Medicine and Health Sciences Commons^™

The Cardiac Atlas Project--An Imaging Database For Computational Modeling And Statistical Atlases Of The Heart, Carissa G. Fonseca, Michael Backhaus, David A. Bluemke, Randall D. Britten, Jae Do Chung, Brett R. Cowan, Alan H. Kadish

Office of the President Publications and Research

MOTIVATION: Integrative mathematical and statistical models of cardiac anatomy and physiology can play a vital role in understanding cardiac disease phenotype and planning therapeutic strategies. However, the accuracy and predictive power of such models is dependent upon the breadth and depth of noninvasive imaging datasets. The Cardiac Atlas Project (CAP) has established a large-scale database of cardiac imaging examinations and associated clinical data in order to develop a shareable, web-accessible, structural and functional atlas of the normal and pathological heart for clinical, research and educational purposes. A goal of CAP is to facilitate collaborative statistical analysis of regional heart shape …

Descending Into And Out Of The Maelstrom: Soma And The Survival Struggle, Rachel M. Urbano

Antioch University Dissertations & Theses

The purpose of this qualitative phenomenological study is to highlight the ways “surviving therapists” adapt to the inner-spaces in which they are still affected by their traumas. Surviving therapists are defined as therapists who identify as having experienced a trauma caused by another human being while maintaining an observational stance in relation to their body and self-experience. Therapists are not immune to the lasting effects of trauma: they may experience somatic reactivity and painful affective states in working with trauma patients. As surviving therapists have experienced events they may unconsciously choose to keep out of awareness, they may rely on …

Investigations Into The Use Of The M-Protein For The Production Of A Vaccine Against Streptococcus Equi Subspecies Equi Using Chicken Igy, Rachel Lantz

Senior Honors Theses

Strangles is a destructive disease in horses caused by an infection of the bacteria Streptococcus equi subspecies equi. Current vaccines designed to protect horse populations for this infection are only 50% effective at preventing the disease. The aim of this study was to develop a vaccine against Streptococcus equi by targeting the antiphagocytic virulence factor of the bacteria, the M-Protein (SeM18). SeM18 was expressed using the ampicillin resistant pET vector system and purified by metal affinity column using Cu(II). Purified protein was used to vaccinate chickens, and the anti-SeM18 IgY present in the yolk of the eggs produced by …

Intervention Intensity For Speech Sound Disorders: How Much And For How Long?, Elise Baker, A. Lynn Williams

ETSU Faculty Works

Seminar Outline 1) What is intervention intensity? 2) What do we know about the intensity of intervention for SSD in children? 3) How might SLPs use the evidence on intervention intensity in their everyday management of SSD in children?

Exploring Separable Components Of Institutional Confidence, Joseph A. Hamm, Lisa M. Pytlik Zillig, Alan Tomkins, Mitchel Herian, Brian H. Bornstein, Elizabeth Neeley

Department of Psychology: Faculty Publications

Despite its contemporary and theoretical importance in numerous social scientific disciplines, institutional confidence research is limited by a lack of consensus regarding the distinctions and relationships among related constructs (e.g., trust, confidence, legitimacy, distrust, etc.). This study examined four confidence-related constructs that have been used in studies of trust/confidence in the courts: dispositional trust, trust in institutions, obligation to obey the law, and cynicism. First, the separability of the four constructs was examined by exploratory factor analyses. Relationships among the constructs were also assessed. Next, multiple regression analyses were used to explore each construct’s independent contribution to confidence in the …

Generalization Or Specialization In High School Based Health Careers Transition Programs: What Is The Impact On The Health Care Work Force Shortage?, James Wm. Taylor

Dissertations

Background: Health care experts are predicting major shortages of caregivers as a result of aging demographics and anticipated retirements of health workers. Numerous approaches are being used to increase the supply of health care workers, but little, if any, literature demonstrates the role of secondary Career and Technical Education (CTE) programs in helping meet the anticipated demand.

Methods: Data from secondary educational health career programs were obtained from students completing five area programs (Allied Health, Health Occupations, Emergency Medical Technology, Dental Assisting, and Pharmacy Technician). Data analysis was performed on student demographics (chi-square), academic performance on standardized exams (ANOVA), and …

Medicaid Managed Care: Background, Issues, And Options, Julie T. Fralich Mba

Disability & Aging

Managed care is a fundamental shift from the historical fee-for-service payment systems. It provides opportunities for states to transform the delivery and financing of Medicaid financed services and promote and reward improved care outcomes. Implementation of such programs requires thoughtful planning, active stakeholder engagement and an effective administrative infrastructure to manage and operate in a value based purchasing environment.

Physical Activity Promotion Among School-Aged Children Using Pedometers And Rewards, Kari E. Ek

USF Tampa Graduate Theses and Dissertations

Physical activity is important for children as many children are considered overweight or obese. The benefits of exercise have been demonstrated in empirical studies across all age ranges (Horne, Hardman, Lowe, & Rowlands, 2009; Kelly et al., 2004; Louie & Chan, 2003; Southard & Southard, 2006). In the current study, a multiple baseline design across participants was used to assess the effectiveness of goal setting, reinforcement contingencies, and pedometers that provide feedback to increase step count of 5 participants. During baseline each participant wore a sealed pedometer to assess the average steps the participants took per day. After baseline, each …

Forgetting Constrains The Emergence Of Cooperative Decision Strategies, Jeffrey R. Stevens, Jenny Volstorf, Lael J. Schooler, Jörg Rieskamp

Department of Psychology: Faculty Publications

Theoretical studies of cooperative behavior have focused on decision strategies that depend on a partner’s last choices. The findings from this work assume that players accurately remember past actions. The kind of memory that these strategies employ, however, does not reflect what we know about memory. Here, we show that human memory may not meet the requirements needed to use these strategies. When asked to recall the previous behavior of simulated partners in a cooperative memory task, participants performed poorly, making errors in 10–24% of the trials. Participants made more errors when required to track more partners. We conducted agent-based …

The Need To Quantify Ecosystem Services Provided By Birds, Daniel G. Wenny, Travis L. Devault, Matthew D. Johnson, Dave Kelly, Cagan H. Sekercioglu, Diana F. Tomback, Christopher J. Whelan

United States Department of Agriculture Wildlife Services: Staff Publications

What are the birds worth--what is their actual dollar value to human society? To most of us in the ornithological community, birds are invaluable. But in these times we need more specific rationales to convince policy makers and business leaders to include bird conservation in land-use and development decisions. Over the past two decades, awareness of our dependence on a variety of ecosystem services (natural ecological processes that benefit human society) and of their importance and prevalence has progressed toward the goal of making conservation a mainstream value. Building strategies for the protection of ecosystem services into conservation and land-use …

Contact Investigation Of Bus Travelers Exposed To A Passenger With Contagious Tuberculosis, Parvathy Pillai, Andrea Saunders, Tiffany Bateman, G. Allen Heimann, Paul J. Edelson, Curi Kim

Michigan Journal of Public Health

Multiple barriers exist to conducting contact investigations for tuberculosis after bus travel, and the degree of transmission risk to bus contacts is uncertain. We describe a patient with active infectious tuberculosis and the contact investigation that took place following her 5 hour bus trip across the United States-Canadian border.

Wisewoman Gardening Project, Robin Roberts, Vicki Lorraine, Helen Deflorio

Michigan Journal of Public Health

No abstract provided.

A Review Of Infant Mortality In Wayne County, Michigan, Gerry Polverento, Heidi Hilliard

Michigan Journal of Public Health

No abstract provided.

Community Health Assessments: Successful Strategies In Working With Collaborating Competitors, Cathy Raevsky, Mary Kay Van Drie

Michigan Journal of Public Health

No abstract provided.

Serum Monocyte Chemoattractant Protein-1 In Pancreatic Cancer., Jennifer Sullivan, Qiaoke Gong, Terry Hyslop, Harish Lavu, Galina Chipitsyna, Charles Yeo, Hwyda A Arafat

Department of Surgery Faculty Papers

Background/Aims. Pancreatic ductal adenocarcinoma (PDA) has etiological association with chronic inflammation. Elevated circulating levels of inflammatory mediators, such as monocyte chemoattractant protein-1 (MCP-1), are found in obese individuals. We hypothesized that serum MCP-1 levels are elevated in obese PDA patients. Methods. ELISA was used to analyze MCP-1 serum levels in PDA (n = 62) and intraductal papillary mucinous neoplasms (IPMN) (n = 27). Recursive partitioning statistical analysis investigated the relationship between log MCP-1 and clinicopathological parameters. Results. Log MCP-1 values were significantly (P < 0.05) elevated in patients with BMI ≥ 37.5. In patients with BMI < 37.5, average log MCP-1 values were significantly elevated in PDA patients when compared to IPMN patients. Within the IPMN group, higher log MCP-1 levels correlated with increased age. Recursive partitioning analysis of IPMN versus PDA revealed a strategy of predicting characteristics of patients who are more likely to have cancer. This strategy utilizes log MCP-1 as the primary factor and also utilizes smoking status, gender, and age. Conclusion. MCP-1 is a promising biomarker in pancreatic cancer. The potential of using MCP-1 to distinguish PDA from IPMN patients must be studied in larger populations to validate and demonstrate its eventual clinical utility.

Segmenting Motivation: An Analysis Of Fantasy Baseball Motives And Mediated Sport Consumption, Brendan Dwyer, Stephen L. Shapiro, Joris Drayer

Human Movement Studies & Special Education Faculty Publications

Fantasy sport consumer behavior research is a burgeoning area of inquiry as this growing segment of sport fans exhibits unconventional, yet robust media consumption habits. In addition, consumer motivation and market segmentation represent core principles within the study of marketing, yet the integration of these two essential concepts with regard to sport consumers is limited. The purpose of this study was to explore fantasy baseball motives, develop a motive-based taxonomy of users, and quantify the differences between segments through an examination of mediated sport consumption. An exploratory hierarchal cluster analysis with a subsequent K-means analysis was conducted to determine the …

Patient Empowerment And Multimodal Hand Hygiene Promotion: A Win-Win Strategy., Maryanne Mcguckin, Julie Storr, Yves Longtin, Benedetta Allegranzi, Didier Pittet

College of Population Health Faculty Papers

Patient empowerment is a new concept in health care that has now been extended to the domain of patient safety. Within the framework of the development of the new World Health Organization (WHO) Guidelines on Hand Hygiene in Health Care, the authors conducted a review of the literature from 1997 to 2008 to identify the evidence supporting programs aimed at encouraging patients to take an active role in their care. Patient empowerment is an integral part of the WHO hand hygiene multimodal strategy. Hand hygiene promotion strategies that have demonstrated evidence of successfully empowering patients include one or all of …

Use Of Structure-And Ligand-Based Drug Design Tools For The Discovery Of Small Molecule Inhibitors Of Cysteine Proteases For The Treatment Of Malaria And Sars Infection, Falgun Shah

Electronic Theses and Dissertations

A wide array of molecular modeling tools were utilized to design and develop inhibitors against cysteine protease of P. Falciparum Malaria and Severe Acute Respiratory Syndrome (SARS). A number of potent inhibitors were developed against cysteine protease and hemoglobinase of P. falciparum , referred as Falcipains (FPs), by the structure-based virtual screening of the focused libraries enriched in soft-electrophiles containing compounds. Twenty one diverse, non-peptidic, low micromolar hits were identified. A combined data mining and combinatorial library synthesis approach was performed to discover analogs of virtual screening hits and establish the structure-activity relationships (SAR). However, the resulting SAR of the …

New Synthetic Methodologies For The Construction And Optimization Of Natural Products, Amir E. Wahba

Electronic Theses and Dissertations

Toxicity associated with bioactive natural products is considered as a major obstacle in the process of drug discovery. Manzamine A (MA) is one such candidate that requires optimization to overcome the toxicity problem. The manzamine alkaloids represents a unique class of natural products that have shown a diverse range of bioactivities including antimicrobial, antiparasitic, cytotoxicity, anti-inflammatory, pesticidial, and was shown to possess activity against HIV-1 and AIDS opportunistic infections. The greatest potential for the manzamine alkaloids appears to be against malaria and neuroinflammation. Experimental and modeling studies suggested that the planer ?-carboline moiety can act as DNA intercalator and hence …

Gussie Klorer Uses Art To Help Children Heal, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

Do Statins Improve Outcomes In Patients With Asthma On Inhaled Corticosteroid Therapy? A Retrospective Analysis Of The Mississippi Medicaid Database 2002-2004., Tasneem Taher Lokhandwala

Electronic Theses and Dissertations

Animal model studies and clinical trials have looked at the potential benefits of the anti-inflammatory properties of statins in asthma management with contradictory results. Therefore, the objective of this study is to determine if asthma patients on concurrent statin therapy are less likely to have asthma-related hospitalizations and emergency room (ER) visits. We conducted a retrospective cohort study using Medicaid data for 2002–2004. Asthma patients ?18 years old were identified using the ICD9 code 493.xx, from Jul 1, 2002 through Dec 31, 2003. The index date for an exposed subject was any date within the identification period, 180 days prior …

Functional Improvement Of Stroke Patients At Thai Red Cross Rehabilitation Center, N Tantisiriwat, A. Srinkapaibulaya

Chulalongkorn Medical Journal

Objective : To determine functional outcome as well as correlations between functional status at admission and length of hospital stay (LOHS) of stroke patients who completely attended rehabilitation program at Thai Red Cross Rehabilitation Center from year 2006 to 2008. Method : Reviewed medical record of stroke patients admitted during August 1, 2006 to December 31, 2008. LOHS, location after discharge and functional status as the following; modified Barthel activity of daily living index (BAI), household and community ambulation were obtained. BAI at admission and discharge were compared. The correlations between functional status at admission and LOHS were determined. Result …

Happiness And Related Factors Of Managing Directors In Industrial Plants In Bangkok, J Wattanasup, R. Kalayasiri

Chulalongkorn Medical Journal

Objective : To study levels of happiness and related factors of managing directors in industrial plants in Bangkok. Participants : Four hundred and thirty-one subjects from industrial plants in Bangkok. Methods : Levels of happiness were obtained by using the Thai Mental Health Indicators-66 (TMHI-66). Demographic, work, and social data were also collected. Managing directors with different levels of happiness were compared with respect to their demographic, work, and social variables by using chi-square tests. Then, the variables that were statistically significantly associated with the level of happiness in the initial analysis were analyzed by using multiple logistic regression analysis. …

Pupil Sizes Of Bodies With Variant Post-Mortem Intervals, P Sinpajakpon, K. Vongpaisarnsin

Chulalongkorn Medical Journal

Objective : To determine the relationship between the pupil sizes and the post- mortem intervals in order to estimate the time of death. Setting : Chulalongkorn Forensics Center, Faculty of Medicine, Chulalongkorn University Research design : Prospective descriptive study Materials and Methods : The pupil sizes of the bodies are measured by using pupil gauge with 2, 3, 4, 5, 6, 7, 8 and 9 millimeters scale. Results : Pupils of 171 bodies (141 males and 30 females) with age ranging from 20 to 70 years old are measured by using pupil gauge in particular post-mortem intervals. The average pupil …

Risk Factors For Driving Cessation Vary By Race And Ethnicity, Elizabeth Dugan, Frank Porell, Chae Man Lee

Gerontology Institute Publications

Driving is related to our identity and independence as well as allowing us to get needed goods, services, and social opportunities that enrich daily life. Yet with increasing age, the risk for developing threats to medical fitness to drive increases. Driving cessation is related to a long list of negative outcomes, such as: depression, social isolation, diminished access to health care, and diminished quality of life. We investigated risks for driving cessation, paying close attention to racial differences. This study used data from the Health and Retirement Study (HRS), 1998-2008. The study included N=46, 528 older people (age 65 and …

Towards The Total Synthesis Of The Capuramycin Family Of Natural Products, Jesse M. Jacobsen

University of Kentucky Master's Theses

Despite over a century of advancement, tuberculosis remains a grave threat to world health. In particular, third world countries continue to struggle with the crushing weight of the disease. Furthermore, the emergence of drug resistance in TB strains poses a significant threat to the first world where incidence and mortality is low. The dwindling efficacy of current drug regimens necessitates research into new small molecules capable of arresting the growth and spread of TB. The capuramycin family of nucleoside antibiotics shows strong potential to become part of this new generation of anti-TB small molecules. Indeed, their ability to inhibit Translocase …

Analysis Of Student & Teacher Outcomes From Pre-Existing Data Obtained Through The Low Incidence Initiative: Teaching Academic Age-Appropriate Learning Via Communication Project, April M. Holman

University of Kentucky Master's Theses

Students with significant cognitive disabilities frequently exhibit reduced communicative and academic competence. The Low Incidence Initiative (LII) project was a professional development model designed to train school-based teams to facilitate increased communicative and academic competence with such students via distance-technology coaching. This study analyzed pre-existing data from year one of the LII. Data were analyzed to determine effectiveness of the project on communication status of students and on training school personnel to accurately identify student levels of communication, and for overall satisfaction with the project. Results indicated that all student participants demonstrated improvement in expressive communication output. 100% of students …

Military Forces, Global Health, And The International Health Regulations (2005), David P. Fidler

Articles by Maurer Faculty

Security, economic, development, and humanitarian threats created by infectious diseases have heightened the importance of military forces to national and global public health responses. This article explores the increasing need for military involvement in public and global health surveillance and response to infectious disease threats, and focuses on how military forces can more effectively support implementation of the World Health Organization’s International Health Regulations (2005) (IHR (2005)). The article explains the major changes made in negotiations that produced the IHR (2005) and the importance of these changes to military-to-military activities and civilian-military cooperation. It identifies five areas in which military …

Strategies For Targeting Lentiviral Vectors, Christopher Matthew Trimby

University of Kentucky Doctoral Dissertations

Lentiviral gene therapy has held great promise for treating a wide range of neurological disorders due to its ability to stably integrate into the genome of nondividing cells like neurons, in addition to dividing cells. The nervous system is a complex and highly heterogeneous system, and while a therapeutic intervention may have beneficial effects in one population of cells it may have severe side effects in another. For this reason, specific targeting of lentiviral vectors is crucial for their ultimate utility for research and clinical research use.

Two different approaches for focusing the targeting of lentiviral vectors were employed in …

Regulation Of Abcg5 And Abcg8 Sterol Transporters In Biliary Cholesterol Elimination, Reverse Cholesterol Transport And Dyslipidemia, Nadezhda Steliyanova Sabeva

University of Kentucky Doctoral Dissertations

ATP-binding cassette transporters ABCA1 and ABCG1 initiate reverse cholesterol transport generating HDL particles, whereas ABCG5/G8 promote biliary cholesterol secretion thereby facilitating the last step of reverse cholesterol transport. Mutations in the leptin axis result in obesity and dyslipidemia in ob/ob and db/db mice. These mice have defective HDL clearance, increased plasma cholesterol and decreased biliary cholesterol elimination. My studies demonstrate that ABCG5/G8 protein is low in these animals and can be restored with caloric restriction or leptin replacement. To directly test whether ABCG5/G8 alone is able to correct reverse cholesterol transport defect, liver specific ABCG5/G8 expression was achieved in db/db …