Medicine and Health Sciences Commons^™

Last Names Begin With M-O.

Jefferson Medical College 19th century matriculates

Last names beginning with M and O. 803 total Jefferson Medical College matriculates from the 19th century.

Last Names Begin With K-L.

Jefferson Medical College 19th century matriculates

Last names beginning with K and L. 440 total Jefferson Medical College matriculates from the 19th century.

Last Names Begin With H-J.

Jefferson Medical College 19th century matriculates

Last names beginning with H and J. 730 total Jefferson Medical College matriculates from the 19th century.

Last Names Begin With E-G.

Jefferson Medical College 19th century matriculates

Last names beginning with E and G. 583 total Jefferson Medical College matriculates from the 19th century.

Last Names Begin With C-D.

Jefferson Medical College 19th century matriculates

Last names beginning with C and D. 753 total Jefferson Medical College matriculates from the 19th century.

Last Names Begin With A-B

Jefferson Medical College 19th century matriculates

Last names beginning with A and B. 773 total Jefferson Medical College matriculates from the 19th century.

Kalrn Promoter Usage And Isoform Expression Respond To Chronic Cocaine Exposure, Richard E. Mains, Drew D. Kiraly, Jodi E. Eipper-Mains, Xin-Ming Ma, Betty A. Eipper

UCHC Articles - Research

Background The long-term effects of cocaine on behavior are accompanied by structural changes in excitatory glutamatergic synapses onto the medium spiny neurons of the striatum. The Kalrn gene encodes several functionally distinct isoforms; these multidomain guanine nucleotide exchange factors (GEFs) contain additional domains known to interact with phosphatidylinositides as well as with a number of different proteins. Through their activation of Rho proteins and their interactions with other proteins, the different Kalirin isoforms affect cytoskeletal organization. Chronic exposure of adult male rodents to cocaine increases levels of Kalirin 7 in the striatum. When exposed chronically to cocaine, mice lacking Kalirin …

Imaging—And Imagining—Immune Responses To Infections, Kamal M. Khanna, Leo Lefrancois

UCHC Articles - Research

The use of sophisticated microscopy continues apace in analysis of infection and the induction of immune responses. Continued technological improvements in microscopy, fluorescent dyes, and transgenic reporter systems will allow constant improvements of our view of the microbial and immunological landscape. Understanding how anatomy, cellular movement and microbial pathogenesis are linked to the outcome of the immune response will allow us to make informed decisions regarding vaccine formulations and treatments for infectious diseases and their sequelae.

Spontaneous Electrical Activity In The Human Fetal Cortex In Vitro, Anna R. Moore, Wen-Liang Zhou, Igor Jakovcevski, Nada Zecevic, Srdjan D. Antic

UCHC Articles - Research

Our knowledge about the developing human cerebral cortex is based on the analysis of fixed postmortem material. Here we utilize electrical recordings from unfixed human postmortem tissue to characterize the synaptic physiology and spontaneous network activity of pioneer cortical neurons (“subplate neurons”). Our electrophysiological experiments show that functional glutamate or GABA ionotropic receptors are expressed on human subplate (SP) neurons as early as 20 gestational weeks. Extracellular (synaptic) stimulations evoked postsynaptic potentials in a very small fraction of SP neurons, suggesting that functional synaptic contacts are rare at mid-gestation. Although synaptic inputs were scarce, we regularly observed spontaneous (unprovoked) electrical …

Potential Pathophysiological Mechanisms In Osteonecrosis Of The Jaw, Regina L. Landesberg

UCHC Articles - Research

Bisphosphonates are used in the treatment of hypercalcemia of malignancy, skeletal complications associated with metastastic bone disease, Paget’s disease, and osteoporosis. Osteonecrosis of the jaw (ONJ) is a recently described clinical condition that has been associated with the use of nitrogen-containing bisphosphonates. Reports describing this entity first appeared in the literature in 2003. While there have been significant numbers of case reports and a limited number of retrospective and prospective studies examining risk factors associated with ONJ, the pathophysiology of this condition remains elusive. In this review, we explore proposed mechanisms underlying ONJ development and identify potential areas for future …

Dietary Protein And Skeletal Health: A Review Of Recent Human Research, Jane E. Kerstette, Anne M. Kenny

UCHC Articles - Research

Purpose of review

Both dietary calcium and vitamin D are undoubtedly beneficial to skeletal health. In contrast, despite intense investigation, the impact of dietary protein on calcium metabolism and bone balance remains controversial. A widely held view is that high intakes of animal protein result in increased bone resorption, reduced bone mineral density, and increased fractures because of its ability to generate a high fixed metabolic acid load. The purpose of this review is to present the recent or most important epidemiological and clinical trials in humans that evaluated dietary protein’s impact on skeletal health.

Recent findings

Many epidemiological studies …

Pedagogical Design For A Cross-Functional Course In The Accelerated Mba Program, Bhanu Balasubramnian, Tanja Steigner, Kevin R. Coulson

Administrative Issues Journal

The sub-prime financial crisis exposed weaknesses in the financial risk management of several prominent firms. A deficient risk management is mainly attributed to the lack of integration of finance with other business disciplines. In this paper, we describe a tested implementation of a cross-functional project that improves students’ understanding of firm-value creation and risk management. While this approach can be implemented in any MBA program, we focus specifically on accelerated MBA programs with tight time constraints. Our methods are different from most other integrated courses in several ways. Our cross-functional project bridges the knowledge gaps of students in the area …

A Survey Of Oxidative Paracatalytic Reactions Catalyzed By Enzymes That Generate Carbanionic Intermediates: Implications For Ros Production, Cancer Etiology, And Neurodegenerative Diseases, Victoria Bunik, John Schloss, John T. Pinto, Natalia Dudareva, Arthur J L Cooper

NYMC Faculty Publications

Enzymes that generate carbanionic intermediates often catalyze paracatalytic reactions with O2 and other electrophiles not considered “normal” reactants. For example, pyridoxal 5′-phosphate (PLP)—containing pig kidney dopa decarboxylase oxidizes dopamine with molecular O2 to 3,4-dihydroxyphenylacetaldehyde at about 1% of the rate at which it catalyzes nonoxidative dopa decarboxylation. The mutant Y332F enzyme, however, catalyzes stoichiometric conversion of dopa to 3,4-dihydroxyphenylacetaldehyde, suggesting that even minor structural changes may alter or initiate paracatalytic reactions catalyzed by certain enzymes. Carbanions generated by several thiamine diphosphate (ThDP)—dependent enzymes react with different electrophiles, transforming some xenobiotics and endogenous compounds into potentially biologically hazardous products. The detrimental …

Prone Torso Rotation Exercise Using A Stability Ball, Kim Fischer

Health and Sport Sciences Faculty Scholarship

THIS COLUMN PROVIDES A DETAILED DESCRIPTION AND PHOTOGRAPHS OF THE PROPER EXERCISE TECHNIQUE FOR A PRONE TORSO ROTATION EXERCISE USING A STABILITY BALL.

Parental Perceptions Of The Rural School’S Role In Addressing Childhood Obesity, Ann M. Stalter, Mary Beth Kaylor, Jessica D. Steinke, Rosanta M. Barker

Nursing Faculty Publications

This study employed cross-sectional, descriptive design with convenience sampling to explore rural parent perceptions of child obesity, use of Body Mass Index (BMI) in schools, preferences for receipt of BMI information and, the rural school’s role in obesity prevention/treatment. The survey “Parental Perceptions of BMI and Obesity in the School-Age Child” was used. Of the 183 surveys distributed, 65 were returned (35.5%). Fifty-five percentage of parents were in agreement of school-based BMI screening. Fifty-four percentage of parents selected a combination of ways to receive BMI information (letter from school nurse, face-to-face conference with nurse, or via report card). Few parents …

Final Report: The Practice And Impact Of Shared Decision-Making, Shared Decision-Making Study Group For The Dirigo Health Agency’S Maine Quality Forum

Population Health & Health Policy

Several recent developments are likely to address those factors seen as contributing to shared decision-making’s mixed results: the lack of a nationally recognized certification process; insufficient funds to adequately invest in the training and infrastructure to support shared decision-making; and adequate methods for monitoring its effectiveness.

Administrative Issues Journal: Table Of Contents

Administrative Issues Journal

No abstract provided.

Letter From The Editor-In-Chief, Tami Moser

Administrative Issues Journal

No abstract provided.

The Interim Superintendent: A Case Study, Gary Bigham, Susan J. Nix

Administrative Issues Journal

Considering the vitally important role that the superintendent plays in the overall functioning and wellbeing of any school district, the filling of that position should never be done in haste. Due to the importance of this process and the time it requires, school districts often employ an interim superintendent. In this single case study, one researcher engaged in qualitative research by actually assuming the role of an interim superintendent in a small West Texas school. The findings that emerged from this study consisted of identifying duties and roles of the interim superintendent in comparison with those of the regular superintendent. …

The District-Wide Sustainability Of A Professionallearning Community During Leadership Changesat The Superintendency Level, Chuey Abrego, Anita Pankake

Administrative Issues Journal

The purpose of this mixed methods follow-up single case study was two-fold: to determine if a school district was able to sustain a professional learning community (PLC) and to identify factors that enhanced, inhibited, or promoted the sustainability of a PLC from a district-wide perspective, with particular focus on how a change in leadership, i.e. a new superintendent, affected the sustainability of PLC attributes. In addition, the role of trust in influencing the sustainability of a professional learning community will be discussed in this paper.

Mentoring Postsecondary Tenure-Trackfaculty: A Theory-Building Case Study Andimplications For Institutional Policy, Dannielle Joy Davis, Patricia Boyer, Isela Russell

Administrative Issues Journal

The featured research uses theory-building case study to understand the experiences of junior faculty in a mentoring program. Findings suggest the importance of professional interaction for faculty members’ integration into their campus communities. An explanatory model illustrates the findings and supplements discussion of the implications for administrators in terms of retention of new faculty members in postsecondary settings.

Sticker Shock: Management Professors’Perspectives On The Rising Costs Of Collegetextbooks, Stan Williamson, Robert E. Stevens, Lawrence S. Silver, Kenneth E. Clow

Administrative Issues Journal

This study uses Internet survey methodology to target management instructors’ views on the cost of textbooks and the strategies that might be exercised by universities, publishers, and legislatures to control cost increases. From a random sample of 2,893 management professors selected, using university websites, from universities throughout the United States, 228 provided useable responses. Findings suggest that management instructors, particularly those with years of experience, acknowledge the concerns their students have over high textbook prices. They are willing to have legislation enacted to force changes in the marketing of the textbooks by publishers, but they do not want university policies …

2011 February 1 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

A Study Of Riders' Noise Exposure On Bay Area Rapid Transit Trains, Alexis Dinno, Cynthia Powell, Margaret Mary King

Community Health Faculty Publications and Presentations

Excessive noise exposure may present a hazard to hearing, cardiovascular and psychosomatic health. Mass transit systems, such as the Bay Area Rapid Transit (BART) system, are potential sources of excessive noise. The purpose of this study was to characterize transit noise and riders' exposure to noise on the BART system using three dosimetry metrics. We made 268 dosimetry measurements on a convenience sample of 51 line segments. Dosimetry measures were modeled using linear and non-linear multiple regression as functions of average velocity, tunnel enclosure, flooring, and wet weather conditions, and presented visually on a map of the BART system. This …

Chhs February 2011 Enewsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services

College of Health & Human Services Publications

No abstract provided.

Sleep Duration, Sleep Regularity, Body Weight, And Metabolic Homeostasis In School-Aged Children, Karen Spruyt, Dennis L. Molfese, David Gozal

Center for Brain, Biology, and Behavior: Faculty Publications

OBJECTIVE: The goal was to explore the effects of duration and regularity of sleep schedules on BMI and the impact on metabolic regulation in children.

METHODS: Sleep patterns of 308 community-recruited children 4 to 10 years of age were assessed with wrist actigraphs for 1 week in a cross-sectional study, along with BMI assessment. Fasting morning plasma levels of glucose, insulin, lipids, and high-sensitivity C-reactive protein also were measured for a subsample.

RESULTS: Children slept 8 hours per night, on average, regardless of their weight categorization. A nonlinear trend between sleep and weight emerged. For obese children, …

Himmelfarb Headlines - February/March 2011, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Headlines (2009 - present)

News and information about Himmelfarb Health Sciences Library of interest to users. Includes articles on large LCD monitors, GWUMC Research Commons, and profiles of Karen McDonnell, PhD, and Catherine Harris.

Human Spinal Cord Injury Causes Specific Increases In Surface Expression Of Beta Integrins On Leukocytes, Feng Bao, Christopher S. Bailey, Kevin R. Gurr, Stewart I. Bailey, M. Patricia Rosas-Arellano, Arthur Brown, Gregory A. Dekaban, Lynne C. Weaver

Paediatrics Publications

Spinal cord injury (SCI) activates circulating leukocytes that migrate into the injured cord and bystander organs using adhesion molecule-mediated mechanisms. These cells cause oxidative damage, resulting in secondary injury to the spinal cord, as well as injury to bystander organs. This study was designed to examine, over a 6-h to 2-week period, changes in adhesion molecule surface expression on human peripheral leukocytes after SCI (9 subjects), using as controls 10 uninjured subjects and 6 general trauma patients (trauma controls, TC). Both the percentage of cells expressing a given adhesion molecule and the average level of its expression was quantified for …

Hyperfiltration Affects Accuracy Of Creatinine Egfr Measurement, Shih Han S. Huang, Ajay P. Sharma, Abeer Yasin, Robert M. Lindsay, William F. Clark, Guido Filler

Paediatrics Publications

Background and objectives: Surrogate markers such as creatinine, cystatin C (CysC), and beta trace protein (BTP) have been used to estimate GFR (eGFR). The accuracy of eGFR may be altered with hyperfiltration and differences in filtration fraction (FF). It is hypothesized that the accuracy of creatinine for eGFR may be affected by hyperfiltration and different effective renal plasma flow (ERPF). Design, setting, participants, & measurements: A total of 127 pediatric patients with various renal diseases underwent simultaneous measurements of GFR using 51Cr-EDTA renal scan and ERPF ( 131I-hippurate clearance) to calculate the FF (FF = GFR/ERPF). The eGFRs were calculated …

Applying The Icf Framework To Study Changes In Quality-Of-Life For Youth With Chronic Conditions, Janette Mcdougall, Virginia Wright, Jonathan Schmidt, Linda Miller, Karen Lowry

Occupational Therapy Publications

Objective: The objective of this paper is to describe how the ICF framework was applied as the foundation for a longitudinal study of changes in quality-of-life (QoL) for youth with chronic conditions.

Method: This article will describe the study’s aims, methods, measures and data analysis techniques. It will point out how the ICF framework was used—and expanded upon—to provide a model for studying the impact of factors on changes in QoL for youth with chronic conditions. Further, it will describe the instruments that were chosen to measure the components of the ICF framework and the data analysis techniques that will …