Medicine and Health Sciences Commons^™

Femoroacetabular Impingement: Saving The Joint, Ronald Huang, Javad Parvizi

Department of Orthopaedic Surgery Faculty Papers

Many factors have been linked to the development of osteoarthritis (OA) of the hip, but often, cases are still considered “idiopathic.” Femoroacetabular impingement (FAI) has been suggested as a possible etiologic factor for the otherwise “idiopathic” cases. It is theorized that the subtle morphologic abnormalities seen at the head-neck junction and acetabulum in FAI may lead to labral tears, chondral damage, and subsequent progression of OA. Prevalence of FAI has been suggested to be as high as 14% in the general population. It often presents in young active patients that subject their hip joint to repetitive micro trauma associated with …

Effect Of Topical Menthol On Ipsilateral And Contralateral Superficial Blood Flow Following A Bout Of Maximum Voluntary Muscle Contraction, Robert V. Topp, Lee J. Winchester, Jessica Schilero, Dean E. Jacks

College of Nursing Faculty Research and Publications

Purpose/Background: Various doses of topical menthol are commonly applied prior to, during, and after exercise to relieve pain although there is limited empirical evidence examining the physiological effects of this treatment. The purpose of this study was to examine the effects of two different doses of menthol (3.5% and 10%) on blood flow and arterial diameter before and after an acute bout of three isokinetic maximum voluntary muscular contraction (MVMC) of the quadriceps and hamstrings.

Methods: Blood flow and arterial diameter of the right and left popliteal arteries were measured with an ultrasound Doppler prior to and after subjects completed …

So2426 Is A Positive Regulator Of Siderophore Expression, K. L. Henne, X. -F. Wan, W. Wei, D. K. Thompson

Pharmaceutical Sciences

No abstract provided.

Rocky Mountain Highs And Lows: Efforts To Improve Health And Reduce Costs In Denver, Michele J. Orza, Jessamyn Taylor

National Health Policy Forum

In late May–early June 2011, the Forum sponsored a site visit to Denver, Colorado, to observe innovative efforts to improve the health of Coloradans and reduce the cost of health care. The three-day agenda was designed to convey the breadth and interconnectedness of the efforts underway in Denver and to highlight both successes and challenges. The exploration concentrated on how three themes of national interest are unfolding in Denver: building and sustaining a robust and effective safety net in an evolving health care market; improving the health of people and their communities to prevent and reduce the need for health …

Religious Experiences Shrink Part Of The Brain, Andrew Newberg, M.D.

Marcus Institute of Integrative Health Faculty Papers

A study links life-changing religious experiences, like being born again, with atrophy in the hippocampus.

The article, “Religious factors and hippocampal atrophy in late life,” by Amy Owen and colleagues at Duke University represents an important advance in our growing understanding of the relationship between the brain and religion. The study showed greater atrophy in the hippocampus in individuals who identify with specific religious groups as well as those with no religious affiliation. It is a surprising result, given that many prior studies have shown religion to have potentially beneficial effects on brain function, anxiety, and depression.

The Pace Eportfolio As Educational Passport: Enhancing Students' Interdisciplinary, Co-Curricular And Experiential Learning, Beth Klingner, Linda Anstendig

Cornerstone 3 Reports : Interdisciplinary Informatics

No abstract provided.

Establishing An Interdepartmental Fluorescent Microscopy Facility, Marcy Kelly, David Zuzga

Cornerstone 3 Reports : Interdisciplinary Informatics

No abstract provided.

The Implementation Of Conflict Management Training Into The Post Anesthesia Care Setting For Staff Nurses During Yearly Competency Day, Ann Leary

Critical and Creative Thinking Capstones Collection

I am a Nurse in Charge of the Post Anesthesia Care Unit (PACU) at Brigham and Women’s Hospital in Boston and believe conflict can be managed better by using critical and creative thinking skills. Conflicts in the healthcare workplace are common and can take on a variety of forms: nurse to physician, nurse to nurse, and nurse to patient/family. Both my research and experience suggests that nurses commonly avoid conflict, rather than engaging in collaborative problem solving about conflict, which would often lead to better solutions. The Critical and Creative Thinking Program has given me the confidence and provided the …

Accf/Aha 2011 Expert Consensus Document On Hypertension In The Elderly: A Report Of The American College Of Cardiology Foundation Task Force On Clinical Expert Consensus Documents, Wilbert S. Aronow, Jerome J. Fleg, Carl J. Pepine, Nancy Trygar Artinian, George Bakris, Alan S. Brown, Keith C. Ferdinand, Mary Ann Forciea, William H. Frishman, Cheryl Jaigobin, John B. Kostis, Giuseppi Mancia, Suzanne Oparil, Eduardo Ortiz, Efrain Reisin, Michael W. Rich, Douglas D. Schocken, Michael A. Weber, Deborah J. Wesley

Nursing Faculty Research Publications

This document was written with the intent to be a complete reference at the time of publication on the topic of managing hypertension in the elderly. This document has been developed as an expert consensus document by the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA), in collaboration with the American Academy of Neurology (AAN), the American College of Physicians (ACP), the American Geriatrics Society (AGS), the American Society of Hypertension (ASH), the American Society of Nephrology (ASN), the American Society for Preventive Cardiology (ASPC), the Association of Black Cardiologists (ABC), and the European Society of …

Building A Learning Community For Dental Hygiene Faculty, Nancy Baccari

Critical and Creative Thinking Capstones Collection

Have you ever felt isolated in your work environment that left you feeling perplexed and stuck only to find out that colleagues felt the same way you did but had no idea to work around it? Through this practioner’s narrative, I journey through my struggle of teacher isolation to my action plan to make it better. Finding a way to identify my feelings, strengths and weaknesses and move towards change to improve my own work environment describes my experience in the Critical and Creative Thinking (CCT) graduate program. This new awareness changed the way I see myself as a leader …

My Journey To Develop An Innovative Approach To Unplanned Pregnancy, Gina Dillon Podolsky

Critical and Creative Thinking Capstones Collection

This paper is my personal journey in developing the non-profit Pennies for Pause that addresses the issue of unplanned pregnancy in the 18-29 populations through the use of incentives, social media, long-acting reversible contraception and the development of critical and creative thinking skills. The paper begins with an insight into my family, how my own thinking skills developed informally throughout my life, and how my personal experiences lead to the development of the 501 (c)(3) organization Pennies for Pause. It also provides insight into my casual observations that I used to create theories, which I then researched, S.C.A.M.P.E.R.E.D, and then …

Recreation Participation And Conservation Attitudes: Differences Between Mail And Online Respondents In A Mixed-Mode Survey, Alan R. Graefe, Andrew J. Mowen, Elizabeth Covelli, Nate E. Trauntvein

Kinesiology and Health Science Faculty Publications

This study reports a comparison of demographics, outdoor recreation activity patterns, and attitudes toward conservation issues collected via mail and online survey methods within a mixed-mode survey. Pennsylvania residents, randomly sampled by Survey Sampling, Inc., were invited in a pre-survey letter to complete the survey online, or through a paper survey mailed to their homes. Differences in outdoor recreation participation were generally small for wildlife-related activities, and were greater among non-wildlife-related outdoor recreation activities, with the Internet respondents generally reporting higher rates of participation. Analyses controlling for demographic variables showed a confounding influence on the relationships examined. Internet respondents tended …

Dissolution Of Disintegrating Solid Dosage Forms In A Modified Dissolution Testing Apparatus 2, Shrutiben Rameshbhai Parekh

Theses

Dissolution tests are routinely carried out in the pharmaceutical industry to determine the dissolution rate of solid dosage forms. Dissolution testing serves as a surrogate for drug bioavailability through in vitro–in vivo correlation (IVIVR), and it additionally helps in guiding the development of new formulations and in assessing lot-to-lot consistency, thus ensuring product quality. The United States Pharmacopoeia (USP) Dissolution Testing Apparatus 2 is the device most commonly used for this purpose. Despite its widespread use, dissolution testing using this apparatus remains susceptible to significant error and test failures. There is documented evidence that this apparatus is sensitive to several …

Dissolution Testing Of Prednisone And Salicylic Acid Calibrator Tablets At Different Tablet Locations, Anandhavalavan Arulmozhi

Theses

Dissolution testing is routinely carried out in the pharmaceutical industry to determine the rate of dissolution of solid dosage forms. This test is one of the several tests that pharmaceutical companies typically conduct on oral dosage formulations (e.g., tablets) to determine compliance. The USP Dissolution Testing Apparatus 2 is the most common of the apparatuses listed in the USP. However, it has been shown previously that the dissolution profile of a tablet undergoing dissolution in the USP Dissolution Apparatus 2 can be affected by the tablet location in the apparatus.

In this work, the dissolution rates of both non-disintegrating tablets …

Renin-Angiotensin-Aldosterone Genotype Influences Ventricular Remodeling In Infants With Single Ventricle., Seema Mital, Wendy K. Chung, Steven D. Colan, Lynn A. Sleeper, Cedric Manlhiot, Cammon B. Arrington, James F. Cnota, Eric M. Graham, Michael E. Mitchell, Elizabeth Goldmuntz, Jennifer S. Li, Jami C. Levine, Teresa M. Lee, Renee Margossian, Daphne T. Hsu, Pediatric Heart Network Investigators, Girish S. Shirali

Manuscripts, Articles, Book Chapters and Other Papers

Background: We investigated the effect of polymorphisms in the renin-angiotensin-aldosterone system (RAAS) genes on ventricular remodeling, growth, renal function, and response to enalapril in infants with single ventricle.

Methods and results: Single ventricle infants enrolled in a randomized trial of enalapril were genotyped for polymorphisms in 5 genes: angiotensinogen, angiotensin-converting enzyme, angiotensin II type 1 receptor, aldosterone synthase, and chymase. Alleles associated with renin-angiotensin-aldosterone system upregulation were classified as risk alleles. Ventricular mass, volume, somatic growth, renal function using estimated glomerular filtration rate, and response to enalapril were compared between patients with ≥2 homozygous risk genotypes (high risk), and those …

Diagnostic Accuracy Of Fine Needle Aspiration Cytology In Parotid Lesions, Naeem Sultan Ali, Shabbir Akhtar, Montasir Junaid, Sohail Awan, Kanwal Aftab

Section of Otolaryngology, Head & Neck Surgery

Objective:Histopathology of parotid gland tumors is extremely varied and complex due to heterogeneous cellular composition. Preoperative diagnostic tools include fine needle aspiration cytology, the role of which remains controversial. The aim of this paper is to evaluate the usefulness and accuracy of fine needle aspiration cytology (FNAC) in the diagnosis of parotid gland tumors.

Methods:

We retrospectively reviewed charts of 129 Patients who underwent parotidectomy for parotid lesions at Aga Khan University Hospital from 2002 to 2010. We compared the results of preoperative FNAC with final histopathological diagnosis.

Results:

Concordance with histological results was observed in 86%, specificity was …

Discovery Of A Functional Ecdysone Response Element In Brugia Malayi, Tracy Enright

USF Tampa Graduate Theses and Dissertations

The aim of this study was to determine whether functional ecdysone response elements (EcREs) exist within the genome of Brugia malayi, a parasitic nematode that causes lymphatic filariasis. The hypothesis that EcREs exist in B. malayi stemmed from previous demonstration of a functional ecdysone response system in B. malayi (Tzertzinis et al., 2010). Real-time PCR (qPCR) experiments were conducted to measure gene expression levels for twelve genes proximal to five putative EcREs in 20-OH ecdysone treated and untreated B. malayi embryos. Seven genes showed consistent upregulation with 20-OH ecdysone treatment. Each of the five putative EcREs had at least one …

Biomechanical Analysis Of Asymmetric And Dynamic Lifting Task, Xiaopeng Jiang

Theses

Lifting tasks is one of the leading causes of occupational lower back disorders (LBD). Aimed at deriving internal forces of human musculoskeletal system during lifting, biomechanical models are utilized to address this problem. This thesis provides an indepth literature review of such modeling, and the results of experiments used to address LBD issues.

An isometric pulling experiment was conducted to study the correlation between electromyography (EMG) and predicted muscle forces by AnyBody Modeling System™ with increasing hand loads. An infinite order polynomial (min/max) optimization criterion predicted percentage of maximum muscle forces, which achieved 98% correlation with normalized EMG. In a …

Transdermal And Transbuccal Delivery Of Lidocaine And Nicotine : Combined Effects Of Iontophoresis And Chemical Enhancers, Ran Wei

Theses

This study focused on the effects of iontophoresis and chemical enhancers on drug release. The transport of Lidocaine HCl (LHCl) and Nicotine Hydrogen Tartrate (NHT) through the skin and mucosa was evaluated for potential clinical applications. These two potential delivery routes have the advantage of avoiding first-pass effect. Samples were pretreated with enhancer solutions for one hour before the experiments. Passive or 0.3 mA iontophoresis-assisted drug diffusion was conducted for 8 hours to monitor the cumulative amount of drug released. Graphical methods and mathematical optimization techniques were implemented to analyze the data. The effects of chemical enhancers on the delivery …

Primary School Vision Screening Involving Teachers In Nampula, Mozambique, Aoife Phelan, Lisa O'Donoghue, Kathryn Saunders, Stephen Thompson, Vivien Ocampo, Kevin Naidoo, James Loughman

Conference Papers

Purpose: There is no plan for a national child eye care programme or existing human resource infrastructure to address the immediate challenge of child eye health in Mozambique.This study aims to design, implement and evaluate a school based pediatric vision screening service, to identify those in need of eye care services, among Mozambique’s 11,561,000 children.

Methods: Primary School Screening took place in three schools in Nampula, Mozambique in September 2010 and March 2011. The children’s vision was screened by an optometry student, optometrist or teacher with Log MAR ETDRS letters at 4 Meters. Ophthalmoscopy was performed on all children by …

Cardiometabolic Results From An Armband-Based Weight Loss Trial, John C. Sieverdes, Xuemei Sui, Gregory A. Hand, Vaughn W. Barry, Sarah Wilcox, Rebecca A. Meriwether, James W. Hardin, Amanda C. Mcclain, Steven N. Blair

Faculty Publications

Purpose: This report examines the blood chemistry and blood pressure (BP) results from the Lifestyle Education for Activity and Nutrition (LEAN) study, a randomized weight loss trial. A primary purpose of the study was to evaluate the effects of real-time self-monitoring of energy balance (using the SenseWear^TM Armband, BodyMedia, Inc Pittsburgh, PA) on these health factors.

Methods: 164 sedentary overweight or obese adults (46.8 ± 10.8 years; BMI 33.3 ± 5.2 kg/m²; 80% women) took part in the 9-month study. Participants were randomized into 4 conditions: a standard care condition with an evidence-based weight loss manual (n …

Medical School Watercooler Newsletter - May 29, 2011, Lindsey Lyle

Watercooler Newsletter

This is the May 29, 2011 edition of the Frederick P. Whiddon College of Medicine's newsletter - watercooler

Contents Include

• If You Love The College of Medicine - "Like" Us Too!

• Clista Clanton Receives Excellence in the Advancement of Nursing Scholarship Award

• "Cardiologist and Colonel"

• USA Alumna Wins Young Investigator Award

• USA Biomedical Librarians Approved for Membership in Academy of Health Information Professionals

S.O.S. For Huntington's Disease Families, And An Important Bill In Congress, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

The Yin And Yang Actions Of North American Ginseng Root In Modulating The Immune Function Of Macrophages, Chike Godwin Azike, Paul Abrahams Charpentier, Jirui Hou, Hua Pei, Edmund Man King Lui

Physiology and Pharmacology Publications

BACKGROUND: Immuno-modulatory effects of ginseng, including both immuno-stimulatory and immuno-suppressive effects, have been widely reported. This study aims to determine whether the paradoxical immuno-modulatory effect is related to unique phytochemical profiles of different North American (NA) ginseng, namely aqueous (AQ) and alcoholic (ALC) extracts.

METHODS: AQ and ALC extracts were prepared and their immuno-bioactivity were studied in vitro in murine macrophages (Raw 264.7) through measuring the direct stimulatory production of pro-inflammatory mediator and cytokines as well as the suppression of lipopolysaccharide (LPS)-stimulatory response by the two extracts. Gel permeation chromatography was used to fractionate and isolate phytochemicals for characterization of …

Variations In Mre11/Rad50/Nbs1 Status And Dna Damage-Induced S-Phase Arrest In The Cell Lines Of The Nci60 Panel, Kristen M. K. Garner, Alan Eastman

Dartmouth Scholarship

The Mre11/Rad50/Nbs1 (MRN) complex is a regulator of cell cycle checkpoints and DNA repair. Defects in MRN can lead to defective S-phase arrest when cells are damaged. Such defects may elicit sensitivity to selected drugs providing a chemical synthetic lethal interaction that could be used to target therapy to tumors with these defects. The goal of this study was to identify these defects in the NCI60 panel of cell lines and identify compounds that might elicit selective cytotoxicity.

Home, But Not Alone: Evidence-Based Maternal, Infant, And Early Childhood Home Visitation, Eileen Salinsky

National Health Policy Forum

Home visitation services for young and expectant families have the potential to improve child and parent outcomes in a broad variety of ways, but the effectiveness of home visits may depend on the nature, frequency, and duration of these services. The Patient Protection and Affordable Care Act of 2010 (PPACA) created a new federal funding stream to promote the development and implementation of evidence-based home visiting programs. This issue brief provides an overview of the newly established Maternal, Infant, and Early Childhood Home Visiting program, describes existing approaches to home visitation, and discusses the implications of federal funding for state …

Efficacy Of Different Retention Types Post-Orthodontic Treatment, Monica Sonia Kaur Dosanjh

Master's Theses

Introduction: Despite major advances in orthodontic tooth movement, orthodontic retention still remains a major problem. It has been estimated that only 10% of the population who have received orthodontics are still in acceptable occlusion as judged by orthodontists 20 years after retention. (Little, Riedel et al. 1988) In addition, very little is known about patient’s perception in relation to orthodontic relapse. Therefore, the goal of this study was to evaluate the efficacy of 3 different types of retainers (Hawley removable, Essix removable and Fixed) of the mandibular and maxillary anterior sextant and to assess patient perception of crowding. Materials and …

Tryptophan Degradation In Women With Breast Cancer: A Pilot Study, Debra E. Lyon, Jeanne M. Walter, Angela R. Starkwater, Christine M. Schubert, Nancy L. Mccain

Faculty Publications

Background: Altered tryptophan metabolism and indoleamine 2,3-dioxygenase activity are linked to cancer development and progression. In addition, these biological factors have been associated with the development and severity of neuropsychiatric syndromes, including major depressive disorder. However, this biological mechanism associated with both poor disease outcomes and adverse neuropsychiatric symptoms has received little attention in women with breast cancer. Therefore, a pilot study was undertaken to compare levels of tryptophan and other proteins involved in tryptophan degradation in women with breast cancer to women without cancer, and secondarily, to examine levels in women with breast cancer over the course of chemotherapy. …

Hivtoolbox, An Integrated Web Application For Investigating Hiv, David P. Sargeant, Sandeep Deverasetty, Yang Luo, Angel Villahoz Baleta, Stephanie Zobrist, Viraj Rathnayake, Jacqueline C. Russo, Jay Vyas, Mark A. Muesing, Martin Schiller

Life Sciences Faculty Research

Many bioinformatic databases and applications focus on a limited domain of knowledge federating links to information in other databases. This segregated data structure likely limits our ability to investigate and understand complex biological systems. To facilitate research, therefore, we have built HIVToolbox, which integrates much of the knowledge about HIV proteins and allows virologists and structural biologists to access sequence, structure, and functional relationships in an intuitive web application. HIV-1 integrase protein was used as a case study to show the utility of this application. We show how data integration facilitates identification of new questions and hypotheses much more rapid …

Today - May 25, 2011, Loma Linda University

TODAY

Inside this issue:

-- Loma Linda University prepares to graduate more than 1,300 students
-- 'Loma Linda 360' nominated for eight Emmys
-- Connection between mental and physical health suggested by Biopsychosocial Religion and Health Study
-- First annual medical simulation conference
-- Counseling and family sciences department conducts study for Housing Authority
-- Loma Linda University Medical Center announces administrative reorganization
-- Large crowd attends Women's Works at LLU Heart & Surgical Hospital
-- LLUMC East Campus Hospital administrator transitions to active retirement
-- Child life seminar looks to hospitalized children and their unique needs
-- New director comes …