison between known catheterization venous pressures and sonographic Doppler-derived pressure gradients. This study …

Gestational Diabetes, Depression, And The Impact On Maternal Child Health Outcomes, Mary Alice Byrn

Dissertations

Antenatal depression occurs in about 20% of all pregnancies and gestational diabetes occurs in up to 14% of all pregnancies. Although there is sufficient information on (1) depression during pregnancy and (2) depression and diabetes, there is little information about depression and gestational diabetes. This comparative, longitudinal research study was done to better understand the relationship between gestational diabetes and depression. The study aims were the following: (1) to determine whether women with gestational diabetes had more depression than women without gestational diabetes, (2) to determine whether factors predictive of depression in pregnant women with gestational diabetes were different from …

Development Of A Novel Metallo-Lipid Microparticle Delivery System For A Leishmania Mexicana Dna Vaccine Candidate, Joanna B. Valencia

Open Access Theses & Dissertations

ABSTRACT

Background and Significance.

The leishmaniases are an important group of neglected tropical parasitic diseases caused by parasitic protozoa of the genus Leishmania. International health authorities estimate that 350 million people around the world are at risk for contracting leishmaniasis. Two million new cases occur each year and 12 million people are presently infected worldwide. Leishmaniasis is endemic throughout the Americas region including all of Central America, most of South America, Mexico and southern Texas. Leishmania is also considered a threat to the military readiness of U.S. troops deployed to the Middle East or Latin America.

First- and second-line treatments …

The Energy Landscape Analysis Of Cancer Mutations In Protein Kinases, Anshuman Dixit, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

The growing interest in quantifying the molecular basis of protein kinase activation and allosteric regulation by cancer mutations has fueled computational studies of allosteric signaling in protein kinases. In the present study, we combined computer simulations and the energy landscape analysis of protein kinases to characterize the interplay between oncogenic mutations and locally frustrated sites as important catalysts of allostetric kinase activation. While structurally rigid kinase core constitutes a minimally frustrated hub of the catalytic domain, locally frustrated residue clusters, whose interaction networks are not energetically optimized, are prone to dynamic modulation and could enable allosteric conformational transitions. The results …