Medicine and Health Sciences Commons^™

Addressing The Challenges Of Reporting On Childhood Asthma In A Changing Health Care System: Building Better Evidence For High Performance, Meagan Lyon, Anne Rossier Markus, Maya Tuchman Gerstein, Sara J. Rosenbaum

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

Childhood asthma is a serious and costly chronic disease that burdens children and families as well as the health care systems that serve them. A key element to improving asthma outcomes is access to timely and useful data that can improve the quality of care and inform programs and policies to best serve those communities most burdened by asthma. This Policy Brief examines the nation’s data collection framework for childhood asthma and considers steps that might be taken to strengthen it, including the development, collection and refinement of community-level data to inform local health care systems. Through a review of …

Imaging Mass Spectrometry Detection Of Gangliosides Species Within The Mouse Brain Following Transient Focal Cerebral Ischemia, Shawn N. Whitehead, Kenneth H. N. Chan, Sandhya Gangaraju, Jacqueline Slinn, Jianjun Li, Sheng T. Hou

Anatomy and Cell Biology Publications

Gangliosides, a member of the glycosphingolipid family, are heterogeneously expressed in biological membranes and are particularly enriched within the central nervous system. Gangliosides consist of mono- or poly-sialylated oligosaccharide chains of variable lengths attached to a ceramide unit and are found to be intimately involved in brain disease development. The purpose of this study is to examine the spatial profile of ganglioside species using matrix-assisted laser desorption/ionization (MALDI) imaging (IMS) following middle cerebral artery occlusion (MCAO) reperfusion injury in the mouse. IMS is a powerful method to not only discriminate gangliosides by their oligosaccharide components, but also by their carbon …

Prefrontal Cortex Deactivation In Macaques Alters Activity In The Superior Colliculus And Impairs Voluntary Control Of Saccades, Michael J. Koval, Stephen G. Lombar, Stefan Everling

Brain and Mind Institute Researchers' Publications

The cognitive control of action requires both the suppression of automatic responses to sudden stimuli and the generation of behavior specified by abstract instructions. Though patient, functional imaging and neurophysiological studies have implicated the dorsolateral prefrontal cortex (dlPFC) in these abilities, the mechanism by which the dlPFC exerts this control remains unknown. Here we examined the functional interaction of the dlPFC with the saccade circuitry by deactivating area 46 of the dlPFC and measuring its effects on the activity of single superior colliculus neurons in monkeys performing a cognitive saccade task. Deactivation of the dlPFC reduced preparatory activity and increased …

The Huntington's Disease High-Wire Act, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Smoking Cessation And Relapse Among Pregnant African-American Smokers In Washington, Dc, Ayman El-Mohandes, M. Nabil El-Khorazaty, Michele Kieley, Marie G. Gantz

Publications and Research

Smoking is the single most preventable cause of perinatal morbidity. This study examines smoking behaviors during pregnancy in a high risk population of African Americans. The study also examines risk factors associated with smoking behaviors and cessation in response to a cognitive behavioral therapy (CBT) intervention. This study is a secondary analysis of data from a randomized controlled trial addressing multiple risks during pregnancy. Five hundred African-American Washington, DC residents who reported smoking in the 6 months preceding pregnancy were randomized to a CBT intervention. Psycho-social and behavioral data were collected. Self-reported smoking and salivary cotinine levels were measured prenatally …

Research On Healthcare Worker Personal Protective Equipment: Minimum Requirements For Isolation Gowns, F.Selcen Kilinc-Balci, Phd

Building the Chain of Safety: Stakeholders Summit

F. Selcen Kilinc-Balci, PhD, is a Senior Service Fellow at the National Personal Protective Technology Laboratory (NPPTL) of Centers for Disease Control and Prevention (CDC)/National Institute for Occupational Safety and Health (NIOSH). She works in the area of protective clothing and ensembles, including personal protective equipment for healthcare workers, mine rescue ensembles, fire fighter turnout gear, and chemical protective garments. Prior to joining NIOSH in February 2010, she worked as a senior engineer at DuPont Protection Technologies. Her work at DuPont focused on product development, product testing and certification, and promotional claim validation in personal protective clothing. She has more …

Adoption Of Protective Uniforms, Thomas J. Walsh, Md, Facp, Fccp, Faam, Fidsa

Building the Chain of Safety: Stakeholders Summit

Thomas J. Walsh, MD, FACP, FCCP, FAAM, FISDA, is Professor of Medicine (appointment pending) and Director of the new Transplantation-Oncology Infectious Diseases Program at Weill Medical College of Cornell University. Following graduation from Johns Hopkins University School of Medicine, Dr. Walsh completed ten post-doctoral years of laboratory investigation, clinical research and patient care leading to boards in Medicine, Infectious Diseases and Oncology and laboratory expertise in pharmacology, innate host defenses, and medical mycology.

Following a distinguished career in the Pediatric Oncology Branch of the National Cancer Institute, Dr. Walsh was recruited to direct the new Transplantation-Oncology Infectious Diseases Program of …

Overcoming Barries To Compliance, Janine C. Jagger, Phd

Building the Chain of Safety: Stakeholders Summit

Janine Jagger, PhD, is an epidemiologist specializing in injury prevention and control.  Early in her career, her research and advocacy focused on brain trauma and motor vehicle safety.

Over the last 20 years, Dr. Jagger has devoted herself to reducing healthcare workplace transmission of bloodborne pathogens.  In 1988, Dr. Jagger and colleagues published a landmark study in the New England Journal of Medicine which detailed the characteristics of medical devices causing needlestick injuries, and criteria for protective needle designs.  This pioneering research provided the foundation for the development of a new generation of safer medical devices.

In 1991, Dr. Jagger …

Exposure Risks And The Chain Of Healthcare-Associated Infection, Amber Hogan Mitchell, Drph, Mph, Cph

Building the Chain of Safety: Stakeholders Summit

Amber Hogan Mitchell, DrPH(c), MPH, CPH is the Worldwide Director of Professional Education and Learning Solutions for Advanced Sterilization Products (ASP), a Johnson & Johnson Company located in Irvine, CA.  Amber is responsible for educational initiatives for ASP and its customers related to infection prevention, healthcare associated infections, sterilization, disinfection, environmental hygiene, and quality initiatives in healthcare related to safe care and quality patient outcomes.  Amber is a Doctor of Public Health Candidate (all but dissertation) in occupational and environmental health sciences at the University of Texas School of Public Health in Houston, TX.  She was a Centers for Disease …

Progress In Controlling Healthcare Associated Infections: A Historical Perspective, Richard Wenzel, Md

Building the Chain of Safety: Stakeholders Summit

Richard P. Wenzel, MD, MSc, is professor and former chairman of the Department of Internal Medicine at the Medical College of Virginia, Virginia Commonwealth University, in Richmond, Virginia (1995-2009).  From 2003-2008, he was President of MCV Physicians, the clinical practice plan for over 600 physicians, and Senior Associate Dean for Clinical Affairs.

For eight years (1992 to 2000), he was a member of the editorial board of The New England Journal of Medicine, and, in September 2001, became the journal’s first Editor-at-Large, a position he still holds.  He is the prolific author of over 500 publications, the editor of …

The State Of Safety, John Combes, Md

Building the Chain of Safety: Stakeholders Summit

John Combes, MD, is a Senior Vice President at the American Hospital Association (AHA) and the President of the Center for Healthcare Governance (CHG), an AHA affiliate organization. CHG is a dynamic community of board members, executives and thought leaders dedicated to advancing excellence, innovation and accountability in healthcare governance through education, tool development and research.  Dr. Combes also serves as Senior Fellow at the Hospital Research and Education Trust (HRET), and in that role focuses on quality and leadership issues in Patient Safety, End of Life Care and Clinical Performance Improvement.

Dr. Combes received his medical degree from Cornell …

2011 June 7 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

A Comparison Of Two Headless Compression Screws For Operative Treatment Of Scaphoid Fractures, Ruby Grewal, Joseph Assini, David Sauder, Louis Ferreira, Jim Johnson, Kenneth Faber

Surgery Publications

PURPOSE: The purpose of this study was to compare the interfragmentary compression force across a simulated scaphoid fracture by two commonly used compression screw systems; the Acutrak 2 Standard and the 3.0 mm Synthes headless compression screw.

METHODS: Sixteen (8 pairs; 6 female, 2 male) cadaver scaphoids were randomly assigned to receive either the Acutrak 2 or Synthes screw with the contralateral scaphoid designated to receive the opposite. Guide wires were inserted under fluoroscopic control. Following transverse osteotomy, the distal and proximal fragments were placed on either side of a custom load cell, to measure interfragmentary compression. Screws were placed …

Temperature Control Device With A Flexible Temperature Control Surface, Phil D. Belgrader, Christopher G. Cooney, Robert D. Doebler, Anna D. Hickerson, Bruce D. Irvine, Ali D. Nadim, James D. Sterling, Reza Miraghale

Business and Information Technology Faculty Research & Creative Works

A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior Volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive Surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal …

Stabilité Des Chariots Élévateurs : Élaboration D’Un Module De Formation À L’Aide D’Une Démarche De Didactique Participative, Denys Denis, Sylvie Beaugrand, Henri Boudreault, Christian Larue

Rapports de recherche scientifique

Initiée par une demande de membres du défunt comité SISEC, qui disaient éprouver des difficultés à enseigner et à faire apprendre aux caristes les notions en lien avec la stabilité des chariots élévateurs, une démarche d'accompagnement leur a été proposée. Cette dernière, développée par un spécialiste en didactique lors de ses études doctorales et expérimentée à maintes reprises antérieurement au projet actuel, visait à développer – en collaboration avec des formateurs impliqués dans ce type de formations – un nouvel environnement didactique. La formation dont il est question est de nature théorique et porte sur la conduite sécuritaire des chariots …

La Charge De Travail Et La Dépense Énergétique De L’Éducateur Physique, François Trudeau, Louis Laurencelle

Rapports de recherche scientifique

La documentation scientifique ne rapporte aucune étude sur le niveau de dépense énergétique chez les éducateurs physiques, non plus que sur les différences probables de charge entre les enseignants des différents niveaux et entre les hommes et les femmes. Les auteurs de cette étude voulaient quantifier la dépense énergétique de la tâche de l’éducateur physique dans son milieu de travail, en fonction de sa condition physique déterminée par des tests de laboratoire, mais aussi selon différents critères dont les tâches pédagogiques réalisées.

Il en résulte que la dépense énergétique moyenne des éducateurs physiques varie de faible à modéré, mais comprend …

Ada News - 06/06/2011, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

International Evidence On Medical Spending., Robert D. Lieberthal, Phd

College of Population Health Lectures, Presentations, Workshops

Presented for the Casualty Actuarial Society 2011 Seminar on Reinsurance, Philadelphia, PA.

Handouts are also available at: http://www.casact.org/education/reinsure/2011/handouts/C17-Lieberthal.pdf

the audio is available at: http://www.casact.org/education/reinsure/2011/audio/C17.mp3

and it is associated with the paper: http://jdc.jefferson.edu/healthpolicyfaculty/45/

23 PowerPoint slides.

Prevalence Of Physical Inactivity And Barriers To Physical Activity Among Obese Attendants At A Community Health-Care Center In Karachi, Pakistan., Nafisa Samir, Sadia Mahmud, Ali Khan Khuwaja

Department of Family Medicine

Background: Overweight and obesity are significant public health problems worldwide with serious health consequences. With increasing urbanization and modernization there has been an increase in prevalence of obesity that is attributed to reduced levels of physical activity (PA). However, little is known about the prevalence of physical inactivity and factors that prohibit physical activity among Pakistani population. This cross-sectional study is aimed at estimating the prevalence of physical inactivity, and determining associated barriers in obese attendants accompanying Patients coming to a Community Health Center in Karachi, Pakistan.
Findings: PA was assessed by using international physical activity questionnaire (IPAQ). Barriers to …

Improving Delirium Care In The Intensive Care Unit: The Design Of A Pragmatic Study, Noll L. Campbell, Babar A. Khan, Mark Farber, Tiffany Campbell, Anthony J. Perkins, Siu L. Hui, Greg Abernathy, John Buckley, Regg Sing, Jason Tricker, Mohammad Zawahiri, Malaz A. Boustani

Department of Pharmacy Practice Faculty Publications

Background

Delirium prevalence in the intensive care unit (ICU) is high. Numerous psychotropic agents are used to manage delirium in the ICU with limited data regarding their efficacy or harms.

Methods/Design

This is a randomized controlled trial of 428 patients aged 18 and older suffering from delirium and admitted to the ICU of Wishard Memorial Hospital in Indianapolis. Subjects assigned to the intervention group will receive a multicomponent pharmacological management protocol for delirium (PMD) and those assigned to the control group will receive no change in their usual ICU care. The primary outcomes of the trial are (1) delirium severity …

Gynaecomastia; Management With Liposuction And Glandular Excision, Stanley Ominde Khainga, Ronald Wasike, P. K. Biribwa

General Surgery, East Africa

Gynaecomastia is caused by an increase in ductal tissue, stroma and fat in the male breast. Frequently it occurs at the time of hormonal changes during infancy, adolescence and old age. Galen, introduced the term gynaecomastia in the second century AD and surgical excision was first described by Pauli of Aegina in the seventh AD (1,2). Ultrasound assisted liposuction and surgical excision of glandular tissue through an inferior circumareolar incision is currently the best mode of treatment. In this study seven patients varying from the ages 17-45 years were operated on using this technique at the Aga Khan University teaching …

Three-Dimensional Photographic Evaluation Of Immediate Soft Tissue Changes Following Rapid Maxillary Expansion, Nathan Granillo

Theses and Dissertations

The skeletal and dental changes associated with rapid maxillary expansion (RME) are well documented. Effects on the soft tissues and the potential impact on facial esthetics have not been well researched. The purpose of this study was to evaluate immediate changes in facial soft tissues as a result of RME by comparing threedimensional digital photogrammetric images before and after RME treatment. The 3dMDface System was used to obtain photographic images of 21 patients (mean age = 11.8 years) before and after RME treatment for transverse maxillary deficiency. A control group of 13 patients (mean age = 12.7 years) also had …

Medical School Watercooler Newsletter - June 5, 2011, Lindsey Lyle

Watercooler Newsletter

This is the June 5, 2011 edition of the Frederick P. Whiddon College of Medicine's newsletter - watercooler

Contents Include

• Mobile Medical Museum Director Recognized at MASA Awards Program

• If You Love the College of Medicine - "Like" Us Too!

• Board of Trustees Visits USA Medical Center Campus

• RSVP Today - June Med School Café

• Orthopaedic Residency Program Graduates First Class Since Expansion

Use Of Imaging Biomarkers To Assess Perfusion And Glucose Metabolism In The Skeletal Muscle Of Dystrophic Mice, Nabeel Ahmad, Ian Welch, Robert Grange, Jennifer Hadway, Savita Dhanvantari, David Hill, Ting-Yim Lee, Lisa M Hoffman

Robarts Imaging Publications

BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe neuromuscular disease that affects 1 in 3500 boys. The disease is characterized by progressive muscle degeneration that results from mutations in or loss of the cytoskeletal protein, dystrophin, from the glycoprotein membrane complex, thus increasing the susceptibility of contractile muscle to injury. To date, disease progression is typically assessed using invasive techniques such as muscle biopsies, and while there are recent reports of the use of magnetic resonance, ultrasound and optical imaging technologies to address the issue of disease progression and monitoring therapeutic intervention in dystrophic mice, our study aims to validate …

Studies On Buddleja Asiatica Antibacterial, Antifungal, Antispasmodic And Ca++ Antagonist Activities, Farman Ali, Irshad Ali, Hidayat Ullah Khan, Arif -Ullah Khan, Anwar Hassan Gilani

Department of Biological & Biomedical Sciences

Crude extract of Buddleja asiatica Lour and its fractions, chloroform (F1), ethyl acetate (F2) and nbutanol (F3) were evaluated for antibacterial, antifungal, antispasmodic and Ca++ antagonist activities. The antibacterial activity was performed against 11 types of bacteria. The crude extract and fractions F2 and F3 exhibited significant activity, while F1 showed low activity in killing the Shigella flexenari, Sternostoma boydi and Escherichia coli. In the rest bacteria, the crude extract and all the fractions (F1 to F3) revealed minimum to nil inhibitory effect. The fungicidal activity of the crude extract and all the fractions (F1 to F3) was also performed …

Self-Perception Of Smile Aesthetics And Self-Esteem, Larry Scarborough

Theses and Dissertations

Introduction: Self-perception of smile aesthetics has been suggested as the most common reason for seeking orthodontic treatment. A recent study concluded that an improvement of dental attractiveness at the end of orthodontic treatment had positive effects on self-esteem. The purpose of this study was to determine if a relationship exists between one’s self-perceived smile aesthetics and their self-esteem. Methods: A survey was conducted where each subject completed an evaluation of their smile aesthetics and a Rosenberg Self-esteem Test (RST). A smiling photograph of each subject was evaluated by dental professionals for dental aesthetics and straightness. Results: Female students rated their …

Cmv Vaccine Development Based On Epithelial Entry Mediators Ul128, Ul130, Ul131, Frances Saccoccio

Theses and Dissertations

Congenital cytomegalovirus infection is the leading cause of sensorineural hearing loss in the U.S. CMV vaccines developed to date do not protect the majority of women of childbearing age from primary CMV infection. Insufficient vaccine-induced epithelial entry neutralizing activity may be the reason for poor performance of these vaccines. CMV entry into endothelial and epithelial but not fibroblast cells requires the virion envelope complex gH/gL/UL128-131. Since current vaccines do not target this complex, epithelial entry mediators UL128-131 are attractive subunit CMV vaccine candidates, since they should target mucosal immunity. The mucosal immune response, specifically salivary epithelial entry neutralizing activity, has …

Three-Dimensional Evaluation Of The Effect Of Maxillary Incisor Retraction On The Palatal Bone And Root Resorption, Jessica R. Lynch Dmd

Master's Theses

Introduction: The objective of this study was to compare pre-treatment and post-treatment cone-beam computed tomography images of patients to quantitatively evaluate the effect of orthodontically retracting maxillary incisors on the height and labiolingual thickness of labial and palatal alveolar bone and incisor apical root resorption. Methods: Maxillary central incisor apical root resorption, labial and palatal alveolar bone height, and labiolingual thickness were assessed on pre-treatment and post-treatment cone-beam computed tomography scans of 59 subjects (mean age, 13.00 years) with premolar extractions and 63 subjects (mean age, 13.40 years) who were treated with non-extraction therapy. Results: The mean incisor apical root …

Occupational Disease In Connecticut 2011, Tim Morse, Paula Schenck

UCHC Articles - Research

This report focuses on occupational disease reports from 2009 and 2008, and recent trends in reported cases. It does not address traumatic occupational injuries, which are addressed in the annual report on occupational injuries and illnesses by the Connecticut Department of Labor (http://www.ctdol.state.ct.us/osha/shstats.htm). Occupational diseases are typically harder to detect than injuries, since they often occur over longer periods of time, and can have multiple (including non-occupational) risks. Therefore, this report uses data from three primary sources as a way of establishing a more complete picture of occupational disease: Workers’ Compensation First Report of Injury cases (WCC), physicians’ reports under …

Modulation Of Fibroblast Inflammatory Response By Surface Modification Of A Perfluorinated Ionomer, Thelma Iris Valdes

UCHC Articles - Research

An ideal surface for implantable glucose sensors would be able to evade the events leading to chronic inflammation and fibrosis, thereby extending its utility in an in vivo environment. Nafion™, a perfluorinated ionomer, is the membrane material preferred for in situ glucose sensors. Unfortunately, the surface properties of Nafion™ promote random protein adsorption and eventual foreign body encapsulation, thus leading to loss of glucose signal over time. Details of the techniques to render Nafion™ nonprotein fouling are given in a previous article [T. I. Valdes et al., Biomaterials 29, 1356 (2008)]. Once random protein adsorption is prevented, a …