Medicine and Health Sciences Commons^™

Migration And Hiv In India: Study Of Select Districts, Niranjan Saggurti, Bidhubhusan Mahapatra, Suvakanta N. Swain, Madhusudana Battala, Alka Narang, Umesh Chawla

HIV and AIDS

Report of a study assessing the important role of migration in the spread of HIV in districts with high out-migration in India. The study suggests a considerable spread of HIV linked to migrants’ extramarital sexual behaviors, and subsequent delay in treatment for infected spouses. In order to control the spread of HIV, the study provides programmatic recommendations made by the study participants and the counselors from ICTCs and ART centers. These suggestions include village-level mapping of at-risk persons, mainstreaming HIV prevention interventions within current health resources, improving various village level HIV prevention programs, and involving women left behind by migrant …

Hiv Transmission Among Married Men And Women In Districts With High Out-Migration In India: Study Brief, Niranjan Saggurti, Bidhubhusan Mahapatra, Suvakanta N. Swain, Madhusudana Battala, Umesh Chawla, Alka Narang

HIV and AIDS

This brief describes a study examining the links between male out-migration and HIV transmission among married men and women and other mechanisms by which HIV is transmitted within marital relationships in districts with high out-migration.

Facilitating Regulatory Approval Of Multipurpose Prevention Technologies For Sexual And Reproductive Health, Martha Brady

HIV and AIDS

This brief describes multipurpose prevention technologies (MPTs) that address women's sexual and reproductive health (SRH) needs, and how to go about facilitating regulatory approval of this technology. It outlines a strategic framework to examine current regulatory guidance, as well a product development pathway to bring MPTs to market.

What Regulatory Guidance Exists For Multipurpose Prevention Technologies (Mpts)? A Review Of Key Guidance Documents And Their Applicability To Mpts, Martha Brady, Heeyoung Park

HIV and AIDS

This brief reviews regulatory guidance documents and how they may apply to multi-purpose technologies (MPTs). It examines guidance documents from the Food and Drug Administration (FDA), the European Medicines Agency (EMA) and the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The brief concludes by anticipating increased interactions with US regulatory agencies in hopes of finding new regulatory pathways that address MPTs specifically.

Evaluation Of The Informed Consent Process For Male Circumcision Scale-Up In Swaziland, Barbara Friedland, Louis Apicella, Katie D. Schenk, Meredith Sheehy, Paul C. Hewett

HIV and AIDS

This report evaluates the informed consent process for male circumcision conducted through the Male Circumcision Partnership for Swaziland, led by Population Services International, in partnership with Jhpiego, Marie Stopes International, and the Population Council. The study assesses participants' comprehension of the circumcision process, the informed consent process, as well as the affect of male circumcision counseling on their experience.

Education During Humanitarian Emergencies: The Situation Of Displaced Children And Youth In Darfur, Sudan, Safaa El-Kogali

Poverty, Gender, and Youth

More than 39 million children and youth who live in conflict-affected fragile states do not have access to education. With an increase in the average duration of refugee displacement from 9 years in the early 1990s to 17 years today, whole generations of children have little chance to recoup the potential educational investment lost during their years living in the midst of a humanitarian emergency. The Population Council and the Women’s Refugee Commission launched a research project to identify the link between education and children’s protection and well-being in Darfur, Sudan. The objective was to document the educational environment in …

Female Wages In The Egyptian Textiles And Clothing Industry: Low Pay Or Discrimination?, Amirah El-Haddad

Poverty, Gender, and Youth

This Population Council working paper analyzes data collected from a survey of firms and workers in the textiles and clothing sector in Egypt. These data allow for the explanation of the sector’s gender wage gap by poorer endowments, and relegation of women to low-paying firms and occupations; and by within-firm and within-occupation differential in returns. There is a pay gap in this sector, with men receiving an hourly wage 29 percent higher than that of women, partly because women are concentrated in the lower paid occupations, with a clear glass ceiling in effect, and outright discrimination occurs. The largest of …

Effects Of Personality And Situation Upon Appraisal And Coping, Daniel Henry Mcgrath

Theses, Dissertations and Capstones

Stress and coping represent one of the most studied areas in the field of psychology. There is little agreement regarding the proper conceptualization of coping. Cognitive processesand personality traits have been proposed as important determinants of coping responses. Low correlations have been consistently found between personality traits, appraisal, and coping. Many studies in the stress and coping literature suffer from methodological issues. This study was designed to improve upon typical methodology, determine the relative predictive utility ofpersonality cluster approaches over dimensional approaches, and determine the effect of personality and situation upon appraisal and coping. Participants read hypothetical stressor scenarios. Primary …

Bioethics And Human Rights: Toward A New Constitutionalism, George P. Smith Ii

Scholarly Articles

No abstract provided.

Student Nurse Perceptions Of Effective Medication Administration Education, Lorretta C. Krautscheid, Valorie J. Orton, Lori Chorpenning, Rachel Ryerson

Faculty Publications - College of Nursing

Nursing faculty strive to educate students in a manner that prevents errors, promoting quality, patient-centered care. This endeavor is dependent upon meaningful and effective education that incorporates educational experiences reflective of the service sector. Anecdotal reports from clinical faculty and student nurses suggest that academic medication administration education may not optimally prepare students for safe entry into clinical practice. The aim of this phenomenologic qualitative research is to understand student nurse perceptions regarding teaching strategies and learning activities that prepared them for safe medication administration in acute care clinical settings. Focus group interviews resulted in two broad themes that are …

Objective Physical Activity And Sleep Characteristic Measurements Using A Triaxial Accelerometer In Eight Year Olds, Susan Ann Harrington

Wayne State University Dissertations

Background: Secular trends demonstrate that young children are less active and sleep less. Inequity in an individual's energy balance is known to have poor health outcomes. Academic achievement, academic behavior, and weight status are proxy indicators for health and psychosocial outcomes in this study. Current guidelines in place for sleep and physical activity in childhood are the result of data collected in the form of self-reports. Quantification and qualification of physical activity dimensions and sleep characteristics are essential not only for the purpose of clearly establishing parameters but also for the intent of verifying optimal health outcomes and evaluating interventions …

The Effects Of Racially-Motivated Emotional Arousal On The Eating Behaviors Of African American Women, Lenwood W. Hayman

Wayne State University Dissertations

Disparities between African Americans and Caucasians remain vast across a wide variety of health indicators. Chronic stress has been identified as a risk factor for a variety of chronic illnesses and poor health outcomes. One type of chronic stress that has been linked to health disparities is the stress associated with experiences of racial discrimination. The stress African Americans encounter as a result of their racist experiences contributes to a chronic elevation of their physiological stress response. In addition to stress, a major risk factor for coronary heart disease and diabetes is obesity, which has been established as a major …

Effect Of Dimethylarginine Dimethylaminohydrolase In The Development Of Salt Sensitivity, Samar Abdulla Nasser

Wayne State University Dissertations

Salt sensitivity is associated with a rise in blood pressure (BP) occurring during sodium loading and/or a fall in BP during sodium restriction that exceeds random fluctuations in BP. Salt sensitivity is more common in African American than Caucasian hypertensives and is also present, in normotensive African Americans. The mechanism or mechanisms resulting in salt-sensitive hypertension are multiple and include both activation of the renin angiotensin system via increases in angiotensin II and reductions in the endogenous vasodilator, nitric oxide (NO). An important means of NO downregulation is through asymmetric dimethylarginine (ADMA), an endogenous NO inhibitor, which is largely metabolized …

Evaluation Of Vancomycin Dosing And Corresponding Drug Concentrations In Pediatric Patients, Lauren Maurer Pharmd, Jenny Boucher Pharmd, Bcps, Ejd

Department of Pharmacy

No abstract provided.

2011 Cardinal Athletics Vol. 5, Issue 1, Winter, Otterbein University

Cardinal Athletics Newsletter

The Cardinal Athletics Newsletter is published three times per year and covers all athletic activities at the Otterbein University.

Heat Shock Protein Induced Protection Against Cisplatin-Induced Hair Cell Death, Tiffany Gray Baker

MUSC Theses and Dissertations

Cisplatin is a highly successful and widely used chemotherapy for the treatment of various solid malignancies in both adult and pediatric patients. Side effects of cisplatin include nephrotoxicity and ototoxicity. Cisplatin's ototoxic effect results in part from damage to and death of cochlear hair cells. Mechanisms underlying cisplatin-induced hair cell death are poorly understood and have been attributed to DNA damage, oxidative stress, and inflammation. This study was designed to determine the role of p53 in cisplatin-induced hair cell death and to investigate heat shock proteins (HSPs) as potential protectants against cisplatin-induced hair cell death using adult mouse utricle as …

Potential For Interdependent Development Of Trna Determinants For Aminoacylation And Ribosome Decoding., Cuiping Liu, Howard Gamper, Hanqing Liu, Barry S Cooperman, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

Although the nucleotides in tRNA required for aminoacylation are conserved in evolution, bacterial aminoacyl-transfer RNA synthetases are unable to acylate eukaryotic tRNA. The cross-species barrier may be due to the absence of eukaryote-specific domains from bacterial aminoacyl-transfer RNA synthetases. Here we show that whereas Escherichia coli CysRS cannot acylate human tRNA(Cys), the fusion of a eukaryote-specific domain of human CysRS overcomes the cross-species barrier in human tRNA(Cys). In addition to enabling recognition of the sequence differences in the tertiary core of tRNA(Cys), the fused eukaryotic domain redirects the specificity of E. coli CysRS from the A37 present in bacterial tRNA(Cys) …

Genetics Of Sputum Gene Expression In Chronic Obstructive Pulmonary Disease, Weiliang Qiu, Michael H. Cho, John H. Riley, Wayne H. Anderson, Dave Singh, Per Bakke, Amund Gulsvik, Augusto A. Litonjua, David A. Lomas, James D. Crapo, Terri H. Beaty, Bartolome R. Celli, Stephen I. Rennard, Ruth Tal-Singer, Steven M. Fox, Edwin K. Silverman, Craig P. Hersh, Eclipse Investigators

Journal Articles: Pulmonary & Critical Care Med

Previous expression quantitative trait loci (eQTL) studies have performed genetic association studies for gene expression, but most of these studies examined lymphoblastoid cell lines from non-diseased individuals. We examined the genetics of gene expression in a relevant disease tissue from chronic obstructive pulmonary disease (COPD) patients to identify functional effects of known susceptibility genes and to find novel disease genes. By combining gene expression profiling on induced sputum samples from 131 COPD cases from the ECLIPSE Study with genomewide single nucleotide polymorphism (SNP) data, we found 4315 significant cis-eQTL SNP-probe set associations (3309 unique SNPs). The 3309 SNPs were tested …

3d Mapping Of The Spry2 Domain Of Ryanodine Receptor 1 By Single-Particle Cryo-Em, Alex Peralvaerz-Marin, Hanshen Tae, Phillip G. Board, Marco G. Casarotto, Angela F. Dulhunty, Montserrat Samsó

Physiology and Biophysics Publications and Presentations

The type 1 skeletal muscle ryanodine receptor (RyR1) is principally responsible for Ca2+release from the sarcoplasmic reticulum and for the subsequent muscle contraction. The RyR1 contains three SPRY domains. SPRY domains are generally known to mediate protein-protein interactions, however the location of the three SPRY domains in the 3D structure of the RyR1 is not known. Combining immunolabeling and single-particle cryo-electron microscopy we have mapped the SPRY2 domain (S1085-V1208) in the 3D structure of RyR1 using three different antibodies against the SPRY2 domain. Two obstacles for the image processing procedure; limited amount of data and signal dilution introduced by the …

Cholesterol Sensitivity Of Kir2.1 Is Controlled By A Belt Of Residues Around The Cytosolic Pore, Avia Rosenhouse-Dantsker, Diomedes E. Logothetis, Irena Levitan

Physiology and Biophysics Publications and Presentations

Abstract

Kir channels play an important role in setting the resting membrane potential and modulating membrane excitability. A common feature of several Kir channels is that they are regulated by cholesterol. Yet, the mechanism by which cholesterol affects channel function is unclear. We recently showed that the cholesterol sensitivity of Kir2 channels depends on several CD-loop residues. Here we show that this cytosolic loop is part of a regulatory site that also includes residues in the G-loop, the N-terminus, and the connecting segment between the C-terminus and the inner transmembrane helix. Together, these residues form a cytosolic belt that surrounds …

State-Dependent Camp Binding To Functioning Hcn Channels Studied By Patch-Clamp Fluorometry, Shengjun Wu, Zhanna V. Vysotskaya, Xinping Xu, Changan Xie, Qinglian Liu, Lei Zhou

Physiology and Biophysics Publications and Presentations

Abstract

One major goal of ion channel research is to delineate the molecular events from the detection of the stimuli to the movement of channel gates. For ligand-gated channels, it is challenging to separate ligand binding from channel gating. Here we studied the cyclic adenosine monophosphate (cAMP)-dependent gating in hyperpolarization-activated cAMP-regulated (HCN) channel by simultaneously recording channel opening and ligand binding, using the patch-clamp fluorometry technique with a unique fluorescent cAMP analog that fluoresces strongly in the hydrophobic binding pocket and exerts regulatory effects on HCN channels similar to those imposed by cAMP. Corresponding to voltage-dependent channel activation, we observed …

An Investigation On Hiv Related Stigma To Improve Hiv Prevention Efforts In North Dakota, Krissie Lynn Mayer-Guerard

All Graduate Theses, Dissertations, and Other Capstone Projects

This study examines HIV stigma to improve HIV prevention in North Dakota. A survey was administered to North Dakotan adults between January 15 and February 15, 2011, in eight selected towns. The study focused on North Dakotan perceptions of HIV in their state. Research found that most North Dakotans do not view HIV as a problem in their state. There is, however, a belief that there is stigma associated with HIV in North Dakota, as 65 percent of survey respondents believe that. The study also shows that there is a need for education regarding the transmission of HIV. Sixty percent …

Evaluation Of Health Newsletter Effectiveness On Dietary Habits In Low-Income Middle-Aged Women, Nichole Jennifer Hassebroek

All Graduate Theses, Dissertations, and Other Capstone Projects

There is little known about the effectiveness of the SagePlus newsletters at motivating dietary habit changes. The purpose of this study was to determine the effectiveness of the SagePlus newsletter in motivating low-income, middle-aged women who are participating in the SagePlus program to adopt healthier eating habits, specifically to eat more fruits and vegetables. A nonexperimental, descriptive correlational design was used in this study. Phone calls were placed to current SagePlus participants who had been enrolled in the program between six and 12 months. Forty English-speaking participants were contacted and agreed to participate in the telephone survey from a potential …

Gender Perceptions In Rheumatic Disease: A Secondary Analysis, Jean Heise

All Graduate Theses, Dissertations, and Other Capstone Projects

Problem: Rheumatoid arthritis affects approximately 1.3 million people in the United States. A chronic disease with a variable course leaves affected individuals in a state of uncertainty. Many individuals experience joint and muscle pain, a major symptom of the disease. Current literature provides varying information of gender perceptions and management of joint and muscle pain in rheumatic diseases. Purpose: The purpose of this secondary analysis was to explore (1) gender perception of seriousness of joint and muscle pain in rheumatoid arthritis, (2) gender perception of joint and muscle pain interference with daily life, (3) gender perception of controllability of joint …

Barriers To Using Motivational Interviewing For Lifestyle Counseling, Heidi June Sannes

All Graduate Theses, Dissertations, and Other Capstone Projects

The Minnesota Department of Health has sponsored Motivational Interviewing Continuing Education sessions for SagePlus providers to increase their knowledge and skill in the utilization of MI in their clinical practice. The impact of these educational sessions on skill development as well as utilization of MI by these providers is unknown. The purpose of this study was to determine if healthcare providers perceive any barriers in utilizing MI techniques to do lifestyle counseling with SagePlus program particiants. A descriptive quantitative design was used for this study. Of the 22 healthcare providers that were doing lifestyle counseling 16 completed the questionnaires. The …

Motivational Interviewing Training And Provider Proficiency, Jeremy Jay Waldo

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this descriptive study was to determine if there was a relationship between the amount and type of Motivational Interviewing (MI) training a SagePlus provider receives, motivation to utilize MI training, and the proficiency of the provider in using MI in lifestyle counseling in clinical practice. This study was comprised of 16 healthcare professionals who provide SagePlus lifestyle counseling interventions in clinics that participated in the Minnesota Department of Health (MDH) funded SagePlus program. A demographic questionnaire, modified Preventative Medicine Attitudes and Activities Questionnaire (PMAAQ) and Behaviour Change Counseling Index tool (BECCI) were utilized to assess provider's amount …

Assessing Students' Risk Factors For Type Ii Diabetes At A Midwest Public University, Nicole Decourcy Ferrian

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this study was to assess students' risk factors for type II diabetes at a Midwest public university. It further examined students' perceived susceptibility, perceived severity, and self-efficacy of the disease. The design of the cross-sectional study was based on risk factors for type II diabetes listed by the American Diabetes Association and the Health Belief Model's constructs of perceived susceptibility, perceived seriousness, and self-efficacy. A survey was distributed to non-diabetic college students aged 18 and older enrolled in general education courses at a Midwest public university. A purposive sampling of 432 students enrolled in Health 101 and …

Effect Of Ejaculation Frequency On Spermatozoa Survival In Diluted Semen From Pleven Blackhead Rams, Stanimir Yotov, Ivan Fasulkov, Nasko Vassilev

Turkish Journal of Veterinary & Animal Sciences

The effect of ejaculation frequency on spermatozoa survival in diluted Pleven Blackhead ram semen was investigated. Thirty-two ejaculates were examined. From each ram 4 ejaculates were collected at 10-min intervals in the morning and in the afternoon. Semen parameters, namely, color, density, transparency, volume, concentration, motility, and abnormal sperm, for each ejaculate were determined. The sperm motility was assessed from the moment of dilution up to 60 min at 10-min intervals, then again at 90 min and 120 min. The semen characteristics were determined by means of "Motic Image Plus" equipment and the data were processed statistically. Sperm volume and …

Biobanking Newborn Bloodspots For Genetic Research Without Consent, Sandra J. Carnahan

Journal of Health Care Law and Policy

No abstract provided.

Increasing Organ Donation In Ireland : Social Marketing And Infrastructural Improvements., Ronan O'Sullivan

Theses

There were over 600 patients on the organ waiting list in Ireland in November 2010. This is a substantial increase on the 414 patients on the waiting list in 2008. Ireland also witnessed a dramatic decline in the number of donors from 90 donors in 2009 to 58 donors in 2010. This thesis focuses on investigating the current state of organ donation in the Republic of Ireland, with the eventual goal of recommending alterations to improve the system. In depth- interviews were conducted with eleven leading personnel from the fields of organ donation and social marketing in Ireland as well …