Medicine and Health Sciences Commons^™

More To Lose Than Ever', Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Hepatitis C Virus Core-Derived Peptides Inhibit Genotype 1b Viral Genome Replication Via Interaction With Ddx3x, Chaomin Sun, Cara T. Pager, Guangxiang Luo, Peter Sarnow, Jamie H. D. Cate

Microbiology, Immunology, and Molecular Genetics Faculty Publications

The protein DDX3X is a DEAD-box RNA helicase that is essential for the hepatitis C virus (HCV) life cycle. The HCV core protein has been shown to bind to DDX3X both in vitro and in vivo. However, the specific interactions between these two proteins and the functional importance of these interactions for the HCV viral life cycle remain unclear. We show that amino acids 16-36 near the N-terminus of the HCV core protein interact specifically with DDX3X both in vitro and in vivo. Replication of HCV replicon NNeo/C-5B RNA (genotype 1b) is significantly suppressed in HuH-7-derived cells expressing green fluorescent …

The Health Of Latinos In Massachusetts: A Snapshot, Dharma Cortés, Rodolfo R. Vega

Gastón Institute Publications

People’s health outcomes are shaped in part by non-biological factors. Most immediately, limited access to health care services can have a deleterious impact on individuals’ health outcomes (Andrulis, 1998). In turn, access to healthcare services is influenced by socioeconomic factors such as whether a person has health insurance or the financial means to pay for their health care. Familiarity with the health care system is another important factor that may influence an individual’s access to healthcare services (Morgan et al., 2008). Language also plays an important role in health outcomes. For instance, individuals with limited English proficiency may find it …

Injury In Nevada, Michelle Chino, Jonathon Lavalley, Darlene R. Haff, Deborah A. Harris, Andrea R. Rivers

School of Public Health Faculty Research

Injury is a major threat to health and safety. In a typical day in the US, 400 people will die as the result of an injury, 7,500 will be hospitalized due to an injury, and more than 150,000 will suffer an injury severe enough to restrict activities and seek medical attention. Many of these deaths, hospitalizations, and disabling events will be the result of motor vehicle crashes. Others will result from vio­lence, falls, drowning, and poisoning – all of which are considered injuries.

The costs of injury are high. In the United States, the cost of injuries is estimated to …

The Use Of Audience Response Systems In Nursing Education: Best Practice Guidelines, Nicole Mareno, Marie Bremner, Christie Emerson

Faculty Articles

The use of Audience Response Systems (ARS) or 'clickers' as an active learning strategy in nursing education has been steadily on the rise. ARS technology allows the dynamic engagement of students in the classroom by providing immediate two-way communication between faculty and students. ARS can be used to explore knowledge and common misconceptions, act as a springboard for classroom discussions, and can be used for testing or evaluation. The aim of this paper is to present best practice guidelines for both novice and experienced ARS technology users. A summary of the state of the research in this area will be …

Cesarean And Vbac Rates Among Immigrant Vs. Native-Born Women: A Retrospective Observational Study From Taiwan Cesarean Delivery And Vbac Among Immigrant Women In Taiwan, Jung Chung Fu, Sudha Xirasagar Mbbs., Ph.D, Jihong Liu Sc.D., Janice C. Probst

Publications

Background. Cultural and ethnic roots impact women's fertility and delivery preferences This study investigated whether the likelihood of cesarean delivery, primary cesarean, and vaginal delivery after cesarean (VBAC) varies by maternal national origin. Methods. We conducted a nation-wide, population-based, observational study using secondary data from Taiwan. De-identified data were obtained on all 392,246 singleton live births (500 g; 20 weeks) born to native-born Taiwanese, Vietnamese and mainland Chinese-born mothers between January 1 2006 and December 31 2007 from Taiwan's nation-wide birth certificate data. Our analytic samples consisted of the following: for overall cesarean likelihood 392,246 births, primary cesarean 336,766 (excluding …

Manutention : Comparaison Des Façons De Faire Entre Les Experts Et Les Novices, André Plamondon, Denys Denis, Sophie Bellefeuille, Alain Delisle, Maud Gonella, Erik Salazar, Denis Gagnon, Christian Larivière, Marie St-Vincent, Iuliana Nastasia

Rapports de recherche scientifique

Il a déjà été démontré que des manutentionnaires d’expérience, reconnus par leurs collègues comme étant des experts, ont développé des façons de faire différentes de celles des novices qui pourraient être à la fois sécuritaires et plus efficientes. Les auteurs croient que ces façons de faire pourraient inspirer l’élaboration de programmes de formation mieux adaptés au travail. Pour les fins de cette étude des experts en manutention et des travailleurs novices ont été invités à reproduire en laboratoire leurs façons de faire dans des conditions de travail variées. Cela a permis aux chercheurs de recueillir des données biomécaniques et de …

Materials For Pharmaceutical Dosage Forms: Molecular Pharmaceutics And Controlled Release Drug Delivery Aspects, Heidi M. Mansour, Minji Sohn, Abeer Al-Ghananeem, Patrick P. Deluca

Pharmaceutical Sciences Faculty Publications

Controlled release delivery is available for many routes of administration and offers many advantages (as microparticles and nanoparticles) over immediate release delivery. These advantages include reduced dosing frequency, better therapeutic control, fewer side effects, and, consequently, these dosage forms are well accepted by patients. Advances in polymer material science, particle engineering design, manufacture, and nanotechnology have led the way to the introduction of several marketed controlled release products and several more are in pre-clinical and clinical development.

Sialic Acid Transport And Catabolism Are Cooperatively Regulated By Siar And Crp In Nontypeable Haemophilus Influenzae, Jason W. Johnston, Haider Shamsulddin, Anne-Frances Miller, Michael A. Apicella

Microbiology, Immunology, and Molecular Genetics Faculty Publications

BACKGROUND: The transport and catabolism of sialic acid, a critical virulence factor for nontypeable Haemophilus influenzae, is regulated by two transcription factors, SiaR and CRP.

RESULTS: Using a mutagenesis approach, glucosamine-6-phosphate (GlcN-6P) was identified as a co-activator for SiaR. Evidence for the cooperative regulation of both the sialic acid catabolic and transport operons suggested that cooperativity between SiaR and CRP is required for regulation. cAMP was unable to influence the expression of the catabolic operon in the absence of SiaR but was able to induce catabolic operon expression when both SiaR and GlcN-6P were present. Alteration of helical phasing supported …

Using Hospital Discharge Abstract Data To Identify Incident Breast Cancer Cases And Assess Quality Of Care, Elaine J. Yuen, Daniel Z. Louis, Carol Rabinowitz, Vittorio Maio, L. Cisbani, R. Depalma, R. Grilli

College of Population Health Faculty Papers

No abstract provided.

Cardiovascular Risk Associated With Interactions Among Polymorphisms In Genes From The Renin-Angiotensin, Bradykinin, And Fibrinolytic Systems, John P. Bentley, Folkert W. Asselbergs, Christopher S. Coffey, Patricia R. Hebert, Jason H. Moore, Hans L. Hillege, Wiek H. Van Gilst

Dartmouth Scholarship

Background: Vascular fibrinolytic balance is maintained primarily by interplay of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1). Previous research has shown that polymorphisms in genes from the renin- angiotensin (RA), bradykinin, and fibrinolytic systems affect plasma concentrations of both t-PA and PAI-1 through a set of gene-gene interactions. In the present study, we extend this finding by exploring the effects of polymorphisms in genes from these systems on incident cardiovascular disease, explicitly examining two-way interactions in a large population- based study.

Methodology/Principal Findings: Data from the population-based PREVEND study in Groningen, The Netherlands (n = 8,138) …

Connecting With Your Asperger Partner: Negotiating The Maze Of Intimacy, P. S. Mcmillen

Library Faculty Research

Weston, a "neurotypical" (NT) registered nurse, has been married to a man with Asperger's syndrome (AS) since 1999 and ran an Asperger's partners support group. The book reflects the author's utilization of self-help books about AS and relationships with accumulated wisdom from support groups.

Research Priorities In Hypertrophic Cardiomyopathy: Report Of A Working Group Of The National Heart, Lung, And Blood Institute., Thomas Force, Robert O Bonow, Steven R Houser, R John Solaro, Ray E Hershberger, Bishow Adhikari, Mark E Anderson, Robin Boineau, Barry J Byrne, Thomas P Cappola, Raghu Kalluri, Martin M Lewinter, Martin S Maron, Jeffery D Molkentin, Steve R Ommen, Michael Regnier, W H Wilson Tang, Rong Tian, Marvin A Konstam, Barry J Maron, Christine E Seidman

Center for Translational Medicine Faculty Papers

Hypertrophic cardiomyopathy (HCM) is a myocardial disorder characterized by left ventricular (LV) hypertrophy without dilatation and without apparent cause (ie, it occurs in the absence of severe hypertension, aortic stenosis, or other cardiac or systemic diseases that might cause LV hypertrophy). Numerous excellent reviews and consensus documents provide a wealth of additional background.1–8 HCM is the leading cause of sudden death in young people and leads to significant disability in survivors. It is caused by mutations in genes that encode components of the sarcomere. Cardiomyocyte and cardiac hypertrophy, myocyte disarray, interstitial and replacement fibrosis, and dysplastic intramyocardial arterioles characterize the …

A Mi'kmaq First Nation Cosmology: Investigating The Practice Of Contemporary Aboriginal Traditional Medicine In Dialogue With Counselling – Toward An Indigenous Therapeutics, Kisiku Sa'qawei Paq'tism Randolph Bowers

Aboriginal Policy Research Consortium International (APRCi)

This paper explores from a Mi’kmaq and Aboriginal standpoint foundational knowledge in Indigenous therapeutics. Based on an eco-social-psycho-spiritual way of working, the article proposes Indigenous cultural models that open a window to a rich cultural repository of meanings associated with Indigenous cosmology, ontology and epistemology. The three layers of meaning, theory and practice within the symbolic ‘Medicine Lodge’ or ‘Place of The Dreaming’ give rise to ways of working that are deeply integrative and wholistic. These forms of Indigenous theory and practice have much to offer the counselling and complimentary health professions.

Living In Limbo, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Development Of A Macromolecular Prodrug For The Treatment Of Inflammatory Arthritis: Mechanisms Involved In Arthrotropism And Sustained Therapeutic Efficacy., Ling-Dong Quan, P. Edward Purdue, Xin-Ming Liu, Michael D. Boska, Subodh M. Lele, Geoffrey M. Thiele, Ted R. Mikuls, Huanyu Dou, Steven R. Goldring, Dong Wang

Journal Articles: Radiology

INTRODUCTION: The purpose of the present manuscript is to test the hypothesis that arthrotropic localization and synovial cell internalization account for the unique capacity of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-dexamethasone conjugate (P-Dex, a macromolecular prodrug of dexamethasone) to induce sustained amelioration of joint inflammation and inhibition of tissue damage in an animal model of inflammatory arthritis.

METHODS: Rats with adjuvant-induced arthritis (AA) were treated with P-Dex, free dexamethasone, saline or HPMA homopolymer. To define the biodistribution of P-Dex, conjugates with different imaging labels were given to AA rats and analyzed. Isolated joint tissues were evaluated by fluorescence-activated cell sorting (FACS) and immunohistochemical …

Demographic And Clinical Features Of Dengue Fever In Pakistan From 2003-2007: A Retrospective Cross-Sectional Study., Erum Khan, Mehreen Kisat, Nabil Khan, Amna Nasir, Salma Ayub, Rumina Hasan

Department of Pathology and Laboratory Medicine

Background: Demographic features of dengue fever have changed tremendously in Pakistan over the past two decades. Small scale studies from all over the country have reported different aspects of individual outbreaks during this time. However, there is scarcity of data looking at the overall trend of dengue virus infection in the country. In this study, we examined annual trends, seasonality, and clinical features of dengue fever in the Pakistani population.
Methods: Demographic information and dengue IgM status of all patients tested for dengue IgM antibody at Aga Khan University Hospital from January 2003 to December 2007 were analyzed to look …

Trail, Dr5 And Caspase 3-Dependent Apoptosis In Vessels Of Diseased Human Temporomandibular Joint Disc. An Immunohistochemical Study, Carla Loreto, Luis Eduardo Almeida, M. R. Migliore, M. Caltabiano, Rosalia Leonardi

School of Dentistry Faculty Research and Publications

To evaluate the apoptosis involvement in the angiogenesis as a self-limiting process in patients with temporomandibular joint (TMJ) degenerated disc vessels, we assessed, by immunohistochemistry, the detection of TRAIL, its death receptor DR5 and caspase 3. TRAIL, its death receptor DR5 and caspase 3 expression were studied by immunohistochemistry in 15 TMJ discs displaced without reduction and in 4 unaffected discs. These apoptosis molecules were detected in the intima and media layers of newly formed vessels affected discs. In conclusion, vessels apoptosis activation in TMJ disc with ID could be regarded as a self-limiting process that try to leads to …

Medical School Watercooler Newsletter - September 12, 2010, Lindsey Lyle

Watercooler Newsletter

This is the September 12, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Next Week's DSS - Dr. Thomas Rothstein
• Tyler Gaston Receives Eran and N.Q. Adams Endowed Scholarship in Neurology
• Summer Internship Opportunity -- COM Partners with Cleveland Clinic's Center for Reproductive Medicine
• COM Welcomes Dr. Melanie Helene Clark
• USA Comprehensive Sickle Cell Center Presents Sickle Cell Today Newsletter
• COM Welcomes Surgical Oncologist to Faculty
• This Week's DSS - Dr. Charles Roberts

The Relationship Of Two Types Of Trauma Exposure To Current Physical And Psychological Symptom Distress In A Community Sample Of Colombian Women: Why Interpersonal Violence Deserves More Attention, Ruth Ann Belknap, Ashley Marie Schumacher, Bernal De Pheils, Janice Carrol Humphreys, Diva Jaramillo, Agnes Tiwari, Gladys Eugenia Canaval

College of Nursing Faculty Research and Publications

Our purpose in this study was to examine the relationship between interpersonal violence and background traumas and symptom distress in a community sample of Colombian women (N = 217). We utilized the Life Stressor Checklist-Revised (LSC-R) to measure lifetime interpersonal violence (IPV) and background trauma exposure and the Brief Symptom Inventory (BSI) to measure current symptom distress. Although both exposures were common in this sample, IPV was strongly correlated with current symptom distress; background traumas made no unique contribution to the variance in current symptom distress. Based on our findings, it is suggested that interpersonal events may be particularly …

The Importance Of Examining Movements Within The Us Health Caresystem: Sequential Logit Modeling, Chioun Lee, Stephanie L L. Ayers, Jennie Jacobs Kronenfeld, Jemima A. Frimpong, Patrick A. Rivers, Sam S. Kim

Dartmouth Scholarship

Utilization of specialty care may not be a discrete, isolated behavior but rather, a behavior of sequential movements within the health care system. Although patients may often visit their primary care physician and receive a referral before utilizing specialty care, prior studies have underestimated the importance of accounting for these sequential movements. The sample included 6,772 adults aged 18 years and older who participated in the 2001 Survey on Disparities in Quality of Care, sponsored by the Commonwealth Fund. A sequential logit model was used to account for movement in all stages of utilization: use of any health services (i.e., …

Physician Leadership And Medical Group Performance: A National Study

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Changing Social Environments To Promote Health: Evidence, Opportunities And Challenges

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Consumer Health Informatics And Healthcare Disparities

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Online Presence And Social Media: The Jsph Experience, Laura Kimberly Mbe, Msw, Lisa Chosed Ma, Emily Frelick Ms

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

How Pennsylvania's Budget Shapes Service Delivery

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Greater Philadelphia Schweitzer Program Welcomes New Fellows, Nicole Moore Ma

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Functional: Students Taking An Active Role In Shaping Health Policy, Bridget Peterson, Irmina Haq

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The Value Of Interdisciplinary Education: Learning Together Helps Make Care Safer, Valerie P. Pracilio Mph

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Moving Philadelphia! Creating Healthier Communities, Laura Kimberly Msw, Mbe

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.