Medicine and Health Sciences Commons^™

Differentiation Of Embryonic Stem Cells Into Fibroblast-Like Cells In Three-Dimensional Type I Collagen Gel Cultures, Shinsaku Togo, Tadashi Sato, Hisatoshi Sugiura, Xingqi Wang, Hesham Basma, Amy J. Nelson, Xiangde Liu, Tom W. Bargar, J. Graham Sharp, Stephen I. Rennard

Journal Articles: Pulmonary & Critical Care Med

Fibroblasts are heterogeneous mesenchymal cells that play important roles in the production and maintenance of extracellular matrix. Although their heterogeneity is recognized, progenitor progeny relationships among fibroblasts and the factors that control fibroblast differentiation are poorly defined. The current study was designed to develop a reliable method that would permit in vitro differentiation of fibroblast-like cells from human and murine embryonic stem cells (ESCs). Undifferentiated ESCs were differentiated into embryoid bodies (EBs) with differentiation media. EBs were then cast into type I collagen gels and cultured for 21 d with basal media. The spindle-shaped cells that subsequently grew from the …

Trauma And Alcoholism Brochure

Brochure

No abstract provided.

Evaluation Of A Cultural Competancy Program, Cheryl Delgado, Linda Eileen Wolf

Nursing Faculty Publications

No abstract provided.

College Of Pharmacy Student Handbook, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Bachelor Of Science In Nursing-Entry Level 2011, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Mccraken Knows Ulcers And Parasitic Worms, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

Perceptions Of Nepalese Physicians And Nurses On The Shortage Of Health Care Professionals In Nepal, Shyamala Shiwakoti

Regis University Student Publications (comprehensive collection)

Non-conventional therapies have been termed and captured by the phrase Complementary and Alternative Medicine (CAM), since the establishment of The National Center for Complementary and Alternative Medicine (NCCAM), by the Federal Government in 1992. With the use of CAM on the rise in the baby boom population and the expectation that the number of nursing home residents is expected to double by 2020, it is imperative that healthcare providers gain more knowledge in effective means for treating the geriatric population holistically. The purpose of this study was to determine whether the implementation of a CAM intervention program in a sample …

Response Shift Theory: An Application For Health-Related Quality Of Life In Rehabilitation Research And Practice, Jennifer S. Howard, Carl G. Mattacola, Dana Howell, Christian Latterman

Occupational Science and Occupational Therapy Faculty and Staff Research

Evaluating change in patients over time can be challenging to any health care provider. Response shift theory is based on the change typology of alpha, beta, and gamma change and proposes that residual changes in self-response measures occur over time. These changes are the result of recalibration, reconceptualization, and reprioritization of internal standards and references utilized for self-appraisal. Failing to account for response shift may result in over- or under-reporting of true physiologic change. The purpose of this paper is to review the components of response shift, identify research designs used to detect it, and present a model for its …

Dysglycemia Induces Abnormal Circadian Blood Pressure Variability, Sivarajan Kumarasamy, Kathirvel Gopalakrishnan, Dong Hyun Kim, Nader G. Abraham, William D. Johnson, Bina Joe, Alok K. Gupta

Biochemistry and Microbiology

Background: Prediabetes (PreDM) in asymptomatic adults is associated with abnormal circadian blood pressure variability (abnormal CBPV).

Hypothesis: Systemic inflammation and glycemia influence circadian blood pressure variability.

Methods: Dahl salt-sensitive (S) rats (n = 19) after weaning were fed either an American (AD) or a standard (SD) diet. The AD (high-glycemic-index, high-fat) simulated customary human diet, provided daily overabundant calories which over time lead to body weight gain. The SD (low-glycemic-index, low-fat) mirrored desirable balanced human diet for maintaining body weight. Body weight and serum concentrations for fasting glucose (FG), adipokines (leptin and adiponectin), and proinflammatory cytokines [monocyte chemoattractant protein-1 (MCP-1) …

Understanding Health Profile Of The Middle-Aged Residents In Tsuen Wan, Tsuen Wan Safe And Health Community, Tsuen Wan Adventist Hospital, Asia-Pacific Institute Of Ageing Studies, Lingnan University

APIAS Research Report 研究報告

Modernization marked the progress of society and posed various changes to human life as well as the epidemiological transition. Improvements in public health care, living conditions, income and the control of infectious diseases were important factors in the first half of the twentieth century that led to the increases in life expectancy, while in the second half it was improvements in social conditions, health technologies such as antibiotics, and widespread immunization. The existences of advanced medical services effectively get rid of the prevalence of infectious disease that caused immediate human threats such as Measles and Smallpox.

Given that technological advancement …

Can Law Improve Prevention And Treatment Of Cancer?, Roger Magnusson, Lawrence O. Gostin, David Studdert

O'Neill Institute Papers

The December 2011 issue of Public Health (the Journal of the Royal Society for Public Health) contains a symposium entitled: Legislate, Regulate, Litigate? Legal approaches to the prevention and treatment of cancer. This symposium explores the possibilities for using law and regulation – both internationally and at the national level – as the policy instrument for preventing and improving the treatment of cancer and other leading non-communicable diseases (NCDs). In this editorial, we argue that there is an urgent need for more legal scholarship on cancer and other leading NCDs, as well as greater dialogue between lawyers, public health practitioners …

Ua60/5 Wku Dental Hygiene Class Of 2011, Wku Dental Hygiene

WKU Administration Documents

Members of the 2011 dental hygiene class: Eiman Al Eissa, historian; Johanna Higdon, vice president; Mandy Lowry, president; Kristina Marshall, treasurer; Leslie West, historian; Audrey Bateman, SDHA representative; Samantha Sarisky, secretary; Elizabeth Brussell, SDHA representative; Stacy Allen, Tabitha Allen, Alyssa Bishop, Kenya Brown, Kristi Bunting, Svetlana Deffin, Sarah Dudak, Jessica Durrant, Megan Elsenboss, Elizabeth Henry, Nicole Hopper, Heather Hunt, Angela Jaworsky, Catherine Morgan, Laura Newton, Thao Nguyen, Julie Swearingen, Brittany Wade, Kate Wakeling, Brittany Warner and Amanda White.

Composite Tissue Allotransplantation To Treat Veterans With Complex Amputation Injuries, Vivian Mcalister, Ray Kao, Brian Church, Markus Besemann, Rob Stiegelmar

Data and Test Instruments

Amputee rehabilitation may be limited by complexity of injury (e.g. bilateral arm amputation), associated injury (e.g. colostomy) or by the level of amputation (e.g. high above knee). Our objective is to assess the potential for composite tissue allotransplantation (CTA) to overcome these barriers. Medical literature was searched and programs were surveyed regarding the current status of CTA. Results CTA remains an experimental reconstructive option that involves a large collaborative (physiatry, orthopaedic, plastic and transplant surgeons). Limb transplantation has evolved out of limb reimplantation surgery and organ transplantation. Approximately 10 programs world wide, with almost a decade of experience, report 90% …

Findings From A Global Survey Of Certified Professional Co-Active Coaches, Courtney Newnham-Kanas, Jennifer Irwin, Don Morrow

Health Studies Publications

Currently, research supporting the validity of coaching is rising in both executive and life coaching arenas. Research has revealed that co-active life coaching (CALC), a particular style of coaching, is compatible with health-behaviour theory. However, very little information is known about co-active coaches themselves. The purpose of this study was to develop a comprehensive, applied coaching profile using a global sample of English-reading and -writing certified professional co-active coaches (CPCCs). The survey used for this study was a revised version of the Grant and Zackon (2004) coaching survey. A total of 390 CPCCs who were over 18 years of age, …

Histamine Deficiency Promotes Inflammation-Associated Carcinogenesis Through Reduced Myeloid Maturation And Accumulation Of Cd11b +Ly6g+ Immature Myeloid Cells, Xiang Dong Yang, Walden Ai, Samuel Asfaha, Govind Bhagat, Richard A. Friedman, Guangchun Jin, Heuijoon Park, Benjamin Shykind, Thomas G. Diacovo, Andras Falus, Timothy C. Wang

Paediatrics Publications

Histidine decarboxylase (HDC), the unique enzyme responsible for histamine generation, is highly expressed in myeloid cells, but its function in these cells is poorly understood. Here we show that Hdc-knockout mice show a high rate of colon and skin carcinogenesis. Using Hdc-EGFP bacterial artificial chromosome (BAC) transgenic mice in which EGFP expression is controlled by the Hdc promoter, we show that Hdc is expressed primarily in CD11b +Ly6G+ immature myeloid cells (IMCs) that are recruited early on in chemical carcinogenesis. Transplant of Hdc-deficient bone marrow to wild-type recipients results in increased CD11b + Ly6G + cell mobilization and reproduces the …

Single Mother’S Adverse And Traumatic Experiences And Post-Traumatic Stress Symptoms, Joan A. Samuels-Dennis, Marilyn Ford-Gilboe, Susan Ray

Nursing Publications

A random sample of 247 Canadian single mothers currently receiving social assistance participated in a study designed to: a) provide a comprehensive description of mother’s lifetime exposure to 11 adversities, four psychological traumas, and eight assaultive traumas; b) examine the association between exposure to childhood and adulthood adversities and traumas, and mother’s current post-traumatic stress symptom. Of those surveyed, 31% met the criteria for a probable PTSD diagnosis. Between 78% and 80% reported 1 or more lifetime adversity, psychological trauma, and assaultive trauma. Rates of adversities were similar to the general female population. However, rates of psychological and assaultive trauma …

Ouabain Stimulates A Na+/K+-Atpase-Mediated Sfk-Activated Signalling Pathway That Regulates Tight Junction Function In The Mouse Blastocyst., Holly Giannatselis, Michele Calder, Andrew J Watson

Obstetrics & Gynaecology Publications

The Na(+)/K(+)-ATPase plays a pivotal role during preimplantation development; it establishes a trans-epithelial ionic gradient that facilitates the formation of the fluid-filled blastocyst cavity, crucial for implantation and successful pregnancy. The Na(+)/K(+)-ATPase is also implicated in regulating tight junctions and cardiotonic steroid (CTS)-induced signal transduction via SRC. We investigated the expression of SRC family kinase (SFK) members, Src and Yes, during preimplantation development and determined whether SFK activity is required for blastocyst formation. Embryos were collected following super-ovulation of CD1 or MF1 female mice. RT-PCR was used to detect SFK mRNAs encoding Src and Yes throughout preimplantation development. SRC and …

Uwomj Volume 80, Issue 2, Fall 2011, Western University

University of Western Ontario Medical Journal

Schulich School of Medicine & Dentistry

Uwomj Volume 80, Issue 1, Spring 2011, Western University

University of Western Ontario Medical Journal

Schulich School of Medicine & Dentistry

Uwomj Volume 80, Supplement S1, Summer 2011, Western University

University of Western Ontario Medical Journal

Schulich School of Medicine & Dentistry

Exercise Preconditioning Provides Long-Term Protection Against Early Chronic Doxorubicin Cariotoxicity, David S. Hydock, Chia-Ying Lien, Brock T. Jenson, Carole M. Schneider, Reid Hayward

School of Sport & Exercise Science Faculty Publications

Acute doxorubicin (DOX) cardiotoxicity can be attenuated by exercise preconditioning, but little is known of whether this cardioprotection continues beyond 10 days post-DOX administration. The purpose of this study was to determine the effects of exercise preconditioning on early chronic DOX-induced cardiotoxicity. Male rats were randomly assigned to sedentary, treadmill, or wheel running groups. Treadmill and wheel running animals participated in a progressive treadmill training protocol or voluntary wheel running, respectively, for 10 weeks. Following the intervention, animals were further randomized to receive either DOX (sedentary + DOX, treadmill + DOX, wheel running + DOX) or saline (sedentary + saline, …

Learning From Mistakes: Improving Initial Fingertip Force Scaling By Observing Lifting Errors, Gavin Buckingham, Minnie Tang, Paul Gribble, Melvyn A. Goodale

Psychology Presentations

• When lifting objects that are lighter or heaver than we expect them to be, individuals typically misapply forces in a way that reflects their prior expectations of heaviness.

• Because we lift in this predictive way, large and small cubes elicit these characteristic errors even when they are adjusted to have equal mass. Lifters will apply too much force to a large cube and substantially less force to a small cube – errors that are rapidly corrected with repeated lifts (Flanagan & Beltzner, 2000).

• When watching others lift objects, an observer’s motor system automatically reacts in a way …

Integrin-Linked Kinase Is Required For Tgf-_1 Induction Of Dermal Myofibroblast Differentiation, Linda Vi, Cristina De Lasa, Gianna M. Diguglielmo, Lina Dagnino

Paediatrics Publications

Cutaneous repair after injury requires activation of resident dermal fibroblasts and their transition to myofibroblasts. The key stimuli for myofibroblast formation are activation of transforming growth factor-b (TGF-b) receptors and mechanotransduction mediated by integrins and associated proteins. We investigated the role of integrin-linked kinase (ILK) in TGF-b1 induction of dermal fibroblast transition to myofibroblasts. ILK-deficient fibroblasts treated with TGF-b1 exhibited attenuation of Smad 2 and 3 phosphorylation, accompanied by impaired transcriptional activation of Smad targets, such as a-smooth muscle actin. These alterations were not limited to Smad-associated TGF-b1 responses, as stimulation of noncanonical mitogenactivated protein kinase pathways by this growth …

Chest Compressions And Epinephrine During Resuscitation Of Infants Born At The Border Of Viability: Yes, No Or Maybe?, Gregory P. Moore, Thierry Daboval, Kevin W. Coughlin

Paediatrics Publications

Neonatology, in large part due to its population of babies born at the edge of viability, is rife with bioethical issues. This unique population is at high risk of mortality and considerable neurodevelopmental morbidity. One contentious, ongoing debate concerns whether these extremely low birth weight infants born at the border of viability should, if required by the Neonatal Resuscitation Program guidelines, receive chest compressions and epinephrine as part of their delivery room resuscitation. The present article, through a case presentation and discussion based on the ethical framework of principlism, provides readers with a thoughtful approach to the controversial issue of …

Using The Commons To Facilitate Health Communication, Anna Liebzeit, Karen Adams, Mat Jakobi

Aboriginal Policy Research Consortium International (APRCi)

No abstract provided.

Negative Associations Between Corpus Callosum Midsagittal Area And Iq In A Representative Sample Of Healthy Children And Adolescents., Hooman Ganjavi, John D Lewis, Pierre Bellec, Penny A Macdonald, Deborah P Waber, Alan C Evans, Sherif Karama, The Brain Development Cooperative Group

Brain and Mind Institute Researchers' Publications

Documented associations between corpus callosum size and cognitive ability have heretofore been inconsistent potentially owing to differences in sample characteristics, differing methodologies in measuring CC size, or the use of absolute versus relative measures. We investigated the relationship between CC size and intelligence quotient (IQ) in the NIH MRI Study of Normal Brain Development sample, a large cohort of healthy children and adolescents (aged six to 18, n = 198) recruited to be representative of the US population. CC midsagittal area was measured using an automated system that partitioned the CC into 25 subregions. IQ was measured using the Wechsler …

Nitric Oxide And Osteoporosis: What A Gas!, Sophie Jamal

Canadian Centre for Activity and Aging Presentations

No abstract provided.

Tet-Inducible Lymphoma In A New Tax Transgenic Mouse Model, Daniel Rauch, Sirosh Bokhari, John Harding, Lee Ratner

Open Access Publications

No abstract provided.

A Temporal Role Of Type I Interferon Signaling In Cd8+ T Cell Maturation During Acute West Nile Virus Infection, Amelia K. Pinto, Stephane Daffis, James D. Brien, Maria D. Gainey, Wayne M. Yokoyama, Kathleen C.F Sheehan, Kenneth M. Murphy, Robert D. Schreiber, Michael S. Diamond

Open Access Publications

No abstract provided.

Editorial Lung Cancer, What Is New ?, Edward Yu

Data and Test Instruments

Lung cancer is the major cause of cancer – related mortality in men and women world wide. In the last three decades the management of lung cancer has changed and the mortality of this disease has improved. This is partly due to rapid progress in the research, diagnosis, and treatment of lung cancer. The present Special Hot Topic Series entitled “Lung Cancer - What Is New? “reviews the progress of management of thoracic cancer. This work is the result of diligent efforts of many investigators, authors, reviewers and support personnel who we are indebted to for their perseverance. This special …